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List of works by Hilton C. Whittle

139 HIV-2 Capsids Distinguishing High and Low Virus Load Patients in a West African Community Cohort

article

20 years into the Gambia Hepatitis Intervention Study: assessment of initial hypotheses and prospects for evaluation of protective effectiveness against liver cancer.

scientific article published in November 2008

249(ser) TP53 mutation in plasma DNA, hepatitis B viral infection, and risk of hepatocellular carcinoma.

scientific article

A Gambian infant with fever and an unexpected blood film

scientific article

A national DNA bank in The Gambia, West Africa, and genomic research in developing countries

scientific article

A randomized trial of a standard dose of Edmonston-Zagreb measles vaccine given at 4.5 months of age: effect on total hospital admissions

scientific article

Acceptability and feasibility of a screen-and-treat programme for hepatitis B virus infection in The Gambia: the Prevention of Liver Fibrosis and Cancer in Africa (PROLIFICA) study

scientific article published on August 2016

Aetiological differences in demographical, clinical and pathological characteristics of hepatocellular carcinoma in The Gambia

scientific article published on 8 December 2010

Aflatoxin exposure and viral hepatitis in the etiology of liver cirrhosis in the Gambia, West Africa

scientific article published on 10 July 2008

Age-dependent maturation of Toll-like receptor-mediated cytokine responses in Gambian infants

scientific article (publication date: 13 April 2011)

An epidemiological study of RSV infection in the Gambia

scientific article published on 30 July 2002

Are plasma biomarkers of immune activation predictive of HIV progression: a longitudinal comparison and analyses in HIV-1 and HIV-2 infections?

scientific article

Assuring trial safety for children

scientific article published on 01 July 2008

Autoreactivity against induced or upregulated abundant self-peptides in HLA-A*0201 following measles virus infection

scientific article published on January 2003

BCG scar and positive tuberculin reaction associated with reduced child mortality in West Africa. A non-specific beneficial effect of BCG?

scientific article

CD4 intragenic SNPs associate with HIV-2 plasma viral load and CD4 count in a community-based study from Guinea-Bissau, West Africa

scientific article published on January 2011

CD4(+) T cell responses to cytomegalovirus in early life: a prospective birth cohort study

scientific article

Cause of death among people with retroviral infection in rural Guinea-Bissau.

scientific article published in July 2010

Comparison of Cytotoxic activity and Interferon-g secretion by Natural Killer Cells in HIV-1 and HIV-2 infected individuals.

scientific article

Comprehensive analysis of HIV Gag-specific IFN-gamma response in HIV-1- and HIV-2-infected asymptomatic patients from a clinical cohort in The Gambia

scientific article published in December 2008

Correction. The presence of prolines in the flanking region of an immunodominant HIV-2 gag epitope influences the quality and quantity of the epitope generated.

scientific article

Correction: Effect of early measles vaccine on pneumococcal colonization: A randomized trial from Guinea-Bissau

scientific article published on 30 October 2019

Correlates of T-cell-mediated viral control and phenotype of CD8(+) T cells in HIV-2, a naturally contained human retroviral infection.

scientific article published on 4 April 2013

Cytomegalovirus infection induces T-cell differentiation without impairing antigen-specific responses in Gambian infants

scientific article published on 11 January 2008

Declining trend of serological syphilis among genitourinary medicine patients in the Gambia, West Africa

scientific article published in December 2009

Delaying bacillus Calmette-Guérin vaccination from birth to 4 1/2 months of age reduces postvaccination Th1 and IL-17 responses but leads to comparable mycobacterial responses at 9 months of age.

scientific article

Dendritic cells are less susceptible to human immunodeficiency virus type 2 (HIV-2) infection than to HIV-1 infection

scientific article

Development, evaluation, and validation of an oligonucleotide probe hybridization assay to subtype human immunodeficiency virus type 1 circulating recombinant form CRF02_AG.

