List of works - Osamu Matsubara

A proposal for diagnostically meaningful criteria to classify increased epidermal growth factor receptor and c-erbB-2 gene copy numbers in gastric carcinoma, based on correlation of fluorescence in situ hybridization and immunohistochemical measurem

scientific article published on 28 July 2004

A simple immunohistochemical panel comprising 2 conventional markers, Ki67 and p53, is a powerful tool for predicting patient outcome in luminal-type breast cancer

scientific article

ACTN4 gene amplification and actinin-4 protein overexpression drive tumour development and histological progression in a high-grade subset of ovarian clear-cell adenocarcinomas

scientific article published on 20 February 2012

Aberrant expression of p27(Kip1)-interacting cell-cycle regulatory proteins in ovarian clear cell carcinomas and their precursors with special consideration of two distinct multistage clear cell carcinogenetic pathways.

scientific article published on 24 October 2009

Aberrant expression of the mammalian target of rapamycin, hypoxia-inducible factor-1α, and glucose transporter 1 in the development of ovarian clear-cell adenocarcinoma.

scientific article

Abstract 318: Hierarchical clustering analysis of array CGH data identifies clinicopathologically distinct groups of lymph-node-negative invasive breast cancer

scientific article published in 2011

Accumulative copy number increase of MET drives tumor development and histological progression in a subset of ovarian clear-cell adenocarcinomas.

scientific article published on 7 October 2011

Actinin-4 expression in ovarian cancer: a novel prognostic indicator independent of clinical stage and histological type

scientific article published on 14 September 2007

Actinin-4 gene amplification in ovarian cancer: a candidate oncogene associated with poor patient prognosis and tumor chemoresistance

scientific article published on 16 January 2009

Activation of Galectin-1 gene in human hepatocellular carcinoma involves methylation-sensitive complex formations at the transcriptional upstream and downstream elements

scientific article published on December 1, 2003

Activation of a system A amino acid transporter, ATA1/SLC38A1, in human hepatocellular carcinoma and preneoplastic liver tissues.

scientific article

Allelotyping analysis suggesting a consecutive progression from intratubular germ cell neoplasia to seminoma and then to embryonal carcinoma of the adult testis

scientific article

Altered expression of p27(Kip1) -interacting cell-cycle regulators in the adult testicular germ cell tumors: potential role in tumor development and histological progression.

scientific article published on 24 May 2012

Alternative tyrosine phosphorylation of signaling kinases according to hormone receptor status in breast cancer overexpressing the insulin-like growth factor receptor type 1

scientific article published on 01 July 2006

An Inter-subunit Disulfide Bond Affects Affinity of Human Lung Extracellular Superoxide Dismutase to Heparin ⬇️

scientific article published on 01 August 2003

An allelotype analysis indicating the presence of two distinct ovarian clear-cell carcinogenic pathways: endometriosis-associated pathway vs. clear-cell adenofibroma-associated pathway

scientific article published on 5 August 2009

Analysis of sentinel node involvement in gastric cancer

scientific article published on 13 July 2007

Array comparative genomic hybridization analysis discloses chromosome copy number alterations as indicators of patient outcome in lymph node-negative breast cancer.

scientific article

Clear cell adenocarcinoma associated with clear cell adenofibromatous components: a subgroup of ovarian clear cell adenocarcinoma with distinct clinicopathologic characteristics

scientific article published on 01 July 2007

Clear cell adenocarcinoma with a component of poorly differentiated histology: a poor prognostic subgroup of ovarian clear cell adenocarcinoma

scientific article

Clinical implications of occult metastases and isolated tumor cells in sentinel and non-sentinel lymph nodes in early breast cancer patients: serial step section analysis with long-term follow-up

scientific article published on 12 October 2011

Clinical significance of DJ-1 as a secretory molecule: retrospective study of DJ-1 expression at mRNA and protein levels in ductal carcinoma of the breast

scientific article published on 02 March 2012

Clinico-pathological analysis referring hemeoxygenase-1 in acute fibrinous and organizing pneumonia patients

scientific article

Clinicopathological significance of WT1 expression in ovarian cancer: a possible accelerator of tumor progression in serous adenocarcinoma

scientific article published on 27 June 2007

Clinicopathological significance of cervical adenocarcinoma associated with lobular endocervical glandular hyperplasia.

scientific article published on 23 January 2009

Combined hepatocellular carcinoma and cholangiocarcinoma with components of mucinous carcinoma arising in a cirrhotic liver

scientific article published on 01 April 2006

Community-acquired lobar pneumonia caused by Pseudomonas aeruginosa infection in Japan: a case report with histological and immunohistochemical examination.

