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List of works by Atsushi Ohtsu

12-Gene Recurrence Score Assay Stratifies the Recurrence Risk in Stage II/III Colon Cancer With Surgery Alone: The SUNRISE Study

scientific article published on 20 June 2016

A Case of Descending Necrotizing MediastinitisPenetrating to the Esophagus

scientific article

A Phase I study of intravenous PI3K inhibitor copanlisib in Japanese patients with advanced or refractory solid tumors

scientific article published on 03 December 2016

A Phase II study of irinotecan in combination with 120-h infusion of 5-fluorouracil in patients with metastatic colorectal carcinoma: Japan Clinical Oncology Group Study (JCOG9703).

scientific article published in January 2003

A Pilot Study of Post-operative Radiotherapy with Concurrent Chemotherapy for High-risk Squamous Cell Carcinoma of the Cervical Esophagus ⬇️

scientific article published on February 18, 2011

A Proposal for Progression-Free Survival Assessment in Patients with Early Progressive Cancer

scientific article

A laterally-spreading tumor in a colonic interposition treated by endoscopic submucosal dissection

scientific article

A model chemosensitivity test examining apoptosis in small specimens of gastric cancer

scientific article published on 01 August 2000

A multicenter phase II study of TAS-102 monotherapy in patients with pre-treated advanced gastric cancer (EPOC1201).

scientific article

A new technique for endoscopic mucosal resection with an insulated-tip electrosurgical knife improves the completeness of resection of intramucosal gastric neoplasms

scientific article published on 01 April 2002

A novel gene-protein assay for evaluating HER2 status in gastric cancer: simultaneous analyses of HER2 protein overexpression and gene amplification reveal intratumoral heterogeneity

scientific article published on 11 June 2014

A phase I study evaluating cixutumumab, a type 1 insulin-like growth factor receptor inhibitor, given every 2 or 3 weeks in Japanese patients with advanced solid tumors

scientific article published on 30 April 2016

A phase I study of intravenous aflibercept with FOLFIRI in Japanese patients with previously treated metastatic colorectal cancer ⬇️

scientific article published on November 20, 2012

A phase I study of sorafenib in combination with S-1 plus cisplatin in patients with advanced gastric cancer

scientific article published on 27 March 2013

A phase I study of the human anti-activin receptor-like kinase 1 antibody PF-03446962 in Asian patients with advanced solid tumors

scientific article

A phase II study of biweekly mitomycin C and irinotecan combination therapy in patients with fluoropyrimidine-resistant advanced gastric cancer: a report from the Gastrointestinal Oncology Group of the Japan Clinical Oncology Group (JCOG0109-DI Tria

scientific article published on April 19, 2011

A phase II study of doxifluridine in elderly patients with advanced gastric cancer: the Japan Clinical Oncology Group Study (JCOG 9410).

scientific article

A phase II study of sequential methotrexate and 5-fluorouracil chemotherapy in previously treated gastric cancer: a report from the Gastrointestinal Oncology Group of the Japan Clinical Oncology Group, JCOG 9207 trial

scientific article published on 30 May 2008

A prospective, multicenter phase I/II study of induction chemotherapy with docetaxel, cisplatin and fluorouracil (DCF) followed by chemoradiotherapy in patients with unresectable locally advanced esophageal carcinoma.

scientific article published on 18 May 2016

A retrospective observational study of clinicopathological features of KRAS, NRAS, BRAF and PIK3CA mutations in Japanese patients with metastatic colorectal cancer

scientific article

A retrospective study of definitive chemoradiotherapy for elderly patients with esophageal cancer

scientific article

A retrospective study of the safety and efficacy of paclitaxel plus ramucirumab in patients with advanced or recurrent gastric cancer with ascites

scientific article published on 31 January 2018

Additional surgery for non-curative resection after endoscopic submucosal dissection for gastric cancer: a retrospective analysis of 200 cases

scientific article

Additive effects of drug transporter genetic polymorphisms on irinotecan pharmacokinetics/pharmacodynamics in Japanese cancer patients

scientific article published on 22 September 2009

Adjuvant therapy with imatinib mesylate after resection of primary high-risk gastrointestinal stromal tumors in Japanese patients ⬇️

scientific article published on November 23, 2011

Advanced esophageal cancer with esophago-bronchial fistula successfully treated by chemoradiation therapy with additional endoscopic resection: a case report

scientific article

Advances in Systemic Therapy for Metastatic or Advanced Gastric Cancer

scientific article

Amrubicin for the treatment of neuroendocrine carcinoma of the gastrointestinal tract: a retrospective analysis of five cases

scientific article

Analysis of esophagogastric cancer patients enrolled in the National Cancer Institute Cancer Therapy Evaluation Program sponsored phase 1 trials

scientific article

Analysis of neurosensory adverse events induced by FOLFOX4 treatment in colorectal cancer patients: a comparison between two Asian studies and four Western studies ⬇️

scientific article published on August 6, 2012

Application of a combination of a knowledge-based algorithm and 2-stage screening to hypothesis-free genomic data on irinotecan-treated patients for identification of a candidate single nucleotide polymorphism related to an adverse effect

scientific article

Artificially Induced Epithelial-Mesenchymal Transition in Surgical Subjects: Its Implications in Clinical and Basic Cancer Research ⬇️

scientific article published on April 21, 2011

Association between aldehyde dehydrogenase gene polymorphisms and the phenomenon of field cancerization in patients with head and neck cancer

scientific article published in October 2002

Association of carboxylesterase 1A genotypes with irinotecan pharmacokinetics in Japanese cancer patients

scientific article

Association of multiple Lugol-voiding lesions with synchronous and metachronous esophageal squamous cell carcinoma in patients with head and neck cancer

scientific article published in October 2002

Association of quality of life with disease characteristics and treatment outcomes in patients with advanced gastric cancer: Exploratory analysis of RAINBOW and REGARD phase III trials

scientific article published on 14 December 2018

Associations of quality of life (QoL) with adverse events and tumor response in patients with advanced gastric cancer: Exploratory analyses from RAINBOW and REGARD

scientific article published on 01 June 2017

Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a biomarker evaluation from the AVAGAST randomized phase III trial

scientific article published on 07 May 2012

Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a randomized, double-blind, placebo-controlled phase III study

scientific article (publication date: 20 October 2011)

