List of works - Philip G de Groot

A heparin-bonded vascular graft generates no systemic effect on markers of hemostasis activation or detectable heparin-induced thrombocytopenia-associated antibodies in humans

scientific article

A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia

scientific article

A novel nanobody that detects the gain-of-function phenotype of von Willebrand factor in ADAMTS13 deficiency and von Willebrand disease type 2B.

scientific article

A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides

scientific article

ADAMTS13 deficiency with elevated levels of ultra-large and active von Willebrand factor in P. falciparum and P. vivax malaria.

scientific article

Accelerated uptake of VWF/platelet complexes in macrophages contributes to VWD type 2B-associated thrombocytopenia

scientific article

Activated factor V is a cofactor for the activation of factor XI by thrombin in plasma.

scientific article

Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2.

scientific article

Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients

scientific article

Beta2-glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome.

scientific article

Cell-collagen interactions: the use of peptide Toolkits to investigate collagen-receptor interactions.

scientific article published on April 2008

Challenges of molecular nutrition research 6: the nutritional phenotype database to store, share and evaluate nutritional systems biology studies

scientific article (publication date: 3 February 2010)

Clinical and molecular predictors of thrombocytopenia and risk of bleeding in patients with von Willebrand disease type 2B: a cohort study of 67 patients

scientific article

Dimers of beta 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2'

scientific article (publication date: 5 September 2003)

Endocannabinoids control platelet activation and limit aggregate formation under flow

scientific article (publication date: 2014)

Functional platelet defects in children with severe chronic ITP as tested with 2 novel assays applicable for low platelet counts

scientific article

Higher and lower active circulating VWF levels: different facets of von Willebrand disease

scientific article

Imbalance of angiopoietin-1 and angiopoetin-2 in severe dengue and relationship with thrombocytopenia, endothelial activation, and vascular stability

scientific article

Indications for a protective function of beta2-glycoprotein I in thrombotic thrombocytopenic purpura

scientific article

Interference with the host haemostatic system by schistosomes

scientific article (publication date: 2013)

Keeping von Willebrand Factor under Control: Alternatives for ADAMTS13.

scientific article

Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation

scientific article

Molecular Imaging of Activated von Willebrand Factor to Detect High-Risk Atherosclerotic Phenotype ⬇️

scientific article published on September 1, 2010

Mutation and ADAMTS13-dependent modulation of disease severity in a mouse model for von Willebrand disease type 2B.

scientific article

Plasmin cleavage of von Willebrand factor as an emergency bypass for ADAMTS13 deficiency in thrombotic microangiopathy

scientific article

Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Krüppel-like factor (KLF2)

scientific article (publication date: September 2002)

Severe dengue is associated with consumption of von Willebrand factor and its cleaving enzyme ADAMTS-13

scientific article

Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain

scientific article

Synergism between platelet collagen receptors defined using receptor-specific collagen-mimetic peptide substrata in flowing blood

scientific article

Synergistic effects of hypofibrinolysis and genetic and acquired risk factors on the risk of a first venous thrombosis

scientific article (publication date: 6 May 2008)

The effect of recombinant IgG antibodies against the leucine-33 form of the platelet beta3 integrin (HPA-1a) on platelet function

scientific article

The embryonic genes Dkk3, Hoxd8, Hoxd9 and Tbx1 identify muscle types in a diet-independent and fiber-type unrelated way.

scientific article

The functions of the A1A2A3 domains in von Willebrand factor include multimerin 1 binding.

scientific article published on 7 April 2016

The low-frequency allele of the platelet collagen signaling receptor glycoprotein VI is associated with reduced functional responses and expression

scientific article

The presence of active von Willebrand factor under various pathological conditions

scientific article

The rate of hemolysis in sickle cell disease correlates with the quantity of active von Willebrand factor in the plasma.

scientific article

The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice

scientific article

Thrombocytopenia and release of activated von Willebrand Factor during early Plasmodium falciparum malaria

scientific article

Thrombocytopenia in early malaria is associated with GP1b shedding in absence of systemic platelet activation and consumptive coagulopathy

scientific article

beta2-Glycoprotein I inhibits von Willebrand factor dependent platelet adhesion and aggregation

scientific article

List of works by Philip G de Groot

A heparin-bonded vascular graft generates no systemic effect on markers of hemostasis activation or detectable heparin-induced thrombocytopenia-associated antibodies in humans

A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia

A novel nanobody that detects the gain-of-function phenotype of von Willebrand factor in ADAMTS13 deficiency and von Willebrand disease type 2B.

A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides

ADAMTS13 deficiency with elevated levels of ultra-large and active von Willebrand factor in P. falciparum and P. vivax malaria.

Accelerated uptake of VWF/platelet complexes in macrophages contributes to VWD type 2B-associated thrombocytopenia

Activated factor V is a cofactor for the activation of factor XI by thrombin in plasma.

Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2.

Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients

Beta2-glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome.

Cell-collagen interactions: the use of peptide Toolkits to investigate collagen-receptor interactions.

Challenges of molecular nutrition research 6: the nutritional phenotype database to store, share and evaluate nutritional systems biology studies

Clinical and molecular predictors of thrombocytopenia and risk of bleeding in patients with von Willebrand disease type 2B: a cohort study of 67 patients

Dimers of beta 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2'

Endocannabinoids control platelet activation and limit aggregate formation under flow

Functional platelet defects in children with severe chronic ITP as tested with 2 novel assays applicable for low platelet counts

Higher and lower active circulating VWF levels: different facets of von Willebrand disease

Imbalance of angiopoietin-1 and angiopoetin-2 in severe dengue and relationship with thrombocytopenia, endothelial activation, and vascular stability

Indications for a protective function of beta2-glycoprotein I in thrombotic thrombocytopenic purpura

Interference with the host haemostatic system by schistosomes

Keeping von Willebrand Factor under Control: Alternatives for ADAMTS13.

Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation

Molecular Imaging of Activated von Willebrand Factor to Detect High-Risk Atherosclerotic Phenotype ⬇️

Mutation and ADAMTS13-dependent modulation of disease severity in a mouse model for von Willebrand disease type 2B.

Plasmin cleavage of von Willebrand factor as an emergency bypass for ADAMTS13 deficiency in thrombotic microangiopathy

Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Krüppel-like factor (KLF2)

Severe dengue is associated with consumption of von Willebrand factor and its cleaving enzyme ADAMTS-13

Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain

Synergism between platelet collagen receptors defined using receptor-specific collagen-mimetic peptide substrata in flowing blood

Synergistic effects of hypofibrinolysis and genetic and acquired risk factors on the risk of a first venous thrombosis

The effect of recombinant IgG antibodies against the leucine-33 form of the platelet beta3 integrin (HPA-1a) on platelet function

The embryonic genes Dkk3, Hoxd8, Hoxd9 and Tbx1 identify muscle types in a diet-independent and fiber-type unrelated way.

The functions of the A1A2A3 domains in von Willebrand factor include multimerin 1 binding.

The low-frequency allele of the platelet collagen signaling receptor glycoprotein VI is associated with reduced functional responses and expression

The presence of active von Willebrand factor under various pathological conditions

The rate of hemolysis in sickle cell disease correlates with the quantity of active von Willebrand factor in the plasma.

The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice

Thrombocytopenia and release of activated von Willebrand Factor during early Plasmodium falciparum malaria

Thrombocytopenia in early malaria is associated with GP1b shedding in absence of systemic platelet activation and consumptive coagulopathy

beta2-Glycoprotein I inhibits von Willebrand factor dependent platelet adhesion and aggregation