List of works by Atze T Das

A Combinatorial CRISPR-Cas9 Attack on HIV-1 DNA Extinguishes All Infectious Provirus in Infected T Cell Cultures

scientific article published on December 2016

A conditionally replicating HIV-based vector that stably expresses an antiviral shRNA against HIV-1 replication

scientific article published on 11 May 2006

A conditionally replicating SIV variant that can be used to study the mechanism of protection conferred by live attenuated SIV vaccines.

scientific article published on 3 October 2011

A conditionally replicating virus as a novel approach toward an HIV vaccine

scientific article published in January 2004

A human immunodeficiency virus type 1-infected individual with low viral load harbors a virus variant that exhibits an in vitro RNA dimerization defect

scientific article

A novel splice donor site in the gag-pol gene is required for HIV-1 RNA stability

scientific article published on 4 May 2006

A regulatable AAV vector mediating GDNF biological effects at clinically-approved sub-antimicrobial doxycycline doses

scientific article published on 30 March 2016

A sensitive cell-based assay to measure the doxycycline concentration in biological samples.

scientific article

A short sequence motif in the 5' leader of the HIV-1 genome modulates extended RNA dimer formation and virus replication

scientific article

Alternative tRNA priming of human immunodeficiency virus type 1 reverse transcription explains sequence variation in the primer-binding site that has been attributed to APOBEC3G activity

scientific article published on March 2005

An AUG codon upstream of rev and env open reading frames ensures optimal translation of the simian immunodeficiency virus Env protein

scientific article published on 20 December 2012

CRISPR-Cas based antiviral strategies against HIV-1.

scientific article

CRISPR-Cas9 Can Inhibit HIV-1 Replication but NHEJ Repair Facilitates Virus Escape

scientific article published on 22 January 2016

CRISPR-Cas9 Dual-gRNA Attack Causes Mutation, Excision and Inversion of the HIV-1 Proviral DNA

scientific article published on 18 March 2020

Characterization of microRNAs derived from the HIV-1 TAR RNA hairpin.

scientific article published on 19 September 2013

Combinatorial CRISPR-Cas9 and RNA Interference Attack on HIV-1 DNA and RNA Can Lead to Cross-Resistance

scientific article published on 11 September 2017

Comparison of single regulated lentiviral vectors with rtTA expression driven by an autoregulatory loop or a constitutive promoter

scientific article

Conditional live virus as a novel approach towards a safe live attenuated HIV vaccine

scientific article

Conditional virus replication as an approach to a safe live attenuated human immunodeficiency virus vaccine

scientific article

Conditionally replicating HIV and SIV variants

scientific article published on 14 May 2015

Conditionally-live attenuated SIV upregulates global T effector memory cell frequency under replication permissive conditions

scientific article published on 05 June 2013

Construction of Nef-positive doxycycline-dependent HIV-1 variants using bicistronic expression elements.

scientific article

Construction of a doxycycline-dependent simian immunodeficiency virus reveals a nontranscriptional function of tat in viral replication.

scientific article

Establishment of a mouse xenograft model of metastatic adrenocortical carcinoma

scientific article published on 7 April 2017

Factor correction as a tool to eliminate between-session variation in replicate experiments: application to molecular biology and retrovirology

scientific article

Functional analysis of the complex trans-activating response element RNA structure in simian immunodeficiency virus

scientific article published on 2 July 2008

HIV-1 RNAs: sense and antisense, large mRNAs and small siRNAs and miRNAs.

scientific article published on March 2015

HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome

scientific article

HIV-1 evolution: frustrating therapies, but disclosing molecular mechanisms

scientific article published on June 2010

HIV-1 splicing is controlled by local RNA structure and binding of splicing regulatory proteins at the major 5' splice site

scientific article

HIV-1 transcriptional silencing caused by TRIM22 inhibition of Sp1 binding to the viral promoter

scientific article published on 18 December 2015

Hairpin-induced tRNA-mediated (HITME) recombination in HIV-1.