Biased discordance of KRAS mutation detection in archived colorectal cancer specimens between the ARMS-Scorpion method and direct sequencing

scientific article

Biological markers as a predictor for response and prognosis of unresectable gastric cancer patients treated with irinotecan and cisplatin

scientific article published on 22 November 2005

Biomarker analysis of the GATSBY study of trastuzumab emtansine versus a taxane in previously treated HER2-positive advanced gastric/gastroesophageal junction cancer

scientific article published on 31 January 2019

Biopsy specimen microvessel density is a useful prognostic marker in patients with T(2-4)M(0) esophageal cancer treated with chemoradiotherapy.

scientific article published in January 2002

Carcinoma coexisting with esophageal leiomyoma

scientific article published on 01 August 2002

Causal relationships between esophageal squamous cell carcinoma and nephrotic syndrome

scientific article published on 01 January 2009

Characterization of the large‐scale Japanese patient‐derived xenograft (J‐PDX) library

scientific article published on 24 March 2021

Chemoradiotherapy for esophageal cancer: current status and perspectives

scientific article

Chemotherapy for metastatic gastric cancer: past, present, and future

scientific article published on 06 May 2008

Chemotherapy induced neutropenia at 1-month mark is a predictor of overall survival in patients receiving TAS-102 for refractory metastatic colorectal cancer: a cohort study.

scientific article

Chemotherapy with molecular targeting agents for colorectal cancer

scientific article published on 01 November 2012

Chronological change in chemo-biologic therapy, gastrointestinal cancer

scientific article published on 01 October 2017

Clinical impact of criteria for complete response (CR) of primary site to treatment of esophageal cancer

scientific article published on 16 June 2005

Clinical impact of surveillance for head and neck cancer in patients with esophageal squamous cell carcinoma

scientific article published on February 2017

Clinical outcome of Japanese metastatic colorectal cancer patients harbouring the KRAS p.G13D mutation treated with cetuximab + irinotecan

scientific article published on 15 October 2012

Clinical outcomes in 66 patients with advanced gastric cancer treated in phase I trials: the NCCHE experience

scientific article published on 15 March 2015

Clinical significance of BRAF non-V600E mutations on the therapeutic effects of anti-EGFR monoclonal antibody treatment in patients with pretreated metastatic colorectal cancer: the Biomarker Research for anti-EGFR monoclonal Antibodies by Comprehen

scientific article published on 3 October 2017

Clinical utility of circulating tumor DNA sequencing in advanced gastrointestinal cancer: SCRUM-Japan GI-SCREEN and GOZILA studies

scientific article published on 05 October 2020

Clinicopathological and molecular features of responders to nivolumab for patients with advanced gastric cancer

scholarly article by Saori Mishima et al published 31 January 2019 in Journal for Immunotherapy of Cancer

Clinicopathological features of 22C3 PD-L1 expression with mismatch repair, Epstein-Barr virus status, and cancer genome alterations in metastatic gastric cancer.

scientific article

Clinicopathological features of PD-L1 expression with MMR, EBV status and cancer genome alterations in MGC

scientific article published on 01 October 2017

Clinicopathological features of programmed death ligand 1 expression with tumor-infiltrating lymphocyte, mismatch repair, and Epstein-Barr virus status in a large cohort of gastric cancer patients

scientific article published on 14 September 2016

Clinicopathological, endoscopic, and molecular characteristics of the "skirt" - a new entity of lesions at the margin of laterally spreading tumors.

scientific article published on 25 January 2016

Close association of UGT1A9 IVS1+399C>T with UGT1A1*28, *6, or *60 haplotype and its apparent influence on 7-ethyl-10-hydroxycamptothecin (SN-38) glucuronidation in Japanese

scientific article

Comparative sequence analysis of patient-matched primary colorectal cancer, metastatic, and recurrent metastatic tumors after adjuvant FOLFOX chemotherapy

Comparison between neoadjuvant chemotherapy followed by surgery and definitive chemoradiotherapy for overall survival in patients with clinical Stage II/III esophageal squamous cell carcinoma (JCOG1406-A).

scientific article published on 17 March 2017

Comparison of HER2 gene amplification assessed by fluorescence in situ hybridization and HER2 protein expression assessed by immunohistochemistry in gastric cancer.

scientific article

Comprehensive immunohistochemical analysis of tumor microenvironment immune status in esophageal squamous cell carcinoma

scientific article published on 15 June 2016

Computer-assisted analysis of biopsy specimen microvessels predicts the outcome of esophageal cancers treated with chemoradiotherapy

scientific article

Concordance between PIK3CA mutations in endoscopic biopsy and surgically resected specimens of esophageal squamous cell carcinoma

scientific article

Construction of possible integrated predictive index based on EGFR and ANXA3 polymorphisms for chemotherapy response in fluoropyrimidine-treated Japanese gastric cancer patients using a bioinformatic method

scientific article published on 16 October 2015

Controversies in the treatment of esophageal cancer from the viewpoint of medical oncology

scientific article published on 01 September 2003

Correlation between overall survival and other endpoints in clinical trials of second-line chemotherapy for patients with advanced gastric cancer

scientific article

Current progress of cancer chemotherapy The Fifteenth International Symposium of the Hiroshima Cancer Seminar, October 2005.

