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List of works by Ludger Klein-Hitpass

A Systematic Analysis of the 3′UTR of HNF4A mRNA Reveals an Interplay of Regulatory Elements Including miRNA Target Sites ⬇️

scientific article published on November 30, 2011

A comprehensive molecular study on Coffin-Siris and Nicolaides-Baraitser syndromes identifies a broad molecular and clinical spectrum converging on altered chromatin remodeling.

scientific article published in August 2013

A novel physiological role for cardiac myoglobin in lipid metabolism

scientific article published on 23 February 2017

Aberrant hypomethylation of the cancer-testis antigen PRAME correlates with PRAME expression in acute myeloid leukemia

scientific article

Absence of telomerase reverse transcriptase promoter mutations in neuroblastoma

scientific article published on 13 May 2015

Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions

scientific article

Acute myeloid leukemia-induced remodeling of the human bone marrow niche predicts clinical outcome

scientific article published on 01 October 2020

Aging of Xenopus tropicalis eggs leads to deadenylation of a specific set of maternal mRNAs and loss of developmental potential ⬇️

scientific article published on October 22, 2010

Allelic loss in a minimal region on chromosome 16q24 is associated with vitreous seeding of retinoblastoma

scientific article published on January 2007

Altering gene expression by aminocoumarins: the role of DNA supercoiling in Staphylococcus aureus

scientific article

Anti-leukemic effect of CDK9 inhibition in T-cell prolymphocytic leukemia

scientific article published on 13 October 2020

BRAF inhibitors reverse the unique molecular signature and phenotype of hairy cell leukemia and exert potent antileukemic activity

scientific article published on 5 December 2014

Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus-infected individuals

scientific article published on 14 December 2017

CDKN2A deletion in supratentorial ependymoma with RELA alteration indicates a dismal prognosis: a retrospective analysis of the HIT ependymoma trial cohort

scientific article published on 08 June 2020

Centrosomal CAP350 protein stabilises microtubules associated with the Golgi complex

scientific article

Characterization of bursa subacromialis-derived mesenchymal stem cells.

scientific article

Characterization of pancreatic glucagon-producing tumors and pituitary gland tumors in transgenic mice overexpressing MYCN in hGFAP-positive cells

scientific article published on 19 October 2016

Combined PER2 and CRY1 expression predicts outcome in chronic lymphocytic leukemia

scientific article published on 2 June 2009

Common denominator genes that distinguish colorectal carcinoma from normal mucosa.

scientific article

Comparison of clinical and immunological findings in gnotobiotic piglets infected with Escherichia coli O104:H4 outbreak strain and EHEC O157:H7.

scientific article

Complementation of non-tumorigenicity of HPV18-positive cervical carcinoma cells involves differential mRNA expression of cellular genes including potential tumor suppressor genes on chromosome 11q13.

scientific article published on July 2013

Conditional expression of hepatocyte nuclear factor-1beta, the maturity-onset diabetes of the young-5 gene product, influences the viability and functional competence of pancreatic beta-cells

scientific article published on July 2006

Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells

scientific article

Depletion of Foxp3+ regulatory T cells is accompanied by an increase in the relative abundance of Firmicutes in the murine gut microbiome

scientific article published on 12 December 2019

Differential impact of the transcriptional repressor Gfi1 on mature CD4+ and CD8+ T lymphocyte function

scientific article

Epigenetic dynamics of monocyte-to-macrophage differentiation

scientific article published on 29 July 2016

Epigenetic silencing of the circadian clock gene CRY1 is associated with an indolent clinical course in chronic lymphocytic leukemia

scientific article

Everolimus Stabilizes Podocyte Microtubules via Enhancing TUBB2B and DCDC2 Expression

scientific article published on 2 September 2015

Evolutionary origin and methylation status of human intronic CpG islands that are not present in mouse

scientific article

Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3

scientific article

Expanded CD8+ T cells of murine and human CLL are driven into a senescent KLRG1+ effector memory phenotype.

scientific article published in November 2013

Exposure of patient-derived mesenchymal stromal cells to TGFB1 supports fibrosis induction in a pediatric acute megakaryoblastic leukemia model

scientific article published on 08 July 2020

Expression of ribosomal and translation-associated genes is correlated with a favorable clinical course in chronic lymphocytic leukemia.

scientific article published on 27 November 2002

Expression of the TrkA or TrkB receptor tyrosine kinase alters the double-strand break (DSB) repair capacity of SY5Y neuroblastoma cells

scientific article

Expression profiling identifies genes that predict recurrence of breast cancer after adjuvant CMF-based chemotherapy

scientific article

FTO levels affect RNA modification and the transcriptome

scientific article

Functional analysis and secondary expression profiling of candidate genes deregulated in conjunction with oncogenic Ras signaling

scientific article published on 15 July 2005

Functional signature of human islet-derived precursor cells compared to bone marrow-derived mesenchymal stem cells

scientific article published in May 2010

Gains and overexpression identify DEK and E2F3 as targets of chromosome 6p gains in retinoblastoma.

