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List of works by Susan Smyth

A case report of simultaneous thrombosis of two coronary artery stents in association with clopidogrel resistance.

scientific article published in April 2007

A retrospective analysis of catheter-based thrombolytic therapy for acute submassive and massive pulmonary embolism

scientific article published on April 2015

A retrospective comparison of survivors and non-survivors of massive pulmonary embolism receiving veno-arterial extracorporeal membrane oxygenation support

scientific article

Acute Effects of Implantable Cardioverter-Defibrillator Shocks on Biomarkers of Myocardial Injury, Apoptosis, Heart Failure, and Systemic Inflammation

scientific article

Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity

scientific article

Anti-Thrombotic Effects of Statins in Acute Coronary Syndromes: At the Intersection of Thrombosis, Inflammation, and Platelet-Leukocyte Interactions

scientific article published on 3 May 2016

Anti-platelet therapy

scientific article published on 01 November 2011

Antiplatelet therapy in prevention of cardio- and venous thromboembolic events

scientific article published on April 2014

Antithrombotic treatment in transcatheter aortic valve implantation: insights for cerebrovascular and bleeding events

scientific article published on 10 April 2013

Arguing the case for the autotaxin-lysophosphatidic acid-lipid phosphate phosphatase 3-signaling nexus in the development and complications of atherosclerosis

scientific article published on 30 January 2014

Aspirin Resistance in Patients with Stable Coronary Artery Disease with and without a History of Myocardial Infarction

scientific article

Aspirin dose for the prevention of cardiovascular disease: a systematic review

scientific article (publication date: 9 May 2007)

Autotaxin Activity Predicts 30 Day Mortality in Sepsis Patients and Correlates With Platelet Count and Vascular Dysfunction

scientific article published on 20 August 2020

Autotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice

scientific article published on 3 April 2012

Autotaxin induces lung epithelial cell migration through lysoPLD activity-dependent and -independent pathways ⬇️

scientific article published on October 1, 2011

Autotaxin inhibition reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction

scientific article published on 02 October 2020

Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation

scientific article published on October 2013

Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis

scientific article published on 12 January 2009

Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis.

scientific article

Binding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells

scientific article

Bioactive lipids and cationic antimicrobial peptides as new potential regulators for trafficking of bone marrow-derived stem cells in patients with acute myocardial infarction

scientific article published on 19 February 2013

Biomarker science: on a theme of personalized medicine ⬇️

scientific article published on July 1, 2012

Blood relatives: dynamic regulation of bioactive lysophosphatidic acid and sphingosine-1-phosphate metabolism in the circulation

scientific article published on May 2009

Bridging the gap between clinical trials of antiplatelet therapies and applications among elderly patients.

scientific article published on April 2010

CD40 Is Essential in the Upregulation of TRAF Proteins and NF-KappaB-Dependent Proinflammatory Gene Expression after Arterial Injury ⬇️

scientific article published on August 18, 2011

CX3CR1 deficiency confers protection from intimal hyperplasia after arterial injury

scientific article

CYP2C19 Genotyping to Guide Antiplatelet Therapy After Percutaneous Coronary Interventions: One Size Rarely Fits All

scientific article published on 01 August 2020

Calcium Ion Chelation Preserves Platelet Function During Cold Storage

scientific article published on 12 November 2020

Cangrelor in addition to standard therapy reduces cardiac damage and inflammatory markers in patients with ST-segment elevation myocardial infarction

scientific article published on 30 November 2020

Cardiac response to pressure overload in 129S1/SvImJ and C57BL/6J mice: temporal- and background-dependent development of concentric left ventricular hypertrophy

scientific article published on 15 December 2006

Cardiovascular devices and platelet interactions: understanding the role of injury, flow, and cellular responses

scientific article published on April 2012

Cardiovascular disease in women

scientific article

Changes in thromboinflammatory profiles across the generations of transcatheter aortic heart valves

scientific article published on 01 February 2019

Characterization of a Novel Integrin Binding Protein, VPS33B, Which Is Important for Platelet Activation and In Vivo Thrombosis and Hemostasis

scientific article

Characterization of a model to independently study regression of ventricular hypertrophy

scientific article

Clopidogrel treatment and the incidence and severity of community acquired pneumonia in a cohort study and meta-analysis of antiplatelet therapy in pneumonia and critical illness

scientific article

Comparison of Outcomes in Patients Having Acute Myocardial Infarction With Versus Without Sickle-Cell Anemia

scientific article published on 8 August 2017

Consensus review of the treatment of cardiovascular disease in people with hemophilia A and B.