scientific article published on April 2004

Differences in female-male mortality after high-titre measles vaccine and association with subsequent vaccination with diphtheria-tetanus-pertussis and inactivated poliovirus: reanalysis of West African studies

scientific article

Direct relationship between virus load and systemic immune activation in HIV-2 infection

scientific article

Downregulation of the T-cell receptor by human immunodeficiency virus type 2 Nef does not protect against disease progression

scientific article published on 07 October 2009

Early diphtheria-tetanus-pertussis vaccination associated with higher female mortality and no difference in male mortality in a cohort of low birthweight children: an observational study within a randomised trial

scientific article

Effect of 50,000 IU vitamin A given with BCG vaccine on mortality in infants in Guinea-Bissau: randomised placebo controlled trial

scientific article published on 16 June 2008

Effect of HIV-2 infection on HIV-1 disease progression

scientific article published in November 2012

Effect of early measles vaccine on pneumococcal colonization: A randomized trial from Guinea-Bissau

scientific article

Effect of revaccination with BCG in early childhood on mortality: randomised trial in Guinea-Bissau

scientific article (publication date: 15 March 2010)

Effect of vitamin A supplementation on measles-specific antibody levels in Guinea-Bissau

scientific article published in April 2002

Effects of antenatal and postnatal environments on CD4 T-cell responses to Mycobacterium bovis BCG in healthy infants in the Gambia.

scientific article published on 9 April 2008

Effects of cryopreservation on CD4+ CD25+ T cells of HIV-1 infected individuals.

scientific article published on January 2008

Emergence of HBV resistance to lamivudine (3TC) in HIV/HBV co-infected patients in The Gambia, West Africa

scientific article

Epstein-Barr virus but not cytomegalovirus is associated with reduced vaccine antibody responses in Gambian infants

scientific article

Girls may have lower levels of maternal measles antibodies and higher risk of subclinical measles infection before the age of measles vaccination

scientific article published on 9 July 2009

Greater CD8+ TCR heterogeneity and functional flexibility in HIV-2 compared to HIV-1 infection

scientific article published in July 2003

HIV-1 subtype distribution in the Gambia and the significant presence of CRF49_cpx, a novel circulating recombinant form

scientific article

HIV-2 capsids distinguish high and low virus load patients in a West African community cohort

scientific article published in May 2010

HTLV-1 and HIV-2 infection are associated with increased mortality in a rural West African community

scientific article

HTLV-1 in rural Guinea-Bissau: prevalence, incidence and a continued association with HIV between 1990 and 2007.

scientific article

Hepatitis B immunisation induces higher antibody and memory Th2 responses in new-borns than in adults

scientific article published on 01 January 2004

Hepatocellular carcinoma and polymorphisms in carcinogen-metabolizing and DNA repair enzymes in a population with aflatoxin exposure and hepatitis B virus endemicity

scientific article published in February 2005

Heritability of antibody isotype and subclass responses to Plasmodium falciparum antigens

scientific article

High-titer measles vaccination before 9 months of age and increased female mortality: do we have an explanation?

scientific article

High-titre measles vaccine and female mortality.

scientific article published in November 2003

Highly avid, oligoclonal, early-differentiated antigen-specific CD8+ T cells in chronic HIV-2 infection

article

Host Genetic Factors and Vaccine-Induced Immunity to HBV Infection: Haplotype Analysis ⬇️

scientific article published on August 18, 2010

Host genetic factors and vaccine-induced immunity to hepatitis B virus infection

scientific article

Host iron redistribution as a risk factor for incident tuberculosis in HIV infection: an 11-year retrospective cohort study

scientific article

Immune reconstitution inflammatory syndrome and the influence of T regulatory cells: a cohort study in The Gambia

scientific article

Immunological impact of an additional early measles vaccine in Gambian children: responses to a boost at 3 years.

scientific article

Incidence of tuberculosis and survival after its diagnosis in patients infected with HIV-1 and HIV-2.

