List of works - Laura K. Najvar

1954. In vivo Efficacy of Delayed Therapy with the Novel Inositol Acyltransferase Inhibitor Fosmanogepix (APX001) in a Murine Model of Candida auris Invasive Candidiasis ⬇️

scientific article published on 23 October 2019

A murine model of Cryptococcus gattii meningoencephalitis

scientific article

Activity of posaconazole against Pseudallescheria boydii: in vitro and in vivo assays

scientific article

Activity of posaconazole combined with amphotericin B against Aspergillus flavus infection in mice: comparative studies in two laboratories

scientific article

Addition of caspofungin to fluconazole does not improve outcome in murine candidiasis

scientific article

Aerosolized nanostructured itraconazole as prophylaxis against invasive pulmonary aspergillosis.

scientific article published on 13 March 2007

Alternatives to amphotericin B for Candida rugosa infection.

scientific article

Antifungal therapy of experimental cerebral phaeohyphomycosis due to Cladophialophora bantiana

scientific article

Antifungal therapy of murine Aspergillus terreus infection

scientific article published on October 2004

Assessment of Aspergillus fumigatus burden in pulmonary tissue of guinea pigs by quantitative PCR, galactomannan enzyme immunoassay, and quantitative culture

scientific article published on 12 May 2008

Assessment of Aspergillus fumigatus in guinea pig bronchoalveolar lavages and pulmonary tissue by culture and realtime polymerase chain reaction studies

scientific article

Assessment of serum (1->3)-beta-D-glucan concentration as a measure of disease burden in a murine model of invasive pulmonary aspergillosis.

scientific article

Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus

scientific article

Caspofungin and liposomal amphotericin B therapy of experimental murine scedosporiosis

scientific article published on December 2005

Caspofungin dose escalation for invasive candidiasis due to resistant Candida albicans. ⬇️

scientific article published on 18 April 2011

Caspofungin resistance in Candida albicans: correlating clinical outcome with laboratory susceptibility testing of three isogenic isolates serially obtained from a patient with progressive Candida esophagitis

scientific article published on April 2004

Combination antifungal therapy of murine aspergillosis: liposomal amphotericin B and micafungin

scientific article published on 12 September 2003

Comparison of Nonculture Blood-Based Tests for Diagnosing Invasive Aspergillosis in an Animal Model

scientific article published on 20 January 2016

Comparison of lateral flow technology and galactomannan and (1->3)-beta-D-glucan assays for detection of invasive pulmonary aspergillosis

scientific article published on 30 September 2009

Comparison of staining methods and a nested PCR assay to detect Histoplasma capsulatum in tissue sections.

scientific article

Detection and measurement of fungal burden in a guinea pig model of invasive pulmonary aspergillosis by novel quantitative nested real-time PCR compared with galactomannan and (1,3)-β-D-glucan detection

scientific article published on 21 December 2011

Detection of Cryptococcus neoformans DNA in tissue samples by nested and real-time PCR assays

scientific article

Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production

scientific article

Effect of Antifungal Treatment in a Diet-Based Murine Model of Disseminated Candidiasis Acquired via the Gastrointestinal Tract.

scientific article published on 29 August 2016

Efficacies of amphotericin B (AMB) lipid complex, AMB colloidal dispersion, liposomal AMB, and conventional AMB in treatment of murine coccidioidomycosis

scientific article

Efficacy of Delayed Therapy with Fosmanogepix (APX001) in a Murine Model of Candida auris Invasive Candidiasis ⬇️

scientific article published on 22 October 2019

Efficacy of posaconazole as treatment and prophylaxis against Fusarium solani

scientific article published on 11 January 2010

Efficacy of the investigational echinocandin ASP9726 in a guinea pig model of invasive pulmonary aspergillosis

scientific article published on 9 March 2015

Evaluation of aminocandin and caspofungin against Candida glabrata including isolates with reduced caspofungin susceptibility

scientific article published on 25 July 2008

Extended-Interval Dosing of Rezafungin against Azole-Resistant Aspergillus fumigatus

scientific article published on 23 September 2019

Improving the mouse model for studying the efficacy of voriconazole

scientific article published on 13 May 2003

In Vivo Efficacy of VT-1129 against Experimental Cryptococcal Meningitis with the Use of a Loading Dose-Maintenance Dose Administration Strategy

article

In vitro Activity of Fosfomycin, Alone and Combined with Cefepime and Meropenem, Against Carbapenemase-Producing Gram-Negative Bacteria.

scientific article published on 4 October 2017

In vitro and in vivo activities of posaconazole against Coccidioides immitis

scientific article

In vitro pharmacodynamics of anidulafungin and caspofungin against Candida glabrata isolates, including strains with decreased caspofungin susceptibility.

scientific article published on 28 August 2006

In vivo activity of posaconazole against Mucor spp. in an immunosuppressed-mouse model

scientific article published on July 2002

In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis

scientific article

In vivo efficacy of anidulafungin and caspofungin against Candida glabrata and association with in vitro potency in the presence of sera

scientific article published on 16 February 2007

Inhaled voriconazole for prevention of invasive pulmonary aspergillosis.

