List of works - Lawrence H Pinto

3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant.

scientific article published on 15 November 2013

A novel way to go whole-cell in patch-clamp experiments

scientific article published on 28 June 2010

A pH-Dependent Conformational Ensemble Mediates Proton Transport through the Influenza A/M2 Protein ⬇️

scientific article published on November 3, 2010

Allelic variance between GRM6 mutants, Grm6nob3 and Grm6nob4 results in differences in retinal ganglion cell visual responses

scientific article published on 7 August 2008

An amantadine-sensitive chimeric BM2 ion channel of influenza B virus has implications for the mechanism of drug inhibition

scientific article published on 19 October 2009

Asp44 stabilizes the Trp41 gate of the M2 proton channel of influenza A virus

scientific article published on 17 October 2013

Chemical rescue of histidine selectivity filter mutants of the M2 ion channel of influenza A virus

scientific article (publication date: 3 June 2005)

Controlling influenza virus replication by inhibiting its proton channel

scientific article

Demonstrating the intrinsic ion channel activity of virally encoded proteins

scientific article

Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus

scientific article

Different inner retinal pathways mediate rod-cone input in irradiance detection for the pupillary light reflex and regulation of behavioral state in mice

scientific article

Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus

scientific article

Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus

scientific article

Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus

scientific article published on 30 June 2014

Exploring Organosilane Amines as Potent Inhibitors and Structural Probes of Influenza A Virus M2 Proton Channel ⬇️

scientific article published on August 12, 2011

Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in inhibitors of M2 from Influenza A Virus

scientific article published on April 2011

Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus

scientific article published on 05 April 2011

Expression and initial structural insights from solid-state NMR of the M2 proton channel from influenza A virus

scientific article published in September 2002

Flipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus M2 proton channel.

scientific article

Functional studies and modeling of pore-lining residue mutants of the influenza a virus M2 ion channel

scientific article published on February 2010

Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel

scientific article

Gene-environment interactions in a mutant mouse kindred with native airway constrictor hyperresponsiveness

scientific article published on January 2008

Generation, characterization, and molecular cloning of the Noerg-1 mutation of rhodopsin in the mouse

scientific article

Generation, identification and functional characterization of the nob4 mutation of Grm6 in the mouse.

scientific article published on January 2007

Genetic interactions between chromosomes 11 and 18 contribute to airway hyperresponsiveness in mice

scientific article

Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel

scientific article published on 09 July 2009

Identification of the pore-lining residues of the BM2 ion channel protein of influenza B virus

scientific article published on 11 April 2008

Influenza B virus BM2 protein has ion channel activity that conducts protons across membranes

scientific article published in July 2003

Influenza B virus BM2 protein is an oligomeric integral membrane protein expressed at the cell surface.

scientific article published on February 2003

Influenza a virus M2 ion channel activity is essential for efficient replication in tissue culture

scientific article

Influenza virus m2 ion channel protein is necessary for filamentous virion formation

scientific article

Influenza virus proton channels

scientific article published on 30 March 2006

Inhibitors of the influenza A virus M2 proton channel discovered using a high-throughput yeast growth restoration assay

scientific article

Initial structural and dynamic characterization of the M2 protein transmembrane and amphipathic helices in lipid bilayers ⬇️

scientific article published on November 1, 2003

Insertion of the beta Geo promoter trap into the Fem1c gene of ROSA3 mice

scientific article published on May 2004

Interpretation of the mouse electroretinogram.

scientific article published on 17 July 2007

Large-scale mutagenesis and phenotypic screens for the nervous system and behavior in mice.

scientific article

Mechanistic insights from functional characterization of an unnatural His37 mutant of the influenza A/M2 protein

scientific article published on 22 November 2013

Minimizing Cytosol Dilution in Whole-Cell Patch-Clamp Experiments ⬇️

scientific article published on February 21, 2013

Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2.

scientific article published on 21 July 2011

Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies

scientific journal article

Reduced synaptic vesicle density and aberrant synaptic localization caused by a splice site mutation in the Rs1h gene

scientific article published in November 2006

Results from screening over 9000 mutation-bearing mice for defects in the electroretinogram and appearance of the fundus.

scientific article published on December 2004

Role of the viral hemagglutinin in the anti-influenza virus activity of newly synthesized polycyclic amine compounds.

scientific article published on 22 June 2013

Solid-supported membrane technology for the investigation of the influenza A virus M2 channel activity

scientific article

Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus ⬇️

scientific article published on January 9, 2013

Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus

scientific article

Structure–function relationship of the M2 ion channel of influenza A virus

Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities.