scientific article published in September 2005

Gene dosage effects in chronic lymphocytic leukemia

scientific article published in December 2010

Gene expression profiles in murine hematopoietic stem cells revisited: analysis of cDNA libraries reveals high levels of translational and metabolic activities

scientific article published on 30 March 2006

Gene profiling of growth factor independence 1B gene (Gfi-1B) in leukemic cells

scientific article published on 6 December 2007

Genome-Wide Analysis of the Nucleosome Landscape in Individuals with Coffin-Siris Syndrome

scientific article published on 26 October 2019

Genome-wide H4 K16 acetylation by SAS-I is deposited independently of transcription and histone exchange

scientific article

Genomic gains on chromosome 1q in retinoblastoma: consequences on gene expression and association with clinical manifestation

scientific article published in September 2005

Genotype-phenotype correlations in patients with retinoblastoma and interstitial 13q deletions.

scientific article

Gut microbiota in HIV-infected individuals linked to coronary heart disease

article

HNF4 alpha orchestrates a set of 14 genes to down-regulate cell proliferation in kidney cells

scientific article

HNF4alpha reduces proliferation of kidney cells and affects genes deregulated in renal cell carcinoma

scientific article

Heterogeneous in vitro effects of doxorubicin on gene expression in primary human liposarcoma cultures

scientific article

High-resolution genomic analysis does not qualify atypical plexus papilloma as a separate entity among choroid plexus tumors

scientific article published on 01 February 2015

Identification of Tcf-4 as a transcriptional target of p53 signalling

scientific article published on April 2004

Identification of integrin-alpha4, Rb1, and syncytin a as murine placental target genes of the transcription factor GCMa/Gcm1.

scientific article published on 31 December 2007

Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening

scientific article published on January 2004

Identification of target genes of the transcription factor HNF1beta and HNF1alpha in a human embryonic kidney cell line

scientific article

Identifying Genetic Lesions in Ocular Adnexal Extranodal Marginal Zone Lymphomas of the MALT Subtype by Whole Genome, Whole Exome and Targeted Sequencing

scientific article published on 17 April 2020

Improved risk-stratification for posterior fossa ependymoma of childhood considering clinical, histological and genetic features - a retrospective analysis of the HIT ependymoma trial cohort

scientific article published on 14 November 2019

In vitro transcriptome analysis of porcine choroid plexus epithelial cells in response to Streptococcus suis: release of pro-inflammatory cytokines and chemokines

scientific article published on 12 June 2011

Induction of Inflammatory Cytokines by a Keratin Mutation and their Repression by a Small Molecule in a Mouse Model for EBS

scientific article published on 21 June 2007

Interference of peritoneal dialysis fluids with cell cycle mechanisms

scientific article published on 31 July 2014

Irf4-dependent CD103+CD11b+ dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus

scientific article published on 14 June 2017

Krüppel-like factors KLF2 and 6 and Ki-67 are direct targets of zoledronic acid in MCF-7 cells

scientific article

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.

scientific article published on 7 October 2012

Lipoprotein lipase expression is a novel prognostic factor in B-cell chronic lymphocytic leukemia.

scientific article

Locus-Specific DNA Methylation Analysis by Targeted Deep Bisulfite Sequencing

scientific article published in January 2018

Loss at chromosome arm 16q in retinoblastoma: Confirmation of the association with diffuse vitreous seeding and refinement of the recurrently deleted region ⬇️

scientific article published on February 8, 2011

Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy

scientific article (publication date: March 2009)

MYCN regulates oncogenic MicroRNAs in neuroblastoma

scientific article

Malignant fibrous histiocytoma--pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study.

scientific article

Malignant fibrous histiocytoma—pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study.

scientific article

Matricellular protein SPARCL1 regulates tumor microenvironment-dependent endothelial cell heterogeneity in colorectal carcinoma.

scientific article published on 10 October 2016

Mesenchymal Stem Cells Isolated from the Anterior Cruciate Ligament: Characterization and Comparison of Cells from Young and Old Donors

scientific article published on 01 September 2018

Microarray analyses of transdifferentiated mesenchymal stem cells

scientific article published in February 2008

Microarray analysis of gene expression in metastatic gastric cancer cells after incubation with the methylation inhibitor 5-aza-2'-deoxycytidine.

scientific article published on January 2004

Microarray analysis reveals differential gene expression patterns and regulation of single target genes contributing to the opposing phenotype of TrkA- and TrkB-expressing neuroblastomas.

