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List of works by Kuniaki Shirao

A Multicenter Phase-II Study of 5-FU, Leucovorin and Oxaliplatin (FOLFOX6) in Patients with Pretreated Metastatic Colorectal Cancer ⬇️

scientific article published on September 6, 2010

A Phase II study of irinotecan in combination with 120-h infusion of 5-fluorouracil in patients with metastatic colorectal carcinoma: Japan Clinical Oncology Group Study (JCOG9703).

scientific article published in January 2003

A phase 2 clinical trial of panitumumab monotherapy in Japanese patients with metastatic colorectal cancer

scientific article published on 14 March 2009

A phase I escalating single-dose and weekly fixed-dose study of cetuximab pharmacokinetics in Japanese patients with solid tumors

scientific article

A phase I study of single-agent BEZ235 special delivery system sachet in Japanese patients with advanced solid tumors

scientific article published on 16 November 2018

A phase II Study of the global dose and schedule of capecitabine in Japanese patients with metastatic colorectal cancer

scientific article published on 6 July 2006

A phase II study of biweekly mitomycin C and irinotecan combination therapy in patients with fluoropyrimidine-resistant advanced gastric cancer: a report from the Gastrointestinal Oncology Group of the Japan Clinical Oncology Group (JCOG0109-DI Tria

scientific article published on April 19, 2011

A phase II study of sequential methotrexate and 5-fluorouracil chemotherapy in previously treated gastric cancer: a report from the Gastrointestinal Oncology Group of the Japan Clinical Oncology Group, JCOG 9207 trial

scientific article published on 30 May 2008

A phase i study of bolus 5-fluorouracil and leucovorin combined with weekly paclitaxel (FLTAX) as first-line therapy for advanced gastric cancer

scientific article published on 15 July 2008

A randomized phase II study of combination therapy with S-1, oral leucovorin, and oxaliplatin (SOL) and mFOLFOX6 in patients with previously untreated metastatic colorectal cancer.

scientific article

Additive effects of drug transporter genetic polymorphisms on irinotecan pharmacokinetics/pharmacodynamics in Japanese cancer patients

scientific article published on 22 September 2009

Adjuvant chemotherapy with uracil-tegafur for pathological stage III rectal cancer after mesorectal excision with selective lateral pelvic lymphadenectomy: a multicenter randomized controlled trial

scientific article (publication date: April 2006)

Antitumor effect of MCC-465, pegylated liposomal doxorubicin tagged with newly developed monoclonal antibody GAH, in colorectal cancer xenografts

scientific article published in July 2004

Association of carboxylesterase 1A genotypes with irinotecan pharmacokinetics in Japanese cancer patients

scientific article

Bevacizumab safety in Japanese patients with colorectal cancer

scientific article published on 15 January 2016

CD34-negative solitary fibrous tumour resistant to imatinib

scientific article published on 5 July 2013

Characteristics and Outcomes of Patients With Advanced Gastric Cancer Who Declined to Participate in a Randomized Clinical Chemotherapy Trial ⬇️

scientific article published on May 1, 2011

Clinical application of immunoreactivity of dihydropyrimidine dehydrogenase (DPD) in gastric scirrhous carcinoma treated with S-1, a new DPD inhibitory fluoropyrimidine.

scientific article published in July 2005

Clinical efficacy and safety of octreotide (SMS201-995) in terminally ill Japanese cancer patients with malignant bowel obstruction

scientific article

Clinical significance of insulin-like growth factor type 1 receptor and epidermal growth factor receptor in patients with advanced gastric cancer

scientific article published on 11 June 2008

Close association of UGT1A9 IVS1+399C>T with UGT1A1*28, *6, or *60 haplotype and its apparent influence on 7-ethyl-10-hydroxycamptothecin (SN-38) glucuronidation in Japanese

scientific article

Combination chemotherapy with cisplatin and irinotecan in patients with adenocarcinoma of the small intestine

scientific article published in January 2008

Combination of O6-methylguanine-DNA methyltransferase and thymidylate synthase for the prediction of fluoropyrimidine efficacy

scientific article

Comparison of HHV-6 DNA detection in plasma and whole blood in allogeneic hematopoietic stem cell transplant recipients: frequent false-positive results for active HHV-6 infection using whole blood samples

article

Construction of possible integrated predictive index based on EGFR and ANXA3 polymorphisms for chemotherapy response in fluoropyrimidine-treated Japanese gastric cancer patients using a bioinformatic method

scientific article published on 16 October 2015

Correlations of cytokine levels in cerebrospinal fluid and peripheral blood with outcome of HHV-6B encephalitis after hematopoietic stem cell transplantation

scientific article published on 26 September 2019

Ectopic Hepatocellular Carcinoma of the Left Sub-diaphragm with Metastasis ⬇️

scientific article published on July 15, 2011

Effect of a 3-hour interval between methotrexate and 5-fluorouracil in the treatment of metastatic colorectal cancer

scientific article

Efficacy and safety profile of imatinib mesylate (ST1571) in Japanese patients with advanced gastrointestinal stromal tumors: a phase II study (STI571B1202).