scientific article published on 2 December 2011

The M2 proton channels of influenza A and B viruses

scientific article

The gate of the influenza virus M2 proton channel is formed by a single tryptophan residue

scientific article (publication date: 18 October 2002)

The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus

scientific article published on July 2008

The oligomeric state of the active BM2 ion channel protein of influenza B virus

scientific article published on 11 December 2007

Tidal breathing pattern differentially antagonizes bronchoconstriction in C57BL/6J vs. A/J mice

scientific article published on 16 February 2006

Viral ion channels as models for ion transport and targets for antiviral drug action

scientific article published in February 2004

pH-induced conformational change of the influenza M2 protein C-terminal domain

scientific article published on 29 August 2008

List of works by Lawrence H Pinto

3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant.

A novel way to go whole-cell in patch-clamp experiments

A pH-Dependent Conformational Ensemble Mediates Proton Transport through the Influenza A/M2 Protein ⬇️

Allelic variance between GRM6 mutants, Grm6nob3 and Grm6nob4 results in differences in retinal ganglion cell visual responses

An amantadine-sensitive chimeric BM2 ion channel of influenza B virus has implications for the mechanism of drug inhibition

Asp44 stabilizes the Trp41 gate of the M2 proton channel of influenza A virus

Chemical rescue of histidine selectivity filter mutants of the M2 ion channel of influenza A virus

Controlling influenza virus replication by inhibiting its proton channel

Demonstrating the intrinsic ion channel activity of virally encoded proteins

Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus

Different inner retinal pathways mediate rod-cone input in irradiance detection for the pupillary light reflex and regulation of behavioral state in mice

Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus

Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus

Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus

Exploring Organosilane Amines as Potent Inhibitors and Structural Probes of Influenza A Virus M2 Proton Channel ⬇️

Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in inhibitors of M2 from Influenza A Virus

Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus

Expression and initial structural insights from solid-state NMR of the M2 proton channel from influenza A virus

Flipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus M2 proton channel.

Functional studies and modeling of pore-lining residue mutants of the influenza a virus M2 ion channel

Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel

Gene-environment interactions in a mutant mouse kindred with native airway constrictor hyperresponsiveness

Generation, characterization, and molecular cloning of the Noerg-1 mutation of rhodopsin in the mouse

Generation, identification and functional characterization of the nob4 mutation of Grm6 in the mouse.

Genetic interactions between chromosomes 11 and 18 contribute to airway hyperresponsiveness in mice

Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel

Identification of the pore-lining residues of the BM2 ion channel protein of influenza B virus

Influenza B virus BM2 protein has ion channel activity that conducts protons across membranes

Influenza B virus BM2 protein is an oligomeric integral membrane protein expressed at the cell surface.

Influenza a virus M2 ion channel activity is essential for efficient replication in tissue culture

Influenza virus m2 ion channel protein is necessary for filamentous virion formation

Influenza virus proton channels

Inhibitors of the influenza A virus M2 proton channel discovered using a high-throughput yeast growth restoration assay

Initial structural and dynamic characterization of the M2 protein transmembrane and amphipathic helices in lipid bilayers ⬇️

Insertion of the beta Geo promoter trap into the Fem1c gene of ROSA3 mice

Interpretation of the mouse electroretinogram.

Large-scale mutagenesis and phenotypic screens for the nervous system and behavior in mice.

Mechanistic insights from functional characterization of an unnatural His37 mutant of the influenza A/M2 protein

Minimizing Cytosol Dilution in Whole-Cell Patch-Clamp Experiments ⬇️

Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2.

Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies

Reduced synaptic vesicle density and aberrant synaptic localization caused by a splice site mutation in the Rs1h gene

Results from screening over 9000 mutation-bearing mice for defects in the electroretinogram and appearance of the fundus.

Role of the viral hemagglutinin in the anti-influenza virus activity of newly synthesized polycyclic amine compounds.

Solid-supported membrane technology for the investigation of the influenza A virus M2 channel activity

Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus ⬇️

Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus

Structure–function relationship of the M2 ion channel of influenza A virus

Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities.

The M2 proton channels of influenza A and B viruses

The gate of the influenza virus M2 proton channel is formed by a single tryptophan residue

The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus

The oligomeric state of the active BM2 ion channel protein of influenza B virus

Tidal breathing pattern differentially antagonizes bronchoconstriction in C57BL/6J vs. A/J mice

Viral ion channels as models for ion transport and targets for antiviral drug action

pH-induced conformational change of the influenza M2 protein C-terminal domain