List of works - Makoto Suematsu

2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche

scientific article published on 17 August 2020

A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting

scientific article published on 14 November 2013

A novel cardiac hypertrophic factor, neurotrophin-3, is paradoxically downregulated in cardiac hypertrophy

scientific article published on 16 June 2007

A thin layer of sucrose octasulfate protects the oesophageal mucosal epithelium in reflux oesophagitis

scientific article published on 05 March 2019

Activated leukocytes and endothelial cells enhance retention of ultrasound contrast microspheres containing perfluoropropane in inflamed venules

scientific article

Activation of macrophage function by intraperitoneal administration of the streptococcal antitumor agent OK-432

scientific article published on 01 October 1983

Acute CO2-independent vasodilatation of penetrating and pre-capillary arterioles in mouse cerebral parenchyma upon hypoxia revealed by a thinned-skull window method.

scientific article

Adrenocortical zonation in humans under normal and pathological conditions

scientific article published on 3 March 2010

Alpha-ketoglutarate oxidoreductase, an essential salvage enzyme of energy metabolism, in coccoid form of Helicobacter pylori

scientific article published on 26 August 2008

Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell.

scientific article

An ELISA assay for heme oxygenase (HO-1).

scientific article

Aquaporin AqpZ is involved in cell volume regulation and sensitivity to osmotic stress in Synechocystis sp. strain PCC 6803.

scientific article published on 5 October 2012

Autophagy regulates lipid metabolism through selective turnover of NCoR1

scientific article published on 05 April 2019

Biochemical and functional characterization of novel NADH kinase in the enteric protozoan parasite Entamoeba histolytica

scientific article published on 13 October 2012

CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth

scientific article

COHb: a stress-induced marker reflecting surgical insults?

scientific article published on 01 May 2002

Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle.

scientific article published on 22 August 2013

Carbon monoxide from heme oxygenase-2 Is a tonic regulator against NO-dependent vasodilatation in the adult rat cerebral microcirculation

scientific article

Carbon monoxide stimulates global protein methylation via its inhibitory action on cystathionine β-synthase.

scientific article published on 28 December 2010

Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver ⬇️

scientific article published on November 1, 1995

Cell-free synthesis of cytochrome c oxidase, a multicomponent membrane protein.

scientific article

Characterization of skin microbiota in patients with atopic dermatitis and in normal subjects using 16S rRNA gene-based comprehensive analysis.

scientific article

Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye

scientific article published on 31 July 2018

Cilostazol strengthens the endothelial barrier of postcapillary venules from the rat mesentery in situ

scientific article published on 15 July 2013

Conditionally immortalized adrenocortical cell lines at undifferentiated states exhibit inducible expression of glucocorticoid-synthesizing genes

scientific article published in January 2002

Constitutive expression of ICAM-1 in rat microvascular systems analyzed by laser confocal microscopy ⬇️

scientific article published on July 1, 1997

Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by the autotaxin/lysophosphatidic acid axis

scientific article

Coupling of angiogenesis and odontogenesis orchestrates tooth mineralization in mice

scientific article published in 2022

Crosstalk between glucocorticoid receptor and nutritional sensor mTOR in skeletal muscle.

scientific article

Cystathionine beta-synthase as a carbon monoxide-sensitive regulator of bile excretion

scientific article

Cystathionine gamma-Lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury.

scientific article

Cytochrome P-450(17alpha) in beta-cells of rat pancreas and its local steroidogenesis

scientific article published on 13 May 2008

Cytotoxic effect of amide derivatives of trifluoromethionine against the enteric protozoan parasite Entamoeba histolytica

scientific article published on 12 November 2009

Decreased circulating levels of active ghrelin are associated with increased oxidative stress in obese subjects

scientific article published in September 2005

Decreased high-molecular weight adiponectin-to-total adiponectin ratio in sera is associated with insulin resistance in Japanese metabolically obese, normal-weight men with normal glucose tolerance

scientific article published in October 2006

Development of functional zonation in the rat adrenal cortex

scientific article published on 01 July 1999

Disruption of HIF-1α in hepatocytes impairs glucose metabolism in diet-induced obesity mice.

scientific article published on 22 October 2011

Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes

scientific article published on 15 November 2012

Distribution of tubulointerstitial nephritis antigen-like 1 and structural matrix proteins in mouse embryos during preimplantation development in vivo and in vitro.

