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List of works by Denis Duboule

18 Muscle and tendon pattern is altered independently of skeletal pattern in HoxD mutant limbs

scientific article published on 01 November 2002

A complex regulatory landscape involved in the development of mammalian external genitals ⬇️

scientific article published on 17 April 2020

A dual role for Hox genes in limb anterior-posterior asymmetry

scientific article published in June 2004

A function for all posterior Hoxd genes during digit development?

scientific article published on 28 February 2012

A genetic approach to the transcriptional regulation of Hox gene clusters

scientific article published on January 2011

A genetic basis for altered sexual behavior in mutant female mice

scientific article published on 2 August 2012

A global control region defines a chromosomal regulatory landscape containing the HoxD cluster

scientific article

A molecular approach to the evolution of vertebrate paired appendages

scientific article published in March 1996

A mouse gene related to Distal-less shows a restricted expression in the developing forebrain

scientific article published in June 1991

A mouse model for human short-stature syndromes identifies Shox2 as an upstream regulator of Runx2 during long-bone development

scientific journal article

A new homeo-box is present in overlapping cosmid clones which define the mouse Hox-1 locus

scientific article

A regulatory 'landscape effect' over the HoxD cluster

scientific article published on 30 December 2010

A regulatory archipelago controls Hox genes transcription in digits

scientific article

A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus

scientific article published on 19 May 2016

A switch between topological domains underlies HoxD genes collinearity in mouse limbs

scientific article published in June 2013

A systematic enhancer screen using lentivector transgenesis identifies conserved and non-conserved functional elements at the Olig1 and Olig2 locus

scientific article

A t(2;8) balanced translocation with breakpoints near the human HOXD complex causes mesomelic dysplasia and vertebral defects

scientific article published in April 2002

Additive and global functions of HoxA cluster genes in mesoderm derivatives

scientific article published on 18 March 2010

An enhancer-titration effect induces digit-specific regulatory alleles of the HoxD cluster

scientific article published in April 2003

An update of mouse and human HOX gene nomenclature

scientific article published in July 1990

Analysis of the dynamics of limb transcriptomes during mouse development

scientific article

Antagonists go out on a limb

scientific article

Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs

scientific article published on 18 June 2014

Atypical relaxation of structural constraints in Hox gene clusters of the green anole lizard

scientific article published on 18 February 2009

Bimodal control of Hoxd gene transcription in the spinal cord defines two regulatory subclusters

scientific article published on 25 January 2012

Breaking colinearity in the mouse HoxD complex

scientific article published in April 1999

CONSERVATION AND VARIATIONS OF BIMODAL HoxD GENE REGULATION DURING TETRAPOD LIMB DEVELOPMENT

Changes in Hox genes' structure and function during the evolution of the squamate body plan

scientific article published in March 2010

Characterization of mouse Dactylaplasia mutations: a model for human ectrodactyly SHFM3.

scientific article

Characterization of paralogous uncx transcription factor encoding genes in zebrafish

scientific article published on 01 June 2019

Chromatin Architectures and Hox Gene Collinearity

scientific article published on January 1, 2013

Chromatin looping and organization at developmentally regulated gene loci

scientific article published on 03 January 2013

Chromatin organization and global regulation ofHoxgene clusters ⬇️

scientific article published on 06 May 2013

Chromatin topology and the timing of enhancer function at the <i>HoxD</i> locus

scientific article published on 23 November 2020

Classification of limb defects

scientific article published on 01 June 1998

Clustering of mammalian Hox genes with other H3K27me3 targets within an active nuclear domain

scientific article

Colinearity and functional hierarchy among genes of the homeotic complexes

scientific article published on October 1994

Colinearity loops out.

scientific article published on June 2004

Combined function of HoxA and HoxB clusters in neural crest cells

scientific article published on 11 July 2013

Commentary on paper by Leroy C

scientific article published on 01 October 2019

Comparative analysis of genes downstream of the Hoxd cluster in developing digits and external genitalia

scientific article published in July 2005

Comparison of mouse and human HOX-4 complexes defines conserved sequences involved in the regulation of Hox-4.4.