scientific article published in May 2014

Correlation of KIT and EGFR overexpression with invasive ductal breast carcinoma of the solid-tubular subtype, nuclear grade 3, and mesenchymal or myoepithelial differentiation

scientific article published on 01 January 2005

Cumulative alterations of p27-related cell-cycle regulators in the development of endometriosis-associated ovarian clear cell adenocarcinoma.

scientific article published in May 2010

DJ-1 protein expression as a predictor of pathological complete remission after neoadjuvant chemotherapy in breast cancer patients

scientific article published on 17 April 2013

Deficiency of interleukin-1 receptor antagonist deteriorates fatty liver and cholesterol metabolism in hypercholesterolemic mice

scientific article published in December 2004

Deficiency of interleukin-1 receptor antagonist promotes spontaneous femoral artery aneurysm formation in mice

scientific article published on 11 January 2012

Different expression patterns of KIT, EGFR, and HER‐2 (c‐erbB‐2) oncoproteins between epithelial and mesenchymal components in uterine carcinosarcoma ⬇️

scientific article published on 01 November 2003

Differential prognostic significance of morphologic invasive markers in colorectal cancer: tumor budding and cytoplasmic podia

scientific article

Epidermal growth factor-dependent enhancement of invasiveness of squamous cell carcinoma of the breast.

scientific article

Esophageal pleomorphic giant cell carcinoma combined with small cell carcinoma

scientific article published on 01 August 2007

Expression and clinical significance of connective tissue growth factor in advanced head and neck squamous cell cancer

scientific article published on 04 April 2014

Expression of KIT, EGFR, HER-2 and tyrosine phosphorylation in undifferentiated thyroid carcinoma: implication for a new therapeutic approach

scientific article published on December 2005

Expression of platelet-derived growth factors and their receptors in ovarian clear-cell carcinoma and its putative precursors

scientific article published on 14 December 2007

Expression pattern of stromal cell-derived factor-1 chemokine in invasive breast cancer is correlated with estrogen receptor status and patient prognosis

scientific article

Factors associated with steroid phobia in caregivers of children with atopic dermatitis

scientific article published on 2 July 2012

Fatty acid synthase overexpression in adult testicular germ cell tumors: potential role in the progression of non-seminomatous germ cell tumors.

scientific article published on 14 December 2013

Frequent KIT and epidermal growth factor receptor overexpressions in undifferentiated-type breast carcinomas with 'stem-cell-like' features

scientific article published in June 2005

Gene amplification and protein overexpression of MET are common events in ovarian clear-cell adenocarcinoma: their roles in tumor progression and prognostication of the patient

scientific article published on 08 April 2011

Gene expression signatures that can discriminate oral leukoplakia subtypes and squamous cell carcinoma

scientific article published on 18 September 2006

Hemophagocytic syndrome associated with clostridial infection in a pancreatic carcinoma patient

scientific article published on January 2004

High levels of DJ-1 protein and isoelectric point 6.3 isoform in sera of breast cancer patients

scientific article published on 6 May 2015

High levels of DJ-1 protein in nipple fluid of patients with breast cancer

scientific article published on 4 April 2012

High-level Skp2 expression in pancreatic ductal adenocarcinoma: correlation with the extent of lymph node metastasis, higher histological grade, and poorer patient outcome

scientific article published in May 2006

Histological differences between invasive ductal carcinoma with a large central acellular zone and matrix-producing carcinoma of the breast

scientific article published on June 2009

Histological grading of ovarian clear cell adenocarcinoma: proposal for a simple and reproducible grouping system based on tumor growth architecture.

scientific article published in March 2012

Immunohistochemical detection of hepatocyte nuclear factor 1beta in ovarian and endometrial clear-cell adenocarcinomas and nonneoplastic endometrium

scientific article published on 18 April 2007

IκBNS regulates interleukin-6 production and inhibits neointimal formation after vascular injury in mice

scientific article published on 01 December 2011

Loss of ARID1A protein expression occurs as an early event in ovarian clear-cell carcinoma development and frequently coexists with PIK3CA mutations.

scientific article published on 9 December 2011

Massive intra-abdominal undifferentiated carcinoma derived from an endometrioid adenocarcinoma in a "normal-sized" ovary

scientific article published in July 2010

Membranous and cytoplasmic expression of epidermal growth factor receptor in metastatic pancreatic ductal adenocarcinoma

scientific article

Nasal natural killer cell/T-cell lymphoma showing cellular morphology mimicking normal lymphocytes.

