List of works - Shinsaku Nakagawa

Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist

scientific article

Creation of novel cell-penetrating peptides for intracellular drug delivery using systematic phage display technology originated from Tat transduction domain

scientific article

Design of a pH-sensitive polymeric carrier for drug release and its application in cancer therapy.

scientific article published on April 2004

Fast binding kinetics and conserved 3D structure underlie the antagonistic activity of mutant TNF: useful information for designing artificial proteo-antagonists

scientific article

Fine tuning of receptor-selectivity for tumor necrosis factor-α using a phage display system with one-step competitive panning.

scientific article

Novel protein engineering strategy for creating highly receptor-selective mutant TNFs

scientific article published on 13 August 2009

Organelle-targeted delivery of biological macromolecules using the protein transduction domain: potential applications for Peptide aptamer delivery into the nucleus.

scientific article

Quality enhancement of the non-immune phage scFv library to isolate effective antibodies

scientific article

Role of amino acid residue 90 in bioactivity and receptor binding capacity of tumor necrosis factor mutants

scientific article published on 22 May 2007

Selective enhancer of tumor vascular permeability for optimization of cancer chemotherapy.

scientific article published on March 2004

Simple and highly sensitive assay system for TNFR2-mediated soluble- and transmembrane-TNF activity

scientific article published on 26 March 2008

Structure-function relationship of tumor necrosis factor (TNF) and its receptor interaction based on 3D structural analysis of a fully active TNFR1-selective TNF mutant

scientific article

The targeting of anionized polyvinylpyrrolidone to the renal system.

scientific article published in August 2004

The therapeutic effect of TNFR1-selective antagonistic mutant TNF-alpha in murine hepatitis models

scientific article published on 23 September 2008

The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF

scientific article published on 17 September 2009

The use of PVP as a polymeric carrier to improve the plasma half-life of drugs.

scientific article published on July 2004

List of works by Shinsaku Nakagawa

Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist

Creation of novel cell-penetrating peptides for intracellular drug delivery using systematic phage display technology originated from Tat transduction domain

Design of a pH-sensitive polymeric carrier for drug release and its application in cancer therapy.

Fast binding kinetics and conserved 3D structure underlie the antagonistic activity of mutant TNF: useful information for designing artificial proteo-antagonists

Fine tuning of receptor-selectivity for tumor necrosis factor-α using a phage display system with one-step competitive panning.

Novel protein engineering strategy for creating highly receptor-selective mutant TNFs

Organelle-targeted delivery of biological macromolecules using the protein transduction domain: potential applications for Peptide aptamer delivery into the nucleus.

Quality enhancement of the non-immune phage scFv library to isolate effective antibodies

Role of amino acid residue 90 in bioactivity and receptor binding capacity of tumor necrosis factor mutants

Selective enhancer of tumor vascular permeability for optimization of cancer chemotherapy.

Simple and highly sensitive assay system for TNFR2-mediated soluble- and transmembrane-TNF activity

Structure-function relationship of tumor necrosis factor (TNF) and its receptor interaction based on 3D structural analysis of a fully active TNFR1-selective TNF mutant

The targeting of anionized polyvinylpyrrolidone to the renal system.

The therapeutic effect of TNFR1-selective antagonistic mutant TNF-alpha in murine hepatitis models

The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF

The use of PVP as a polymeric carrier to improve the plasma half-life of drugs.

Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice