List of works by Robert N Willette

1-[1-Hexyl-6-(methyloxy)-1H-indazol-3-yl]-2-methyl-1-propanone, a potent and highly selective small molecule blocker of the large-conductance voltage-gated and calcium-dependent K+ channel

scientific article published on 30 June 2008

2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD-307243) causes instantaneous current through human ether-a-go-go-related gene potassium channels

scientific article published on 27 November 2007

Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress

scientific article published on 9 May 2017

Albiglutide, a long lasting glucagon-like peptide-1 analog, protects the rat heart against ischemia/reperfusion injury: evidence for improving cardiac metabolic efficiency

scientific article (publication date: 2011)

An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure

scientific article

Anti-apoptotic effects of rosiglitazone in hypercholesterolemic rabbits subjected to myocardial ischemia and reperfusion

scientific article published in April 2004

Antidiabetic Agents. N4-Arylsulfonylsemicarbazides

article

Antioxidative, Antinitrative, and Vasculoprotective Effects of a Peroxisome Proliferator–Activated Receptor-γ Agonist in Hypercholesterolemia ⬇️

scientific article published on November 10, 2003

Apoptosis signal-regulating kinase 1 inhibition attenuates cardiac hypertrophy and cardiorenal fibrosis induced by uremic toxins: Implications for cardiorenal syndrome

scientific article published on 6 November 2017

Assessing the effects of LXR agonists on cellular cholesterol handling: a stable isotope tracer study

scientific article published on 27 March 2006

Assessment of macrophage infiltration in a murine model of abdominal aortic aneurysm

scientific article published on 01 August 2009

Cardioprotection Resulting from Glucagon-Like Peptide-1 Administration Involves Shifting Metabolic Substrate Utilization to Increase Energy Efficiency in the Rat Heart

scientific article published on 22 June 2015

Cardioprotection by systemic dosing of thymosin beta four following ischemic myocardial injury

scientific article

Chronic inhibition of 11 β -hydroxysteroid dehydrogenase type 1 activity decreases hypertension, insulin resistance, and hypertriglyceridemia in metabolic syndrome

scientific article published on 18 March 2013

Chronic inhibition of hypoxia-inducible factor prolyl 4-hydroxylase improves ventricular performance, remodeling, and vascularity after myocardial infarction in the rat.

scientific article published on August 2010

Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy

scientific article published on 22 January 2014

Comparison of soluble guanylate cyclase stimulators and activators in models of cardiovascular disease associated with oxidative stress.

scientific article

Deletion of the UT receptor gene results in the selective loss of urotensin-II contractile activity in aortae isolated from UT receptor knockout mice

scientific article published on May 2003

Differential effects of p38 mitogen-activated protein kinase and cyclooxygenase 2 inhibitors in a model of cardiovascular disease.

scientific article published on 25 June 2009

Differential uptake of ferumoxtran-10 and ferumoxytol, ultrasmall superparamagnetic iron oxide contrast agents in rabbit: critical determinants of atherosclerotic plaque labeling

scientific article published on 01 April 2005

Eprosartan improves cardiac performance, reduces cardiac hypertrophy and mortality and downregulates myocardial monocyte chemoattractant protein-1 and inflammation in hypertensive heart disease

scientific article published in March 2004

Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature

scientific article

Human-induced pluripotent stem cell-derived cardiomyocytes exhibit temporal changes in phenotype

scientific article published on 5 July 2013

In vivo activation of peroxisome proliferator-activated receptor-delta protects the heart from ischemia/reperfusion injury in Zucker fatty rats

scientific article

In vivo serial assessment of aortic aneurysm formation in apolipoprotein E-deficient mice via MRI

scientific article published on 17 September 2008

Inhibition of Apoptosis Signal-Regulating Kinase 1 Attenuates Myocyte Hypertrophy and Fibroblast Collagen Synthesis

