List of works - Sylvie Robine

A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins

scientific article

APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression

scientific article published on 16 August 2006

APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation

scientific article

Apical invasion of intestinal epithelial cells by Salmonella typhimurium requires villin to remodel the brush border actin cytoskeleton

scientific article

Can villin be used to identify malignant and undifferentiated normal digestive epithelial cells?

scientific article published on December 1985

Changes in villin synthesis and subcellular distribution during intestinal differentiation of HT29-18 clones

scientific article

Colorectal cancer specific conditions promote Streptococcus gallolyticus gut colonization.

scientific article published on 26 December 2017

Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut.

scientific article

Conditional expression of fascin increases tumor progression in a mouse model of intestinal cancer

scientific article published on 16 September 2014

Conditional mouse models of cancer

scientific article published on January 2007

Developmental regulation of villin gene expression in the epithelial cell lineages of mouse digestive and urogenital tracts ⬇️

scientific article published on July 1, 1992

Enhanced sensitivity to irinotecan by Cdk1 inhibition in the p53-deficient HT29 human colon cancer cell line

scientific article published on March 2004

Enterocyte loss of polarity and gut wound healing rely upon the F-actin-severing function of villin

scientific article

Epithelial cell growth and differentiation. IV. Controlled spatiotemporal expression of transgenes: new tools to study normal and pathological states.

scientific article published on October 1997

Epithelial morphogenesis and intestinal cancer: new insights in signaling mechanisms

scientific article published on January 2008

Expression patterns of L-plastin isoform in normal and carcinomatous breast tissues

scientific article

Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer

scientific article (publication date: 15 July 2007)

Functional cystic fibrosis transmembrane conductance regulator tagged with an epitope of the vesicular stomatis virus glycoprotein can be addressed to the apical domain of polarized cells

scientific article

Heterogeneous metastasis efficiency of isogenic orthotopic colon cancer xenografts reveals distinctive gene expression profiles

scientific article published on 18 May 2007

Human colorectal tumors and metastases express Gb3 and can be targeted by an intestinal pathogen-based delivery tool

scientific article published on 7 August 2008

I-SceI-Induced Gene Replacement at a Natural Locus in Embryonic Stem Cells ⬇️

scientific article published on March 1, 1998

IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium

scholarly article

Immunocytochemical detection of bone marrow micrometastases in colorectal carcinoma patients, using a monoclonal antibody to villin

scientific article published on 01 October 2001

In vivo absorption of water and electrolytes in mouse intestine. Application to villin -/- mice

scientific article published in April 2002

In vivo tumor targeting using a novel intestinal pathogen-based delivery approach.

scientific article published in July 2006

In vivo, villin is required for Ca(2+)-dependent F-actin disruption in intestinal brush borders

scientific journal article

Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis.

scientific article published in August 2010

Insertion of a Stent in Obstructive Colon Cancer Can Induce a Metastatic Process in an Experimental Murine Model.

scientific article published on 9 May 2015

Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status

scientific article

Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis

scientific article published in Nature Communications

Mathematical Modelling of Molecular Pathways Enabling Tumour Cell Invasion and Migration

scientific article published on 3 November 2015

Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure.

scientific article

Mouse models of K-ras-initiated carcinogenesis

scientific article

Mouse models of K-ras-initiated oncogenesis

scientific article published in December 2009

Network biology elucidates metastatic colon cancer mechanisms

scientific article published in July 2015

Non-apoptotic concentrations of prodigiosin (H+/Cl- symporter) inhibit the acidification of lysosomes and induce cell cycle blockage in colon cancer cells

scientific article published on 29 August 2005

Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine

scientific journal article

Notch signaling in intestinal homeostasis across species: the cases of Drosophila, Zebrafish and the mouse.

scientific article published on 30 June 2011

Notch signals control the fate of immature progenitor cells in the intestine

scientific article published in Nature

Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-β

scientific article

Opposing functions of IKKbeta during acute and chronic intestinal inflammation

scholarly article

PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1

scientific article published on 14 February 2009

Plasticity of the brush border - the yin and yang of intestinal homeostasis

scientific article published on 3 February 2016

Plastin 1 binds to keratin and is required for terminal web assembly in the intestinal epithelium

scientific journal article

Preclinical study of the DNA repair inhibitor Dbait in combination with chemotherapy in colorectal cancer

scientific article

Regulatory sequences of the mouse villin gene that efficiently drive transgenic expression in immature and differentiated epithelial cells of small and large intestines

scientific article published on 01 March 1999

Regulatory sequences on the human villin gene trigger the expression of a reporter gene in a differentiating HT29 intestinal cell line.

scientific article

Shigella flexneri infection is dependent on villin in the mouse intestine and in primary cultures of intestinal epithelial cells

scientific journal article

Structure of the human villin gene

scientific article

Suppression of villin expression by antisense RNA impairs brush border assembly in polarized epithelial intestinal cells

scientific article published on February 1995

Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice

scientific article

The Power of One ⬇️

scientific article published on April 18, 2012

The co-workers of actin filaments: from cell structures to signals

scientific article published in August 2004

The epithelial cell cytoskeleton and intracellular trafficking. III. How is villin involved in the actin cytoskeleton dynamics in intestinal cells?