scientific article published in April 2006

Current status and future prospects of chemotherapy for metastatic gastric cancer: a review

scientific article

Depressed-type (0-IIc) colorectal neoplasm in patients with family history of first-degree relatives with colorectal cancer: A cross-sectional study

scientific article

Determination of prognostic factors in Japanese patients with advanced gastric cancer using the data from a randomized controlled trial, Japan clinical oncology group 9912.

scientific article

Disparities in gastric cancer chemotherapy between the East and West

scientific article

Diverse eastern and Western approaches to the management of gastric cancer.

scientific article published on March 2007

Docetaxel and cisplatin in patients with advanced or recurrent gastric cancer: a multicenter phase I/II study

scientific article published in January 2002

Does daily alcohol and/or cigarette consumption cause low-grade dysplasia, a precursor of esophageal squamous cell carcinoma?

scientific article published in March 2010

Dose-escalation study for the targeting of CD44v+ cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205).

scientific article published on 7 April 2016

EGFR gene alterations as a prognostic biomarker in advanced esophageal squamous cell carcinoma

scientific article published in January 2010

EMR as salvage treatment for patients with locoregional failure of definitive chemoradiotherapy for esophageal cancer

scientific article published on 01 July 2003

Early clinical outcomes of anal squamous cell carcinoma treated with concurrent chemoradiotherapy with 5-Fluorouracil plus mitomycin C in Japanese patients: experience at a single institution

scientific article published on 19 June 2012

Effect of RECIST revision on classification of target lesions and overall response in advanced gastric cancer patients.

scientific article published on 22 August 2012

Effect of food on the pharmacokinetics of TAS-102 and its efficacy and safety in patients with advanced solid tumors

scientific article published on 26 February 2016

Effect of trifluridine/tipiracil in patients treated in RECOURSE by prognostic factors at baseline: an exploratory analysis

scientific article published on 01 August 2020

Efficacy and Long-term Peripheral Sensory Neuropathy of 3 vs 6 Months of Oxaliplatin-Based Adjuvant Chemotherapy for Colon Cancer: The ACHIEVE Phase 3 Randomized Clinical Trial

scientific article published on 12 September 2019

Efficacy and safety of capecitabine plus cisplatin in Japanese patients with advanced or metastatic gastric cancer: subset analyses of the AVAGAST study and the ToGA study ⬇️

scientific article published on July 11, 2012

Efficacy and safety of ramucirumab-containing chemotherapy in patients with pretreated metastatic gastric neuroendocrine carcinoma

scientific article published on 01 November 2018

Efficacy and safety profile of S-1 in patients with metastatic gastric cancer in clinical practice: results from a post-marketing survey

scientific article published in January 2003

Efficacy and safety profile of imatinib mesylate (ST1571) in Japanese patients with advanced gastrointestinal stromal tumors: a phase II study (STI571B1202).

scientific article published on 14 June 2008

Efficacy of chemoradiotherapy on pain relief in patients with intrapelvic recurrence of rectal cancer

scientific article

Efficacy of concurrent chemoradiotherapy as a palliative treatment in stage IVB esophageal cancer patients with dysphagia

scientific article published on 07 July 2011

Efficacy of preventive endoscopic balloon dilation for esophageal stricture after endoscopic resection

scientific article published in March 2011

Efficacy of trastuzumab in Japanese patients with HER2-positive advanced gastric or gastroesophageal junction cancer: a subgroup analysis of the Trastuzumab for Gastric Cancer (ToGA) study ⬇️

scientific article published on December 17, 2011

Eight novel single nucleotide polymorphisms in ABCG2/BCRP in Japanese cancer patients administered irinotacan

scientific article published in January 2003

Elective nodal irradiation (ENI) in definitive chemoradiotherapy (CRT) for squamous cell carcinoma of the thoracic esophagus

scientific article published on 24 October 2008

Endoscopic balloon dilatation for benign fibrotic strictures after curative nonsurgical treatment for esophageal cancer

scientific article published on 28 April 2012

Endoscopic submucosal dissection using a new scissors-type electrosurgical knife: a first-in-human feasibility study

scientific article published on 25 April 2014

Enhanced antitumor effect of anti-tissue factor antibody-conjugated epirubicin-incorporating micelles in xenograft models.

scientific article published on 23 March 2015

Epidermoid metaplasia of the esophagus: endoscopic feature and differential diagnosis

scientific article published on May 1, 2011

Epstein-Barr virus involvement is a predictive factor for the resistance to chemoradiotherapy of gastric diffuse large B-cell lymphoma

scientific article

Erratum to: Efficacy and safety of capecitabine plus cisplatin in Japanese patients with advanced or metastatic gastric cancer: subset analyses of the AVAGAST study and the ToGA study.

scientific article published on 13 November 2012

Esophageal stenosis after endoscopic mucosal resection of superficial esophageal lesions

scientific article published on 01 February 2003

Establishment of Novel Gastric Cancer Patient-Derived Xenografts and Cell Lines: Pathological Comparison between Primary Tumor, Patient-Derived, and Cell-Line Derived Xenografts ⬇️

scientific article published on 14 June 2019

Evaluation of safety, pharmacokinetics, and efficacy of vorinostat, a histone deacetylase inhibitor, in the treatment of gastrointestinal (GI) cancer in a phase I clinical trial ⬇️

scientific article published on January 11, 2012

Everolimus for previously treated advanced gastric cancer: results of the randomized, double-blind, phase III GRANITE-1 study.

