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List of works by Dennie T Frederick

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

article

A melanocyte lineage program confers resistance to MAP kinase pathway inhibition

scientific article published on 3 November 2013

A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors

scientific article

A potential role for immunotherapy in thyroid cancer by enhancing NY-ESO-1 cancer antigen expression

scientific article

Adjuvant Therapy Failure Patterns in the Modern Era of Melanoma Management

scientific article published on 23 May 2020

An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition

scientific article

BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition.

scientific article published on 27 February 2013

BRAF Inhibition Increases Tumor Infiltration by T cells and Enhances the Antitumor Activity of Adoptive Immunotherapy in Mice ⬇️

scientific article published on November 30, 2012

BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma.

scientific article published on 10 January 2013

BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes

scientific article published on 15 October 2013

Clinical profiling of BCL-2 family members in the setting of BRAF inhibition offers a rationale for targeting de novo resistance using BH3 mimetics

scientific article

Co-clinical assessment identifies patterns of BRAF inhibitor resistance in melanoma

scientific article

Combining checkpoint inhibitors and BRAF-targeted agents against metastatic melanoma.

scientific article published on May 2013

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

scientific article published on April 2016

Distinct clinical patterns and immune infiltrates are observed at time of progression on targeted therapy versus immune checkpoint blockade for melanoma

scientific article published on 2 February 2016

Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation.

scientific article

Dramatic Response of BRAF V600E Mutant Papillary Craniopharyngioma to Targeted Therapy.

scientific article published on 23 October 2015

EPHA2 is a mediator of vemurafenib resistance and a novel therapeutic target in melanoma

scientific article

Elucidating distinct roles for NF1 in melanomagenesis

scientific article

Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR

scientific article published on June 2015

Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2.

scientific article published on 08 October 2013

Immune checkpoint inhibition (ICI) in advanced cutaneous squamous cell carcinoma (cSCC): Clinical response and correlative biomarker analysis.

scientific article published on 05 September 2018

Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy

scientific article published on March 2016

Inhibition of mTORC1/2 overcomes resistance to MAPK pathway inhibitors mediated by PGC1α and oxidative phosphorylation in melanoma

scientific article published on 8 October 2014

Ki-67, p53, and p16 expression, and G691S RET polymorphism in desmoplastic melanoma (DM): A clinicopathologic analysis of predictors of outcome

scientific article published on September 2016

Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment

scientific article (publication date: 2015)

Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma

scientific article published on 08 August 2016

MAP kinase pathway alterations in BRAF-mutant melanoma patients with acquired resistance to combined RAF/MEK inhibition

scientific article

MITF Modulates Therapeutic Resistance through EGFR Signaling

scientific article published on 19 March 2015

Melanocytic nevi excised during B-Raf proto-oncogene (BRAF) inhibitor therapy: A study of 19 lesions from 10 patients

scientific article published on 16 July 2015

Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy.

scientific article

Mixed Response to Immunotherapy in Patients with Metastatic Melanoma

scientific article published on 29 May 2020

Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF ⬇️

scientific article published on March 7, 2013

Oncogenic BRAF(V600E) promotes stromal cell-mediated immunosuppression via induction of interleukin-1 in melanoma

scientific article

One Hippo and many masters: differential regulation of the Hippo pathway in cancer

scientific article

Overexpression of Mcl-1 confers resistance to BRAFV600E inhibitors alone and in combination with MEK1/2 inhibitors in melanoma

scientific article published on 14 October 2015

PDGFRα up-regulation mediated by sonic hedgehog pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation

scientific article

Pathway signatures derived from on-treatment tumor specimens predict response to anti-PD1 blockade in metastatic melanoma

scientific article published on 15 October 2021

Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine

scientific article published on September 2017

Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance

scientific article published on 16 March 2016

Resistance to checkpoint blockade therapy through inactivation of antigen presentation.

scientific article published on 26 October 2017

Response to BRAF inhibition in melanoma is enhanced when combined with immune checkpoint blockade

scientific article

Targeted Next Generation Sequencing Identifies Markers of Response to PD-1 Blockade

scientific article published on 26 September 2016

Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure

scientific article published on 12 June 2017

Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors

scientific article published on 4 April 2016

Targeting the MAGE A3 antigen in pancreatic cancer ⬇️

scientific article published on July 6, 2012

The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

scientific article published on 09 February 2015

The immune microenvironment confers resistance to MAPK pathway inhibitors through macrophage-derived TNFα

scientific article

Tumor-associated B-cells induce tumor heterogeneity and therapy resistance

scientific article published on 19 September 2017

Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells

scientific article

sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

scientific article published on 4 April 2016

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