scientific article published in May 2002

Novel TNF-α receptor 1 antagonist treatment attenuates arterial inflammation and intimal hyperplasia in mice

scientific article

Nuclear expression of cIAP-1, an apoptosis inhibiting protein, predicts lymph node metastasis and poor patient prognosis in head and neck squamous cell carcinomas

scientific article published on 01 June 2005

Nuclear translocation of extracellular superoxide dismutase

scientific article published on August 2002

Overexpression of HER2 signaling to WAVE2-Arp2/3 complex activates MMP-independent migration in breast cancer

scientific article

PIK3CA mutation is an early event in the development of endometriosis-associated ovarian clear cell adenocarcinoma.

scientific article

PIK3CA mutations and loss of ARID1A protein expression are early events in the development of cystic ovarian clear cell adenocarcinoma

scientific article published on 26 November 2011

Pleuroparenchymal fibroelastosis as a series of airway complications associated with chronic graft-versus-host disease following allogeneic bone marrow transplantation

scientific article published on January 2014

Potential crosstalk between insulin-like growth factor receptor type 1 and epidermal growth factor receptor in progression and metastasis of pancreatic cancer

scientific article published on 01 June 2006

Prognostic implication of laminin-5 gamma 2 chain expression in the invasive front of colorectal cancers, disclosed by area-specific four-point tissue microarrays

scientific article published on 01 February 2005

Protein overexpression and gene amplification of epidermal growth factor receptor in adult testicular germ cell tumors: potential role in tumor progression.

scientific article published in September 2010

Pulmonary tumor thrombotic microangiopathy

scientific article published on 01 February 2007

Pulmonary tumor thrombotic microangiopathy caused by a gastric carcinoma expressing vascular endothelial growth factor and tissue factor.

scientific article published on January 2005

Salivary cortisol response to stress in young children with atopic dermatitis

scientific article published on 21 May 2012

Significance of RhoC expression in terms of invasion and metastasis of colorectal cancer

scientific article published on 01 September 2003

Stathmin is involved in the cooperative effect of Zoledronic acid and gefitinib on bone homing breast cancer cells in vitro

scientific article

The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: poor prognosis in patients with pancreatic ductal adenocarcinoma

scientific article published on July 2004

The knockdown of endogenous replication factor C4 decreases the growth and enhances the chemosensitivity of hepatocellular carcinoma cells

scientific article published on 19 May 2008

The subserosal elastic lamina: an anatomic landmark for stratifying pT3 colorectal cancer

scientific article published on 04 March 2004

Transformation-associated gene regulation by ATF6alpha during hepatocarcinogenesis

scientific article published on 9 December 2005

Tumor buds show reduced expression of laminin-5 gamma 2 chain in DNA mismatch repair deficient colorectal cancer.

scientific article

Usefulness and limitation of multiple endoscopic biopsy sampling for epidermal growth factor receptor and c-erbB-2 testing in patients with gastric adenocarcinoma

scientific article published on 31 May 2005

Vascular endothelial growth factor mRNA levels quantified by reverse transcription-polymerase chain reaction in microdissected breast carcinoma tissues are correlated with histological type and grade of both invasive and intraductal components

scientific article

Wide local extension and higher proliferation indices are characteristic features of symptomatic lobular neoplasias (LNs) and LNs with an early invasive component

scientific article published on 08 March 2014

List of works by Osamu Matsubara

A proposal for diagnostically meaningful criteria to classify increased epidermal growth factor receptor and c-erbB-2 gene copy numbers in gastric carcinoma, based on correlation of fluorescence in situ hybridization and immunohistochemical measurem

A simple immunohistochemical panel comprising 2 conventional markers, Ki67 and p53, is a powerful tool for predicting patient outcome in luminal-type breast cancer

ACTN4 gene amplification and actinin-4 protein overexpression drive tumour development and histological progression in a high-grade subset of ovarian clear-cell adenocarcinomas

Aberrant expression of p27(Kip1)-interacting cell-cycle regulatory proteins in ovarian clear cell carcinomas and their precursors with special consideration of two distinct multistage clear cell carcinogenetic pathways.

Aberrant expression of the mammalian target of rapamycin, hypoxia-inducible factor-1α, and glucose transporter 1 in the development of ovarian clear-cell adenocarcinoma.

