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List of works by Fionula Brennan

A novel mechanism for TNF-alpha regulation by p38 MAPK: involvement of NF-kappa B with implications for therapy in rheumatoid arthritis

scientific article

A novel upstream enhancer of FOXP3, sensitive to methylation-induced silencing, exhibits dysregulated methylation in rheumatoid arthritis Treg cells.

scientific article published on 18 August 2014

Activation of p38 mitogen-activated protein kinase is critical step for acquisition of effector function in cytokine-activated T cells, but acts as a negative regulator in T cells activated through the T-cell receptor ⬇️

scientific article published on September 28, 2010

Anti-TNF therapy: where have we got to in 2005?

scientific article

Anti-TNFalpha therapy of rheumatoid arthritis: what can we learn about chronic disease?

scientific article published on January 2004

Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis

scientific article published on 2 June 2010

Bruton's tyrosine kinase is required for TLR2 and TLR4-induced TNF, but not IL-6, production

scientific article published in March 2006

Bruton's tyrosine kinase is required for lipopolysaccharide-induced tumor necrosis factor alpha production

scientific article

Conventional protein kinase C and atypical protein kinase Czeta differentially regulate macrophage production of tumour necrosis factor-alpha and interleukin-10.

scientific article published in May 2004

Could toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue

scientific article published on November 2007

Cytokine regulation in RA synovial tissue: role of T cell/macrophage contact-dependent interactions

scientific article

Cytokine-stimulated T cells induce macrophage IL-10 production dependent on phosphatidylinositol 3-kinase and p70S6K: implications for rheumatoid arthritis

scientific article

Cytokines and anti-cytokine biologicals in autoimmunity: present and future

scientific article

Design and optimisation of bioactive cyclic peptides: generation of a down-regulator of TNF secretion.

scientific article published on 22 December 2014

Evidence that cytokines play a role in rheumatoid arthritis

scientific article

Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis

scientific article published in January 2002

Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors

scientific article published in March 2010

Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy

scholarly article by Evangelos Andreakos et al published July 2003 in Arthritis and Rheumatism

High-efficiency gene transfer into nontransformed cells: utility for studying gene regulation and analysis of potential therapeutic targets.

scientific article

Identification and characterization of 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide (TMI-1), a novel dual tumor necrosis factor-alpha-converting enzyme/matrix metalloprotease inhibitor for the treatment o

scientific article

Ikappa B kinase 2 but not NF-kappa B-inducing kinase is essential for effective DC antigen presentation in the allogeneic mixed lymphocyte reaction

scholarly article by E. Andreakos et al published 19 September 2002 in Blood

Impact of VIP and cAMP on the regulation of TNF-alpha and IL-10 production: implications for rheumatoid arthritis

scientific article

In memoriam: Professor Brian Maurice John Foxwell, 1956 to 2008.

scientific article published on 27 February 2009

Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures

scientific article published on December 2008

Interleukin-10 regulates TNF-alpha-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism

scientific article

Invasive potential of human rheumatoid tenosynovial cells is in part MT1-MMP dependent.

scientific article published on 12 July 2009

Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis

scientific article published on 08 October 2009

Methotrexate Restores Regulatory T Cell Function Through Demethylation of the FoxP3 Upstream Enhancer in Patients With Rheumatoid Arthritis.

scientific article published in May 2015

Molecular profile of peripheral blood mononuclear cells from patients with rheumatoid arthritis

scientific article

Nonsteroidal anti-inflammatory drugs increase TNF production in rheumatoid synovial membrane cultures and whole blood

scientific article published on 16 August 2010

Oligodeoxynucleotide inhibition of Toll-like receptors 3, 7, 8, and 9 suppresses cytokine production in a human rheumatoid arthritis model

scientific article published on 16 December 2015

Production of TNF-α in macrophages activated by T cells, compared with lipopolysaccharide, uses distinct IL-10-dependent regulatory mechanism

scientific article published on 4 January 2012

Rac mediates TNF-induced cytokine production via modulation of NF-kappaB.

scientific article published on 06 February 2008

Recent developments in the immunobiology of rheumatoid arthritis

scientific article published on 14 March 2008

Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopic foxp3 expression in pathogenic synovial T cells ⬇️

scientific article published on September 16, 2011

Resting CD4+ effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function.

scientific article published on 19 March 2008

Selective Blockade of Tumor Necrosis Factor Receptor I Inhibits Proinflammatory Cytokine and Chemokine Production in Human Rheumatoid Arthritis Synovial Membrane Cell Cultures ⬇️

scientific article published on September 1, 2013

Simplified production and concentration of lentiviral vectors to achieve high transduction in primary human T cells

scientific article

T-cell contact-dependent regulation of CC and CXC chemokine production in monocytes through differential involvement of NFkappaB: implications for rheumatoid arthritis

scientific article published on January 2006

TCRzetadim lymphocytes define populations of circulating effector cells that migrate to inflamed tissues

scientific article published on 25 January 2007

The Role of TNFα in the Pathogenesis of Rheumatoid Synovitis.

scientific article published on 15 November 1999

The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis

scientific article published on February 2007

The role of Natural Killer cells in the pathogenesis of rheumatoid arthritis: Major contributors or essential homeostatic modulators? ⬇️

scientific article published on November 10, 2010

The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis

scientific article published on February 2004

Treg cell function in rheumatoid arthritis is compromised by ctla-4 promoter methylation resulting in a failure to activate the indoleamine 2,3-dioxygenase pathway.

scientific article published in September 2014

Update on cytokines in rheumatoid arthritis

scientific article published on May 2007

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