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List of works by Christopher J Earley

A 10-year, longitudinal assessment of dopamine agonists and methadone in the treatment of restless legs syndrome

scientific article published on 15 January 2011

A case of compulsive behaviors observed in a restless legs syndrome patient treated with a dopamine agonist

scientific article published in May 2009

A comparison of MRI tissue relaxometry and ROI methods used to determine regional brain iron concentrations in restless legs syndrome

scientific article published on 30 July 2015

A direct interaction between two Restless Legs Syndrome predisposing genes: MEIS1 and SKOR1

scientific article published in Scientific Reports

A further evaluation of the cognitive deficits associated with restless legs syndrome (RLS).

scientific article published on 14 September 2007

A randomized, double-blind, placebo-controlled trial of intravenous iron sucrose in restless legs syndrome

scientific article published on 14 February 2008

Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome

scientific article published on 01 April 2000

Abnormally increased CSF 3-Ortho-methyldopa (3-OMD) in untreated restless legs syndrome (RLS) patients indicates more severe disease and possibly abnormally increased dopamine synthesis

scientific article

Adenosine receptors as markers of brain iron deficiency: Implications for Restless Legs Syndrome

scientific article published on 3 September 2016

Allocating provider resources to diagnose and treat restless legs syndrome: a cost-utility analysis

scientific article

Alterations in pain responses in treated and untreated patients with restless legs syndrome: Associations with sleep disruption ⬇️

scientific article published on May 12, 2011

Altered brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis-Ekbom Disease).

scientific article published on 16 June 2014

Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome

scientific article published on 25 May 2009

Altered iron metabolism in lymphocytes from subjects with restless legs syndrome.

scientific article published on June 2008

Altered white matter integrity in primary restless legs syndrome patients: diffusion tensor imaging study

scientific article published on 11 February 2014

An algorithm for the management of restless legs syndrome

scientific article

An update on the dopaminergic treatment of restless legs syndrome and periodic limb movement disorder.

scientific article published on May 2004

Analysis of functional GLO1 variants in the BTBD9 locus and restless legs syndrome

scientific article published on 17 June 2015

Another dopamine agonist for treatment of restless legs syndrome ⬇️

scientific article published on June 24, 2011

Assessing health-related quality of life in patients with restless legs syndrome in Korea: Comparison with other chronic medical diseases ⬇️

scientific article published on August 30, 2012

Assessment of change in restless legs syndrome symptoms during the acute drug-withdrawal period

scientific article published on 17 August 2018

Association of restless legs syndrome variants in Korean patients with restless legs syndrome

scientific article published on December 2013

Augmentation as a treatment complication of restless legs syndrome: concept and management

scientific article published on January 2007

Augmentation of the restless legs syndrome with carbidopa/levodopa.

scientific article published on April 1996

Brain iron deficiency in idiopathic restless legs syndrome measured by quantitative magnetic susceptibility at 7 tesla

scientific article published on 21 June 2016

CSF dopamine, serotonin, and biopterin metabolites in patients with restless legs syndrome

scientific article

Case-Control and Family-Based Association Study of Specific PTPRD Variants in Restless Legs Syndrome

scientific article published on 09 January 2016

Childhood and adult factors associated with restless legs syndrome (RLS) diagnosis

scientific article published on 18 May 2007

Circadian changes in CSF dopaminergic measures in restless legs syndrome

scientific article published on 24 March 2006

Clinical efficacy and safety of IV ferric carboxymaltose (FCM) treatment of RLS: A multi-centred, placebo-controlled preliminary clinical trial ⬇️

scientific article published on October 5, 2011

Clinical efficacy of ferric carboxymaltose treatment in patients with restless legs syndrome

scientific article

Clinical practice. Restless legs syndrome

scientific article

Co-registration of magnetic resonance spectroscopy and transcranial magnetic stimulation.

scientific article published on 3 January 2015

Cognitive deficits associated with restless legs syndrome (RLS).

scientific article published on 28 September 2005

Connecting clinical aspects to corticomotor excitability in restless legs syndrome: a TMS study

scientific article published on 31 May 2018

Connectome and molecular pharmacological differences in the dopaminergic system in restless legs syndrome (RLS): plastic changes and neuroadaptations that may contribute to augmentation

scientific article

Correction: Genome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1

Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome

scientific article

Default mode network disturbances in restless legs syndrome/Willis-Ekbom disease

scientific article published on 6 July 2016

Defining morphology of periodic leg movements in sleep: an evidence-based definition of a minimum window of sustained activity.