Abstract 318: Hierarchical clustering analysis of array CGH data identifies clinicopathologically distinct groups of lymph-node-negative invasive breast cancer

Accumulative copy number increase of MET drives tumor development and histological progression in a subset of ovarian clear-cell adenocarcinomas.

Actinin-4 expression in ovarian cancer: a novel prognostic indicator independent of clinical stage and histological type

Actinin-4 gene amplification in ovarian cancer: a candidate oncogene associated with poor patient prognosis and tumor chemoresistance

Activation of Galectin-1 gene in human hepatocellular carcinoma involves methylation-sensitive complex formations at the transcriptional upstream and downstream elements

Activation of a system A amino acid transporter, ATA1/SLC38A1, in human hepatocellular carcinoma and preneoplastic liver tissues.

Allelotyping analysis suggesting a consecutive progression from intratubular germ cell neoplasia to seminoma and then to embryonal carcinoma of the adult testis

Altered expression of p27(Kip1) -interacting cell-cycle regulators in the adult testicular germ cell tumors: potential role in tumor development and histological progression.

Alternative tyrosine phosphorylation of signaling kinases according to hormone receptor status in breast cancer overexpressing the insulin-like growth factor receptor type 1

An Inter-subunit Disulfide Bond Affects Affinity of Human Lung Extracellular Superoxide Dismutase to Heparin ⬇️

An allelotype analysis indicating the presence of two distinct ovarian clear-cell carcinogenic pathways: endometriosis-associated pathway vs. clear-cell adenofibroma-associated pathway

Analysis of sentinel node involvement in gastric cancer

Array comparative genomic hybridization analysis discloses chromosome copy number alterations as indicators of patient outcome in lymph node-negative breast cancer.

Clear cell adenocarcinoma associated with clear cell adenofibromatous components: a subgroup of ovarian clear cell adenocarcinoma with distinct clinicopathologic characteristics

Clear cell adenocarcinoma with a component of poorly differentiated histology: a poor prognostic subgroup of ovarian clear cell adenocarcinoma

Clinical implications of occult metastases and isolated tumor cells in sentinel and non-sentinel lymph nodes in early breast cancer patients: serial step section analysis with long-term follow-up

Clinical significance of DJ-1 as a secretory molecule: retrospective study of DJ-1 expression at mRNA and protein levels in ductal carcinoma of the breast

Clinico-pathological analysis referring hemeoxygenase-1 in acute fibrinous and organizing pneumonia patients

Clinicopathological significance of WT1 expression in ovarian cancer: a possible accelerator of tumor progression in serous adenocarcinoma

Clinicopathological significance of cervical adenocarcinoma associated with lobular endocervical glandular hyperplasia.

Combined hepatocellular carcinoma and cholangiocarcinoma with components of mucinous carcinoma arising in a cirrhotic liver

Community-acquired lobar pneumonia caused by Pseudomonas aeruginosa infection in Japan: a case report with histological and immunohistochemical examination.

Correlation of KIT and EGFR overexpression with invasive ductal breast carcinoma of the solid-tubular subtype, nuclear grade 3, and mesenchymal or myoepithelial differentiation

Cumulative alterations of p27-related cell-cycle regulators in the development of endometriosis-associated ovarian clear cell adenocarcinoma.

DJ-1 protein expression as a predictor of pathological complete remission after neoadjuvant chemotherapy in breast cancer patients

Deficiency of interleukin-1 receptor antagonist deteriorates fatty liver and cholesterol metabolism in hypercholesterolemic mice

Deficiency of interleukin-1 receptor antagonist promotes spontaneous femoral artery aneurysm formation in mice

Different expression patterns of KIT, EGFR, and HER‐2 (c‐erbB‐2) oncoproteins between epithelial and mesenchymal components in uterine carcinosarcoma ⬇️

Differential prognostic significance of morphologic invasive markers in colorectal cancer: tumor budding and cytoplasmic podia

Epidermal growth factor-dependent enhancement of invasiveness of squamous cell carcinoma of the breast.

Esophageal pleomorphic giant cell carcinoma combined with small cell carcinoma

Expression and clinical significance of connective tissue growth factor in advanced head and neck squamous cell cancer

Expression of KIT, EGFR, HER-2 and tyrosine phosphorylation in undifferentiated thyroid carcinoma: implication for a new therapeutic approach

Expression of platelet-derived growth factors and their receptors in ovarian clear-cell carcinoma and its putative precursors

Expression pattern of stromal cell-derived factor-1 chemokine in invasive breast cancer is correlated with estrogen receptor status and patient prognosis

Factors associated with steroid phobia in caregivers of children with atopic dermatitis

Fatty acid synthase overexpression in adult testicular germ cell tumors: potential role in the progression of non-seminomatous germ cell tumors.