scientific article published on 14 June 2008

Eight novel single nucleotide polymorphisms in ABCG2/BCRP in Japanese cancer patients administered irinotacan

scientific article published in January 2003

Evaluation of safety, pharmacokinetics, and efficacy of vorinostat, a histone deacetylase inhibitor, in the treatment of gastrointestinal (GI) cancer in a phase I clinical trial ⬇️

scientific article published on January 11, 2012

Final results of randomized trials by the National Surgical Adjuvant Study of Colorectal Cancer (NSAS-CC)

scientific article published on 19 May 2010

Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study

scientific article published on 7 October 2009

Fourteen novel genetic variations and haplotype structures of the TYMS gene encoding human thymidylate synthase (TS)

scientific article published on 01 December 2006

Functional Characterization of Human UDP-Glucuronosyltransferase 1A9 Variant, D256N, Found in Japanese Cancer Patients ⬇️

scientific article published on May 1, 2003

Functional Characterization of Wild-type and Variant (T202I and M59I) Human UDP-glucuronosyltransferase 1A10 ⬇️

scientific article (publication date: May 2003)

Functional analysis of four naturally occurring variants of human constitutive androstane receptor

scientific article published on 28 June 2005

Functional analysis of six human aryl hydrocarbon receptor variants in a Japanese population

scientific article published on 28 April 2005

Functional characterization of three naturally occurring single nucleotide polymorphisms in the CES2 gene encoding carboxylesterase 2 (HCE-2).

scientific article published on 20 July 2005

Genetic polymorphisms of UGT1A6 in a Japanese population

scientific article published on 01 February 2005

Genetic variation and haplotype structure of the ABC transporter gene ABCG2 in a Japanese population

scientific article published on 01 April 2006

Genetic variations and frequencies of major haplotypes in SLCO1B1 encoding the transporter OATP1B1 in Japanese subjects: SLCO1B1*17 is more prevalent than *15

scientific article published on 01 December 2007

Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences

scientific article published on 09 September 2007

Genetic variations and haplotypes of ABCC2 encoding MRP2 in a Japanese population

scientific article published in January 2008

Genetic variations and haplotypes of UGT1A4 in a Japanese population

scientific article published on 01 April 2005

Genetic variations of the AHR gene encoding aryl hydrocarbon receptor in a Japanese population

scientific article published on 01 August 2004

Genomic Loss of DUSP4 Contributes to the Progression of Intraepithelial Neoplasm of Pancreas to Invasive Carcinoma

scientific article published on 3 March 2016

Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan

scientific article published on December 2003

Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population.

scientific article published in January 2004

Hemophagocytic lymphohistiocytosis following influenza vaccination in a patient with aplastic anemia undergoing allogeneic bone marrow stem cell transplantation

scientific article published on 4 January 2017

Hypofibrinogenemia associated with steroid therapy for the patients who developed GVHD after allogeneic stem cell transplantation

scientific article published on 01 July 2015

Identification of a candidate single-nucleotide polymorphism related to chemotherapeutic response through a combination of knowledge-based algorithm and hypothesis-free genomic data.

scientific article

Identification of prognostic biomarkers in gastric cancer using endoscopic biopsy samples

scientific article

Impact of CYP3A4 haplotypes on irinotecan pharmacokinetics in Japanese cancer patients

scientific article published on 8 November 2007

Impact of insulin-like growth factor type 1 receptor, epidermal growth factor receptor, and HER2 expressions on outcomes of patients with gastric cancer

scientific article published in May 2008

Impact of vascular endothelial growth factor receptor 1, 2, and 3 expression on the outcome of patients with gastric cancer

scientific article published in February 2009

Importance of UDP-glucuronosyltransferase 1A1*6 for irinotecan toxicities in Japanese cancer patients

scientific article

Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28

scientific article published on 01 July 2007

Long-term results for patients with unresectable gastric cancer who received chemotherapy in the Japan Clinical Oncology Group (JCOG) trials

scientific article

Long-term survival and prognostic factors in patients with metastatic gastric cancers treated with chemotherapy in the Japan Clinical Oncology Group (JCOG) study

