Search filters

List of works by Richard Weindruch

A TrkA-to-p75NTR molecular switch activates amyloid beta-peptide generation during aging

scientific article published on October 2005

A conserved transcriptional signature of delayed aging and reduced disease vulnerability is partially mediated by SIRT3.

scientific article

A design and statistical perspective on microarray gene expression studies in nutrition: the need for playful creativity and scientific hard-mindedness

scientific article published on November 2003

A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice

scientific article published in 2008

A methyl-deficient diet modifies histone methylation and alters Igf2 and H19 repression in the prostate

scientific article published in August 2008

A shift in energy metabolism anticipates the onset of sarcopenia in rhesus monkeys

scientific article

Adipose tissue energy metabolism: altered gene expression profile of mice subjected to long-term caloric restriction

scientific article published on 19 December 2003

Age-associated alterations of the mitochondrial genome

scientific article published on January 1997

Age-associated mitochondrial DNA deletions in mouse skeletal muscle: comparison of different regions of the mitochondrial genome

scientific article published on 01 January 1996

Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis.

scientific article

Age-related impairment of the transcriptional responses to oxidative stress in the mouse heart

scientific article published on 16 April 2003

Aging and cancer-related loss of insulin-like growth factor 2 imprinting in the mouse and human prostate

scientific article

Aging in rodents fed restricted diets

scientific article

Assessment of nutritional status in rhesus monkeys: comparison of dual-energy X-ray absorptiometry and stable isotope dilution

scientific article published on 01 June 2005

Attenuation of sarcopenia by dietary restriction in rhesus monkeys

scientific article

Auditory function in rhesus monkeys: effects of aging and caloric restriction in the Wisconsin monkeys five years later

scientific article

Biomarkers of aging: from primitive organisms to humans

scientific article

Caloric Intake, Oxidative Stress and Aging

scientific article published on 01 May 2001

Caloric Restriction and Healthy Life Span: Frail Phenotype of Nonhuman Primates in the Wisconsin National Primate Research Center Caloric Restriction Study

scientific article published on 8 April 2017

Caloric restriction and aging: studies in mice and monkeys

scientific article

Caloric restriction counteracts age-related changes in the activities of sorbitol metabolizing enzymes from mouse liver

scientific article published on 25 October 2008

Caloric restriction delays aging-induced cellular phenotypes in rhesus monkey skeletal muscle

scientific article

Caloric restriction delays disease onset and mortality in rhesus monkeys

scientific article

Caloric restriction improves health and survival of rhesus monkeys

scientific article

Caloric restriction increases gluconeogenic and transaminase enzyme activities in mouse liver

scientific article

Caloric restriction lowers plasma lipoprotein (a) in male but not female rhesus monkeys

scientific article

Caloric restriction mimetics: metabolic interventions

scientific article

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

scientific article

Caloric restriction reduces fiber loss and mitochondrial abnormalities in aged rat muscle ⬇️

scientific article published on June 1, 1997

Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis

scientific article published on 4 August 2006

Caloric restriction, aging, and antioxidant enzymes

scientific article published on December 1993

Caloric restriction, gene expression, and aging

scientific article published in April 2003

Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents

scientific article published on April 1996

Calorie restriction: progress during mid-2005-mid-2006.

scientific article published on 27 November 2006

Cellular adaptation contributes to calorie restriction-induced preservation of skeletal muscle in aged rhesus monkeys

scientific article

Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells.

scientific article published on 17 August 2012

Controlling caloric consumption: protocols for rodents and rhesus monkeys

scientific article

Correction: A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

Correction: A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

Correction: A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice.

scientific article

Decreased mitochondrial RNA levels without accumulation of mitochondrial DNA deletions in aging Drosophila melanogaster

scientific article

Dietary intervention at middle age: caloric restriction but not dehydroepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice

scientific article

Dietary restriction alone and in combination with oral ethoxyquin/2-mercaptoethylamine in mice

scientific article

Dietary restriction and aging in rhesus monkeys: the University of Wisconsin study

scientific article published in December 2000

Dietary restriction and aging: historical phases, mechanisms and current directions