scientific article published on 16 September 2013

Exposure-Response Analyses of Ramucirumab from Two Randomized, Phase III Trials of Second-line Treatment for Advanced Gastric or Gastroesophageal Junction Cancer

scientific article published on 17 July 2017

Exposure-response relationship of ramucirumab in East Asian patients from RAINBOW: a randomized clinical trial in second-line treatment of gastric cancer

scientific article

Expression of thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase, E2F-1, Bak, Bcl-X, and Bcl-2, and clinical outcomes for gastric cancer patients treated with bolus 5-fluorouracil

scientific article

Expression profiles of HER2, EGFR, MET and FGFR2 in a large cohort of patients with gastric adenocarcinoma

scientific article

Expression profiling of esophageal squamous cell carcinoma patients treated with definitive chemoradiotherapy: clinical implications

scientific article published on 01 June 2006

Feasibility and robustness of amplification refractory mutation system (ARMS)-based KRAS testing using clinically available formalin-fixed, paraffin-embedded samples of colorectal cancers

scientific article published on 09 August 2010

Feasibility of oxaliplatin and infusional fluorouracil/leucovorin (FOLFOX4) for Japanese patients with unresectable metastatic colorectal cancer

scientific article published in June 2007

Five-year survivor with liver metastasis from gastric cancer successfully treated with systemic chemotherapy

scientific article published on 01 September 2000

Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study

scientific article published on 7 October 2009

Fourteen novel genetic variations and haplotype structures of the TYMS gene encoding human thymidylate synthase (TS)

scientific article published on 01 December 2006

Functional Characterization of Human UDP-Glucuronosyltransferase 1A9 Variant, D256N, Found in Japanese Cancer Patients ⬇️

scientific article published on May 1, 2003

Functional Characterization of Wild-type and Variant (T202I and M59I) Human UDP-glucuronosyltransferase 1A10 ⬇️

scientific article (publication date: May 2003)

Functional analysis of four naturally occurring variants of human constitutive androstane receptor

scientific article published on 28 June 2005

Functional analysis of six human aryl hydrocarbon receptor variants in a Japanese population

scientific article published on 28 April 2005

Functional characterization of three naturally occurring single nucleotide polymorphisms in the CES2 gene encoding carboxylesterase 2 (HCE-2).

scientific article published on 20 July 2005

Gastric Cancer Working Group Report ⬇️

scientific article published on September 1, 2010

Gastrointestinal Perforation and Fistula Formation in 5 Patients With Colorectal Cancer During Treatment With Regorafenib.

scientific article

Gene expression profiling to predict recurrence of advanced squamous cell carcinoma of the tongue: discovery and external validation

scientific article published on 27 June 2017

Genetic polymorphisms of FCGR2A encoding Fcγ receptor IIa in a Japanese population and functional analysis of the L273P variant.

scientific article published on 18 August 2012

Genetic polymorphisms of FCGRT encoding FcRn in a Japanese population and their functional analysis

scientific article published on 01 October 2010

Genetic polymorphisms of UGT1A6 in a Japanese population

scientific article published on 01 February 2005

Genetic polymorphisms of copper- and platinum drug-efflux transporters ATP7A and ATP7B in Japanese cancer patients

scientific article published on 01 January 2009

Genetic variation and haplotype structure of the ABC transporter gene ABCG2 in a Japanese population

scientific article published on 01 April 2006

Genetic variations and frequencies of major haplotypes in SLCO1B1 encoding the transporter OATP1B1 in Japanese subjects: SLCO1B1*17 is more prevalent than *15

scientific article published on 01 December 2007

Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences

scientific article published on 09 September 2007

Genetic variations and haplotypes of ABCC2 encoding MRP2 in a Japanese population

scientific article published in January 2008

Genetic variations and haplotypes of UGT1A4 in a Japanese population

scientific article published on 01 April 2005

Genetic variations of the AHR gene encoding aryl hydrocarbon receptor in a Japanese population

scientific article published on 01 August 2004

Globalization of clinical trials

scientific article published on April 2003

Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan

scientific article published on December 2003

Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population.

scientific article published in January 2004

Histopathological factors affecting the extraction of high quality genomic DNA from tissue sections for next-generation sequencing

scientific article published on 21 August 2019

Identification of a candidate single-nucleotide polymorphism related to chemotherapeutic response through a combination of knowledge-based algorithm and hypothesis-free genomic data.

scientific article

Impact of CYP3A4 haplotypes on irinotecan pharmacokinetics in Japanese cancer patients

scientific article published on 8 November 2007

Impaired mental health among the bereaved spouses of cancer patients

scientific article published on 2 May 2012

Implantation of self-expanding metallic stent for patients with malignant stricture after failure of definitive chemoradiotherapy for T3 or T4 esophageal squamous cell carcinomas.

scientific article

Induction chemotherapy with docetaxel, cisplatin and S-1 followed by proton beam therapy concurrent with cisplatin in patients with T4b nasal and sinonasal malignancies

scientific article published on 3 July 2012

Initial safety report on the tolerability of modified FOLFOX6 as adjuvant therapy in patients with curatively resected stage II or III colon cancer (JFMC41-1001-C2: JOIN trial)

scientific article published on 16 May 2015

Integrated safety summary for trifluridine/tipiracil (TAS-102).

scientific article published on 24 November 2017

Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28

scientific article published on 01 July 2007

JOIN trial: treatment outcome and recovery status of peripheral sensory neuropathy during a 3-year follow-up in patients receiving modified FOLFOX6 as adjuvant treatment for stage II/III colon cancer

scientific article published on 23 September 2019

Japanese multicenter phase II study of CHOP followed by radiotherapy in stage I-II, diffuse large B-cell lymphoma of the stomach

scientific article published in June 2005

Japanese nationwide post-marketing survey of S-1 in patients with advanced gastric cancer

scientific article published in January 2005

KEYNOTE-585: Phase III study of perioperative chemotherapy with or without pembrolizumab for gastric cancer

scientific article published on 19 February 2019

Lapatinib plus paclitaxel versus paclitaxel alone in the second-line treatment of HER2-amplified advanced gastric cancer in Asian populations: TyTAN--a randomized, phase III study

scientific article

Large-scale analyses of tumor mutation burdens (TMBs) across various advanced gastrointestinal (GI) malignancies in the nationwide cancer genome screening project, SCRUM-Japan GI-SCREEN