scientific article

Conservation and divergence of regulatory strategies at Hox Loci and the origin of tetrapod digits

scientific article

Conservation of a functional hierarchy between mammalian and insect Hox/HOM genes.

scientific article

Conserved elements within open reading frames of mammalian Hox genes

scientific article published on 06 February 2009

Considerations when investigating lncRNA function in vivo.

scientific article

Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape

scientific article

Control of colinearity in AbdB genes of the mouse HoxD complex

scientific article published in January 1998

Control of growth and gut maturation by HoxD genes and the associated lncRNA Haglr

scientific article published on 17 October 2017

Control of limb morphogenesis by the Hox genes

scientific article published in January 1997

Cooperation of regulatory elements involved in the activation of the Hoxd-11 gene.

scientific article published in September 1993

Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation

scientific article published in Nature

Correlation of expression of Wnt-1 in developing limbs with abnormalities in growth and skeletal patterning

scientific article published on April 1993

DNA sequences homologous to the Drosophila opa repeat are present in murine mRNAs that are differentially expressed in fetuses and adult tissues

scientific article published on May 1987

Dbx2 regulation in limbs suggests interTAD sharing of enhancers

scientific article published on 01 March 2021

Deletion of a HoxD enhancer induces transcriptional heterochrony leading to transposition of the sacrum

scientific article

Developmental biology in Geneva: a three century-long tradition.

scientific article

Developmental biology: reproduction in clusters

scientific article published in April 2005

Developmental expression of the mouse Evx-2 gene: relationship with the evolution of the HOM/Hox complex

scientific article published on 01 January 1994

Developmental genetics. A Hox by any other name

scientific article published in February 2000

Differential expression of two different homeobox gene families during mouse tegument morphogenesis

scientific article

Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs

scientific journal article

Distinct roles and regulations for HoxD genes in metanephric kidney development

scientific article

Dorso-ventral limb polarity and origin of the ridge: on the fringe of independence?

scientific article published on July 1997

Duplications of hox gene clusters and the emergence of vertebrates

scientific article published on 15 March 2013

Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene function

scientific article published in June 2005

Ectopic nuclear reorganisation driven by a Hoxb1 transgene transposed into Hoxd

scientific article

Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock

scientific article published on July 2017

Engineering chromosomes in mice through targeted meiotic recombination (TAMERE)

scientific article published on 01 December 1998

Epigenetic regulation of Hox gene activation: the waltz of methyls

scientific article

Epigenetic regulation of vertebrate Hox genes: a dynamic equilibrium

scientific journal article

Epigenetic temporal control of mouse Hox genes in vivo

scientific article published in June 2009

Evolutionary conserved sequences are required for the insulation of the vertebrate Hoxd complex in neural cells

scientific article published in December 2002

Evolving Hox activity profiles govern diversity in locomotor systems

scientific article

Expression of Hox-4 genes in the chick wing links pattern formation to the epithelial-mesenchymal interactions that mediate growth

scientific article published on April 1992

Expression of the homeobox Hox-4 genes and the specification of position in chick wing development

scientific article (publication date: 18 April 1991)

Expression of the zebrafish gene hlx-1 in the prechordal plate and during CNS development

scientific article published in January 1994

Fryns type mesomelic dysplasia of the upper limbs caused by inverted duplications of the HOXD gene cluster

scientific article published on 07 October 2019

Function of posterior HoxD genes in the morphogenesis of the anal sphincter

scientific article published in September 1996

Function of the Evx-2 gene in the morphogenesis of vertebrate limbs

scientific journal article

Functional analysis of CTCF during mammalian limb development

scientific article

Functional equivalence and rescue among group 11 Hox gene products in vertebral patterning

scientific article published on 01 June 1996

Gene transpositions in the HoxD complex reveal a hierarchy of regulatory controls

scientific article published in June 1996

Genetic analysis of a Hoxd-12 regulatory element reveals global versus local modes of controls in the HoxD complex.

