List of works - Tadao Maeda

A critical role of CaBP4 in the cone synapse

scientific article

A microparticle/hydrogel combination drug-delivery system for sustained release of retinoids

scientific article

Aberrant metabolites in mouse models of congenital blinding diseases: formation and storage of retinyl esters.

scientific article

Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization.

scientific article published on 10 December 2012

Biochemical and physiological properties of rhodopsin regenerated with 11-cis-6-ring- and 7-ring-retinals

scientific article

Delayed dark adaptation in 11-cis-retinol dehydrogenase-deficient mice: a role of RDH11 in visual processes in vivo

scientific article

Dietary 9-cis-β,β-carotene fails to rescue vision in mouse models of leber congenital amaurosis

scientific article

Effects of long-term administration of 9-cis-retinyl acetate on visual function in mice

scientific article published on 15 August 2008

Effects of potent inhibitors of the retinoid cycle on visual function and photoreceptor protection from light damage in mice

scientific article

Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function

scientific article

Evaluation of 9-cis-retinyl acetate therapy in Rpe65-/- mice

scientific article

Evaluation of potential therapies for a mouse model of human age-related macular degeneration caused by delayed all-trans-retinal clearance

scientific article published on 03 June 2009

Evaluation of the role of the retinal G protein-coupled receptor (RGR) in the vertebrate retina in vivo

scientific article

Evolutionarily conserved long intergenic non-coding RNAs in the eye

scientific article published on 04 April 2013

Functional characterization of rhodopsin monomers and dimers in detergents

scientific article

Improvement in rod and cone function in mouse model of Fundus albipunctatus after pharmacologic treatment with 9-cis-retinal

scientific article published on October 2006

Inflammatory priming predisposes mice to age-related retinal degeneration

scientific article

Involvement of all-trans-retinal in acute light-induced retinopathy of mice

scientific article published on 20 March 2009

Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver.

scientific article

Lecithin:retinol acyltransferase is responsible for amidation of retinylamine, a potent inhibitor of the retinoid cycle

scientific article published on 10 October 2005

Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina

scientific article published on 24 June 2009

Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate

scientific article published on April 2009

Mechanism of All-trans-retinal Toxicity with Implications for Stargardt Disease and Age-related Macular Degeneration ⬇️

scientific article published on December 19, 2011

Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina

scientific journal article

Modulation of molecular interactions and function by rhodopsin palmitylation

scientific article published on May 2009

Noninvasive multiphoton fluorescence microscopy resolves retinol and retinal condensation products in mouse eyes

scientific article

Palmitoylation stabilizes unliganded rod opsin

scientific article

Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal

scientific article published on 9 April 2013

Positively charged retinoids are potent and selective inhibitors of the trans-cis isomerization in the retinoid (visual) cycle

scientific article

Primary amines protect against retinal degeneration in mouse models of retinopathies ⬇️

scientific article published on December 25, 2011

Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations

scientific article

QLT091001, a 9-cis-retinal analog, is well-tolerated by retinas of mice with impaired visual cycles

scientific article

Recovery of visual functions in a mouse model of Leber congenital amaurosis

scientific journal article

Redundant and unique roles of retinol dehydrogenases in the mouse retina

scholarly article

Retinal cone and rod photoreceptor cells exhibit differential susceptibility to light‐induced damage ⬇️

scientific article published on February 9, 2012

Retinal pigmented epithelial cells obtained from human induced pluripotent stem cells possess functional visual cycle enzymes in vitro and in vivo.

scientific article published on 15 October 2013

Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice

scientific article

Retinopathy in mice induced by disrupted all-trans-retinal clearance

scientific article

Retinyl ester homeostasis in the adipose differentiation-related protein-deficient retina

scientific article

Rhodopsin phosphorylation: 30 years later ⬇️

scientific article published on July 1, 2003

Rhodopsin signaling and organization in heterozygote rhodopsin knockout mice

scientific article

Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo.