scientific article

Microarray versus conventional prediction of lymph node metastasis in colorectal carcinoma

scientific article published in July 2005

Miz-1 Is Required To Coordinate the Expression of TCRβ and p53 Effector Genes at the Pre-TCR “β-Selection” Checkpoint ⬇️

scientific article published on August 12, 2011

Molecular signature for lymphatic metastasis in colorectal carcinomas

scientific article

Mutations in PIGA cause a CD52-/GPI-anchor-deficient phenotype complicating alemtuzumab treatment in T-cell prolymphocytic leukemia

scientific article published on 02 September 2020

Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo.

scientific article published on 11 December 2017

Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia

scientific article published in Nature Communications

Novel target genes of the Wnt pathway and statistical insights into Wnt target promoter regulation

scientific article

Nuclear export is essential for the tumor-promoting activity of survivin

scientific article published on 10 November 2006

OTX2 Defines a Subgroup of Atypical Teratoid Rhabdoid Tumors With Close Relationship to Choroid Plexus Tumors

scientific article published on 26 December 2016

Oral contraceptives prevent the development of endometriosis in the chicken chorioallantoic membrane model.

scientific article published on 9 July 2008

Osteoblast-specific Krm2 overexpression and Lrp5 deficiency have different effects on fracture healing in mice

scientific article

Overexpression of tissue-nonspecific alkaline phosphatase increases the expression of neurogenic differentiation markers in the human SH-SY5Y neuroblastoma cell line

scientific article published on 29 May 2015

Pattern of genes influenced by conditional expression of the transcription factors HNF6, HNF4alpha and HNF1beta in a pancreatic beta-cell line

scientific article

Plasticity in adipogenesis and osteogenesis of human mesenchymal stem cells

scientific article published on 27 March 2007

Prediction of clinical outcome and biological characterization of neuroblastoma by expression profiling

scientific article published in November 2005

Progranulin is a novel independent predictor of disease progression and overall survival in chronic lymphocytic leukemia

scientific article

Protein kinase c-β-dependent activation of NF-κB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo.

scientific article

Pro‑apoptotic effects of pycnogenol on HT1080 human fibrosarcoma cells

scientific article

Recurrent alterations ofTNFAIP3(A20) in T-cell large granular lymphocytic leukemia

scientific article published on 30 July 2015

Recurrent loss, but lack of mutations, of the SMARCB1 tumor suppressor gene in T-cell prolymphocytic leukemia with TCL1A-TCRAD juxtaposition

scientific article published in July 2009

Recurrent mutations in NF-κB pathway components, KMT2D, and NOTCH1/2 in ocular adnexal MALT-type marginal zone lymphomas

scientific article published on 23 August 2016

Regions of common inter-individual DNA methylation differences in human monocytes: genetic basis and potential function

scientific article

Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways

scientific article

Resveratrol induces apoptosis and alters gene expression in human fibrosarcoma cells

scientific article

SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia

scientific article published on 19 January 2018

SMAF-1 inhibits the APC/beta-catenin pathway and shows properties similar to those of the tumor suppressor protein APC.

scientific article published on September 2004

Shorter telomeres correlate with an increase in the number of uniparental disomies in patients with chronic lymphocytic leukemia

scientific article published on 12 October 2015

Somatic mosaicism for maternal uniparental disomy 15 in a girl with Prader-Willi syndrome: confirmation by cell cloning and identification of candidate downstream genes

scientific article published on 27 August 2003

Stringent regulation of DNA repair during human hematopoietic differentiation: a gene expression and functional analysis

scientific article published on 29 September 2005

Supratentorial ependymomas of childhood carry C11orf95-RELA fusions leading to pathological activation of the NF-κB signaling pathway.

scientific article

Synergistic apoptotic effects of taurolidine and TRAIL on squamous carcinoma cells of the esophagus

scientific article

Synergistic effects of sonoporation and taurolidin/TRAIL on apoptosis in human fibrosarcoma

scientific article published on 27 September 2010

TRAIL and Taurolidine induce apoptosis and decrease proliferation in human fibrosarcoma.

scientific article

The first five years of the Wnt targetome

scientific article

The survivin isoform survivin-3B is cytoprotective and can function as a chromosomal passenger complex protein

scientific article

The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors

scientific article

The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus

scientific article

Tissue-specific transcription factor HNF4alpha inhibits cell proliferation and induces apoptosis in the pancreatic INS-1 beta-cell line

scientific article published on January 2007

Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells

scientific article published on 23 September 2004

Uncovering the cellular and molecular changes in tendon stem/progenitor cells attributed to tendon aging and degeneration

scientific article published on 22 July 2013

WISP 1 is an important survival factor in human mesenchymal stromal cells

scientific article published on 06 September 2014

WT1 and BCR-ABL specific small interfering RNA have additive effects in the induction of apoptosis in leukemic cells

scientific article published on 01 March 2005

Widespread regulation of gene expression in the Drosophila genome by the histone acetyltransferase dTip60.

scientific article published in December 2009

microRNA expression and its potential role in cardioprotection by ischemic postconditioning in pigs

scientific article published on 05 January 2014

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