Frequent KIT and epidermal growth factor receptor overexpressions in undifferentiated-type breast carcinomas with 'stem-cell-like' features

Gene amplification and protein overexpression of MET are common events in ovarian clear-cell adenocarcinoma: their roles in tumor progression and prognostication of the patient

Gene expression signatures that can discriminate oral leukoplakia subtypes and squamous cell carcinoma

Hemophagocytic syndrome associated with clostridial infection in a pancreatic carcinoma patient

High levels of DJ-1 protein and isoelectric point 6.3 isoform in sera of breast cancer patients

High levels of DJ-1 protein in nipple fluid of patients with breast cancer

High-level Skp2 expression in pancreatic ductal adenocarcinoma: correlation with the extent of lymph node metastasis, higher histological grade, and poorer patient outcome

Histological differences between invasive ductal carcinoma with a large central acellular zone and matrix-producing carcinoma of the breast

Histological grading of ovarian clear cell adenocarcinoma: proposal for a simple and reproducible grouping system based on tumor growth architecture.

Immunohistochemical detection of hepatocyte nuclear factor 1beta in ovarian and endometrial clear-cell adenocarcinomas and nonneoplastic endometrium

IκBNS regulates interleukin-6 production and inhibits neointimal formation after vascular injury in mice

Loss of ARID1A protein expression occurs as an early event in ovarian clear-cell carcinoma development and frequently coexists with PIK3CA mutations.

Massive intra-abdominal undifferentiated carcinoma derived from an endometrioid adenocarcinoma in a "normal-sized" ovary

Membranous and cytoplasmic expression of epidermal growth factor receptor in metastatic pancreatic ductal adenocarcinoma

Nasal natural killer cell/T-cell lymphoma showing cellular morphology mimicking normal lymphocytes.

Novel TNF-α receptor 1 antagonist treatment attenuates arterial inflammation and intimal hyperplasia in mice

Nuclear expression of cIAP-1, an apoptosis inhibiting protein, predicts lymph node metastasis and poor patient prognosis in head and neck squamous cell carcinomas

Nuclear translocation of extracellular superoxide dismutase

Overexpression of HER2 signaling to WAVE2-Arp2/3 complex activates MMP-independent migration in breast cancer

PIK3CA mutation is an early event in the development of endometriosis-associated ovarian clear cell adenocarcinoma.

PIK3CA mutations and loss of ARID1A protein expression are early events in the development of cystic ovarian clear cell adenocarcinoma

Pleuroparenchymal fibroelastosis as a series of airway complications associated with chronic graft-versus-host disease following allogeneic bone marrow transplantation

Potential crosstalk between insulin-like growth factor receptor type 1 and epidermal growth factor receptor in progression and metastasis of pancreatic cancer

Prognostic implication of laminin-5 gamma 2 chain expression in the invasive front of colorectal cancers, disclosed by area-specific four-point tissue microarrays

Protein overexpression and gene amplification of epidermal growth factor receptor in adult testicular germ cell tumors: potential role in tumor progression.

Pulmonary tumor thrombotic microangiopathy

Pulmonary tumor thrombotic microangiopathy caused by a gastric carcinoma expressing vascular endothelial growth factor and tissue factor.

Salivary cortisol response to stress in young children with atopic dermatitis

Significance of RhoC expression in terms of invasion and metastasis of colorectal cancer

Stathmin is involved in the cooperative effect of Zoledronic acid and gefitinib on bone homing breast cancer cells in vitro

The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: poor prognosis in patients with pancreatic ductal adenocarcinoma

The knockdown of endogenous replication factor C4 decreases the growth and enhances the chemosensitivity of hepatocellular carcinoma cells

The subserosal elastic lamina: an anatomic landmark for stratifying pT3 colorectal cancer

Transformation-associated gene regulation by ATF6alpha during hepatocarcinogenesis

Tumor buds show reduced expression of laminin-5 gamma 2 chain in DNA mismatch repair deficient colorectal cancer.

Usefulness and limitation of multiple endoscopic biopsy sampling for epidermal growth factor receptor and c-erbB-2 testing in patients with gastric adenocarcinoma

Vascular endothelial growth factor mRNA levels quantified by reverse transcription-polymerase chain reaction in microdissected breast carcinoma tissues are correlated with histological type and grade of both invasive and intraductal components