Large-scale comprehensive immunohistochemical biomarker analyses in esophageal squamous cell carcinoma

scientific article published on 29 July 2017

Local efficacy and survival outcome of salvage endoscopic therapy for local recurrent lesions after definitive chemoradiotherapy for esophageal cancer

scientific article published on 27 February 2016

Local recurrence of squamous-cell carcinoma of the esophagus after EMR

scientific article published on 01 February 2005

Long-term efficacy and predictive correlates of response to nivolumab in Japanese patients with esophageal cancer

scientific article published on 11 March 2020

Long-term outcome of transoral organ-preserving pharyngeal endoscopic resection for superficial pharyngeal cancer.

scientific article published on 25 June 2011

Long-term outcomes of patients with metastatic gastric cancer after initial S-1 monotherapy

scientific article published on 25 July 2007

Long-term results for patients with unresectable gastric cancer who received chemotherapy in the Japan Clinical Oncology Group (JCOG) trials

scientific article

Long-term survival and prognostic factors in patients with metastatic gastric cancers treated with chemotherapy in the Japan Clinical Oncology Group (JCOG) study

scientific article published in November 2004

Long-term toxicity after definitive chemoradiotherapy for squamous cell carcinoma of the thoracic esophagus

scientific article

Magnifying narrow-band imaging versus magnifying white-light imaging for the differential diagnosis of gastric small depressive lesions: a prospective study

scientific article published on 01 March 2010

Multicenter phase II study of everolimus in patients with previously treated metastatic gastric cancer

scientific article published on 15 March 2010

NC-6004 Phase I study in combination with gemcitabine for advanced solid tumors and population PK/PD analysis.

scientific article published on 21 February 2017

Napabucasin versus placebo in refractory advanced colorectal cancer: a randomised phase 3 trial

scientific article published on 31 January 2018

Neoadjuvant chemotherapy with S-1 for scirrhous gastric cancer: a pilot study

scientific article published in January 2003

Nivolumab treatment for oesophageal squamous-cell carcinoma: an open-label, multicentre, phase 2 trial

scientific article published on 14 March 2017

Non-surgical approach to small cell carcinoma of the esophagus: does this rare disease have the same tumor behavior as SCLC?

scientific article published on 27 October 2011

Nonplatinum-based chemotherapy with irinotecan plus docetaxel for advanced or metastatic olfactory neuroblastoma: a retrospective analysis of 12 cases.

scientific article

Nonrandomized comparison between definitive chemoradiotherapy and radical surgery in patients with T(2-3)N(any) M(0) squamous cell carcinoma of the esophagus

scientific article published in October 2003

Novel Genetic Polymorphisms in the NR3C1 (Glucocorticoid receptor) Gene in a Japanese Population

article

Overview of adjuvant therapy for resected gastric cancer: differences in Japan and the United States

scientific article published on 01 December 2005

Panitumumab in Japanese patients with unresectable colorectal cancer: a post-marketing surveillance study of 3085 patients

scientific article published on 12 February 2014

Patients' perception of the usefulness of a question prompt sheet for advanced cancer patients when deciding the initial treatment: a randomized, controlled trial ⬇️

scientific article published on March 22, 2011

Pembrolizumab versus paclitaxel for previously treated, advanced gastric or gastro-oesophageal junction cancer (KEYNOTE-061): a randomised, open-label, controlled, phase 3 trial

scientific article published on 04 June 2018

Peritonitis related to percutaneous endoscopic gastrostomy using the direct method for cancer patients.

scientific article published on 17 December 2014

Pertuzumab plus trastuzumab and chemotherapy for HER2-positive metastatic gastric or gastro-oesophageal junction cancer (JACOB): final analysis of a double-blind, randomised, placebo-controlled phase 3 study

scientific article published on 11 September 2018

Pharmacodynamic Studies of Gefitinib in Tumor Biopsy Specimens From Patients With Advanced Gastric Carcinoma

scientific article published on 01 September 2006

Pharmacokinetic analysis of capecitabine and cisplatin in combination with trastuzumab in Japanese patients with advanced HER2-positive gastric cancer ⬇️

scientific article published on November 25, 2011

Pharmacokinetic and exposure-response analysis of pertuzumab in patients with HER2-positive metastatic gastric or gastroesophageal junction cancer

scientific article published on 10 June 2019

Pharmacokinetics, safety, and efficacy of FOLFIRI plus bevacizumab in Japanese colorectal cancer patients with UGT1A1 gene polymorphisms

scientific article

Phase 1 pharmacokinetic study of MK-0646 (dalotuzumab), an anti-insulin-like growth factor-1 receptor monoclonal antibody, in combination with cetuximab and irinotecan in Japanese patients with advanced colorectal cancer

scientific article published on 07 August 2013

Phase 1 pharmacokinetic study of the oral pan-AKT inhibitor MK-2206 in Japanese patients with advanced solid tumors

scientific article published on 24 June 2015

Phase 1 study of efatutazone, a novel oral peroxisome proliferator-activated receptor gamma agonist, in combination with FOLFIRI as second-line therapy in patients with metastatic colorectal cancer

scientific article

Phase 1 study of ganitumab (AMG 479), a fully human monoclonal antibody against the insulin-like growth factor receptor type I (IGF1R), in Japanese patients with advanced solid tumors

scientific article

Phase 1 study of sulfasalazine and cisplatin for patients with CD44v-positive gastric cancer refractory to cisplatin (EPOC1407).

scientific article published on 2 May 2017

Phase 1 study of trebananib (AMG 386), an angiogenesis targeting angiopoietin-1/2 antagonist, in Japanese patients with advanced solid tumors

scientific article published on 3 November 2012

Phase 2 study of nilotinib as third-line therapy for patients with gastrointestinal stromal tumor.