scientific article published in October 2012

Dynamic simulation and metabolome analysis of long-term erythrocyte storage in adenine-guanosine solution

scientific article

Effects of serine protease inhibitors on oxyradical burst from phagocytizing neutrophils--analysis by chemiluminescence counting and its microscopic imaging

scientific article

Endogenous prostaglandin D2 and its metabolites protect the heart against ischemia-reperfusion injury by activating Nrf2.

scientific article

Endothelial-derived nitric oxide preserves anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells

scientific article published on 01 November 1997

Energy management by enhanced glycolysis in G1-phase in human colon cancer cells in vitro and in vivo

scientific article published on 5 June 2013

Epidermal cell turnover across tight junctions based on Kelvin's tetrakaidecahedron cell shape

scientific article

Expression of heme oxygenase-1 in rat ontogeny

scientific article published on 01 May 2003

Gas biology: tiny molecules controlling metabolic systems.

scientific article published on 30 March 2012

Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia

scientific article published on 25 March 2008

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival.

scientific article published on 19 April 2018

Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion

scientific article published on 28 September 2021

HIF-1 in T cells ameliorated dextran sodium sulfate-induced murine colitis

scientific article published on 27 March 2012

HIF-1α induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice

scientific article published on 05 September 2011

Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance

scientific article published on 18 March 2016

Heme oxygenase-1 inhibits cytokine production by activated mast cells

scientific journal article

High-performance affinity purification for identification of 15-deoxy-Δ 12,14 -PGJ₂ interacting factors using magnetic nanobeads.

scientific article

Human serum albumin incorporating synthetic heme: red blood cell substitute without hypertension by nitric oxide scavenging

scientific article published in February 2003

Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration

scientific article

Hypotaurine is an Energy-Saving Hepatoprotective Compound against Ischemia-Reperfusion Injury of the Rat Liver

scientific article

Hypoxia-inducible factor-1 is a determinant of lobular structure and oxygen consumption in the liver

scientific article published in July 2013

Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression

scientific article published on March 2014

Hypoxia-sensitive fluorescent probes for in vivo real-time fluorescence imaging of acute ischemia

scientific article published on October 27, 2010

Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway.

scientific article

IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

scientific article published on 01 August 2019

Identification and local manipulation of bone marrow vasculature during intravital imaging

scientific article published on 14 April 2020

Identification of mutations in the prostaglandin transporter gene SLCO2A1 and its phenotype-genotype correlation in Japanese patients with pachydermoperiostosis

scientific article published on 27 July 2012

In silico modeling and metabolome analysis of long-stored erythrocytes to improve blood storage methods

scientific article published on 18 August 2009

Increased oxidative stress is associated with decreased circulating levels of adiponectin in Japanese metabolically obese, normal-weight men with normal glucose tolerance.

scientific article published on 2 May 2006

Inverse correlation between activated protein C generation and carotid atherosclerosis in Type 2 diabetic patients

scientific article published on 29 October 2007

Involvement of NF-κB-mediated expression of galectin-3-binding protein in TNF-α-induced breast cancer cell adhesion

scientific article

Kupffer cell-mediated recruitment of rat dendritic cells to the liver: roles of N-acetylgalactosamine-specific sugar receptors

scientific article published in December 2001

Maintaining the redox-balance intact: gosha-jinki-gan but not insulin activates retinal soluble guanylate cyclase in diabetic rats

scientific article published on 20 December 2005

MathDAMP: a package for differential analysis of metabolite profiles

scientific article

Mechanism of hepatic parenchyma-specific contrast of microbubble-based contrast agent for ultrasonography: microscopic studies in rat liver

scientific article

Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes

scientific article published in June 2008

Metabolic profiling of the protozoan parasite Entamoeba invadens revealed activation of unpredicted pathway during encystation

scientific article

Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior

scientific article

Metabolome Analysis Revealed Increase in S-Methylcysteine and Phosphatidylisopropanolamine Synthesis upon l-Cysteine Deprivation in the Anaerobic Protozoan Parasite Entamoeba histolytica ⬇️

scientific article published on October 5, 2010

Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine γ-lyase, an animal model of cystathioninuria

scientific article published on 03 March 2012

Microscopic imaging mass spectrometry assisted by on-tissue chemical derivatization for visualizing multiple amino acids in human colon cancer xenografts.

scientific article

Microvascular and systemic effects following top load administration of saturated carbon monoxide-saline solution

scientific article published in April 2007

Midbrain locked-in state with oculomotor subnucleus lesion

scientific article published on September 1985

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

scientific article published on 6 October 2012

Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells.

