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List of works by Sheelagh Frame

A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin

scientific journal article

A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation

scientific article

FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A.

scientific article

Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer

scientific article published on 09 July 2020

Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event ⬇️

scientific article published on January 1, 2004

GSK3 takes centre stage more than 20 years after its discovery

scientific article

Phase I evaluation of seliciclib (R-roscovitine), a novel oral cyclin-dependent kinase inhibitor, in patients with advanced malignancies

scientific article published on 6 September 2010

Phosphorylation of the regulatory subunit of smooth muscle protein phosphatase 1M at Thr850 induces its dissociation from myosin

scientific article (publication date: 11 September 2002)

Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1

scientific article

Synergistic inhibition of ErbB signaling by combined treatment with seliciclib and ErbB-targeting agents

scientific article

Targeting glycogen synthase kinase-3 in insulin signalling

scientific article

Targeting the rheumatoid arthritis synovial fibroblast via cyclin dependent kinase inhibition: An early phase trial

scientific article published on 01 June 2020

The renaissance of GSK3

scientific article (publication date: October 2001)

Therapeutic efficacy of seliciclib in combination with ionizing radiation for human nasopharyngeal carcinoma.

scientific article

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