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List of works by Gregory L. Kearns

A Multicenter, Randomized, Open-Label, Pharmacokinetics and Safety Study of Pantoprazole Tablets in Children and Adolescents Aged 6 Through 16 Years With Gastroesophageal Reflux Disease ⬇️

scientific article published on September 17, 2010

A Population-Based Pharmacokinetic Model Approach to Pantoprazole Dosing for Obese Children and Adolescents

scientific article published on 01 October 2018

Absence of Effect of Terbinafine on the Activity of CYP1A2, NAT‐2, and Xanthine Oxidase ⬇️

scientific article published on May 1, 1998

Absence of a pharmacokinetic interaction between chloramphenicol and acetaminophen in children

scientific article published on July 1985

Acetaminophen intoxication during treatment: what you don't know can hurt you.

scientific article

Acetaminophen overdose with therapeutic intent ⬇️

scientific article published on 01 January 1998

Acetaminophen-associated hepatic injury: evaluation of acetaminophen protein adducts in children and adolescents with acetaminophen overdose

scientific article

Activities of cytochrome P450 1A2, N-acetyltransferase 2, xanthine oxidase, and cytochrome P450 2D6 are unaltered in children with cystic fibrosis

scientific article published in March 2004

Adverse events associated with meropenem versus imipenem/cilastatin therapy in a large retrospective cohort of hospitalized infants

scientific article

Age-Related Differences in Digoxin Toxicity and its Treatment

scientific article published on March 1, 1992

Amikacin dosing in neonates: evaluation of a dosing chart based on population pharmacokinetic data

scientific article

An update on the oxazolidinone antibiotics

scientific article

Appearance of ranitidine in breast milk following multiple dosing

scientific article published in May 1985

Assessment of histamine pharmacodynamics by microvasculature response of histamine using histamine iontophoresis laser Doppler flowimetry

scientific article

Biotransformation of fluticasone: in vitro characterization.

scientific article

Cefotaxime and desacetylcefotaxime in neonates and children: a review of microbiologic, pharmacokinetic, and clinical experience

scientific article published on January 1989

Cefotaxime and desacetylcefotaxime pharmacokinetics in infants and children with meningitis

scientific article published on December 1985

Cefotaxime and desacetylcefotaxime pharmacokinetics in very low birth weight neonates

scientific article published in March 1989

Cefotaxime pharmacokinetics and treatment of meningitis in neonates

scientific article published on 01 September 1989

Cefpodoxime pharmacokinetics in children: effect of food

scientific article published on September 1998

Cerebrospinal fluid penetration of imipenem and cilastatin (primaxin) in children with central nervous system infections

scientific article published on April 1986

Characterization of delayed liquid gastric emptying in children by the 13 C-acetate breath test

scientific article published on November 27, 2009

Cisapride disposition in neonates and infants: in vivo reflection of cytochrome P450 3A4 ontogeny

scientific article published on October 1, 2003

Cisapride: a potential model substrate to assess cytochrome P4503A4 activity in vivo

scientific article published on March 2003

Clinical efficacy and pharmacokinetics of montelukast in dyspeptic children with duodenal eosinophilia

scientific article published in March 2004

Clinical pharmacology: a discipline called to action for maternal and child health

scientific article published on 01 April 2007

Cocaine: clinical pharmacology and toxicology

scientific article published on November 1989

Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail".

scientific article published in October 2000

Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail".

scientific article published in November 2003

Comparative bioavailability of loracarbef chewable tablet vs. oral suspension in children

scientific article published on 01 December 1998

Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity

scientific article

Comparison of the pharmacokinetics of naproxen tablets and suspension in children

scientific article published on January 1994

Concordance between tramadol and dextromethorphan parent/metabolite ratios: the influence of CYP2D6 and non-CYP2D6 pathways on biotransformation

scientific article published in January 2002

Considerations in the rational design and conduct of phase I/II pediatric clinical trials: avoiding the problems and pitfalls

scientific article published on 28 February 2007

Contraceptive Provision to Adolescent Females Prescribed Teratogenic Medications.

