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List of works by Donald C. Lo

A new kinetic framework for synaptic vesicle trafficking tested in synapsin knock-outs

scientific article

Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons

scientific article

BDNF mediates neuroprotection against oxygen-glucose deprivation by the cardiac glycoside oleandrin

scientific article published on January 2014

CNTF II, I presume?

scientific article published on 01 September 2000

CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease

scientific article

Composite primary neuronal high-content screening assay for Huntington's disease incorporating non-cell-autonomous interactions

scientific article

Copper-Binding Small Molecule Induces Oxidative Stress and Cell-Cycle Arrest in Glioblastoma-Patient-Derived Cells.

scientific article published on 7 March 2018

Downregulation of NR3A-containing NMDARs is required for synapse maturation and memory consolidation.

scientific article

Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke.

scientific article published on 12 May 2016

Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1.

scientific article published on 16 April 2006

Experimental Models for Identifying Modifiers of Polyglutamine-Induced Aggregation and Neurodegeneration ⬇️

scientific article published on July 1, 2013

Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models

scientific article

Focal Delivery of Neurotrophins into the Central Nervous System Using Fluorescent Latex Microspheres ⬇️

scientific article published on November 1, 1997

High throughput screening for neurodegeneration and complex disease phenotypes

scientific article

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.

scientific article

IKK/NF-κB signaling contributes to glioblastoma stem cell maintenance

scientific article

IKKβ and mutant huntingtin interactions regulate the expression of IL-34: implications for microglial-mediated neurodegeneration in HD.

scientific article published on 14 August 2017

Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models ⬇️

scientific article published on November 24, 2010

Identification of anti-inflammatory targets for Huntington's disease using a brain slice-based screening assay ⬇️

scientific article published on March 31, 2011

Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements.

scientific article published on 20 September 2017

In vitro and in vivo neuroprotective activity of the cardiac glycoside oleandrin from Nerium oleander in brain slice‐based stroke models ⬇️

scientific article published on September 26, 2011

Induction of electrical excitability by NGF requires autocrine action of a CNTF-like factor

scientific article published on 01 September 1999

Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease.

scientific article published on 6 May 2010

Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins

scientific article

Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicity

scientific article published on September 2008

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

scientific article

Limit on the role of activity in controlling the release-ready supply of synaptic vesicles.

scientific article published in November 2002

MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling

scientific article published on 20 February 2020

NT-4-mediated rescue of lateral geniculate neurons from effects of monocular deprivation

scientific article published in Nature

Neuronal transfection in brain slices using particle-mediated gene transfer.

scientific article

Neurotrophin regulation of cortical dendritic growth requires activity

scientific article published in December 1996

Neurotrophin regulation of ionic currents and cell size depends on cell context

scientific article

Neurotrophins Differentially Regulate Voltage-Gated Ion Channels ⬇️

scientific article published on 01 January 1997

Neurotrophins and synaptic plasticity

scientific article

Neurotrophins in cortical development

scientific article published on January 1, 1996

Neurotrophins regulate dendritic growth in developing visual cortex

scientific article published on October 1995

Opposing roles for endogenous BDNF and NT-3 in regulating cortical dendritic growth.

scientific article published in May 1997

Patient-derived glioblastoma cultures as a tool for small-molecule drug discovery

scientific article published on 28 January 2020

Perturbation with intrabodies reveals that calpain cleavage is required for degradation of huntingtin exon 1

scientific article

Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition

scientific article

Regulation of voltage-gated ion channels by NGF and ciliary neurotrophic factor in SK-N-SH neuroblastoma cells

scientific article published on January 1995

SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models

scientific article published on 9 July 2016

Selective inhibitors of death in mutant huntingtin cells

scientific article published on 31 December 2006

Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B

scientific article

Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective

scientific article

Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models

scientific article published on 14 July 2013

TMOD-31. NOVEL HETEROGENEOUS GLIOBLASTOMA MODELS TO OPTIMIZE HUMAN TUMORICIDAL NEURAL STEM CELL THERAPY

TR-FRET-based duplex immunoassay reveals an inverse correlation of soluble and aggregated mutant huntingtin in huntington's disease

scientific article

Targeting mutant huntingtin for the development of disease-modifying therapy ⬇️

scientific article published on 04 July 2012

Tumoricidal stem cell therapy enables killing in novel hybrid models of heterogeneous glioblastoma

scientific article published on 01 December 2019

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