List of works - Linda S. Kaltenbach

A large scale Huntingtin protein interaction network implicates Rho GTPase signaling pathways in Huntington disease

scientific article published on 09 January 2014

Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons

scientific article

Composite primary neuronal high-content screening assay for Huntington's disease incorporating non-cell-autonomous interactions

scientific article

Contribution of the amino and carboxyl termini for PHA-4/FoxA function in Caenorhabditis elegans

scientific article published on 01 October 2005

Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke.

scientific article published on 12 May 2016

Experimental models for identifying modifiers of polyglutamine-induced aggregation and neurodegeneration

scientific article published on July 2013

Huntingtin interacting proteins are genetic modifiers of neurodegeneration

scientific article

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.

scientific article

Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models ⬇️

scientific article published on November 24, 2010

Identification of anti-inflammatory targets for Huntington's disease using a brain slice-based screening assay ⬇️

scientific article published on March 31, 2011

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

scientific article

Perturbation with intrabodies reveals that calpain cleavage is required for degradation of huntingtin exon 1

scientific article

SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models

scientific article published on 9 July 2016

Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models

scientific article published on 14 July 2013

TR-FRET-based duplex immunoassay reveals an inverse correlation of soluble and aggregated mutant huntingtin in huntington's disease

scientific article

Targeting mutant huntingtin for the development of disease-modifying therapy ⬇️

scientific article published on 04 July 2012

List of works by Linda S. Kaltenbach

A large scale Huntingtin protein interaction network implicates Rho GTPase signaling pathways in Huntington disease

Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons

Composite primary neuronal high-content screening assay for Huntington's disease incorporating non-cell-autonomous interactions

Contribution of the amino and carboxyl termini for PHA-4/FoxA function in Caenorhabditis elegans

Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke.

Experimental models for identifying modifiers of polyglutamine-induced aggregation and neurodegeneration

Huntingtin interacting proteins are genetic modifiers of neurodegeneration

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.

Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models ⬇️

Identification of anti-inflammatory targets for Huntington's disease using a brain slice-based screening assay ⬇️

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

Perturbation with intrabodies reveals that calpain cleavage is required for degradation of huntingtin exon 1

SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models

Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models

TR-FRET-based duplex immunoassay reveals an inverse correlation of soluble and aggregated mutant huntingtin in huntington's disease

Targeting mutant huntingtin for the development of disease-modifying therapy ⬇️