scientific article published on 2 May 2006

Hepatocyte-specific interplay of transcription factors at the far-upstream enhancer of the carbamoylphosphate synthetase gene upon glucocorticoid induction.

scientific article published on 28 November 2006

Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition

scientific article published on March 2004

Human immunodeficiency virus type 1 splicing at the major splice donor site is controlled by highly conserved RNA sequence and structural elements

scientific article published on 17 September 2015

IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation

scientific article published on 04 June 2019

Improved single-chain transactivators of the Tet-On gene expression system

scientific article

Improving the safety of a conditional-live human immunodeficiency virus type 1 vaccine by controlling both gene expression and cell entry

scientific article published on March 2005

In vivo SELEX of single-stranded domains in the HIV-1 leader RNA.

scientific article

Modification of the Tet-On regulatory system prevents the conditional-live HIV-1 variant from losing doxycycline-control

scientific article published on 9 November 2006

Occult replication of a conditionally-live attenuated SIV profoundly upregulates T effector memory cell frequency.

scientific article published on 3 October 2011

Opening of the TAR hairpin in the HIV-1 genome causes aberrant RNA dimerization and packaging

scientific article

Optimization of the doxycycline-dependent simian immunodeficiency virus through in vitro evolution

scientific article published on 5 June 2008

Possible applications for replicating HIV 1 vectors

scientific article published on May 2010

Proceedings of the Frontiers of Retrovirology Conference 2016.

scientific article published on 26 September 2016

Replication kinetics and persistence of a conditionally live attenuated SIV (SIVrtTA) in vivo confers protection against SIVmac239 wild-type challenge in a rhesus macaque model

scientific article

Replication kinetics and persistence of a conditionally live attenuated SIV (SIVrtTA) in vivo confers protection against homologous and heterologous wild-type challenge in macaques

Retroviral microRNAs

scientific article published on 23 April 2014

Role of Occult and Post-acute Phase Replication in Protective Immunity Induced with a Novel Live Attenuated SIV Vaccine

scientific article (publication date: December 2016)

Selecting the optimal Tet-On system for doxycycline-inducible gene expression in transiently transfected and stably transduced mammalian cells

scientific article published on 3 September 2015

Structural requirements of the glucocorticoid-response unit of the carbamoyl-phosphate synthase gene

scientific article published on September 2004

Tackling HIV Persistence: Pharmacological versus CRISPR-Based Shock Strategies.

scientific article published on 29 March 2018

Tat has a dual role in simian immunodeficiency virus transcription

scientific article

Tat-dependent production of an HIV-1 TAR-encoded miRNA-like small RNA.

scientific article

Tet-On Systems For Doxycycline-inducible Gene Expression.

scientific article published on 24 May 2016

The HIV-1 Tat protein enhances splicing at the major splice donor site.

scientific article

The HIV-1 Tat protein has a versatile role in activating viral transcription

scientific article published on 13 July 2011

The Impact of HIV-1 Genetic Diversity on CRISPR-Cas9 Antiviral Activity and Viral Escape

article

The RNA structure of the major splice donor site controls HIV-1 splicing

The allosteric HIV-1 integrase inhibitor BI-D affects virion maturation but does not influence packaging of a functional RNA genome

scientific article

The apical loop of the HIV-1 TAR RNA hairpin is stabilized by a cross-loop base pair

scientific article (publication date: 3 October 2003)

The genetic stability of a conditional live HIV-1 variant can be improved by mutations in the Tet-On regulatory system that restrain evolution

scientific article published on 20 April 2006

Upstream AUG codons in the simian immunodeficiency virus SIVmac239 genome regulate Rev and Env protein translation

scientific article

Viral evolution as a tool to improve the tetracycline-regulated gene expression system

scientific article published on 2 February 2004

Virus evolution as a tool to study HIV-1 biology

scientific article published on January 2009

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