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List of works by D Euan MacIntyre

1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia ⬇️

scientific article published on December 13, 2010

3-Amino-1,5-benzodiazepinones: Potent, state-dependent sodium channel blockers with anti-epileptic activity

article

A novel 3-dimensional micro-ultrasound approach to automated measurement of carotid arterial plaque volume as a biomarker for experimental atherosclerosis

scientific article published on 19 September 2008

A role for the melanocortin 4 receptor in sexual function

scientific article

Activation of melanocortin MC(4) receptors increases erectile activity in rats ex copula

scientific article

Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker

scientific article

Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanamide (MK-0364), in rodents

scientific article

Benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain

article

Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors.

scientific article published in November 2003

Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inhibitors of inducible nitric oxide synthase

scientific article

Characterization of a novel and selective cannabinoid CB1 receptor inverse agonist, Imidazole 24b, in rodents

scientific article published on 25 October 2007

Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats

scientific article published in August 2003

Comparison of Cardiovascular Parameters and/or Serum Chemistry and Hematology Profiles in Conscious and Anesthetized Rhesus Monkeys (Macaca mulatta)

scientific article published on 01 March 1999

Contribution of the tetrodotoxin-resistant voltage-gated sodium channel NaV1.9 to sensory transmission and nociceptive behavior

scientific article

Cyclopentane-based human NK1 antagonists. Part 1: discovery and initial SAR

scientific article published on 07 July 2006

Cyclopentane-based human NK1 antagonists. Part 2: development of potent, orally active, water-soluble derivatives

scientific article published on 10 July 2006

Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor ago

scientific article published in October 2002

Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocorti

scientific article published in August 2005

Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist

scientific article published in January 2005

Discovery of a novel class of benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain

article

Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist

scientific article published on 01 March 2011

Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist

scientific article published on 19 February 2010

Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists

scientific article published on 17 June 2010

Effects of sildenafil on erectile activity in mice lacking neuronal or endothelial nitric oxide synthase

scientific article published in July 2002

Effects of the ventilatory stimulant, doxapram on human TASK-3 (KCNK9, K2P9.1) channels and TASK-1 (KCNK3, K2P3.1) channels

scientific article published on 18 September 2019

GAL-021 and GAL-160 are Efficacious in Rat Models of Obstructive and Central Sleep Apnea and Inhibit BKCa in Isolated Rat Carotid Body Glomus Cells ⬇️

scientific article published on January 2015

Ghrelin neutralization by a ribonucleic acid-SPM ameliorates obesity in diet-induced obese mice

scientific article

Identification and Characterization of GAL-021 as a Novel Breathing Control Modulator

scientific article

Identification of glucose-dependant insulin secretion targets in pancreatic beta cells by combining defined-mechanism compound library screening and siRNA gene silencing

scientific journal article

Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2

scientific journal article

Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension

scientific article published on 25 December 2010

Lead optimization of 5,6-diarylpyridines as CB1 receptor inverse agonists

scientific article published on 13 January 2007

Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism

scientific article (publication date: 5 March 2002)

Melanocortin receptors and erectile function

scientific article published on June 2004

Pharmacokinetics and pharmacodynamics of AR9281, an inhibitor of soluble epoxide hydrolase, in single- and multiple-dose studies in healthy human subjects

scientific article published on 21 March 2011

Pyridopyrimidine based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation

scientific article published on 9 March 2009

Structure-activity relationship of linear tetrapeptides Tic-DPhe-Arg-Trp-NH2 at the human melanocortin-4 receptor and effects on feeding behaviors in rat.

scientific article published in October 2005

Synthesis and SAR of potent and orally bioavailable tert-butylpyrrolidine archetype derived melanocortin subtype-4 receptor modulators

scientific article published on 25 April 2008

Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists

scientific article published on 02 November 2005

The proof of the pudding is in the eating: editorial focus on "Hyperphagia, not hypometabolism, causes early onset obesity in melanocortin-4-receptor knockout mice"

scientific article published on 18 March 2003

The role of melanocortins in body weight regulation: opportunities for the treatment of obesity

scientific article

The role of melanocortins in body weight regulation: opportunities for the treatment of obesity

scientific article published on 01 August 2002

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)

scientific journal article

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