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List of works by Sarah Freemantle

All-trans-retinoic acid antagonizes the Hedgehog pathway by inducing patched

scientific article published on 04 February 2014

Bexarotene plus erlotinib suppress lung carcinogenesis independent of KRAS mutations in two clinical trials and transgenic models

scientific article

Blockade of the Ubiquitin Protease UBP43 Destabilizes Transcription Factor PML/RARα and Inhibits the Growth of Acute Promyelocytic Leukemia ⬇️

scientific article published on October 8, 2010

CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110

scientific article

Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2

scientific article (publication date: 29 May 2002)

Comparing histone deacetylase inhibitor responses in genetically engineered mouse lung cancer models and a window of opportunity trial in patients with lung cancer

scientific article published on 16 May 2013

Cyclin E transgenic mice: discovery tools for lung cancer biology, therapy, and prevention

scientific article

Cyclin degradation for cancer therapy and chemoprevention

scientific article published on November 2007

Developmentally-related candidate retinoic acid target genes regulated early during neuronal differentiation of human embryonal carcinoma

scientific article

Dinaciclib Induces Anaphase Catastrophe in Lung Cancer Cells via Inhibition of Cyclin-Dependent Kinases 1 and 2.

scientific article published on 22 August 2016

Effective capture of circulating tumor cells from a transgenic mouse lung cancer model using dendrimer surfaces immobilized with anti-EGFR

scientific article published on 27 August 2015

Evidence for tankyrases as antineoplastic targets in lung cancer.

scientific article

Evidence for the ubiquitin protease UBP43 as an antineoplastic target

scientific article

Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation

scientific article

G0S2 Suppresses Oncogenic Transformation by Repressing a MYC-Regulated Transcriptional Program

scientific article published on 2 February 2016

G0S2 represses PI3K/mTOR signaling and increases sensitivity to PI3K/mTOR pathway inhibitors in breast cancer

scientific article

High DNA methyltransferase 3B expression mediates 5-aza-deoxycytidine hypersensitivity in testicular germ cell tumors

scientific article

Involvement of microRNAs in lung cancer biology and therapy

scientific article

Mice lacking G0S2 are lean and cold-tolerant

scientific article

Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomas

scientific article published on 10 November 2015

MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors

scientific article

Microarray analysis uncovers retinoid targets in human bronchial epithelial cells

scientific article

Negative feedback at the level of nuclear receptor coregulation. Self-limitation of retinoid signaling by RIP140.

scientific article published on 22 September 2003

Next-Generation CDK2/9 Inhibitors and Anaphase Catastrophe in Lung Cancer

scientific article

Refractory testicular germ cell tumors are highly sensitive to the second generation DNA methylation inhibitor guadecitabine

scientific article

Repression of cyclin D1 as a target for germ cell tumors.

scientific article published on February 2007

Repression of exogenous gene expression by the retinoic acid target gene G0S2.

scientific article published on 28 March 2013

Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations

scientific article published on 22 August 2012

Retinoic acid mediates long-paced oscillations in retinoid receptor activity: evidence for a potential role for RIP140.

scientific article

Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity

scientific article

Retinoid chemoprevention trials: cyclin D1 in the crosshairs

scientific article published on January 2009

Retinoids in cancer therapy and chemoprevention: promise meets resistance ⬇️

scientific article published on October 20, 2003

Selective repression of retinoic acid target genes by RIP140 during induced tumor cell differentiation of pluripotent human embryonal carcinoma cells

scientific article

Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells

scientific article

Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown

scientific article

Testicular Germ Cell Tumors: A Paradigm for the Successful Treatment of Solid Tumor Stem Cells

scientific article published on August 2006

The ISG15-specific protease USP18 regulates stability of PTEN.

scientific article published on 12 December 2016

The direct p53 target gene, FLJ11259/DRAM, is a member of a novel family of transmembrane proteins

scientific article published on 22 February 2007

Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas

scholarly article

UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia

scientific article

UBE1L represses PML/RAR{alpha} by targeting the PML domain for ISG15ylation

scientific article

Uncovering growth-suppressive MicroRNAs in lung cancer

scientific article published on February 2009

Uncovering novel targets for cancer chemoprevention.

scientific article published on January 2007

Wnt pathway activation by ADP-ribosylation.

scientific article published on 3 May 2016

Wnt pathway reprogramming during human embryonal carcinoma differentiation and potential for therapeutic targeting

scientific article

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