scientific article published on September 2004

Increased levels of aflatoxin-albumin adducts are associated with CYP3A5 polymorphisms in The Gambia, West Africa

scientific journal article

Increased prevalence of HTLV-1 among HIV-2-infected women but not HIV-2-infected men in rural Guinea-Bissau

scientific article published in July 2002

Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa

scientific article

Influence of Mycobacterium bovis Bacillus Calmette-Guerin on Antibody and Cytokine Responses to Human Neonatal Vaccination

article

Interaction between neonatal vitamin A supplementation and timing of measles vaccination: a retrospective analysis of three randomized trials from Guinea-Bissau

scientific article

Is HIV-2- induced AIDS different from HIV-1-associated AIDS? Data from a West African clinic

scientific article

Is HIV-2-induced AIDS different from HIV-1-associated AIDS?

article

LOW-BIAS RNA SEQUENCING OF THE HIV-2 GENOME FROM BLOOD PLASMA

article

LOW-BIAS RNA SEQUENCING OF THE HIV-2 GENOME FROM BLOOD PLASMA

Long-term protection against HBV chronic carriage of Gambian adolescents vaccinated in infancy and immune response in HBV booster trial in adolescence

scientific article

Long-term survival after Edmonston-Zagreb measles vaccination in Guinea-Bissau: increased female mortality rate

scientific article

Low level viremia and high CD4% predict normal survival in a cohort of HIV type-2-infected villagers

scientific article published in November 2002

Low mortality after mild measles infection compared to uninfected children in rural west Africa

article

Maintenance of large subpopulations of differentiated CD8 T-cells two years after cytomegalovirus infection in Gambian infants

scientific article

Maternal Priming: Bacillus Calmette-Guérin (BCG) Vaccine Scarring in Mothers Enhances the Survival of Their Child With a BCG Vaccine Scar

scientific article published on 03 February 2019

Maternal measles antibodies and their influence on all-cause mortality following measles vaccination: an alternative to measure very low maternal antibody levels

scientific article published on 01 May 2019

Maternal proviral load and vertical transmission of Human T cell Lymphotropic Virus type 1 in Guinea-Bissau.

scientific article

Maternal proviral load and vertical transmission of human T cell lymphotropic virus type 1 in Guinea-Bissau

scientific article published on 9 March 2012

Mature CD8(+) T lymphocyte response to viral infection during fetal life

scientific article

Measles antibody levels after vaccination with Edmonston-Zagreb and Schwarz measles vaccine at 9 months or at 9 and 18 months of age: a serological study within a randomised trial of different measles vaccines

scientific article published on 28 August 2013

Measles vaccination in the presence or absence of maternal measles antibody: impact on child survival

scientific article

Measles virus antibody responses in children randomly assigned to receive standard-titer edmonston-zagreb measles vaccine at 4.5 and 9 months of age, 9 months of age, or 9 and 18 months of age.

scientific article published on 31 March 2014

Molecular epidemiology of endemic Human T-Lymphotropic virus 1 (HTLV-1) in a community in rural Guinea-Bissau.

scientific article published on 6 June 2011

Molecular epidemiology of endemic human T-lymphotropic virus type 1 in a rural community in Guinea-Bissau.

scientific article

Mortality in HIV infection is independently predicted by host iron status and SLC11A1 and HP genotypes, with new evidence of a gene-nutrient interaction

scientific article published on 27 May 2009

Natural history of chronic HBV infection in West Africa: a longitudinal population-based study from The Gambia

scientific article published on 16 July 2015

Natural killer cell function is well preserved in asymptomatic human immunodeficiency virus type 2 (HIV-2) infection but similar to that of HIV-1 infection when CD4 T-cell counts fall.

scientific article

No differences in cellular immune responses between asymptomatic HIV type 1- and type 2-infected Gambian patients

scientific article published on 21 January 2004

No observed effect of GB virus C coinfection on disease progression in a cohort of African woman infected with HIV-1 or HIV-2.

