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List of works by George Mutwiri

Administration of poly[di(sodium carboxylatoethylphenoxy)]phosphazene (PCEP) as adjuvant activated mixed Th1/Th2 immune responses in pigs

scientific article

Adoptive transfer of BALb/c mouse splenocytes reduces lesion severity and induces intestinal pathophysiologic changes in the Mycobacterium avium Subspecies paratuberculosis beige/scid mouse model.

scientific article

All three classes of CpG ODNs up-regulate IP-10 gene in pigs

scientific article published on 5 November 2009

Approaches to enhancing immune responses stimulated by CpG oligodeoxynucleotides

scientific article published on 07 January 2009

Attenuated cytokine responses in porcine lymph node cells stimulated with CpG DNA are associated with low frequency of IFNalpha-producing cells and TLR9 mRNA expression.

scientific article

Bovine and ovine blood mononuclear leukocytes differ markedly in innate immune responses induced by Class A and Class B CpG-oligodeoxynucleotide

scientific article published in January 2003

Bovine toll-like receptor 9: a comparative analysis of molecular structure, function and expression.

scientific article

Carrier molecules for use in veterinary vaccines

scientific article published on 07 December 2012

Caspase-1 Dependent IL-1β Secretion and Antigen-Specific T-Cell Activation by the Novel Adjuvant, PCEP.

scientific article published on 26 June 2014

Characterization of bovine Toll-like receptor 8: ligand specificity, signaling essential sites and dimerization

scientific article

Chicken TLR21 acts as a functional homologue to mammalian TLR9 in the recognition of CpG oligodeoxynucleotides

scientific article

Co-administration of polyphosphazenes with CpG oligodeoxynucleotides strongly enhances immune responses in mice immunized with Hepatitis B virus surface antigen

scientific article published on 3 April 2008

Co-stimulation with TLR7/8 and TLR9 agonists induce down-regulation of innate immune responses in sheep blood mononuclear and B cells

scientific article published on 7 January 2010

Combination adjuvants: the next generation of adjuvants? ⬇️

scientific article published on January 1, 2011

Corrigendum to "Zika Virus Causes Persistent Infection in Porcine Conceptuses and May Impair Health in Offspring".

scientific article published on 21 October 2017

CpG oligodeoxynucleotide induction of antiviral effector molecules in sheep

scientific article published in January 2004

CpG oligodeoxynucleotides activate innate immune response that suppresses infectious bronchitis virus replication in chicken embryos

scientific article

CpG-ODNs induced changes in cytokine/chemokines genes expression associated with suppression of infectious bronchitis virus replication in chicken lungs

scientific article published on 21 May 2014

Efficacy of poly[di(sodium carboxylatophenoxy)phosphazene] (PCPP) as mucosal adjuvant to induce protective immunity against respiratory pathogens

scientific article

Elastase-dependent live attenuated swine influenza A viruses are immunogenic and confer protection against swine influenza A virus infection in pigs

scientific article published on 22 July 2009

Enhancement of immunoprotective effect of CpG-ODN by formulation with polyphosphazenes against E. coli septicemia in neonatal chickens

scientific article published on January 2009

Failure of a VapA/CpG oligodeoxynucleotide vaccine to protect foals against experimental Rhocococcus equi pneumonia despite induction of VapA-specific antibody and interferon-γ response

scientific article published on July 2013

Identification of RNA sequence motifs stimulating sequence-specific TLR8-dependent immune responses

scientific article

Immune mechanisms and therapeutic potential of CpG oligodeoxynucleotides

scientific article published on May 2006

Immunization with PCEP microparticles containing pertussis toxoid, CpG ODN and a synthetic innate defense regulator peptide induces protective immunity against pertussis

scientific article published on 21 July 2011

Immunogenicity and protective efficacy of an elastase-dependent live attenuated swine influenza virus vaccine administered intranasally in pigs