scientific article

Considerable variability in platelet activity among patients with coronary artery disease in response to an increased maintenance dose of clopidogrel

scientific article

Contemporary Meta-Analysis of Extended Direct Acting Oral Anticoagulant Thromboprophylaxis to Prevent Venous Thromboembolism Among Hospitalized Patients

scientific article published on 06 March 2020

Coronary Artery Disease Risk-Associated Plpp3 Gene and Its Product Lipid Phosphate Phosphatase 3 Regulate Experimental Atherosclerosis

scientific article published on 19 September 2019

Coronary artery remodeling in a model of left ventricular pressure overload is influenced by platelets and inflammatory cells

scientific article

Deep Vein Thrombosis Complicated by Spontaneous Iliopsoas Hematoma in Patient with Septic Shock

scientific article published on 30 October 2017

Developing and Demonstrating the Viability and Availability of the Multilevel Implementation Strategy for Syncope Optimal Care Through Engagement (MISSION) Syncope App: Evidence-Based Clinical Decision Support Tool

scientific article published on 16 November 2021

Direct thrombin inhibition with dabigatran attenuates pressure overload-induced cardiac fibrosis and dysfunction in mice

scientific article

Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signaling

scientific article published on 22 September 2011

Dominant-negative loss of PPARgamma function enhances smooth muscle cell proliferation, migration, and vascular remodeling.

scientific article published on 29 January 2009

Early signatures of bleeding and mortality in patients on left ventricular assist device support: novel methods for personalized risk-stratification

scientific article published on 06 May 2019

Effects of abciximab on the acute pathology of blood vessels after arterial stenting in nonhuman primates

scientific article (publication date: 17 July 2002)

Effects of diet and hyperlipidemia on levels and distribution of circulating lysophosphatidic acid

scientific article published on 04 September 2019

Effects of unfractionated heparin and glycoprotein IIb/IIIa antagonists versus bivalirdin on myeloperoxidase release from neutrophils

scientific article published on 24 May 2007

Effects of vorapaxar on platelet reactivity and biomarker expression in non-ST-elevation acute coronary syndromes

article

Fibrinolytic therapy versus primary percutaneous coronary interventions for ST-segment elevation myocardial infarction in Kentucky: time to establish systems of care?

scientific article published on July 2013

From novice to expert: using simulators to enhance practical skill.

scientific article published on December 9, 2010

Functional characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates in mammalian cells

scientific article

G-protein-coupled receptors as signaling targets for antiplatelet therapy

scientific article

Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development

scientific article

Granule cargo release from bone marrow-derived cells sustains cardiac hypertrophy

scientific article

Guaranteed to make you smile

scientific article published on 01 May 2015

Identifying Guideline-Practice Gaps to Optimize Evaluation and Management for Patients with Syncope

scientific article published on 21 May 2020

In-stent restenosis: more fuel for the fire

scientific article published in October 2002

Incidence, predictors, and outcomes associated with pneumothorax during cardiac electronic device implantation: A 16-year review in over 3.7 million patients

scientific article

Increased mortality among patients taking digoxin--analysis from the AFFIRM study

scientific article published on 27 November 2012

Individual heterogeneity in platelet response to lysophosphatidic acid: evidence for a novel inhibitory pathway

scientific article

Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis

scientific article published on 07 May 2019

Inflammation and thrombosis in cardiovascular disease.

scientific article

Inflammatory properties of diet mediate the effect of depressive symptoms on Framingham risk score in men and women: Results from the National Health and Nutrition Examination Survey (2007-2014)

scientific article published on 23 November 2019

Integrin αIIbβ3: from discovery to efficacious therapeutic target

scientific article published on April 2013

Integrin-mediated cell surface recruitment of autotaxin promotes persistent directional cell migration

scientific article

Invasive Coronary Vasoreactivity Testing to Diagnose Microvascular Dysfunction in Women ⬇️

scientific article published on June 1, 2012

LPA receptor 4 deficiency attenuates experimental atherosclerosis

scientific article published on 22 February 2019

Lipid phosphate phosphatase 3 negatively regulates smooth muscle cell phenotypic modulation to limit intimal hyperplasia

scientific article published on 25 October 2012

Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity

scientific article (publication date: 31 October 2003)

Lipid phosphate phosphatases: more than one way to put the brakes on LPA signaling?