scientific article published in May 1998

Genetic analysis of a conserved sequence in the HoxD complex: regulatory redundancy or limitations of the transgenic approach?

scientific article published in September 1998

Genetic control of limb development

scientific article published in January 1996

Genetic control of murine limb morphogenesis: relationships with human syndromes and evolutionary relevance

scientific article published in May 1998

Genotypic features of lentivirus transgenic mice

scientific article published on 7 May 2008

Global control regions and regulatory landscapes in vertebrate development and evolution

scientific article published on January 2008

HOX-4 genes and the morphogenesis of mammalian genitalia ⬇️

scientific article published on 01 October 1991

HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities

scientific article

Head-tail patterning of the vertebrate embryo: one, two or many unresolved problems?

scientific article

Heterogeneous combinatorial expression of Hoxd genes in single cells during limb development

scientific article published on 18 September 2018

Homeobox genes and pattern formation in the vertebrate limb

scientific article

Homeobox genes d11-d13 and a13 control mouse autopod cortical bone and joint formation

scientific article

Homoeobox gene expression in mouse embryos varies with position by the primitive streak stage

scientific article published on 01 December 1986

Hotair Is Dispensible for Mouse Development ⬇️

scientific article (publication date: December 2016)

How to make a limb?

scientific article published on October 1994

Hox gene expression in limbs: colinearity by opposite regulatory controls.

scientific article

Hox gene expression in teleost fins and the origin of vertebrate digits

scientific article published in Nature

Hox genes and the making of sphincters

scientific article published on 01 October 1999

Hox genes and the morphogenesis of the vertebrate limb.

scientific article published on January 1993

Hox genes in digit development and evolution

scientific article

Hox is in the hair: a break in colinearity?: Figure 1 ⬇️

scientific article published on January 1, 1998

Hox-1.6: a mouse homeo-box-containing gene member of the Hox-1 complex

scientific article published on October 1987

Hox-4 gene expression in mouse/chicken heterospecific grafts of signalling regions to limb buds reveals similarities in patterning mechanisms

scientific article published on 01 June 1992

Hox-5.1 defines a homeobox-containing gene locus on mouse chromosome 2.

scientific article

HoxD cluster scanning deletions identify multiple defects leading to paralysis in the mouse mutant Ironside

scientific article

Impact of copy number variations (CNVs) on long-range gene regulation at the HoxD locus

scientific article

Impact of genome architecture on the functional activation and repression of Hox regulatory landscapes

scientific article published on 12 July 2019

Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice

scientific article

In vivo targeted mutagenesis of a regulatory element required for positioning the Hoxd-11 and Hoxd-10 expression boundaries

scientific article published on September 1996

Induction of a chromatin boundary in vivo upon insertion of a TAD border

scientific article published on 22 July 2021

Integration of Shh and Fgf signaling in controlling Hox gene expression in cultured limb cells

scientific article published on 7 March 2017

Interactions between HOXD and Gli3 genes control the limb apical ectodermal ridge via Fgf10.

scientific article

Interspecies exchange of a Hoxd enhancer in vivo induces premature transcription and anterior shift of the sacrum

scientific article published on 01 October 1997

Inversion-induced disruption of the Hoxd cluster leads to the partition of regulatory landscapes

scientific article

Landscapes and archipelagos: spatial organization of gene regulation in vertebrates

scientific article published on 02 May 2012

Large scale genomic reorganization of topological domains at the HoxD locus

scientific article

Large scale transgenic and cluster deletion analysis of the HoxD complex separate an ancestral regulatory module from evolutionary innovations

scientific article

Local alterations of Krox-20 and Hox gene expression in the hindbrain suggest lack of rhombomeres 4 and 5 in homozygote null Hoxa-1 (Hox-1.6) mutant embryos

scientific article

Localized and transient transcription of Hox genes suggests a link between patterning and the segmentation clock

scientific journal article

Making progress with limb models

scientific article published in Nature

Male accessory sex organ morphogenesis is altered by loss of function of Hoxd-13

scientific journal article

Mammalian-specific ectodermal enhancers control the expression of Hoxc genes in developing nails and hair follicles