scientific article published in November 2004

Long-term survivor of gastric small cell carcinoma

scientific article published in September 2004

Multicenter Phase II study of cetuximab plus irinotecan in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin and fluoropyrimidines

scientific article published on 4 October 2008

Neuroendocrine tumors of the stomach: chemotherapy with cisplatin plus irinotecan is effective for gastric poorly-differentiated neuroendocrine carcinoma ⬇️

scientific article published on February 16, 2011

Neurological Toxicity in Metastatic Colorectal Cancer Patients Treated with Modified FOLFOX6 Plus Bevacizumab

scientific article

Novel Genetic Polymorphisms in the NR3C1 (Glucocorticoid receptor) Gene in a Japanese Population

article

Other Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorder, Hodgkin type, following Epstein-Barr Viral Hepatitis in a Patient with Rheumatoid Arthritis

scientific article published on 27 December 2017

Pharmacodynamic Studies of Gefitinib in Tumor Biopsy Specimens From Patients With Advanced Gastric Carcinoma

scientific article published on 01 September 2006

Pharmacokinetic parameters from 3-Tesla DCE-MRI as surrogate biomarkers of antitumor effects of bevacizumab plus FOLFIRI in colorectal cancer with liver metastasis

scientific article

Phase I Study of Axitinib in Combination with Cisplatin and Capecitabine in Patients with Previously Untreated Advanced Gastric Cancer

scientific article

Phase I and pharmacokinetic study of KRN5500, a spicamycin derivative, for patients with advanced solid tumors

scientific article published in June 2003

Phase I study of combination therapy with irinotecan, leucovorin, and bolus and continuous-infusion 5-fluorouracil (FOLFIRI) for advanced colorectal cancer in Japanese patients

scientific article published in April 2014

Phase I study of irinotecan and S-1 combination therapy in patients with metastatic gastric cancer

scientific article

Phase I study of single-dose oxaliplatin in Japanese patients with malignant tumors

scientific article published on 15 May 2006

Phase I/II study of irinotecan, 5-fluorouracil, and l-leucovorin combination therapy (modified Saltz regimen) in patients with metastatic colorectal cancer

scientific article published on October 2004

Phase I/II study of oxaliplatin with weekly bolus fluorouracil and high-dose leucovorin (ROX) as first-line therapy for patients with colorectal cancer

scientific article

Phase I/II study of sunitinib malate in Japanese patients with gastrointestinal stromal tumor after failure of prior treatment with imatinib mesylate

scientific article published in December 2010

Phase II study of biweekly irinotecan and mitomycin C combination therapy in patients with fluoropyrimidine-resistant advanced colorectal cancer

scientific article

Phase II study of oral S-1 for treatment of metastatic colorectal carcinoma

scientific article published in June 2004

Phase II study of oxaliplatin in japanese patients with metastatic colorectal cancer refractory to fluoropyrimidines

scientific article

Phase II study of sequential methotrexate and 5-fluorouracil chemotherapy against peritoneally disseminated gastric cancer with malignant ascites: a report from the Gastrointestinal Oncology Study Group of the Japan Clinical Oncology Group, JCOG 960

scientific article

Predicting drug efficacy-fluorinated pyrimidines (fluorouracil, S-1 and capecitabine)

scientific article published on 01 November 2012

Prognostic factors for patients with metastatic colorectal cancer receiving protracted venous infusion of 5-FU.

scientific article

Prognostic significance of thymidylate synthase in patients with metastatic colorectal cancer who receive protracted venous infusions of 5-fluorouracil

scientific article published in October 2004

Randomized Phase III study of 5-fluorouracil continuous infusion vs. sequential methotrexate and 5-fluorouracil therapy in far advanced gastric cancer with peritoneal metastasis (JCOG0106).

scientific article published on 7 September 2013

Randomized phase II study of second-line chemotherapy with the best available 5-fluorouracil regimen versus weekly administration of paclitaxel in far advanced gastric cancer with severe peritoneal metastases refractory to 5-fluorouracil-containing r

scientific article published on 19 September 2015

Randomized phase III trial of fluorouracil alone versus fluorouracil plus cisplatin versus uracil and tegafur plus mitomycin in patients with unresectable, advanced gastric cancer: The Japan Clinical Oncology Group Study (JCOG9205).

scientific article published on January 2003

Randomized study of dexamethasone treatment for delayed emesis, anorexia and fatigue induced by irinotecan

scientific article published on 3 July 2003

Rationale and design of the TRUSTY study: a randomised, multicentre, open-label phase II/III study of trifluridine/tipiracil plus bevacizumab versus irinotecan, fluoropyrimidine plus bevacizumab as second-line treatment in patients with metastatic co