scientific article published on 30 September 2014

Lipid-induced epigenomic changes in human macrophages identify a coronary artery disease-associated variant that regulates PPAP2B Expression through Altered C/EBP-beta binding

scientific article

Living the dream

scientific article published on 01 February 2016

Lysophosphatidic Acid Signaling Protects Pulmonary Vasculature From Hypoxia-Induced Remodeling ⬇️

scientific article published on October 20, 2011

Lysophosphatidic acid and cardiovascular disease: seeing is believing ⬇️

scientific article published on March 18, 2013

Lysophosphatidic acid receptors 1 and 2 play roles in regulation of vascular injury responses but not blood pressure

scientific article

Lysophospholipid mediators in the vasculature

scientific article published on 28 March 2015

Lysophospholipids and their receptors: New data and new insights into their function

scientific article published on 13 March 2020

Lysophospholipids in coronary artery and chronic ischemic heart disease

scientific article

Measurement of Lysophosphatidic Acid and Sphingosine-1-Phosphate by Liquid Chromatography-Coupled Electrospray Ionization Tandem Mass Spectrometry.

scientific article published on 3 August 2017

Measurement of autotaxin/lysophospholipase D activity

scientific article published on January 2007

Mechanism of rapid elimination of lysophosphatidic acid and related lipids from the circulation of mice.

scientific article

Meta-Analysis Comparing the Efficacy, Safety, and Cost-Benefit of Direct Acting Oral Anticoagulants Versus Enoxaparin Thromboprophylaxis to Prevent Venous Thromboembolism Among Hospitalized Patients

scientific article published on 05 July 2018

Mice with targeted inactivation of ppap2b in endothelial and hematopoietic cells display enhanced vascular inflammation and permeability

scientific article published on 06 February 2014

NOVEL ROLE FOR BIOACTIVE LIPIDS IN STEM CELL MOBILIZATION DURING MYOCARDIAL ISCHEMIA: A POTENTIAL THERAPEUTIC TARGET

scientific article published in March 2012

Neutrophil-Derived S100A8/A9 Amplify Granulopoiesis After Myocardial Infarction

scientific article published on 16 January 2020

Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and edema

scientific article published on 17 April 2009

Novel mediators and biomarkers of thrombosis

scientific article

Obesity and Antiplatelets-Does One Size Fit All?

scientific article published on 16 July 2015

Oral factor Xa inhibitors for the treatment of left ventricular thrombus: a case series

scientific article published on 25 September 2017

Outcomes and Characteristics of Myocardial Infarction in Patients With Cirrhosis

scientific article published on 01 July 2019

Outcomes of fibrinolytic therapy for patients with metastatic cancer and acute pulmonary embolism

scientific article published on 05 April 2019

Parent-of-origin effects on cardiac response to pressure overload in mice

scientific article published on 26 June 2009

Pathophysiology and pharmacologic treatment of venous thromboembolism

scientific article published on February 2014

Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway

scientific article

Pharmacological Elevation of Circulating Bioactive Phosphosphingolipids Enhances Myocardial Recovery After Acute Infarction

scientific article published on 14 September 2015

Phosphodiesterase type 4 blockade prevents platelet-mediated neutrophil recruitment at the site of vascular injury

scientific article published on 12 June 2014

Phospholipase Cgamma activation drives increased production of autotaxin in endothelial cells and lysophosphatidic acid-dependent regression.

scientific article

Plasma levels of sphingosine 1-phosphate are strongly correlated with haematocrit, but variably restored by red blood cell transfusions

scientific article

Platelet activation and its patient-specific consequences

scientific article published on 22 October 2007

Platelet biology and response to antiplatelet therapy in women: implications for the development and use of antiplatelet pharmacotherapies for cardiovascular disease

scientific article published on March 2012

Platelet function analysis: at the edge of meaning.

scientific article published in February 2009

Platelet secretion and hemostasis require syntaxin-binding protein STXBP5.

scientific article

Platelet-Mediated Thrombosis and Drug-Eluting Stents ⬇️

scientific article published on December 1, 2011

Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway

scientific article

Platelets unplugged: an ATVB special series focused on platelet biology

scientific article

Predicting in-hospital mortality after an in-hospital cardiac arrest: A multivariate analysis

scientific article published on 07 November 2020

Predictors, Morbidity, and Costs Associated with Pneumothorax during Electronic Cardiac Device Implantation

scientific article

Preventing platelet thrombosis with a PAR1 pepducin

scientific article published on 15 June 2012

QRS duration predicts death and hospitalization among patients with atrial fibrillation irrespective of heart failure: evidence from the AFFIRM study

scientific article published on 23 December 2013

Rap1b is required for normal platelet function and hemostasis in mice

scientific article

Rap1b is required for normal platelet function and hemostasis in mice.