scientific article published on 16 November 2020

Mesomelic dysplasias associated with the HOXD locus are caused by regulatory reallocations

scientific article published on 18 August 2021

Modeling Hox gene regulation in digits: reverse collinearity and the molecular origin of thumbness

scientific article

Mouse homeo-genes within a subfamily, Hox-1.4, -2.6 and -5.1, display similar anteroposterior domains of expression in the embryo, but show stage- and tissue-dependent differences in their regulation

scientific article published on 01 September 1989

Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression

scientific journal article

Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids

scientific article published in Nature

Multiple enhancers regulate Hoxd genes and the Hotdog LncRNA during cecum budding

scientific article

Murine Homeo-Genes: Some Aspects of their Organisation and Structure

article

Murine genes related to the Drosophila AbdB homeotic genes are sequentially expressed during development of the posterior part of the body

scientific article published on August 1991

Nanoscale spatial organization of the HoxD gene cluster in distinct transcriptional states

scientific article

No milk today (my Hox have gone away).

scientific article

Noncoding copy-number variations are associated with congenital limb malformation.

scientific article published on 12 October 2017

Of fingers, toes and penises.

scientific article published in November 1997

Organizing axes in time and space; 25 years of colinear tinkering

scientific article

Patterning in the vertebrate limb ⬇️

scientific article published on August 1, 1991

Primary structure and embryonic expression pattern of the mouse Hox-4.3 homeobox gene

scientific article published in November 1990

Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain

scientific article

Regulation of number and size of digits by posterior Hox genes: A dose-dependent mechanism with potential evolutionary implications

scientific article

Regulatory constraints in the evolution of the tetrapod limb anterior-posterior polarity

scientific article published in October 2006

Reorganisation of Hoxd regulatory landscapes during the evolution of a snake-like body plan

scientific article published on August 2016

Rescue of an aggressive female sexual courtship in mice by CRISPR/Cas9 secondary mutation in vivo

scientific article published on 27 March 2018

Reshuffling genomic landscapes to study the regulatory evolution of Hox gene clusters

scientific article

Response to Peron et al.

scientific article published in March 2018

Role of Hoxc genes in the development of the limb integumentary organ (nail, claw, or hoof).

scientific article published in April 2018

Role of a polymorphism in a Hox/Pax-responsive enhancer in the evolution of the vertebrate spine

scientific article (publication date: 25 June 2013)

Rostral and caudal pharyngeal arches share a common neural crest ground pattern

scientific article published on February 2009

Serial deletions and duplications suggest a mechanism for the collinearity of Hoxd genes in limbs

scientific article published in November 2002

Similarities and differences in the regulation of HoxD genes during chick and mouse limb development

scientific article published on 26 November 2018

Snakes: hatching of a model system for Evo-Devo?

scientific article published in January 2014

SnapShot: Hox gene regulation

scientific article published in February 2014

Structural and functional differences in the long non-coding RNA hotair in mouse and human

scientific article

Structure and activity of regulatory elements involved in the activation of the Hoxd-11 gene during late gastrulation.

scientific article

Structure, function and evolution of topologically associating domains (TADs) at HOX loci.

scientific article published on 22 April 2015

Synpolydactyly in mice with a targeted deficiency in the HoxD complex

scientific journal article

Tail Bud Progenitor Activity Relies on a Network Comprising Gdf11, Lin28, and Hox13 Genes

scientific article published on 17 January 2019

Targeted inversion of a polar silencer within the HoxD complex re-allocates domains of enhancer sharing

scientific article published in December 2000

Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations

scientific article published on July 1992

Teleost HoxD and HoxA genes: comparison with tetrapods and functional evolution of the HOXD complex

scientific article published in January 1996

Temporal colinearity and the phylotypic progression: a basis for the stability of a vertebrate Bauplan and the evolution of morphologies through heterochrony

scientific article published on 01 January 1994

Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci

scientific article

Tetrapod axial evolution and developmental constraints; Empirical underpinning by a mouse model

scientific article

The European dimension for the mouse genome mutagenesis program

scientific article

The Evolution of Genomics ⬇️

scientific article published on October 24, 1997

The HOX-5 and surfeit gene clusters are linked in the proximal portion of mouse chromosome 2.