Reduced phosphorylation of ribosomal protein S6 is associated with sensitivity to MEK inhibition in gastric cancer cells

scientific article published on 03 October 2016

Relationship between expression of vascular endothelial growth factor in tumor tissue from gastric cancers and chemotherapy effects: comparison between S-1 alone and the combination of S-1 plus CDDP

scientific article published on 01 July 2007

Relationships of insulin-like growth factor-1 receptor and epidermal growth factor receptor expression to clinical outcomes in patients with colorectal cancer

scientific article published on 26 November 2008

Retrospective analysis of clinical results and predictors of response in chemo-naive patients with advanced gastric cancer treated with S-1, an oral fluoropyrimidine derivative, as single-agent chemotherapy

scientific article published in January 2004

Safety and pharmacokinetics of panitumumab in Japanese patients with advanced solid tumors

scientific article published on 25 August 2009

Second-line chemotherapy with irinotecan plus cisplatin after the failure of S-1 monotherapy for advanced gastric cancer ⬇️

scientific article published on September 5, 2010

Sequential chemotherapy with methotrexate and 5-fluorouracil for chemotherapy-naive advanced gastric cancer with disseminated intravascular coagulation at initial diagnosis

scientific article

Significance of and problems in adopting response evaluation criteria in solid tumor RECIST for assessing anticancer effects of advanced gastric cancer

scientific article published on 01 December 2000

Significance of biological markers for predicting prognosis and selecting chemotherapy regimens of advanced gastric cancer patients between continuous infusion of 5-FU and a combination of 5-FU and cisplatin

scientific article published on 01 April 2007

Small cell carcinoma of the esophagus. Analysis of 14 cases and literature review.

scientific article

Successful Cord Blood Stem Cell Transplantation for an Adult Case of Chronic Active Epstein-Barr Virus Infection

scientific article

Sunitinib-resistant gastrointestinal stromal tumors harbor cis-mutations in the activation loop of the KIT gene.

scientific article published on 24 April 2009

Survival analysis of adjuvant chemotherapy with S-1 plus cisplatin for stage III gastric cancer

scientific article published on 30 May 2013

Survival prolongation after treatment failure of first-line chemotherapy in patients with advanced gastric cancer: combined analysis of the Japan Clinical Oncology group trials JCOG9205 and JCOG9912.

scientific article published on 26 October 2013

Synergistic antitumor activity of the novel SN-38-incorporating polymeric micelles, NK012, combined with 5-fluorouracil in a mouse model of colorectal cancer, as compared with that of irinotecan plus 5-fluorouracil

scientific article published on May 2008

Three novel single nucleotide polymorphisms in UGT1A10.

scientific article published in January 2002

Three novel single nucleotide polymorphisms in UGT1A9

scientific article published on 01 January 2003

Toxicities associated with chemotherapy in colorectal cancer

scientific article published on September 1, 2003

Toxoplasmic Encephalitis with Untreated Hairy Cell Leukemia Variant

scientific article

Twelve novel single nucleotide polymorphisms in the CES2 gene encoding human carboxylesterase 2 (hCE-2)

scientific article

Twenty-six novel single nucleotide polymorphisms and their frequencies of the NR1I3 (CAR) gene in a Japanese population

scientific article published in January 2003

Two Elderly Patients with Philadelphia Chromosome Positive Mixed Phenotype Acute Leukemia Who Were Successfully Treated with Dasatinib and Prednisolone

scientific article published on 01 May 2016

UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer

scientific article

Vascular endothelial growth factor receptor expression as a prognostic marker for survival in colorectal cancer.

scientific article

Vesicocutaneous fistula formation during treatment with sunitinib malate: Case report ⬇️

scientific article published on November 1, 2010

Weekly hepatic arterial infusion of 5-fluorouracil and subsequent systemic chemotherapy for liver metastases from colorectal cancer

scientific article

[Neoadjuvant therapy for esophageal cancer - indication and efficacy]

scientific article published on 01 October 2007

[Oncology at medical school]

scientific article published on 01 June 2008

[Philadelphia chromosome-positive acute lymphoblastic leukemia relapsing with an anterior chamber lesion of the eye]

scientific article published on 01 January 2019

[S-1 plus cisplatin(SP) for advanced gastric cancer]

[Successful delivery after chemotherapy for acute myeloid leukemia diagnosed in the second trimester]

scientific article published on 01 January 2020

[Successful treatment of secondary graft failure in a mixed-phenotype acute leukemia patient with haploidentical hematopoietic stem cell transplantation and post-transplant cyclophosphamide administration]

scientific article published on 01 January 2018

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