scientific article published in August 2005

Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice

scientific article published on 15 May 2009

Reduced dose thrombolysis with ultrasound-facilitated catheter-directed administration for acute pulmonary embolism reduces length of stay

scientific article published on 03 December 2019

Regulation of Lysophosphatidic Acid Metabolism and Signaling by Lipoproteins

scientific article published on October 2016

Regulation of PLPP3 gene expression by NF-κB family transcription factors

scientific article published on 30 July 2019

Relation of CHA2DS2VASC Score With Hemorrhagic Stroke and Mortality in Patients Undergoing Fibrinolytic Therapy for ST Elevation Myocardial Infarction

scientific article published on 18 October 2018

Reply to: A protocolized approach to veno-arterial extracorporeal membrane oxygenation for massive pulmonary embolism

scientific article published on 01 May 2018

Roles for lysophosphatidic acid signaling in vascular development and disease

scientific article published on 03 May 2020

Roles of lysophosphatidic acid in cardiovascular physiology and disease

scientific article published on 10 June 2008

Securing the Future for a Major Academic Cardiovascular Program: Hardwiring a Referral Network and Preparing for a Transition to Value-Based Reimbursement

scientific article published on 17 August 2020

Sex differences in the contemporary management of HIV patients admitted for acute myocardial infarction.

scientific article published on 19 April 2018

Spontaneous coronary thrombosis following thrombolytic therapy for acute cardiovascular accident and stroke: a case study ⬇️

scientific article published on November 1, 2012

Src family kinases mediate neutrophil adhesion to adherent platelets

scientific article published on 9 November 2006

Src-family kinases mediate an outside-in signal necessary for beta2 integrins to achieve full activation and sustain firm adhesion of polymorphonuclear leucocytes tethered on E-selectin

scientific article published on May 2006

Synergistic effect of anemia and red blood cells transfusion on inflammation and lung injury

scientific article published on 7 August 2012

Targeting platelet thrombin receptor signaling to prevent thrombosis

scientific article published on 02 August 2013

Temporal trends, characteristics and outcomes of fibrinolytic therapy for ST-elevation myocardial infarction among patients 80 years or older

scientific article published on 30 September 2018

The 2019 FASEB Science Research Conference on Lysophospholipid and Related Mediators: From Bench to Clinic, July 28 to August 2, 2019, Lisbon, Portugal

scientific article published on 01 November 2019

The P2Y(12) antagonists, 2MeSAMP and cangrelor, inhibit platelet activation through P2Y(12)/G(i)-dependent mechanism

scientific article

The effect of rosuvastatin on platelet-leukocyte interactions in the setting of acute coronary syndrome

scientific article

The effect of rosuvastatin on thromboinflammation in the setting of acute coronary syndrome

scientific article

The implementation of a pulmonary embolism response team in the management of intermediate- or high-risk pulmonary embolism

scientific article published on 29 March 2019

Therapeutic potential of autotaxin/lysophospholipase d inhibitors

scientific article published on August 2008

Thromboinflammatory response and predictors of outcomes in patients undergoing transcatheter aortic valve replacement

scientific article

Thrombosis and antithrombotic therapy in women

scientific article

Ticagrelor Reduces Thromboinflammatory Markers in Patients With Pneumonia

scholarly article by Travis R Sexton et al published August 2018 in JACC. Basic to translational science

Tiny dancers: the integrin-growth factor nexus in angiogenic signaling

scientific article

Tissue necrosis factor α and targeting its receptor in ischaemic heart disease

scientific article published on 22 May 2013

Training the translational workforce: Expanding beyond translational research to include translational science

scientific article published on 06 April 2020

Transgenic 6F tomatoes act on the small intestine to prevent systemic inflammation and dyslipidemia caused by Western diet and intestinally derived lysophosphatidic acid

scientific article published on October 2013

Translational Implications of Platelets as Vascular First Responders

scientific article

Treatment Bias in Management of HIV Patients Admitted for Acute Myocardial Infarction: Does It Still Exist?

scientific article published on 11 November 2019

Trends in the Incidence and In-Hospital Outcomes of Patients With Atrial Fibrillation Complicated by Non-ST-Segment Elevation Myocardial Infarction

scientific article published on 19 September 2018

Trends, Management Patterns, and Predictors of Leaving Against Medical Advice among Patients with Documented Noncompliance Admitted for Acute Myocardial Infarction

scientific article published on 01 April 2019

Value-based assessment of implementing a Pulmonary Embolism Response Team (PERT)

scientific article published on 15 June 2020

Value-based syncope evaluation and management: Perspectives of health care professionals on readiness, barriers and enablers

scientific article published on 16 May 2020

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