scientific article

Phase I Study of NK012, a Novel SN-38–Incorporating Micellar Nanoparticle, in Adult Patients with Solid Tumors ⬇️

scientific article published on October 13, 2010

Phase I clinical and pharmacokinetic study of RAD001 (everolimus) administered daily to Japanese patients with advanced solid tumors

scientific article

Phase I dose-escalation study of buparlisib (BKM120), an oral pan-class I PI3K inhibitor, in Japanese patients with advanced solid tumors

scientific article

Phase I dose-escalation study of the HSP90 inhibitor AUY922 in Japanese patients with advanced solid tumors

scientific article

Phase I dose-escalation study of the safety, tolerability, and pharmacokinetics of aflibercept in combination with S-1 in Japanese patients with advanced solid malignancies

scientific article published on 06 January 2020

Phase I study of TAS-102 and irinotecan combination therapy in Japanese patients with advanced colorectal cancer

scientific article published on 12 July 2015

Phase I study of olaratumab in Japanese patients with advanced solid tumors

scientific article

Phase I study of single-dose oxaliplatin in Japanese patients with malignant tumors

scientific article published on 15 May 2006

Phase I study of sunitinib plus modified FOLFOX6 in Japanese patients with treatment-naive colorectal cancer

scientific article published on March 1, 2012

Phase I trial of chemoradiotherapy with the combination of S‐1 plus cisplatin for patients with unresectable locally advanced squamous cell carcinoma of the head and neck ⬇️

scientific article published on 07 December 2010

Phase I/II study of oxaliplatin with weekly bolus fluorouracil and high-dose leucovorin (ROX) as first-line therapy for patients with colorectal cancer

scientific article

Phase I/II study of radiologic hepatic arterial infusion of fluorouracil plus systemic irinotecan for unresectable hepatic metastases from colorectal cancer: Japan Clinical Oncology Group Trial 0208-DI

scientific article published on 24 August 2012

Phase I/II study of sunitinib malate in Japanese patients with gastrointestinal stromal tumor after failure of prior treatment with imatinib mesylate

scientific article published in December 2010

Phase I/II trial of chemoradiotherapy with concurrent S-1 and cisplatin for clinical stage II/III esophageal carcinoma (JCOG 0604)

scientific article

Phase II Study of Chemoradiotherapy With 5-Fluorouracil and Cisplatin for Stage II–III Esophageal Squamous Cell Carcinoma: JCOG Trial (JCOG 9906) ⬇️

scientific article published on October 6, 2010

Phase II feasibility trial of adjuvant chemoradiotherapy with 3-weekly cisplatin for Japanese patients with post-operative high-risk squamous cell carcinoma of the head and neck

scientific article published on 23 August 2012

Phase II study of biweekly irinotecan and mitomycin C combination therapy in patients with fluoropyrimidine-resistant advanced colorectal cancer

scientific article

Phase II study of oral S-1 for treatment of metastatic colorectal carcinoma

scientific article published in June 2004

Phase II study of oxaliplatin in japanese patients with metastatic colorectal cancer refractory to fluoropyrimidines

scientific article

Phase II study of sequential methotrexate and 5-fluorouracil chemotherapy against peritoneally disseminated gastric cancer with malignant ascites: a report from the Gastrointestinal Oncology Study Group of the Japan Clinical Oncology Group, JCOG 960

scientific article

Photodynamic therapy as salvage treatment for local failure after chemoradiotherapy in patients with esophageal squamous cell carcinoma: a phase II study.

scientific article

Photodynamic therapy as salvage treatment for local failures after definitive chemoradiotherapy for esophageal cancer

scientific article

Poster abstracts of the 18th Pan Arab Cancer Congress. TUNISIA. April 19-21, 2018

scientific article published on 01 April 2018

Preclinical efficacy of Sym004, novel anti-EGFR antibody mixture, in esophageal squamous cell carcinoma cell lines.

scientific article published on 26 December 2016

Predictive factors for hyperprogressive disease during nivolumab as anti-PD1 treatment in patients with advanced gastric cancer

scientific article published on 09 January 2019

Present status of chemotherapy for colorectal cancer in countries outside of Japan

scientific article published on September 1, 2003

Prognostic Factor Analysis of Overall Survival in Gastric Cancer from Two Phase III Studies of Second-line Ramucirumab (REGARD and RAINBOW) Using Pooled Patient Data

scientific article

Prognostic impact of HER2, EGFR, and c-MET status on overall survival of advanced gastric cancer patients

scientific article published on 15 February 2015

Prognostic significance of tumor regression grade for patients with esophageal squamous cell carcinoma after neoadjuvant chemotherapy followed by surgery

scientific article

Progression-free survival and post-progression survival in patients with advanced gastric cancer treated with first-line chemotherapy

scientific article published on 25 May 2013

Progression-free survival as a surrogate for overall survival in advanced/recurrent gastric cancer trials: a meta-analysis

scientific article published on 09 October 2013

Prophylactic Use of Oral Dexamethasone to Alleviate Fatigue During Regorafenib Treatment for Patients With Metastatic Colorectal Cancer

scientific article published on 18 August 2016

Prophylactic steroid administration for strictures after endoscopic resection of large superficial esophageal squamous cell carcinoma.

scientific article

Proxies of quality of life in metastatic colorectal cancer: analyses in the RECOURSE trial

scientific article published on 23 November 2017

Psychological states and coping strategies after bereavement among spouses of cancer patients: a quantitative study in Japan ⬇️

scientific article published on April 18, 2012

Pulmonary tumor thrombotic microangiopathy associated with esophageal squamous cell carcinoma

scientific article

QTWiST analysis of the RECOURSE trial of trifluridine/tipiracil in metastatic colorectal cancer.

scientific article published on 23 November 2017

Quality of life in the trastuzumab for gastric cancer trial

scientific article

Ramucirumab for gastric cancer

scientific article

Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial

scientific article (publication date: October 2014)

Randomized Phase III study of 5-fluorouracil continuous infusion vs. sequential methotrexate and 5-fluorouracil therapy in far advanced gastric cancer with peritoneal metastasis (JCOG0106).