scientific article

STRA6 is critical for cellular vitamin A uptake and homeostasis

scientific article

Self-Assembly of a Multifunctional Lipid With Core-Shell Dendrimer DNA Nanoparticles Enhanced Efficient Gene Delivery at Low Charge Ratios into RPE Cells

scientific article published on 13 August 2015

Serum levels of lipid metabolites in age-related macular degeneration

scientific article

Sponge transgenic mouse model reveals important roles for the microRNA-183 (miR-183)/96/182 cluster in postmitotic photoreceptors of the retina

scientific article

Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation

scientific article

Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration

scientific article published on 15 November 2013

The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors

scientific journal article

Toll-like Receptor 3 Is Required for Development of Retinopathy Caused by Impaired All-trans-retinal Clearance in Mice ⬇️

scientific article published on March 7, 2011

Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice

scientific article published on 24 March 2014

Vaccination with recoverin, a cancer-associated retinopathy antigen, induces autoimmune retinal dysfunction and tumor cell regression in mice

scientific article

WITHDRAWN: Retinol dehydrogenase RDH11 protects the mouse retina from light-induced degeneration

retracted scientific article published on 13 August 2009

List of works by Tadao Maeda

A critical role of CaBP4 in the cone synapse

A microparticle/hydrogel combination drug-delivery system for sustained release of retinoids

Aberrant metabolites in mouse models of congenital blinding diseases: formation and storage of retinyl esters.

Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization.

Biochemical and physiological properties of rhodopsin regenerated with 11-cis-6-ring- and 7-ring-retinals

Delayed dark adaptation in 11-cis-retinol dehydrogenase-deficient mice: a role of RDH11 in visual processes in vivo

Dietary 9-cis-β,β-carotene fails to rescue vision in mouse models of leber congenital amaurosis

Effects of long-term administration of 9-cis-retinyl acetate on visual function in mice

Effects of potent inhibitors of the retinoid cycle on visual function and photoreceptor protection from light damage in mice

Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function

Evaluation of 9-cis-retinyl acetate therapy in Rpe65-/- mice

Evaluation of potential therapies for a mouse model of human age-related macular degeneration caused by delayed all-trans-retinal clearance

Evaluation of the role of the retinal G protein-coupled receptor (RGR) in the vertebrate retina in vivo

Evolutionarily conserved long intergenic non-coding RNAs in the eye

Functional characterization of rhodopsin monomers and dimers in detergents

Improvement in rod and cone function in mouse model of Fundus albipunctatus after pharmacologic treatment with 9-cis-retinal

Inflammatory priming predisposes mice to age-related retinal degeneration

Involvement of all-trans-retinal in acute light-induced retinopathy of mice

Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver.

Lecithin:retinol acyltransferase is responsible for amidation of retinylamine, a potent inhibitor of the retinoid cycle

Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina

Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate

Mechanism of All-trans-retinal Toxicity with Implications for Stargardt Disease and Age-related Macular Degeneration ⬇️

Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina

Modulation of molecular interactions and function by rhodopsin palmitylation

Noninvasive multiphoton fluorescence microscopy resolves retinol and retinal condensation products in mouse eyes

Palmitoylation stabilizes unliganded rod opsin

Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal

Positively charged retinoids are potent and selective inhibitors of the trans-cis isomerization in the retinoid (visual) cycle

Primary amines protect against retinal degeneration in mouse models of retinopathies ⬇️

Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations

QLT091001, a 9-cis-retinal analog, is well-tolerated by retinas of mice with impaired visual cycles

Recovery of visual functions in a mouse model of Leber congenital amaurosis

Redundant and unique roles of retinol dehydrogenases in the mouse retina

Retinal cone and rod photoreceptor cells exhibit differential susceptibility to light‐induced damage ⬇️

Retinal pigmented epithelial cells obtained from human induced pluripotent stem cells possess functional visual cycle enzymes in vitro and in vivo.

Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice

Retinopathy in mice induced by disrupted all-trans-retinal clearance

Retinyl ester homeostasis in the adipose differentiation-related protein-deficient retina

Rhodopsin phosphorylation: 30 years later ⬇️

Rhodopsin signaling and organization in heterozygote rhodopsin knockout mice

Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo.

STRA6 is critical for cellular vitamin A uptake and homeostasis

Self-Assembly of a Multifunctional Lipid With Core-Shell Dendrimer DNA Nanoparticles Enhanced Efficient Gene Delivery at Low Charge Ratios into RPE Cells

Serum levels of lipid metabolites in age-related macular degeneration

Sponge transgenic mouse model reveals important roles for the microRNA-183 (miR-183)/96/182 cluster in postmitotic photoreceptors of the retina

Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation

Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration

The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors

Toll-like Receptor 3 Is Required for Development of Retinopathy Caused by Impaired All-trans-retinal Clearance in Mice ⬇️

Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice

Vaccination with recoverin, a cancer-associated retinopathy antigen, induces autoimmune retinal dysfunction and tumor cell regression in mice

WITHDRAWN: Retinol dehydrogenase RDH11 protects the mouse retina from light-induced degeneration