scientific article published on October 1987

Dietary restriction and aging: the initiation of a primate study

scientific article published in September 1990

Dietary restriction benefits learning and motor performance of aged mice

scientific article published in January 1987

Dietary restriction from middle age attenuates age-associated lymphoma development and interleukin 6 dysregulation in C57BL/6 mice

scientific article published on 01 June 1994

Dietary restriction of adult male rhesus monkeys: design, methodology, and preliminary findings from the first year of study

scientific article published in January 1993

Dietary restriction, tumors, and aging in rodents

scientific article published on November 1989

Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response

scientific article

Effect of antioxidants on androgen-induced AP-1 and NF-kappaB DNA-binding activity in prostate carcinoma cells

scientific article published on July 1999

Effects of caloric restriction on age-related hearing loss in rodents and rhesus monkeys

scientific article

Effects of caloric restriction on gene expression.

scientific article published on January 2002

Effects of caloric restriction on skeletal muscle mitochondrial proton leak in aging rats

scientific article published in March 2001

Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice

scientific article

Effects of energy restriction on mouse mammary tumor virus mRNA levels in mammary glands and uterus and on uterine endometrial hyperplasia and pituitary histology in C3H/SHN F1 mice

scientific article published in November 1990

Effects of short- and medium-term calorie restriction on muscle mitochondrial proton leak and reactive oxygen species production.

scientific article

Egr-1 and Hipk2 are required for the TrkA to p75(NTR) switch that occurs downstream of IGF1-R.

scientific article

Empirical Bayes estimation of gene-specific effects in micro-array research

Empirical Bayes estimation of gene-specific effects in micro-array research

article

Energy expenditure of rhesus monkeys subjected to 11 years of dietary restriction

scientific article published on 01 January 2003

Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue

scientific article published on 01 February 2006

Enzymes of glycerol and glyceraldehyde metabolism in mouse liver: effects of caloric restriction and age on activities

scientific article published on April 2008

Erratum to “Statistical methods for testing effects on ‘maximum lifespan”’ [Mech. Ageing Dev. 125 (2004) 629–632]

scholarly article published in Mechanisms of Ageing and Development

Fructose metabolizing enzymes from mouse liver: influence of age and caloric restriction

scientific journal article

Gene expression profile of aging and its retardation by caloric restriction

scientific article (publication date: 27 August 1999)

Gene expression profile of the aging brain

scientific article published in November 2002

Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidants

scientific article published on 25 June 2009

Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program

scientific article

Gene expression profiling of aging using DNA microarrays ⬇️

scientific article published on January 1, 2002

Gene expression profiling reveals differential effects of sodium selenite, selenomethionine, and yeast-derived selenium in the mouse.

scientific article published on 17 August 2011

Gene-expression profile of the ageing brain in mice

scientific article published on 01 July 2000

How does dietary restriction retard diseases and aging?

scientific article published on 01 January 1989

Identification of tissue-specific transcriptional markers of caloric restriction in the mouse and their use to evaluate caloric restriction mimetics.

scientific article published on 26 May 2017

Immunogerontologic Outcomes of Dietary Restriction Started in Adulthood ⬇️

scientific article published on April 1, 1995

Impairment of the transcriptional responses to oxidative stress in the heart of aged C57BL/6 mice.

scientific article published in June 2004

Influence of age and caloric restriction on liver glycolytic enzyme activities and metabolite concentrations in mice

scientific article

Influence of dietary restriction and aging on natural killer cell activity in mice

scientific article published on 01 February 1983

Influence of fat intake and caloric restriction on bone in aging male rats

scientific article published on January 1997

Influences of age and dietary restriction on gastrocnemius electron transport system activities in mice

scientific article published on 01 September 1996

Influences of caloric restriction on age-associated skeletal muscle fiber characteristics and mitochondrial changes in rats and mice

scientific article published in November 1998

Influences of calorie restriction and age on energy expenditure in the rhesus monkey

scientific article published on 08 August 2006

Influences of dietary restriction and age on liver enzyme activities and lipid peroxidation in mice

scientific article published in February 1987

Influences of dietary restriction on immunity to influenza in aged mice

scientific article published in July 1991

Insulin resistance and impaired insulin secretion in prenatally androgenized male rhesus monkeys

scientific article published in December 2004

Intentional weight loss reduces mortality rate in a rodent model of dietary obesity