scientific article published on 12 August 2010

Immunogenicity of a receptor-binding domain of SARS coronavirus spike protein in mice: implications for a subunit vaccine

scientific article published on 02 August 2006

Innate immune responses induced by CpG oligodeoxyribonucleotide stimulation of ovine blood mononuclear cells ⬇️

scientific article published on 01 October 2003

Innate immune responses induced by classes of CpG oligodeoxynucleotides in ovine lymph node and blood mononuclear cells

scientific article published on 26 September 2006

Intradermal immunization using coated microneedles containing an immunoadjuvant

scientific article published on June 2012

Intranasal immunization of mice with a formalin-inactivated bovine respiratory syncytial virus vaccine co-formulated with CpG oligodeoxynucleotides and polyphosphazenes results in enhanced protection

scientific article published in January 2008

Mechanisms of action of adjuvants

scientific article published on 16 May 2013

Microparticles for oral delivery of vaccines

scientific article

Modulation of B cell responses by Toll-like receptors.

scientific article published on 08 September 2010

Mucosal delivery of vaccines in domestic animals

scientific article

Multiple molecular regions confer intracellular localization of bovine Toll-like receptor 8

scientific article published on 18 November 2008

Nucleic acids exert a sequence-independent cooperative effect on sequence-dependent activation of Toll-like receptor 9.

scientific article published on 13 March 2007

Oral antigen exposure in newborn piglets circumvents induction of oral tolerance in response to intraperitoneal vaccination in later life.

scientific article

PCEP enhances IgA mucosal immune responses in mice following different immunization routes with influenza virus antigens ⬇️

scientific article published on August 24, 2010

PCPP (poly[di(carboxylatophenoxy)-phosphazene]) microparticles co-encapsulating ovalbumin and CpG oligo-deoxynucleotides are potent enhancers of antigen specific Th1 immune responses in mice

scientific article published on 29 October 2010

Pathotypic and molecular characterization of a fowl adenovirus associated with inclusion body hepatitis in Saskatchewan chickens

scientific article published in March 2012

Poly[di(carboxylatophenoxy)phosphazene] is a potent adjuvant for intradermal immunization.

scientific article published on 28 October 2009

Porcine TLR8 and TLR7 are both activated by a selective TLR7 ligand, imiquimod

scientific article published on 24 April 2008

Protein-prime/modified vaccinia virus Ankara vector-boost vaccination overcomes tolerance in high-antigenemic HBV-transgenic mice

scientific article

Stimulation of innate immune responses by CpG oligodeoxynucleotide in newborn lambs can reduce bovine herpesvirus-1 shedding

scientific article published on 01 January 2006

Strategies for enhancing the immunostimulatory effects of CpG oligodeoxynucleotides

scientific article published on May 2004

Strategies to link innate and adaptive immunity when designing vaccine adjuvants

scientific article

Subcutaneous, but not intratracheal administration of the TLR9 agonist, CpG DNA transiently reduces parainfluenza-3 virus shedding in newborn lambs

scientific article published on 8 July 2010

Systemic innate immune responses following intrapulmonary delivery of CpG oligodeoxynucleotides in sheep

scientific article published on 01 December 2006

TLR9 agonists: immune mechanisms and therapeutic potential in domestic animals

scientific article published on 06 June 2011

The adjuvant PCEP induces recruitment of myeloid and lymphoid cells at the injection site and draining lymph node

scientific article published on 21 March 2014

The potential of polyphosphazenes for delivery of vaccine antigens and immunotherapeutic agents

scientific article published on January 2010

The recombinant globular head domain of the measles virus hemagglutinin protein as a subunit vaccine against measles

scientific article

Vaccine Potentiation by Combination Adjuvants ⬇️

scientific article published on 14 April 2014

Zika Virus Causes Persistent Infection in Porcine Conceptuses and may Impair Health in Offspring

scientific article published on 21 September 2017

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