scientific article published on 16 March 2009

Interlaboratory and interstudy reproducibility of a novel lateral-flow device and influence of antifungal therapy on detection of invasive pulmonary aspergillosis.

scientific article published on 21 November 2012

Isavuconazole Is Effective for the Treatment of Experimental Cryptococcal Meningitis

scientific article published on 20 June 2016

Limited activity of miltefosine in murine models of cryptococcal meningoencephalitis and disseminated cryptococcosis

scientific article published on 19 November 2012

Modified release itraconazole amorphous solid dispersion to treat Aspergillus fumigatus: importance of the animal model selection.

scientific article

New guinea pig model of Cryptococcal meningitis

scientific article published on 11 June 2007

Oral glucan synthase inhibitor SCY-078 is effective in an experimental murine model of invasive candidiasis caused by WT and echinocandin-resistant Candida glabrata ⬇️

scientific article published on 21 November 2017

Polymerase Chain Reaction Detection ofAspergillusDNA in Experimental Models of Invasive Aspergillosis

scientific article published on 01 April 2002

Posaconazole therapy of disseminated phaeohyphomycosis in a murine model

scientific article

Prolyl endopeptidase activity in bronchoalveolar lavage fluid: a novel diagnostic biomarker in a guinea pig model of invasive pulmonary aspergillosis

scientific article

Prophylactic efficacy of single dose pulmonary administration of amphotericin B inhalation powder in a guinea pig model of invasive pulmonary aspergillosis

scientific article published on 11 January 2012

Retinal function assessed by ERG before and after induction of ocular aspergillosis and treatment by the anti-fungal, micafungin, in rabbits

scientific article

Standardization of an experimental murine model of invasive pulmonary aspergillosis

scientific article

The Fungal Cyp51 Inhibitor VT-1129 Is Efficacious in an Experimental Model of Cryptococcal Meningitis

scientific article published on 27 August 2018

The Fungal Cyp51-Specific Inhibitor VT-1598 Demonstrates and Activity against Candida auris

scholarly article by Nathan P Wiederhold et al published March 2019 in Antimicrobial Agents and Chemotherapy

The Novel Arylamidine T-2307 Demonstrates In Vitro and In Vivo Activity against Candida auris

scientific article published on 21 February 2020

The Novel Fungal Cyp51 Inhibitor VT-1598 is Efficacious in Experimental Models of Central Nervous System Coccidioidomycosis Caused by Coccidioides posadasii and Coccidioides immitis.

scientific article published on 5 February 2018

The Orotomide Olorofim Is Efficacious in an Experimental Model of Central Nervous System Coccidioidomycosis

scientific article published on 27 August 2018

The investigational agent E1210 is effective in treatment of experimental invasive candidiasis caused by resistant Candida albicans ⬇️

scientific article

The novel arylamidine T-2307 demonstrates in vitro and in vivo activity against echinocandin-resistant Candida glabrata

scientific article published on 29 November 2015

The novel arylamidine T-2307 maintains in vitro and in vivo activity against echinocandin-resistant Candida albicans.

scientific article

Therapeutic efficacy of caspofungin alone and in combination with amphotericin B deoxycholate for coccidioidomycosis in a mouse model

scientific article published on 12 October 2007

Topical voriconazole as a novel treatment for fungal keratitis

scientific article

List of works by Laura K. Najvar

1954. In vivo Efficacy of Delayed Therapy with the Novel Inositol Acyltransferase Inhibitor Fosmanogepix (APX001) in a Murine Model of Candida auris Invasive Candidiasis ⬇️

A murine model of Cryptococcus gattii meningoencephalitis

Activity of posaconazole against Pseudallescheria boydii: in vitro and in vivo assays

Activity of posaconazole combined with amphotericin B against Aspergillus flavus infection in mice: comparative studies in two laboratories

Addition of caspofungin to fluconazole does not improve outcome in murine candidiasis

Aerosolized nanostructured itraconazole as prophylaxis against invasive pulmonary aspergillosis.

Alternatives to amphotericin B for Candida rugosa infection.

Antifungal therapy of experimental cerebral phaeohyphomycosis due to Cladophialophora bantiana

Antifungal therapy of murine Aspergillus terreus infection

Assessment of Aspergillus fumigatus burden in pulmonary tissue of guinea pigs by quantitative PCR, galactomannan enzyme immunoassay, and quantitative culture

Assessment of Aspergillus fumigatus in guinea pig bronchoalveolar lavages and pulmonary tissue by culture and realtime polymerase chain reaction studies

Assessment of serum (1->3)-beta-D-glucan concentration as a measure of disease burden in a murine model of invasive pulmonary aspergillosis.

Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus

Caspofungin and liposomal amphotericin B therapy of experimental murine scedosporiosis

Caspofungin dose escalation for invasive candidiasis due to resistant Candida albicans. ⬇️

Caspofungin resistance in Candida albicans: correlating clinical outcome with laboratory susceptibility testing of three isogenic isolates serially obtained from a patient with progressive Candida esophagitis

Combination antifungal therapy of murine aspergillosis: liposomal amphotericin B and micafungin

Comparison of Nonculture Blood-Based Tests for Diagnosing Invasive Aspergillosis in an Animal Model

Comparison of lateral flow technology and galactomannan and (1->3)-beta-D-glucan assays for detection of invasive pulmonary aspergillosis

Comparison of staining methods and a nested PCR assay to detect Histoplasma capsulatum in tissue sections.

Detection and measurement of fungal burden in a guinea pig model of invasive pulmonary aspergillosis by novel quantitative nested real-time PCR compared with galactomannan and (1,3)-β-D-glucan detection

Detection of Cryptococcus neoformans DNA in tissue samples by nested and real-time PCR assays

Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production

Effect of Antifungal Treatment in a Diet-Based Murine Model of Disseminated Candidiasis Acquired via the Gastrointestinal Tract.

Efficacies of amphotericin B (AMB) lipid complex, AMB colloidal dispersion, liposomal AMB, and conventional AMB in treatment of murine coccidioidomycosis

Efficacy of Delayed Therapy with Fosmanogepix (APX001) in a Murine Model of Candida auris Invasive Candidiasis ⬇️

Efficacy of posaconazole as treatment and prophylaxis against Fusarium solani

Efficacy of the investigational echinocandin ASP9726 in a guinea pig model of invasive pulmonary aspergillosis

Evaluation of aminocandin and caspofungin against Candida glabrata including isolates with reduced caspofungin susceptibility

Extended-Interval Dosing of Rezafungin against Azole-Resistant Aspergillus fumigatus

Improving the mouse model for studying the efficacy of voriconazole

In Vivo Efficacy of VT-1129 against Experimental Cryptococcal Meningitis with the Use of a Loading Dose-Maintenance Dose Administration Strategy

In vitro Activity of Fosfomycin, Alone and Combined with Cefepime and Meropenem, Against Carbapenemase-Producing Gram-Negative Bacteria.

In vitro and in vivo activities of posaconazole against Coccidioides immitis

In vitro pharmacodynamics of anidulafungin and caspofungin against Candida glabrata isolates, including strains with decreased caspofungin susceptibility.

In vivo activity of posaconazole against Mucor spp. in an immunosuppressed-mouse model

In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis

In vivo efficacy of anidulafungin and caspofungin against Candida glabrata and association with in vitro potency in the presence of sera

Inhaled voriconazole for prevention of invasive pulmonary aspergillosis.

Interlaboratory and interstudy reproducibility of a novel lateral-flow device and influence of antifungal therapy on detection of invasive pulmonary aspergillosis.

Isavuconazole Is Effective for the Treatment of Experimental Cryptococcal Meningitis

Limited activity of miltefosine in murine models of cryptococcal meningoencephalitis and disseminated cryptococcosis

Modified release itraconazole amorphous solid dispersion to treat Aspergillus fumigatus: importance of the animal model selection.

New guinea pig model of Cryptococcal meningitis

Oral glucan synthase inhibitor SCY-078 is effective in an experimental murine model of invasive candidiasis caused by WT and echinocandin-resistant Candida glabrata ⬇️

Polymerase Chain Reaction Detection ofAspergillusDNA in Experimental Models of Invasive Aspergillosis

Posaconazole therapy of disseminated phaeohyphomycosis in a murine model

Prolyl endopeptidase activity in bronchoalveolar lavage fluid: a novel diagnostic biomarker in a guinea pig model of invasive pulmonary aspergillosis

Prophylactic efficacy of single dose pulmonary administration of amphotericin B inhalation powder in a guinea pig model of invasive pulmonary aspergillosis

Retinal function assessed by ERG before and after induction of ocular aspergillosis and treatment by the anti-fungal, micafungin, in rabbits

Standardization of an experimental murine model of invasive pulmonary aspergillosis

The Fungal Cyp51 Inhibitor VT-1129 Is Efficacious in an Experimental Model of Cryptococcal Meningitis

The Fungal Cyp51-Specific Inhibitor VT-1598 Demonstrates and Activity against Candida auris

The Novel Arylamidine T-2307 Demonstrates In Vitro and In Vivo Activity against Candida auris

The Novel Fungal Cyp51 Inhibitor VT-1598 is Efficacious in Experimental Models of Central Nervous System Coccidioidomycosis Caused by Coccidioides posadasii and Coccidioides immitis.

The Orotomide Olorofim Is Efficacious in an Experimental Model of Central Nervous System Coccidioidomycosis

The investigational agent E1210 is effective in treatment of experimental invasive candidiasis caused by resistant Candida albicans ⬇️

The novel arylamidine T-2307 demonstrates in vitro and in vivo activity against echinocandin-resistant Candida glabrata

The novel arylamidine T-2307 maintains in vitro and in vivo activity against echinocandin-resistant Candida albicans.

Therapeutic efficacy of caspofungin alone and in combination with amphotericin B deoxycholate for coccidioidomycosis in a mouse model

Topical voriconazole as a novel treatment for fungal keratitis