scientific article published on 21 February 2005

Non-specific effects of standard measles vaccine at 4.5 and 9 months of age on childhood mortality: randomised controlled trial

scientific article

Observational study of vaccine efficacy 14 years after trial of hepatitis B vaccination in Gambian children

scientific article

Observational study of vaccine efficacy 24 years after the start of hepatitis B vaccination in two Gambian villages: no need for a booster dose

scientific article

Oral polio vaccine influences the immune response to BCG vaccination. A natural experiment

scientific article

Partially randomized, non-blinded trial of DNA and MVA therapeutic vaccines based on hepatitis B virus surface protein for chronic HBV infection

scientific article

Phase-out of smallpox vaccination and the female/male HIV-1 prevalence ratio: an ecological study from Guinea-Bissau

scientific article published on 30 October 2019

Placental malaria is associated with attenuated CD4 T-cell responses to tuberculin PPD 12 months after BCG vaccination

scientific article

Placental malaria is associated with reduced early life weight development of affected children independent of low birth weight

scientific article

Plasma viral load, CD4 cell percentage, HLA and survival of HIV-1, HIV-2, and dually infected Gambian patients

scientific article published in July 2003

Polyfunctional T cell responses are a hallmark of HIV-2 infection

scientific article published on February 2008

Population dynamics of HIV-2 in rural West Africa: comparison with HIV-1 and ongoing transmission at the heart of the epidemic

scientific article

Potent autologous and heterologous neutralizing antibody responses occur in HIV-2 infection across a broad range of infection outcomes

scientific article published on 9 November 2011

Predicting the extinction of HIV-2 in rural Guinea-Bissau

scientific article

Predominant influence of environmental determinants on the persistence and avidity maturation of antibody responses to vaccines in infants

scientific article

Presence of a multidrug-resistance mutation in an HIV-2 variant infecting a treatment-naive individual in Caio, Guinea Bissau.

scientific article published in June 2009

Protection versus pathology in aviremic and high viral load HIV-2 infection-the pivotal role of immune activation and T-cell kinetics

scientific article

Quantification of Human T-lymphotropic virus type I (HTLV-I) provirus load in a rural West African population: no enhancement of human immunodeficiency virus type 2 pathogenesis, but HTLV-I provirus load relates to mortality

scientific article published on 14 November 2003

Quantitative association tests of immune responses to antigens of Mycobacterium tuberculosis: a study of twins in West Africa

scientific article published in December 2004

Randomized Trial of 2 Versus 1 Dose of Measles Vaccine: Effect on Hospital Admission of Children After 9 Months of Age.

scientific article published on 15 June 2017

Randomized trial of BCG vaccination at birth to low-birth-weight children: beneficial nonspecific effects in the neonatal period?

scientific article

Randomized trial: The effect of oral polio vaccine at birth on polio antibody titers at 6weeks and 6months of age

scholarly article by Anna Sofie Hansen et al published 2014 in Trials in vaccinology

Regional differences in HIV trends in The Gambia: results from sentinel surveillance among pregnant women

scientific article published on August 2003

Revaccination with Live Attenuated Vaccines Confer Additional Beneficial Nonspecific Effects on Overall Survival: A Review

scientific article

Risk factors for and clinical outcome of congenital cytomegalovirus infection in a peri-urban West-African birth cohort

scientific article

Risk factors for measles in young infants in an urban African area with high measles vaccination coverage

scientific article

Robust Gag-specific T cell responses characterize viremia control in HIV-2 infection

scientific article published in October 2007

Seasonal variation in TP53 R249S-mutated serum DNA with aflatoxin exposure and hepatitis B virus infection

scientific article published on 18 July 2011

Ser-249TP53 mutation in tumour and plasma DNA of hepatocellular carcinoma patients from a high incidence area in the Gambia, West Africa