scientific article published on 16 December 2015

Correlation of MCP1 with toxicity in acetaminophen overdose

scientific article

Cromolyn sodium decreases the pulmonary vascular response to alveolar hypoxia in lambs

scientific article published in September 1986

Cyclic Antidepressant Toxicity in Children and Adolescents ⬇️

scientific article published on 01 April 1995

Cytochrome P450 3A: ontogeny and drug disposition

scientific article

Cytochrome P450 Involvement in the biotransformation of cisapride and racemic norcisapride in vitro: differential activity of individual human CYP3A isoforms ⬇️

scientific article published on December 1, 2001

Cytokines and toxicity in acetaminophen overdose

scientific article

Decreased Pregnane X Receptor Expression in Children with Active Crohn's Disease

scientific article

Determination of Menthol in Plasma and Urine by Gas Chromatography/Mass Spectrometry (GC/MS)

scientific article published on 01 January 2016

Determining population and developmental pharmacokinetics of metronidazole using plasma and dried blood spot samples from premature infants

scientific article

Developmental Changes in Pharmacokinetics and Pharmacodynamics

scientific article published on 01 October 2018

Dose dependency of dextromethorphan for cytochrome P450 2D6 (CYP2D6) phenotyping

scientific article published on 01 November 1999

Dosing implications of altered gentamicin disposition in patients with cystic fibrosis

scientific article published on 01 February 1982

Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail

scientific article

Effect of diet on the development of drug metabolism by cytochrome P-450 enzymes in healthy infants

scientific article published on 25 October 2006

Effect of fluvoxamine therapy on the activities of CYP1A2, CYP2D6, and CYP3A as determined by phenotyping*

scientific article published on September 1, 1998

Efficacy, disposition and pharmacodynamics of aspirin, acetaminophen and choline salicylate in young febrile children

scientific article

Elevation of serum interleukin 8 levels in acetaminophen overdose in children and adolescents

scientific article

Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults

scientific article published on 12 March 2019

Evaluation of occult acetaminophen hepatotoxicity in hospitalized children receiving acetaminophen. Pediatric Pharmacology Research Unit Network

scientific article

Famotidine disposition in children and adolescents with chronic renal insufficiency

scientific article

Gentamicin disposition and effect on development of renal function in the very low birth weight infant.

scientific article

Gentamicin disposition in children with chronic renal failure.

scientific article published on January 1982

Gentamicin disposition in patients with cystic fibrosis: erratum

scientific article published on 01 May 1984

Gentamicin pharmacokinetics in cystic fibrosis

scientific article published in August 1987

Glucuronidation in humans. Pharmacogenetic and developmental aspects

scientific article

Granzyme B and miR-378a Interaction in Acetaminophen Toxicity in Children

scientific article published on 01 January 2020

How to Conduct Clinical Trials in Children: A Tutorial

Hydroxycarbamide in children with sickle cell anaemia after first-dose vs. chronic therapy: pharmacokinetics and predictive models for drug exposure.

scientific article published on 8 September 2017

Impact of ontogeny on linezolid disposition in neonates and infants

scientific article published in November 2003

Impact of the CYP2C19*17 allele on the pharmacokinetics of omeprazole and pantoprazole in children: evidence for a differential effect

scientific article

Innovative clinical trial design for pediatric therapeutics

scientific article

Interpreting Pharmacogenetic Data in the Developing Neonate: The Challenge of Hitting a Moving Target

scientific article published on September 5, 2012

Introduction to pharmacokinetics: aminoglycosides in cystic fibrosis as a prototype

scientific article published on 01 May 1986

Investigation of terbinafine as a CYP2D6 inhibitor in vivo.

scientific article

Isotope-dilution gas chromatography-mass spectrometry method for the analysis of hydroxyurea

scientific article published on 01 June 2015

Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity

scientific article published on 26 September 2018

Levofloxacin pharmacokinetics in children

scientific article published in February 2005

Limitations of dextromethorphan N-demethylation as a measure of CYP3A activity

scientific article published on 01 August 1999

Measurement of acetaminophen-protein adducts in children and adolescents with acetaminophen overdoses. .