scientific article published on 21 September 2016

Defining the phenotype of the restless legs syndrome (RLS) using age-of-symptom-onset

scientific article

Developing a behavioral model of Restless Legs Syndrome utilizing mice with natural variances in ventral midbrain iron

scientific article published on 08 January 2020

Diagnostic standards for dopaminergic augmentation of restless legs syndrome: report from a World Association of Sleep Medicine-International Restless Legs Syndrome Study Group consensus conference at the Max Planck Institute

scientific article published on June 2007

Diminished iron concentrations increase adenosine A(2A) receptor levels in mouse striatum and cultured human neuroblastoma cells

scientific article published on 28 October 2008

Dissociative changes in the Bmax and KD of dopamine D2/D3 receptors with aging observed in functional subdivisions of the striatum: a revisit with an improved data analysis method

scientific article

Diurnal cycle influences peripheral and brain iron levels in mice

scientific article

Diurnal variation of default mode network in patients with restless legs syndrome

scientific article published on 25 October 2017

Diurnal variations in brain iron concentrations in BXD RI mice

scientific article published on 07 January 2014

Drug hoarding: a case of atypical dopamine dysregulation syndrome in a RLS patient

scientific article published in March 2009

Effects of IV iron isomaltoside-1000 treatment on regional brain iron status in an iron-deficient animal ⬇️

scientific article published on May 7, 2013

Effects of new PLM scoring rules on PLM rate in relation to sleep and resting wake for RLS and healthy controls

scientific article published on 25 June 2020

Effects of rest-duration, time-of-day and their interaction on periodic leg movements while awake in restless legs syndrome

scientific article published in September 2005

Efficacy of ferric carboxymaltose (FCM) 500 mg dose for the treatment of Restless Legs Syndrome

scientific article published on 6 December 2017

Epidemiology of insomnia in korean adults: prevalence and associated factors

scientific article published on 31 March 2009

Epidemiology of restless legs syndrome in Korean adults

scientific article

Erratum to “Diagnostic standards for dopaminergic augmentation of restless legs syndrome: Report from a World Association of Sleep Medicine – International Restless Legs Syndrome Study Group consensus conference at the Max Planck Institute” [Sl

scientific article published in November 2007

Evaluating daytime alertness in individuals with Restless Legs Syndrome (RLS) compared to sleep restricted controls

scientific article published on 28 January 2008

Evaluating the quality of life of patients with restless legs syndrome

scientific article

Evidence for communication of peripheral iron status to cerebrospinal fluid: clinical implications for therapeutic strategy

scientific article published on 16 April 2020

Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report

scientific article published on 24 November 2017

Extracellular vesicles reveal abnormalities in neuronal iron metabolism in restless legs syndrome

scientific article published on 01 July 2019

Family history study of the restless legs syndrome ⬇️

scientific article published on November 1, 2002

Ferritin levels in the cerebrospinal fluid and restless legs syndrome: effects of different clinical phenotypes

scientific article published in September 2005

Ferritin subunits in CSF are decreased in restless legs syndrome

scientific article published in February 2006

Functional connectivity alternation of the thalamus in restless legs syndrome patients during the asymptomatic period: a resting-state connectivity study using functional magnetic resonance imaging

scientific article published on 30 January 2014

Genetic analysis of iron-deficiency effects on the mouse spleen ⬇️

scientific article published on July 6, 2011

Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1

scientific journal article

Gray matter alteration in patients with restless legs syndrome: a voxel-based morphometry study

scientific article

Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis

scientific article

In Reply-Additional Safety Considerations Before Prescribing Opioids to Manage Restless Legs Syndrome

scientific article published on 01 July 2018

In search of alternatives to dopaminergic ligands for the treatment of restless legs syndrome: iron, glutamate, and adenosine

scientific article published on November 2016

Increased CSF hypocretin-1 (orexin-A) in restless legs syndrome

scientific article published in August 2002

Increased synaptic dopamine in the putamen in restless legs syndrome

scientific article

Insight into the pathophysiology of restless legs syndrome

scientific article

Inter-movement interval as a primary stable measure of periodic limb movements of sleep.