scientific article published in April 2005

Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction

scientific article published on 01 August 1993

Krebs cycle enzymes from livers of old mice are differentially regulated by caloric restriction

scientific article

Lifelong voluntary exercise in the mouse prevents age-related alterations in gene expression in the heart

scientific article published on 15 January 2003

Long-term caloric restriction increases UCP3 content but decreases proton leak and reactive oxygen species production in rat skeletal muscle mitochondria

scientific article

Long-term calorie restriction decreases metabolic cost of movement and prevents decrease of physical activity during aging in rhesus monkeys

scientific article published on 13 August 2013

Long-term calorie restriction reduces proton leak and hydrogen peroxide production in liver mitochondria

scientific article published on 23 November 2004

Longitudinal analysis of early stage sarcopenia in aging rhesus monkeys

scientific article published on 17 October 2008

Measures of body size and growth in rhesus and squirrel monkeys subjected to long-term dietary restriction

scientific article published on 01 January 1995

Metabolic adaptations to fasting and chronic caloric restriction in heart, muscle, and liver do not include changes in AMPK activity.

scientific article published on 13 July 2004

Metabolic reprogramming in dietary restriction

scientific article published on January 2007

Metabolic reprogramming, caloric restriction and aging

scientific article

Metabolic shifts due to long-term caloric restriction revealed in nonhuman primates

scientific article

Metabolizable energy intake during long-term calorie restriction in rhesus monkeys

scientific article

Microarray profiling of gene expression in aging and its alteration by caloric restriction in mice

scientific article

Molecular analyses of mtDNA deletion mutations in microdissected skeletal muscle fibers from aged rhesus monkeys.

scientific article

Multiple age-associated mitochondrial DNA deletions in skeletal muscle of mice

scientific article published on 01 June 1994

Multiple mitochondrial DNA deletions associated with age in skeletal muscle of rhesus monkeys.

scientific article published in November 1993

Muscle mass loss in Rhesus monkeys: age of onset

scientific article published on 01 July 2005

Oxidative stress and aging reduce COX I RNA and cytochrome oxidase activity in Drosophila

scientific article published in October 1998

Oxidative stress, caloric restriction, and aging

scientific article (publication date: 5 July 1996)

Pennington scientific symposium on mechanisms and retardation of aging

scientific article published on 01 October 2003

Prostatic localization of spontaneous early invasive carcinoma in Lobund-Wistar rats ⬇️

scientific article published on November 15, 1994

Proton leak and hydrogen peroxide production in liver mitochondria from energy-restricted rats

scientific article

Reference body composition in adult rhesus monkeys: glucoregulatory and anthropometric indices

scientific article published in December 2005

Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss

scientific article published on 25 July 2006

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

scientific article

Serine utilization in mouse liver: influence of caloric restriction and aging

scientific article published in March 2005

Skeletal effects of long-term caloric restriction in rhesus monkeys

scientific article

Statistical methods for testing effects on “maximum lifespan”

scientific article published on 01 September 2004

The caloric restriction paradigm: Implications for healthy human aging ⬇️

scientific article published on January 30, 2012

The effects of intentional weight loss as a latent variable problem

scientific article published in March 2005

The expression of heat shock protein 70 decreases with age in lymphocytes from rats and rhesus monkeys

scientific article published on May 1995

The impact of alpha-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice

scientific article

The retardation of aging by caloric restriction: its significance in the transgenic era.

scientific article published on November 2003

The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake

scientific article

The role of calories and caloric restriction in carcinogenesis.

scientific article published on February 1991

The role of mtDNA mutations in the pathogenesis of age-related hearing loss in mice carrying a mutator DNA polymerase gamma

scientific article

Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts

scientific article

Transcriptomics and Metabonomics Identify Essential Metabolic Signatures in Calorie Restriction (CR) Regulation across Multiple Mouse Strains

scientific article published on 11 October 2013

Tympanometry in rhesus monkeys: effects of aging and caloric restriction

scientific article published in April 2008

Use of caloric restriction to investigate neuroendocrine involvement in aging

scientific article published on September 1995

Will dietary restriction work in primates?

scientific article published on 01 June 2006

alpha- and gamma-Tocopherol prevent age-related transcriptional alterations in the heart and brain of mice

scientific article published on June 2008

Paulina is supported by:

About Paulina

Help