scientific article

Tissue-specific and inducible Cre-mediated recombination in the gut epithelium

scientific article

Villin enhances hepatocyte growth factor-induced actin cytoskeleton remodeling in epithelial cells

scientific journal article

Villin expression in the visceral endoderm and in the gut anlage during early mouse embryogenesis

scientific article

Villin severing activity enhances actin-based motility in vivo

scientific article

Villin: a cytoskeletal protein and a differentiation marker expressed in some human adenocarcinomas

scientific article published on 01 January 1987

Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells

scientific article

[Notch signals control the fate of immature progenitor cells in the intestine]

scientific article published on 01 August 2005

List of works by Sylvie Robine

A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins

APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression

APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation

Apical invasion of intestinal epithelial cells by Salmonella typhimurium requires villin to remodel the brush border actin cytoskeleton

Can villin be used to identify malignant and undifferentiated normal digestive epithelial cells?

Changes in villin synthesis and subcellular distribution during intestinal differentiation of HT29-18 clones

Colorectal cancer specific conditions promote Streptococcus gallolyticus gut colonization.

Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut.

Conditional expression of fascin increases tumor progression in a mouse model of intestinal cancer

Conditional mouse models of cancer

Developmental regulation of villin gene expression in the epithelial cell lineages of mouse digestive and urogenital tracts ⬇️

Enhanced sensitivity to irinotecan by Cdk1 inhibition in the p53-deficient HT29 human colon cancer cell line

Enterocyte loss of polarity and gut wound healing rely upon the F-actin-severing function of villin

Epithelial cell growth and differentiation. IV. Controlled spatiotemporal expression of transgenes: new tools to study normal and pathological states.

Epithelial morphogenesis and intestinal cancer: new insights in signaling mechanisms

Expression patterns of L-plastin isoform in normal and carcinomatous breast tissues

Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer

Functional cystic fibrosis transmembrane conductance regulator tagged with an epitope of the vesicular stomatis virus glycoprotein can be addressed to the apical domain of polarized cells

Heterogeneous metastasis efficiency of isogenic orthotopic colon cancer xenografts reveals distinctive gene expression profiles

Human colorectal tumors and metastases express Gb3 and can be targeted by an intestinal pathogen-based delivery tool

I-SceI-Induced Gene Replacement at a Natural Locus in Embryonic Stem Cells ⬇️

IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium

Immunocytochemical detection of bone marrow micrometastases in colorectal carcinoma patients, using a monoclonal antibody to villin

In vivo absorption of water and electrolytes in mouse intestine. Application to villin -/- mice

In vivo tumor targeting using a novel intestinal pathogen-based delivery approach.

In vivo, villin is required for Ca(2+)-dependent F-actin disruption in intestinal brush borders

Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis.

Insertion of a Stent in Obstructive Colon Cancer Can Induce a Metastatic Process in an Experimental Murine Model.

Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status

Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis

Mathematical Modelling of Molecular Pathways Enabling Tumour Cell Invasion and Migration

Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure.

Mouse models of K-ras-initiated carcinogenesis

Mouse models of K-ras-initiated oncogenesis

Network biology elucidates metastatic colon cancer mechanisms

Non-apoptotic concentrations of prodigiosin (H+/Cl- symporter) inhibit the acidification of lysosomes and induce cell cycle blockage in colon cancer cells

Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine

Notch signaling in intestinal homeostasis across species: the cases of Drosophila, Zebrafish and the mouse.

Notch signals control the fate of immature progenitor cells in the intestine

Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-β

Opposing functions of IKKbeta during acute and chronic intestinal inflammation

PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1

Plasticity of the brush border - the yin and yang of intestinal homeostasis

Plastin 1 binds to keratin and is required for terminal web assembly in the intestinal epithelium

Preclinical study of the DNA repair inhibitor Dbait in combination with chemotherapy in colorectal cancer

Regulatory sequences of the mouse villin gene that efficiently drive transgenic expression in immature and differentiated epithelial cells of small and large intestines

Regulatory sequences on the human villin gene trigger the expression of a reporter gene in a differentiating HT29 intestinal cell line.

Shigella flexneri infection is dependent on villin in the mouse intestine and in primary cultures of intestinal epithelial cells

Structure of the human villin gene

Suppression of villin expression by antisense RNA impairs brush border assembly in polarized epithelial intestinal cells

Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice

The Power of One ⬇️

The co-workers of actin filaments: from cell structures to signals

The epithelial cell cytoskeleton and intracellular trafficking. III. How is villin involved in the actin cytoskeleton dynamics in intestinal cells?

Tissue-specific and inducible Cre-mediated recombination in the gut epithelium

Villin enhances hepatocyte growth factor-induced actin cytoskeleton remodeling in epithelial cells

Villin expression in the visceral endoderm and in the gut anlage during early mouse embryogenesis

Villin severing activity enhances actin-based motility in vivo

Villin: a cytoskeletal protein and a differentiation marker expressed in some human adenocarcinomas

Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells

[Notch signals control the fate of immature progenitor cells in the intestine]