scientific article published on 11 November 2015

Intervening Leg Movements Disrupt PLMS Sequences

scientific article

Investigation into the correlation between sensation and leg movement in restless legs syndrome

scientific article published on 01 September 2005

Iron and the restless legs syndrome

scientific article published on June 15, 1998

Iron deficiency alters dopamine uptake and response to L-DOPA injection in Sprague-Dawley rats

scientific journal article

Iron deficiency alters expression of dopamine-related genes in the ventral midbrain in mice.

scientific article published on August 2013

Iron deficiency alters the day-night variation in monoamine levels in mice

scientific article

Iron-deficiency anaemia enhances red blood cell oxidative stress

scientific article published on September 2008

Iron-deficiency and dopaminergic treatment effects on RLS-Like behaviors of an animal model with the brain iron deficiency pattern of the restless legs syndrome

scientific article published on 05 February 2020

Is ferroportin-hepcidin signaling altered in restless legs syndrome?

scientific article published on 8 June 2006

Latest guidelines and advances for treatment of restless legs syndrome

scientific article published on April 2014

Low brain iron effects and reversibility on striatal dopamine dynamics

scientific article

Lower molecular weight intravenous iron dextran for restless legs syndrome

scientific article published on 18 January 2013

MATPLM1, A MATLAB script for scoring of periodic limb movements: preliminary validation with visual scoring

scientific article

MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels

scientific article published on 06 January 2009

MRI measurement of brain iron in patients with restless legs syndrome

scientific article published in January 2001

MRI-determined regional brain iron concentrations in early- and late-onset restless legs syndrome

scientific article

Medication use in patients with restless legs syndrome compared with a control population

scientific article

Medication use in patients with restless legs syndrome compared with a control population

Mitochondrial ferritin in the substantia nigra in restless legs syndrome

scientific article

Moderate to severe but not mild RLS is associated with greater sleep-related sympathetic autonomic activation than healthy adults without RLS

scientific article published on 05 October 2019

Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome

scientific article

New Insights into the Neurobiology of Restless Legs Syndrome

scientific article published on 26 July 2018

Of mice and men, periodic limb movements and iron: how the human genome informs the mouse genome

scientific article published on July 2008

Pergolide and carbidopa/levodopa treatment of the restless legs syndrome and periodic leg movements in sleep in a consecutive series of patients.

scientific article published in December 1996

Pilot study: can machine learning analyses of movement discriminate between leg movements in sleep (LMS) with vs. without cortical arousals?

scientific article published on 26 May 2020

Pivotal Role of Adenosine Neurotransmission in Restless Legs Syndrome.

scientific article published in January 2017

Postmortem and imaging based analyses reveal CNS decreased myelination in restless legs syndrome

scientific article

Pregnancy accounts for most of the gender difference in prevalence of familial RLS

scientific article

Prevalence and clinical characteristics of patients with restless legs syndrome with painful symptoms

scientific article published on 18 March 2015

Prevalence and clinical characteristics of restless legs syndrome in diabetic peripheral neuropathy: comparison with chronic osteoarthritis

scientific article

Profile of altered brain iron acquisition in restless legs syndrome

scientific article

Proteomic analysis of the cerebrospinal fluid of patients with restless legs syndrome/Willis-Ekbom disease ⬇️

scientific article published on 07 June 2013

Quiescegenic nocturnal dyskinesia: A restless legs syndrome (RLS) variant or a new syndrome?

scientific article published on 15 August 2008

RLS and blood donation

scientific article

Race and restless legs syndrome symptoms in an adult community sample in east Baltimore

scientific article

Randomized, double-blind, placebo-controlled trial of pergolide in restless legs syndrome

scientific article published in December 1998

Repeated IV doses of iron provides effective supplemental treatment of restless legs syndrome

scientific article published in April 2005

Response to "Characterization of the painful restless legs syndrome".

scientific article published on 30 April 2015

Response to intravenous iron in patients with iron deficiency anemia (IDA) and restless leg syndrome (Willis-Ekbom disease).

scientific article published on 10 September 2014

Response to the letter "Characterization of the painful restless legs syndrome".