scientific article published in April 1990

The Hox complex - an interview with Denis Duboule. Interviewed by Richardson, Michael K.

scientific article published in January 2009

The Hox-4.8 gene is localized at the 5' extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development

scientific article

The HoxD cluster is a dynamic and resilient TAD boundary controlling the segregation of antagonistic regulatory landscapes

scientific article published on 22 December 2017

The constrained architecture of mammalian Hox gene clusters

scientific article published on 17 June 2019

The dynamic architecture of Hox gene clusters

scientific article

The evo-devo comet

scientific article published on July 2010

The evolution of 'bricolage'.

scientific article published on February 1998

The function of Hox genes in the morphogenesis of the vertebrate limb.

scientific article published on January 1993

The genetics of murine Hox loci: TAMERE, STRING, and PANTHERE to engineer chromosome variants

scientific article published in January 2014

The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system

scientific article

The loss of circadian PAR bZip transcription factors results in epilepsy

scientific article

The mis-expression of posterior Hox-4 genes in talpid (ta3) mutant wings correlates with the absence of anteroposterior polarity

scientific article

The mouse Hox-1.4 gene: primary structure, evidence for promoter activity and expression during development

scientific article published on October 1989

The mouse Hoxd13(spdh) mutation, a polyalanine expansion similar to human type II synpolydactyly (SPD), disrupts the function but not the expression of other Hoxd genes

scientific journal article

The murine even-skipped-like gene Evx-2 is closely linked to the Hox-4 complex, but is transcribed in the opposite direction

scientific article published in January 1992

The murine genes Hox-5.1 and Hox-4.1 belong to the same HOX complex on chromosome 2.

scientific article

The origin of digits: expression patterns versus regulatory mechanisms

scientific article published in April 2010

The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator

scientific article (publication date: 26 July 2002)

The regulatory landscapes of developmental genes

scientific article published on 03 February 2020

The rise and fall of Hox gene clusters

scientific article

The role of Hox genes during vertebrate limb development

scientific article

The segment-specific gene Krox-20 encodes a transcription factor with binding sites in the promoter region of the Hox-1.4 gene

scientific article

The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes

scientific article published on May 1989

The vertebrate limb: a model system to study the Hox/HOM gene network during development and evolution

scientific article published on June 1, 1992

Tissue preference and differentiation of malignant rat x mouse hybrid cells in chimaeric mouse fetuses.

scientific article

Topological Domains, Metagenes, and the Emergence of Pleiotropic Regulations at Hox Loci

scientific article published on 27 January 2016

Topology of mammalian developmental enhancers and their regulatory landscapes

scientific article

Tracing microRNA patterns in mice

scientific article published in October 2004

Transgene- and locus-dependent imprinting reveals allele-specific chromosome conformations

scientific article published on July 2013

Transgenic analysis of Hoxd gene regulation during digit development

scientific article published on 23 March 2007

Transgenic analysis of a potential Hoxd-11 limb regulatory element present in tetrapods and fish

scientific article published in December 1996

Two gene members of the murine HOX-5 complex show regional and cell-type specific expression in developing limbs and gonads

scientific article

Ulnaless (Ul), a regulatory mutation inducing both loss-of-function and gain-of-function of posterior Hoxd genes

scientific journal article

Uncoupling time and space in the collinear regulation of Hox genes

scientific article

Vertebrate Hox gene regulation: clustering and/or colinearity? ⬇️

scientific article published on October 1, 1998

Vertebrate Hox genes and proliferation: an alternative pathway to homeosis? ⬇️

scientific article published on August 1, 1995

Visualizing the HoxD Gene Cluster at the Nanoscale Level

scientific article

Zebrafish Hoxa and Evx-2 genes: cloning, developmental expression and implications for the functional evolution of posterior Hox genes

scientific article published in October 1996

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