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List of works by Alison M Strack

1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: application in the synthesis of potent human melanocortin-4 receptor selective agonists

scientific article published in July 2005

1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity

scientific article published in April 2009

11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice

scientific article

2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity

scientific article published on 24 July 2008

An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes

scientific article published on 9 February 2012

Antiobesity effect of MK-5046, a novel bombesin receptor subtype-3 agonist

scientific article published on 29 October 2010

Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanamide (MK-0364), in rodents

scientific article

ApoA-I mimetic peptides promote pre-β HDL formation in vivo causing remodeling of HDL and triglyceride accumulation at higher dose

scientific article published on 4 November 2010

Body temperature as a mouse pharmacodynamic response to bombesin receptor subtype-3 agonists and other potential obesity treatments

scientific article published on 31 August 2010

Cannabinoid-1 receptor inhibition prevents the reduction of 24-hour energy expenditure with weight loss

scientific article published on 14 October 2011

Characterization of a novel and selective cannabinoid CB1 receptor inverse agonist, Imidazole 24b, in rodents

scientific article published on 25 October 2007

Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats

scientific article published in August 2003

Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor ago

scientific article published in October 2002

Design and synthesis of (ant)-agonists that alter appetite and adiposity

scientific article published on January 2006

Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation

scientific article published on 21 April 2010

Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocorti

scientific article published in August 2005

Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist

scientific article published in January 2005

Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity

scientific article

Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity

scientific article

Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist

scientific article published on 01 March 2011

Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist

scientific article published on 19 February 2010

Discovery of benzodiazepine sulfonamide-based bombesin receptor subtype 3 agonists and their unusual chirality

scientific article published on 3 October 2011

Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists

scientific article published on 17 June 2010

Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists

scientific article published on 4 February 2010

Furo[2,3-b]pyridine-based cannabinoid-1 receptor inverse agonists: synthesis and biological evaluation. Part 1.

scientific article published on 4 January 2010

Ghrelin neutralization by a ribonucleic acid-SPM ameliorates obesity in diet-induced obese mice

scientific article

Glucocorticoids, chronic stress, and obesity

scientific article published on January 2006

Improved efficacy for ezetimibe and rosuvastatin by attenuating the induction of PCSK9 ⬇️

scientific article published on January 24, 2011

Lack of protection with a novel, selective melanocortin receptor subtype-4 agonist RY767 in a rat transient middle cerebral artery occlusion stroke model

scientific article published on 4 December 2008

Lead optimization of 5,6-diarylpyridines as CB1 receptor inverse agonists

scientific article published on 13 January 2007

Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism

scientific article (publication date: 5 March 2002)

Melanocortin-4 receptor (MC4R) agonists for the treatment of obesity

scientific article published on July 2006

Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice

scientific article published on 8 December 2004

Modulation of metabolic syndrome by fibroblast growth factor 19 (FGF19)?

scientific article

Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis ⬇️

scientific article published on October 28, 2012

Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia ⬇️

scientific article published on October 23, 2011

Pyridopyrimidine based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation

scientific article published on 9 March 2009

Reconstituted HDL Elicits Marked Changes in Plasma Lipids Following Single-Dose Injection in C57Bl/6 Mice ⬇️

scientific article published on November 8, 2011

Regulation of body weight and carcass composition by sibutramine in rats

scientific article published in March 2002

Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity

scientific article published on 21 January 2010

Structure-activity relationship of linear tetrapeptides Tic-DPhe-Arg-Trp-NH2 at the human melanocortin-4 receptor and effects on feeding behaviors in rat.

scientific article published in October 2005

Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists

scientific article

Synthesis and SAR of 5,6-diarylpyridines as human CB1 inverse agonists

scientific article published in February 2005

Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists

scientific article published on 02 November 2005

The mu-opioid receptor subtype is required for the anorectic effect of an opioid receptor antagonist

scientific article published on 5 July 2006

The role of melanocortins in body weight regulation: opportunities for the treatment of obesity

scientific article

The role of melanocortins in body weight regulation: opportunities for the treatment of obesity

scientific article published on 01 August 2002

The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity

scientific article

The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species

scientific article

Utilizing HaloTag Technology to Track the Fate of PCSK9 from Intracellular vs. Extracellular Sources

scientific article published on 20 September 2012

Validation of Human ApoB and ApoAI Immunoturbidity Assays for Non-human Primate Dyslipidemia and Atherosclerosis Research ⬇️

scientific article published on March 11, 2011

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