scientific article published on 7 September 2015

Resting-state connectivity and the effects of treatment in restless legs syndrome

scientific article published on 18 November 2019

Restless Legs Syndrome

scientific article published on 01 May 2004

Restless Legs Syndrome is Associated with DSM-IV Major Depressive Disorder and Panic Disorder in the Community

article

Restless legs syndrome and periodic leg movements in sleep

scientific article published on January 1, 2011

Restless legs syndrome augmentation associated with tramadol

scientific article published on 22 August 2006

Restless legs syndrome is associated with DSM-IV major depressive disorder and panic disorder in the community

scientific article

Restless legs syndrome symptomatology, attitudes and beliefs among treated and untreated individuals ⬇️

scientific article published on August 31, 2012

Restless legs syndrome: Understanding its consequences and the need for better treatment ⬇️

scientific article published on October 1, 2010

Restless legs syndrome: a clinical update

scientific article

Restless legs syndrome: a review of clinical and pathophysiologic features

scientific article

Segregation analysis of restless legs syndrome: possible evidence for a major gene in a family study using blinded diagnoses

scientific article published on 24 October 2006

Sleep disruption in systemic sclerosis (scleroderma) patients: clinical and polysomnographic findings

scientific article published in July 2002

Subclinical sensory neuropathy in late-onset restless legs syndrome

scientific article

Systems genetic analysis of multivariate response to iron deficiency in mice

scientific article published on 28 March 2012

Systems genetic analysis of peripheral iron parameters in the mouse

scientific article published on 02 May 2007

Systems genetic analysis of the effects of iron deficiency in mouse brain

scientific article

TOX3 Variants Are Involved in Restless Legs Syndrome and Parkinson's Disease with Opposite Effects

scientific article

Targeting hypersensitive corticostriatal terminals in restless legs syndrome

scientific article published on 24 November 2017

Thalamic glutamate/glutamine in restless legs syndrome: increased and related to disturbed sleep

scientific article published on 26 April 2013

The Appropriate Use of Opioids in the Treatment of Refractory Restless Legs Syndrome

scientific article published in January 2018

The Johns Hopkins telephone diagnostic interview for the restless legs syndrome: preliminary investigation for validation in a multi-center patient and control population ⬇️

scientific article published on March 1, 2003

The dopamine transporter is decreased in the striatum of subjects with restless legs syndrome

scientific article

The dopaminergic neurons of the A11 system in RLS autopsy brains appear normal

scientific article published on 23 March 2009

The effects of dietary iron deprivation on murine circadian sleep architecture

scientific article published on 13 November 2006

The four diagnostic criteria for Restless Legs Syndrome are unable to exclude confounding conditions ("mimics").

scientific article published on 29 January 2009

The importance of oral iron therapy in restless legs syndrome

scientific article published on 12 January 2009

The long-term treatment of restless legs syndrome/Willis-Ekbom disease: evidence-based guidelines and clinical consensus best practice guidance: a report from the International Restless Legs Syndrome Study Group

scientific article

The prevalence and impact of restless legs syndrome on patients with iron deficiency anemia ⬇️

scientific article published on March 12, 2013

The role of iron in restless legs syndrome

scientific article published on January 2007

The treatment of restless legs syndrome and periodic limb movement disorder. An American Academy of Sleep Medicine Review

scientific article

The treatment of restless legs syndrome with intravenous iron dextran

scientific article

Thy1 expression in the brain is affected by iron and is decreased in Restless Legs Syndrome

scientific article

Undiagnosed individuals with first-degree relatives with restless legs syndrome have increased periodic limb movements

scientific article published on 24 August 2006

Up-regulation of striatal adenosine A(2A) receptors with iron deficiency in rats: effects on locomotion and cortico-striatal neurotransmission

scientific article

Valid measures of periodic leg movements (PLMs) during a suggested immobilization test using the PAM-RL leg activity monitors require adjusting detection parameters for noise and signal in each recording

scientific article published on 16 October 2013

Validation of the Hopkins telephone diagnostic interview for restless legs syndrome

scientific article published on 17 July 2007

Validation of the Johns Hopkins restless legs severity scale

scientific article published in May 2001

Validation of the Restless Legs Syndrome Quality of Life questionnaire

scientific article published on 01 March 2005

Validation of the self-completed Cambridge-Hopkins questionnaire (CH-RLSq) for ascertainment of restless legs syndrome (RLS) in a population survey

scientific article

Willis-Ekbom Disease Foundation revised consensus statement on the management of restless legs syndrome

scientific article published on September 2013

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