scientific article published on 7 September 2013

Randomized phase II study of second-line chemotherapy with the best available 5-fluorouracil regimen versus weekly administration of paclitaxel in far advanced gastric cancer with severe peritoneal metastases refractory to 5-fluorouracil-containing r

scientific article published on 19 September 2015

Randomized phase III trial of fluorouracil alone versus fluorouracil plus cisplatin versus uracil and tegafur plus mitomycin in patients with unresectable, advanced gastric cancer: The Japan Clinical Oncology Group Study (JCOG9205).

scientific article published on January 2003

Randomized phase III trial of regorafenib in metastatic colorectal cancer: analysis of the CORRECT Japanese and non-Japanese subpopulations

scientific article

Randomized trial of TAS-102 for refractory metastatic colorectal cancer

scientific article published on May 2015

Rationale and design of the BRAVERY study (EPOC1701): a multicentre phase II study of eribulin in patients with BRAF V600E mutant metastatic colorectal cancer

scientific article published on 13 November 2019

Regional differences in advanced gastric cancer: exploratory analyses of the AVAGAST placebo arm.

scientific article published on 20 October 2017

Relationship Between Thymidine Kinase 1 Expression and Trifluridine/Tipiracil Therapy in Refractory Metastatic Colorectal Cancer: A Pooled Analysis of 2 Randomized Clinical Trials

scientific article published on 26 July 2018

Relationship between Pulmonary Adverse Events and Everolimus Exposure in Japanese and Non-Japanese Patients: A Meta-Analysis of Oncology Trials.

scientific article published on 21 February 2017

Relationship between expression of vascular endothelial growth factor in tumor tissue from gastric cancers and chemotherapy effects: comparison between S-1 alone and the combination of S-1 plus CDDP

scientific article published on 01 July 2007

Relationship between the immune microenvironment of different locations in a primary tumour and clinical outcomes of oesophageal squamous cell carcinoma

scientific article published on 25 November 2019

Report on the use of non-clinical studies in the regulatory evaluation of oncology drugs

scientific article

Retrospective analysis of antiemetic effect in patients receiving cisplatin

scientific article published on July 1, 2011

Risk of multiple squamous cell carcinomas both in the esophagus and the head and neck region

scientific article

SCRUM-Japan GI-SCREEN and MONSTAR-SCREEN: Path to the realization of biomarker-guided precision oncology in advanced solid tumors

Safety Analysis of FOLFOX4 Treatment in Colorectal Cancer Patients: A Comparison Between Two Asian Studies and Four Western Studies ⬇️

scientific article published on November 17, 2011

Safety and Efficacy of Pembrolizumab Monotherapy in Patients With Previously Treated Advanced Gastric and Gastroesophageal Junction Cancer: Phase 2 Clinical KEYNOTE-059 Trial

scientific article

Safety and Efficacy of Trifluridine/Tipiracil Monotherapy in Clinical Practice for Patients With Metastatic Colorectal Cancer: Experience at a Single Institution

scientific article published on 27 November 2015

Safety and Pharmacokinetics of Second-line Ramucirumab plus FOLFIRI in Japanese Patients with Metastatic Colorectal Carcinoma

scientific article

Safety and pharmacokinetics of panitumumab in Japanese patients with advanced solid tumors

scientific article published on 25 August 2009

Safety data from the phase III Japanese ACHIEVE trial: part of an international, prospective, planned pooled analysis of six phase III trials comparing 3 versus 6 months of oxaliplatin-based adjuvant chemotherapy for stage III colon cancer.

scientific article

Safety of irinotecan and infusional fluorouracil/leucovorin (FOLFIRI) in Japan: a retrospective review of 48 patients with metastatic colorectal cancer

scientific article published on April 2008

Salvage photodynamic therapy for local failure after chemoradiotherapy for esophageal squamous cell carcinoma

scientific article published on 19 November 2015

Sequential methotrexate and 5-fluorouracil therapy for gastric cancer patients with bone metastasis

scientific article published on 01 August 2000

Serum HER2 levels and HER2 status in tumor cells in advanced gastric cancer patients

scientific article

Significance of and problems in adopting response evaluation criteria in solid tumor RECIST for assessing anticancer effects of advanced gastric cancer

scientific article published on 01 December 2000

Significance of biological markers for predicting prognosis and selecting chemotherapy regimens of advanced gastric cancer patients between continuous infusion of 5-FU and a combination of 5-FU and cisplatin

scientific article published on 01 April 2007

Simultaneous identification of 36 mutations in KRAS codons 61 and 146, BRAF, NRAS, and PIK3CA in a single reaction by multiplex assay kit.

scientific article

Squamous cell carcinoma in situ at oropharyngeal and hypopharyngeal mucosal sites

scientific article published in September 2004

Subgroup analyses of the safety and efficacy of ramucirumab in Japanese and Western patients in RAINBOW: a randomized clinical trial in second-line treatment of gastric cancer

scientific article published on 28 October 2015

Subgroup analysis of East Asians in RAINBOW: A phase 3 trial of ramucirumab plus paclitaxel for advanced gastric cancer.

scientific article published on 28 August 2015

Successful endosocpic submucosal dissection for esophageal squamous cell carcinoma together with a lipoma

scientific article published on 15 July 2011

Survival prolongation after treatment failure of first-line chemotherapy in patients with advanced gastric cancer: combined analysis of the Japan Clinical Oncology group trials JCOG9205 and JCOG9912.

scientific article published on 26 October 2013

Systemic chemotherapy with cisplatin plus 5-FU (PF) for recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN): efficacy and safety of a lower dose of PF (80/800) at a single institution in Japan.