scientific article published in June 2004

Seroprevalence of hepatitis B and C virus in HIV-1 and HIV-2 infected Gambians

scientific article

Sex differences in the effect of vaccines on the risk of hospitalization due to measles in Guinea-bissau

scientific article

Sex differences in the vaccine-specific and non-targeted effects of vaccines

scientific article published on 5 February 2011

Sex-Differential Non-Vaccine-Specific Immunological Effects of Diphtheria-Tetanus-Pertussis and Measles Vaccination

scientific article

Sex-differential effect on infant mortality of oral polio vaccine administered with BCG at birth in Guinea-Bissau. A natural experiment

scientific article

Small randomized trial among low-birth-weight children receiving bacillus Calmette-Guérin vaccination at first health center contact

scientific article

Survival of HIV-1 and HIV-2 perinatally infected children in The Gambia

scientific article

The Effect of High‐Dose Vitamin A Supplementation Given with Bacille Calmette‐Guérin Vaccine at Birth on Infant Rotavirus Infection and Diarrhea: A Randomized Prospective Study from Guinea‐Bissau

article published in 2010

The Gambia Liver Cancer Study: Infection with hepatitis B and C and the risk of hepatocellular carcinoma in West Africa

scientific article published on January 2004

The effect of high-dose vitamin A supplementation administered with BCG vaccine at birth may be modified by subsequent DTP vaccination

scientific article

The effect of high-dose vitamin A supplementation at birth on measles incidence during the first 12 months of life in boys and girls: an unplanned study within a randomised trial

scientific article

The effect of placental malaria infection on cord blood and maternal immunoregulatory responses at birth

scientific article published in April 2010

The immunological effect of revaccination with Bacille Calmette-Guérin vaccine at 19 months of age

scholarly article by Andreas Andersen et al published April 2013 in Vaccine

The natural history of HIV-1 and HIV-2 infections in adults in Africa: a literature review

scientific article published in June 2004

The new decade of vaccines

scientific article published in The Lancet

The optimal age of measles immunisation in low-income countries: a secondary analysis of the assumptions underlying the current policy

scientific article

The presence of prolines in the flanking region of an immunodominant HIV-2 gag epitope influences the quality and quantity of the epitope generated.

scientific article published on 28 May 2015

The role of CD8+ T-cell responses in the pathogenesis of HIV-2, a naturally contained human retroviral infection

article

The tuberculin skin test (TST) is affected by recent BCG vaccination but not by exposure to non-tuberculosis mycobacteria (NTM) during early life

scientific article

Two distinct epidemics: the rise of HIV-1 and decline of HIV-2 infection between 1990 and 2007 in rural Guinea-Bissau

scientific article

Undetectable plasma viral load predicts normal survival in HIV-2-infected people in a West African village

scientific article published on 19 May 2010

Vaccine programmes must consider their effect on general resistance

scientific article

Vaccinia scars associated with improved survival among adults in rural Guinea-Bissau

scientific article

Variation in Toll-like receptor 4 and susceptibility to group A meningococcal meningitis in Gambian children

scientific article published in November 2003

Vigorous but short-term gamma interferon T-cell responses against a dominant HLA-A*02-restricted measles virus epitope in patients with measles

scientific article

Virological and immunological correlates of mother-to-child transmission of cytomegalovirus in The Gambia.

scientific article published in May 2008

Virological and immunological response to Combivir and emergence of drug resistance mutations in a cohort of HIV-2 patients in The Gambia

scientific article published in June 2006

Virological response to highly active antiretroviral therapy in patients infected with human immunodeficiency virus type 2 (HIV-2) and in patients dually infected with HIV-1 and HIV-2 in the Gambia and emergence of drug-resistant variants.

scientific article published on 06 May 2009

Vitamin A supplementation and BCG vaccination at birth in low birthweight neonates: two by two factorial randomised controlled trial

scientific article

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