scientific article

Measurement of bumetanide in plasma and urine by high-performance liquid chromatography and application to bumetanide disposition ⬇️

scientific article published on September 18, 1991

Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation

scientific article published on 15 July 2016

Microanalytical high-performance liquid chromatographic assay for cefpirome in human milk and urine ⬇️

scientific article published on February 14, 1992

Microanalytical high-performance liquid chromatography assay for cefpirome (HR 810) in serum

scientific article

Montelukast in the treatment of duodenal eosinophilia in children with dyspepsia: effect on eosinophil density and activation in relation to pharmacokinetics

scientific article

Nifedipine poisoning in a child

scientific article

Obese Children Require Lower Doses of Pantoprazole Than Nonobese Peers to Achieve Equal Systemic Drug Exposures

scientific article published in February 2018

Omeprazole disposition in children following single-dose administration

scientific article published in August 2003

Ontogeny of dextromethorphan O- and N-demethylation in the first year of life

scientific article

Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data

scientific article published in December 1999

Pediatric pharmacodynamics of midazolam oral syrup. Pediatric Pharmacology Research Unit Network

scientific article published in June 2000

Peppermint oil effects on the gut microbiome in children with functional abdominal pain

scientific article published on 20 January 2022

Pharmacokinetics and Pharmacodynamics of Ranitidine in Neonates Treated with Extracorporeal Membrane Oxygenation ⬇️

scientific article published on 01 May 1998

Pharmacokinetics and metabolism of intravenous midazolam in preterm infants

scientific article published in December 2001

Pharmacokinetics and pharmacodynamics of bumetanide in critically ill pediatric patients

scientific article published on November 1998

Pharmacokinetics and pharmacodynamics of bumetanide in neonates treated with extracorporeal membrane oxygenation

scientific article published on 01 December 1992

Pharmacokinetics and pharmacodynamics of famotidine in children

scientific article published on 01 January 1996

Pharmacokinetics and pharmacodynamics of famotidine in infants

scientific article published on 01 December 1998

Pharmacokinetics and pharmacodynamics of famotidine in paediatric patients

scientific article published on August 1996

Pharmacokinetics and tolerability of single-dose intravenous ertapenem in infants, children, and adolescents

scientific article

Pharmacokinetics for pediatric nurses

scientific article published on 01 July 1984

Pharmacokinetics of Metoclopramide in Neonates ⬇️

scientific article published on February 1, 1998

Pharmacokinetics of an elevated dosage of micafungin in premature neonates

scientific article

Pharmacokinetics of famotidine in infants

scientific article published in January 2005

Pharmacokinetics of gatifloxacin in infants and children

scientific article

Pharmacokinetics of high dose thiotepa in children undergoing autologous bone marrow transplantation

scientific article published on August 1, 1992

Pharmacokinetics of intravenously administered azithromycin in pediatric patients.

scientific article published on January 2005

Pharmacokinetics of rifapentine in children

scientific article published on May 2006

Pharmacokinetics of two 6-mercaptopurine liquid formulations in children with acute lymphoblastic leukemia

scientific article

Population Pharmacokinetics of Meropenem in Plasma and Cerebrospinal Fluid of Infants With Suspected or Complicated Intra-abdominal Infections ⬇️

scientific article published on October 1, 2011

Population pharmacokinetic model for gatifloxacin in pediatric patients

scientific article published on 12 January 2007

Population pharmacokinetics of hydroxyurea for children and adolescents with sickle cell disease

scientific article published on 11 April 2014

Potent inhibition of cytochrome P-450 2D6-mediated dextromethorphan O-demethylation by terbinafine

scientific article published on 01 July 1999

Practical use of theophylline in children with asthma

scientific article published on 01 September 1984

Proton pump inhibitors in pediatrics : mechanism of action, pharmacokinetics, pharmacogenetics, and pharmacodynamics

scientific article published on April 2013

Pulmonary vascular response to aerosolized cromolyn sodium and repeated epochs of isocapneic alveolar hypoxia in lambs.