scientific article

TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial

scientific article published on 28 August 2012

TAS-102 plus bevacizumab for patients with metastatic colorectal cancer refractory to standard therapies (C-TASK FORCE): an investigator-initiated, open-label, single-arm, multicentre, phase 1/2 study

scientific article published on 28 July 2017

TS gene tandem repeats in esophageal cancer patients receiving chemoradiotherapy ⬇️

scientific article published on January 1, 2011

The CLIP1-LTK fusion is an oncogenic driver in non-small-cell lung cancer

scientific article published on 24 November 2021

The IDEA (International Duration Evaluation of Adjuvant Chemotherapy) Collaboration: Prospective Combined Analysis of Phase III Trials Investigating Duration of Adjuvant Therapy with the FOLFOX (FOLFOX4 or Modified FOLFOX6) or XELOX (3 versus 6 [...]

scientific article (publication date: 2013)

The IDEA Collaboration: Prospective Combined Analysis of Phase III Trials Investigating Duration of Adjuvant Therapy with the FOLFOX Regimen for Patients with Stage III Colon Cancer: Current Status

scientific article published in September 2014

The Nationwide Cancer Genome Screening Project in Japan SCRUM-Japan GI-SCREEN: Efficient identification of cancer genome alterations in advanced non-colorectal (Non-CRC) gastrointestinal cancer

The Nationwide Cancer Genome Screening Project in Japan SCRUM-Japan, GI-screen: Efficient identification of cancer genome alterations in advanced gastric cancer

The Nationwide Cancer Genome Screening Project in Japan, SCRUM-Japan GI-SCREEN: Efficient identification of cancer genome alterations in advanced colorectal cancer

The Nationwide Cancer Genome Screening Project in Japan, SCRUM-Japan GI-screen: Efficient identification of cancer genome alterations in advanced esophageal cancer

The Nationwide Cancer Genome Screening Projects for Gastrointestinal Cancer in Japan (SCRUM-Japan GI-SCREEN): Efficient identification of actionable cancer genome alterations in advanced colorectal and non-colorectal gastrointestinal cancer (GI Scree

The latest advances in chemotherapy for gastrointestinal cancers

scientific article

The nationwide cancer genome screening project in Japan SCRUM-Japan GI-SCREEN: Efficient identification of cancer genome alterations in advanced gastric cancer (GC)

The role of chemotherapy in the current treatment of gastric cancer

scientific article

The subgroups of the phase III RECOURSE trial of trifluridine/tipiracil (TAS-102) versus placebo with best supportive care in patients with metastatic colorectal cancer

scientific article published on 20 December 2017

Therapeutic significance of a D-dimer cut-off level of >3 µg/ml in colorectal cancer patients treated with standard chemotherapy plus bevacizumab

scientific article published on 21 May 2010

Three novel single nucleotide polymorphisms in UGT1A10.

scientific article published in January 2002

Three novel single nucleotide polymorphisms in UGT1A9

scientific article published on 01 January 2003

Trastuzumab emtansine versus taxane use for previously treated HER2-positive locally advanced or metastatic gastric or gastro-oesophageal junction adenocarcinoma (GATSBY): an international randomised, open-label, adaptive, phase 2/3 study

scientific article

Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial

scientific article

Treatment strategy for superficial pharyngeal squamous cell carcinoma synchronously combined with esophageal cancer

scientific article published on 30 October 2012

Tumor response and symptom palliation from RAINBOW, a phase 3 trial of ramucirumab plus paclitaxel in previously treated advanced gastric cancer

scientific article published on 03 December 2020

Twelve novel single nucleotide polymorphisms in the CES2 gene encoding human carboxylesterase 2 (hCE-2)

scientific article

Twenty-six novel single nucleotide polymorphisms and their frequencies of the NR1I3 (CAR) gene in a Japanese population

scientific article published in January 2003

UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer

scientific article

Usefulness of endoscopic radial incision and cutting method for refractory esophagogastric anastomotic stricture (with video).

scientific article published in May 2012

Utility of circulating tumor DNA (ctDNA) versus tumor tissue clinical sequencing for enrolling patients (Pts) with advanced gastrointestinal (GI) cancer to matched clinical trials: SCRUM-Japan GI-SCREEN and GOZILA Combined Analysis

scientific article

Utility of circulating tumor DNA (ctDNA) versus tumor tissue clinical sequencing for enrolling patients (pts) with advanced non-colorectal (non-CRC) gastrointestinal (GI) cancer to matched clinical trials: SCRUM-Japan GI-SCREEN and GOZILA combined an

scientific article

Utility of circulating tumor DNA (ctDNA) versus tumor tissue genotyping for enrollment of patients with metastatic colorectal cancer (mCRC) to matched clinical trials: SCRUM-Japan GI-SCREEN and GOZILA combined analysis

scientific article

Vandetanib in patients with previously treated RET-rearranged advanced non-small-cell lung cancer (LURET): an open-label, multicentre phase 2 trial

scientific article published on 4 November 2016

[109th Scientific Meeting of the Japanese Society of Internal Medicine: symposium:1. Recent treatments and progress in malignant tumors--chemotherapy and molecular targeting agents antibody therapy; introduction]

scientific article published on 01 September 2012

[Chemoradiotherapy]

scientific article published on 01 August 2011

[Current Status and Future Perspectives of SCRUM-Japan].

scientific article published in August 2017

[Current status and issues in early & exploratory oncology clinical trials in Japan]

[Current topics on molecular targeting drugs for gastric cancer].

scientific article published in September 2010

[Japanese nationwide post-marketing survey of S-1 in patients with advanced gastric cancer]

scientific article published on 01 June 2006

[Participation to international registration trials--from the investigator's standpoint]

scientific article published on 01 February 2007

[Two cases of KRAS wild-type unresectable or recurrent colorectal cancer effectively treated by cetuximab after progression of prior chemotherapy].

scientific article published in June 2009

mTOR as a therapeutic target in patients with gastric cancer ⬇️

scientific article published on 05 October 2011

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