scientific article published on 14 December 2017

Inhibition of Rho-kinase protects the heart against ischemia/reperfusion injury

scientific article published in February 2004

Inhibition of apoptosis signal-regulating kinase 1 ameliorates left ventricular dysfunction by reducing hypertrophy and fibrosis in a rat model of cardiorenal syndrome

scientific article published on 06 April 2020

Novel fusion of GLP-1 with a domain antibody to serum albumin prolongs protection against myocardial ischemia/reperfusion injury in the rat

scientific article published on 14 October 2013

PPARdelta activation normalizes cardiac substrate metabolism and reduces right ventricular hypertrophy in congestive heart failure

scientific article published on 01 July 2007

Pharmacological inhibition of C-C chemokine receptor 2 decreases macrophage infiltration in the aortic root of the human C-C chemokine receptor 2/apolipoprotein E-/- mouse: magnetic resonance imaging assessment

scientific article published on 3 December 2009

Phenylbutyrates as potent, orally bioavailable vitronectin receptor (integrin alphavbeta3) antagonists

scientific article published on April 2003

RE: ASK1, a new target in treating cardiorenal syndrome (CRS)

scientific article published on 01 October 2020

RE: Blockade of apoptosis signal-regulating kinase 1 ameliorates cardiac dysfunction in cardiorenal syndrome via enhancing angiogenesis

scientific article published on 17 October 2020

RE: Inhibition of apoptosis signal-regulating kinase 1 might be a novel therapeutic target in the treatment of cardiorenal syndrome

scientific article published on 10 September 2020

SB-267268, a nonpeptidic antagonist of alpha(v)beta3 and alpha(v)beta5 integrins, reduces angiogenesis and VEGF expression in a mouse model of retinopathy of prematurity

scientific journal article

Serial MRI characterization of the functional and morphological changes in mouse lung in response to cardiac remodeling following myocardial infarction

scientific article published on 10 June 2011

Simultaneous assessment of left-ventricular infarction size, function and tissue viability in a murine model of myocardial infarction by cardiac manganese-enhanced magnetic resonance imaging (MEMRI).

scientific article published in December 2004

Soluble epoxide hydrolase inhibition does not prevent cardiac remodeling and dysfunction after aortic constriction in rats and mice

scientific article

Synthetic LXR agonists increase LDL in CETP species

scientific article published on 16 July 2005

Systemic activation of the transient receptor potential vanilloid subtype 4 channel causes endothelial failure and circulatory collapse: Part 2.

scientific article

TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury.

scientific article published on 16 May 2014

The antithrombotic efficacy of lotrafiban (SB 214857) in canine models of acute coronary thrombosis

scientific article (publication date: June 2002)

The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore

scientific article published on 26 June 2013

The peptidic urotensin-II receptor ligand GSK248451 possesses less intrinsic activity than the low-efficacy partial agonists SB-710411 and urantide in native mammalian tissues and recombinant cell systems

scientific article

The prolyl 4-hydroxylase inhibitor GSK360A decreases post-stroke brain injury and sensory, motor, and cognitive behavioral deficits

scientific article published on 7 September 2017

Toward improved myocardial maturity in an organ-on-chip platform with immature cardiac myocytes

scientific article published in January 2017

Unrestrained p38 MAPK activation in Dusp1/4 double-null mice induces cardiomyopathy.

scientific article published on 19 September 2012

p38 MAPK Inhibitors Ameliorate Target Organ Damage in Hypertension: Part 2. Improved Renal Function as Assessed by Dynamic Contrast-Enhanced Magnetic Resonance Imaging ⬇️

scientific article published on October 15, 2003

p38 MAPK inhibition reduces aortic ultrasmall superparamagnetic iron oxide uptake in a mouse model of atherosclerosis: MRI assessment

scientific article published on 27 December 2007

p38 MAPK inhibitors ameliorate target organ damage in hypertension: Part 1. p38 MAPK-dependent endothelial dysfunction and hypertension

scientific article published on 15 October 2003

p38 mitogen-activated protein kinase inhibitors for the treatment of chronic cardiovascular disease

scientific article published on September 1, 2003

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