scientific article

Quantitation of three-month intraindividual variability and influence of sex and menstrual cycle phase on CYP1A2, N-acetyltransferase-2, and xanthine oxidase activity determined with caffeine phenotyping*

scientific article published on May 1, 1998

Rapid estimation of serum theophylline clearance in children with acute asthma

scientific article published on 01 January 1984

Renal clearance of imipenem in children

scientific article published on 01 October 1984

Renal handling of beta 2-microglobulin in patients with cystic fibrosis

scientific article published on 01 December 1989

Reply

scientific article published on 18 April 2018

Rifapentine Pharmacokinetics and Tolerability in Children and Adults Treated Once Weekly With Rifapentine and Isoniazid for Latent Tuberculosis Infection

scientific article published on 16 January 2014

Safety and Effectiveness of Meropenem in Infants With Suspected or Complicated Intra-abdominal Infections ⬇️

scientific article published on September 5, 2012

Sequential, single-dose pharmacokinetic evaluation of meropenem in hospitalized infants and children

scientific article

Single dose pharmacokinetics of linezolid in infants and children

scientific article published in December 2000

Single dose pharmacokinetics of pleconaril in neonates. Pediatric Pharmacology Research Unit Network

scientific article published on September 2000

Single oral dose escalation pharmacokinetics of pleconaril (VP 63843) capsules in adults.

scientific article

Single-Dose Pharmacokinetics of a Pleconaril (VP63843) Oral Solution and Effect of Food ⬇️

scientific article published on October 1, 1998

Single-dose pharmacokinetics and safety of HA-1A, a human IgM anti-lipid-A monoclonal antibody, in pediatric patients with sepsis syndrome

scientific article published in June 1993

Single-dose pharmacokinetics of a pleconaril (VP63843) oral solution in children and adolescents. Pediatric Pharmacology Research Unit Network

scientific article

Single-dose pharmacokinetics of ceftibuten (SCH 39720) in infants and children ⬇️

scientific article published on October 1, 1991

Single-dose pharmacokinetics of daptomycin in children with suspected or proved gram-positive infections.

scientific article published in April 2008

Single-dose pharmacokinetics of imipenem in children

scientific article published on December 1984

Single-dose pharmacokinetics of intravenous itraconazole and hydroxypropyl-beta-cyclodextrin in infants, children, and adolescents

scientific article published on 21 May 2007

Single-dose pharmacokinetics of nizatidine (Axid) in children

scientific article published in October 2002

Single-dose pharmacokinetics of oral and intravenous pantoprazole in children and adolescents

scientific article

Single-dose pharmacokinetics of roflumilast in children and adolescents

scientific article published on 28 May 2008

Single-dose, placebo-controlled comparative study of ibuprofen and acetaminophen antipyresis in children

scientific article published on November 1991

Six-month, prospective, longitudinal, open-label caffeine and dextromethorphan phenotyping study in children with growth hormone deficiency receiving recombinant human growth hormone replacement

scientific article published on September 2008

Systemic exposure to menthol following administration of peppermint oil to paediatric patients

scientific article

Targeted liquid chromatography-mass spectrometry analysis of serum acylcarnitines in acetaminophen toxicity in children

scientific article

Targeted metabolomic profiling indicates structure-based perturbations in serum phospholipids in children with acetaminophen overdose

scientific article published on 23 August 2016

The Need for Pediatric Drug Development.

scientific article published on 21 September 2017

The beta-lactamase inhibitors: clinical pharmacology and rational application to combination antibiotic therapy

scientific article published on 01 December 1998

The bioequivalence of nizatidine (Axid) in two extemporaneously and one commercially prepared oral liquid formulations compared with capsule

scientific article

The pharmacokinetics and safety of micafungin, a novel echinocandin, in premature infants

scientific article published on December 2006

The pharmacokinetics of continuous infusion pralidoxime in children with organophosphate poisoning.

scientific article

The role of human cytochrome P450 enzymes in the formation of 2-hydroxymetronidazole: CYP2A6 is the high affinity (low Km) catalyst

scientific article published on 27 June 2013

The single-dose pharmacokinetics of midazolam and its primary metabolite in pediatric patients after oral and intravenous administration

scientific article published in December 2001

The use of glucagon in nifedipine poisoning complicated by clonidine ingestion ⬇️

scientific article published on 01 December 1997

Ticarcillin/clavulanic acid pharmacokinetics in children and young adults with cystic fibrosis

scientific article published on 01 June 1985

Treatment of neonatal hypertension with enalaprilat

scientific article published on October 1990

Understanding the relative roles of pharmacogenetics and ontogeny in pediatric drug development and regulatory science

scientific article published on 11 February 2010

Use of continuous infusion of pralidoxime for treatment of organophosphate poisoning in children

scientific article published in April 1990

Variability of histamine pharmacodynamic response in children with allergic rhinitis.

scientific article

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