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List of works by Jacek Otlewski

A Conjugate Based on Anti-HER2 Diaffibody and Auristatin E Targets HER2-Positive Cancer Cells

scientific article

A Novel Affibody-Auristatin E Conjugate With a Potent and Selective Activity Against HER2+ Cell Lines.

scientific article published on 25 May 2016

A novel, stable, helical scaffold as an alternative binder - construction of phage display libraries

scientific article published on September 18, 2012

Amyloid-forming peptides selected proteolytically from phage display library

scientific article

Analysis of serine proteinase-inhibitor interaction by alanine shaving

scientific article

Anti-FGFR1 aptamer-tagged superparamagnetic conjugates for anticancer hyperthermia therapy

scientific article

Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity

scientific article published on 2 August 2017

Aptamers: molecules of great potential

scientific article published on 28 April 2013

Assignment of 1H, 13C and 15N resonances of the N-terminal microtubule-binding domain of human doublecortin

scientific article published on 01 January 2003

Biophysical properties of the eukaryotic ribosomal stalk

scientific article

Bivalent peptides as models for multimeric targets of PDZ domains.

scientific article published in March 2007

Correction: Serwotka-Suszczak, A. M. et al. A Conjugate Based on Anti-HER2 Diaffibody and Auristatin E Targets HER2-Positive Cancer Cells. Int. J. Mol. Sci. 2017, 18, 401

scientific article published on 20 November 2018

Cross-Talk between Fibroblast Growth Factor Receptors and Other Cell Surface Proteins

scientific article published on 14 May 2019

Crosstalk between p38 and Erk 1/2 in Downregulation of FGF1-Induced Signaling

scientific article published on 12 April 2019

Crystal structure of Vigna radiata cytokinin-specific binding protein in complex with zeatin

scientific article published on 22 September 2006

Crystal structures of five bovine chymotrypsin complexes with P1 BPTI variants

scientific article published in December 2004

Current methods for the synthesis of homogeneous antibody-drug conjugates

scientific article

Cytokinin-induced structural adaptability of a Lupinus luteus PR-10 protein

scientific article published in March 2009

Cytotoxic Conjugates of Fibroblast Growth Factor 2 (FGF2) with Monomethyl Auristatin E for Effective Killing of Cells Expressing FGF Receptors.

scientific article published on 21 July 2017

Degenerate specificity of PDZ domains from RhoA-specific nucleotide exchange factors PDZRhoGEF and LARG.

scientific article

Design and In Vitro Evaluation of a Cytotoxic Conjugate Based on the Anti-HER2 Affibody Fused to the Fc Fragment of IgG1.

scientific article published on 3 August 2017

Design and characteristics of a stable protein scaffold for specific binding based on variable lymphocyte receptor sequences ⬇️

scientific article published on May 18, 2011

Design and characteristics of cytotoxic fibroblast growth factor 1 conjugate for fibroblast growth factor receptor-targeted cancer therapy

scientific article published on 09 August 2016

Design of fully active FGF-1 variants with increased stability

scientific article published on August 2004

Design, expression and characterization of a highly stable tetratricopeptide-based protein scaffold for phage display application

scientific article published on 17 December 2013

Differential regulation of fibroblast growth factor receptor 1 trafficking and function by extracellular galectins.

scientific article

Dissecting the thermodynamics of GAP-RhoA interactions

scientific article

ERK-mediated phosphorylation of fibroblast growth factor receptor 1 on Ser777 inhibits signaling.

scientific article published on 12 February 2013

Efficient production and purification of extracellular domain of human FGFR-Fc fusion proteins from Chinese hamster ovary cells.

scientific article

Exploring the Sn binding pockets in gingipains by newly developed inhibitors: structure-based design, chemistry, and activity

scientific article published in March 2006

Expression, purification and catalytic activity of Lupinus luteus asparagine beta-amidohydrolase and its Escherichia coli homolog

scientific article

Expression, purification and crystallization of cysteine-rich human protein muskelin in Escherichia coli

scientific article published on 30 March 2008

FGF1-gold nanoparticle conjugates targeting FGFR efficiently decrease cell viability upon NIR irradiation

scientific article published on 29 November 2012

FGF2 Dual Warhead Conjugate with Monomethyl Auristatin E and α-Amanitin Displays a Cytotoxic Effect towards Cancer Cells Overproducing FGF Receptor 1

scientific article published on 19 July 2018

FGF2-Derived PeptibodyF2-MMAE Conjugate for Targeted Delivery of Cytotoxic Drugs into Cancer Cells Overexpressing FGFR1

scientific article published on 15 October 2020

FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization

scientific article published on 08 June 2020

FHF1 is a bona fide fibroblast growth factor that activates cellular signaling in FGFR-dependent manner

scientific article published on 01 May 2020

Femtomolar Zn2+ affinity of LIM domain of PDLIM1 protein uncovers crucial contribution of protein-protein interactions to protein stability.

scientific article

Generation of high-affinity, internalizing anti-FGFR2 single-chain variable antibody fragment fused with Fc for targeting gastrointestinal cancers

scientific article published on 8 February 2018

High Affinity Promotes Internalization of Engineered Antibodies Targeting FGFR1.

scientific article published on 10 May 2018

High-Affinity Internalizing Human scFv-Fc Antibody for Targeting FGFR1-Overexpressing Lung Cancer

scientific article published on 8 May 2017

High-Yield Site-Specific Conjugation of Fibroblast Growth Factor 1 with Monomethylauristatin E via Cysteine Flanked by Basic Residues.

