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List of works by Lesley A McLaughlin

A role for cytochrome b5 in the In vivo disposition of anticancer and cytochrome P450 probe drugs in mice

scientific article published on 10 October 2013

Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability.

scientific article published in February 2015

Cytochrome b5 is a major determinant of human cytochrome P450 CYP2D6 and CYP3A4 activity in vivo.

scientific article published on 5 February 2015

Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model

scientific article published on 11 August 2015

Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5.

scientific article published on 19 September 2008

Deletion of 30 murine cytochrome p450 genes results in viable mice with compromised drug metabolism

scientific article published on 26 March 2014

HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents

scientific article

NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.

scientific article

Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.

scientific article published on June 2004

Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.

scientific article

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