scientific article

Highly stable mutants of human fibroblast growth factor-1 exhibit prolonged biological action

scientific article

Hydrogen bonds in human ubiquitin reflected in temperature coefficients of amide protons

scientific article published on 01 August 2002

Identification of a peptide antagonist of the FGF1-FGFR1 signaling axis by phage display selection

scientific article published on 09 April 2019

Identification of new FGF1 binding partners-Implications for its intracellular function

scientific article published on 2 February 2016

Importance of alpha-helix N-capping motif in stabilization of betabetaalpha fold.

scientific article published on June 2003

Increased protein stability of FGF1 can compensate for its reduced affinity for heparin

scientific article published on 2 July 2009

Instability restricts signaling of multiple fibroblast growth factors.

scientific article

Intracellular partners of fibroblast growth factors 1 and 2 - implications for functions

scientific article published on 18 May 2020

Longer action means better drug: tuning up protein therapeutics

scientific article published on 02 April 2011

Low Stability of Integrin-Binding Deficient Mutant of FGF1 Restricts Its Biological Activity

scientific article published on 15 August 2019

Molecular basis of mitomycin C resistance in streptomyces: structure and function of the MRD protein

scientific article

NMR structures of two variants of bovine pancreatic trypsin inhibitor (BPTI) reveal unexpected influence of mutations on protein structure and stability

scientific article

Novel Method for Preparation of Site-Specific, Stoichiometric-Controlled Dual Warhead Conjugate of FGF2 via Dimerization Employing Sortase A-Mediated Ligation

scientific article published on 24 June 2019

Novel peptide recognized by RhoA GTPase

scientific article

Nuclear Localization Sequence of FGF1 Is Not Required for Its Intracellular Anti-Apoptotic Activity in Differentiated Cells

scientific article published on 2 February 2022

Nucleolin regulates phosphorylation and nuclear export of fibroblast growth factor 1 (FGF1)

scientific article

PDZ domain from Dishevelled -- a specificity study

scientific article published on June 13, 2011

PDZ domains - common players in the cell signaling

scientific article (publication date: 2003)

PDZ tandem of human syntenin: crystal structure and functional properties

scientific article (publication date: April 2003)

Preliminary crystallographic analysis of the complex of the human GTPase RhoA with the DH/PH tandem of PDZ-RhoGEF.

scientific article

Protease resistant variants of FGF1 with prolonged biological activity.

scientific article

Purification and In Vitro Evaluation of an Anti-HER2 Affibody-Monomethyl Auristatin E Conjugate in HER2-Positive Cancer Cells

scientific article published in 2021

Selection and Characterization of Single Chain Antibody Fragments Specific for Hsp90 as a Potential Cancer Targeting Molecule

scientific article published on 21 August 2015

Selection and characterization of human antibody fragments specific for psoriasin - a cancer associated protein

scientific article

Selection of specific interactors from phage display library based on sea lamprey variable lymphocyte receptor sequences

scientific article published on 18 September 2015

Site-Specific, Stoichiometric-Controlled, PEGylated Conjugates of Fibroblast Growth Factor 2 (FGF2) with Hydrophilic Auristatin Y for Highly Selective Killing of Cancer Cells Overproducing Fibroblast Growth Factor Receptor 1 (FGFR1)

scientific article published on 05 June 2020

Specific Antibody Fragment Ligand Traps Blocking FGF1 Activity

scientific article published on 21 August 2018

Stable Fibroblast Growth Factor 2 Dimers with High Pro-Survival and Mitogenic Potential

scientific article published on 09 June 2020

Structural consequences of accommodation of four non-cognate amino acid residues in the S1 pocket of bovine trypsin and chymotrypsin

scientific article

Structural requirements of FGF-1 for receptor binding and translocation into cells

scientific article published on December 2006

Structure of a highly stable mutant of human fibroblast growth factor 1

scientific article published on 18 December 2008

Tailoring small proteins towards biomedical applications

scientific article

Targeting Cellular Trafficking of Fibroblast Growth Factor Receptors as a Strategy for Selective Cancer Treatment

scientific article published on 20 December 2018

The DCX-domain tandems of doublecortin and doublecortin-like kinase

scientific article (publication date: May 2003)

The autoinhibitory function of D1 domain of FGFR1 goes beyond the inhibition of ligand binding

scientific article

The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle

scientific article

The dimerization mechanism of LIS1 and its implication for proteins containing the LisH motif

scientific article

The high Zn(II) affinity of the tetracysteine tag affects its fluorescent labeling with biarsenicals

scientific article

The impact of Glu-->Ala and Glu-->Asp mutations on the crystallization properties of RhoGDI: the structure of RhoGDI at 1.3 A resolution

scientific article

The impact of Lys-->Arg surface mutations on the crystallization of the globular domain of RhoGDI

scientific article

The many faces of protease-protein inhibitor interaction

scientific article

The molecular basis of RhoA specificity in the guanine nucleotide exchange factor PDZ-RhoGEF

scientific article published on 05 September 2006

The structure of the N-terminal domain of the product of the lissencephaly gene Lis1 and its functional implications

scientific article

Thermodynamics of single peptide bond cleavage in bovine pancreatic trypsin inhibitor (BPTI).

scientific article

Translocation of Exogenous FGF1 and FGF2 Protects the Cell against Apoptosis Independently of Receptor Activation

scientific article published on 09 August 2018

Trypsin specificity as elucidated by LIE calculations, X-ray structures, and association constant measurements

scientific article

Tumor-specific hyperthermia with aptamer-tagged superparamagnetic nanoparticles.

scientific article published on 18 December 2013

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