scientific article published on 31 January 2012

Mono-(2-ethylhexyl) phthalate targets glycogen debranching enzyme and affects glycogen metabolism in rat testis

scientific article published on 23 February 2009

Morphine prevents peroxynitrite-induced death of human neuroblastoma SH-SY5Y cells through a direct scavenging action

scientific article published on 01 May 1999

Near-infrared laser adjuvant for influenza vaccine

scientific article (publication date: 2013)

No difference in the level of gastric mucosal cell apoptosis and proliferation in Helicobacter pylori-colonized p53 heterozygous knockout mice

scientific article

Organic phosphates as a new class of soluble guanylate cyclase inhibitors

scientific article published in October 2001

Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction

scientific article published on 13 January 2003

Physiological capacity of the reticuloendothelial system for the degradation of hemoglobin vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusions for 14 days.

scientific article

Possible participation of outer mitochondrial membrane cytonchrome B5 in steroidogenesis in zona glomerulosa of rat adrenal cortex

scientific article published in November 2004

Preservation solutions alter Mrp2-dependent bile flow in cold ischemic rat livers.

scientific article

Primary embryonal carcinoma of heart with SVC syndrome

scientific article published on 01 December 2002

Progesterone receptor membrane associated component 1 enhances obesity progression in mice by facilitating lipid accumulation in adipocytes

scientific article published on 04 September 2020

Purified cardiomyocytes from bone marrow mesenchymal stem cells produce stable intracardiac grafts in mice

scientific article published in February 2005

Pyruvate kinase M2: multiple faces for conferring benefits on cancer cells.

scientific article published on October 2012

ROR gamma t is dispensable for the development of intestinal mucosal T cells

scientific article

Rapid and reversible inhibition of aquaporin-4 by zinc

scientific article published in December 2009

Real-time imaging of mechanically injured femoral artery in mice reveals a biphasic pattern of leukocyte accumulation

scientific article

Rescue of anaemia and autoimmune responses in SOD1-deficient mice by transgenic expression of human SOD1 in erythrocytes.

scientific article

Resolvin E1 maintains macrophage function under cigarette smoke-induced oxidative stress.

scientific article

Restoring metabolism of myeloid cells reverses cognitive decline in ageing

scientific article published on 20 January 2021

Rewiring of embryonic glucose metabolism via suppression of PFK-1 and aldolase during mouse chorioallantoic branching

scientific article published on January 2017

Sensing of the non-essential amino acid tyrosine governs the response to protein restriction in Drosophila

scientific article published in 2022

Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasome complex to prevent Salmonella infection

scientific article published on 29 September 2020

Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin.

scientific article

Subthreshold UV radiation-induced peroxide formation in cultured corneal epithelial cells: the protective effects of lactoferrin.

scientific article

Successful treatment of refractory hepatic lymphorrhea after gastrectomy for early gastric cancer, using surgical ligation and subsequent OK-432 (Picibanil) sclerotherapy.

scientific article published in January 2004

T-state stabilization of hemoglobin by nitric oxide to form alpha-nitrosyl heme causes constitutive release of ATP from human erythrocytes

scientific article published in January 2010

TOF-SIMS imaging of halide/thiocyanate anions and hydrogen sulfide in mouse kidney sections using silver-deposited plates

scientific article published on 27 December 2011

The free-radical scavenger, edaravone, augments NO release from vascular cells and platelets after laser-induced, acute endothelial injury in vivo.

scientific article

The proton pumping pathway of bovine heart cytochrome c oxidase

scientific article

The undifferentiated cell zone is a stem cell zone in adult rat adrenal cortex.

scientific article published on February 2003

Tubulointerstitial nephritis antigen-like 1 is expressed in the uterus and binds with integrins in decidualized endometrium during postimplantation in mice.

scientific article

Two amino acids mutation of ferric uptake regulator determines Helicobacter pylori resistance to metronidazole

scientific article published on 26 August 2010

Various adhesion molecules impair microvascular leukocyte kinetics in ventilator-induced lung injury

scientific article

Visualization and analysis of blood flow and oxygen consumption in hepatic microcirculation: application to an acute hepatitis model.

scientific article

Visualization of three-way comparisons of omics data

scientific article

Visualization of volatile substances in different organelles with an atmospheric-pressure mass microscope

scientific article

alpha 4 integrin plays a critical role in early stages of T lymphocyte migration in Peyer's patches of rats

scientific article published on 01 March 1996

List of works by Makoto Suematsu

2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche

A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting

A novel cardiac hypertrophic factor, neurotrophin-3, is paradoxically downregulated in cardiac hypertrophy

A thin layer of sucrose octasulfate protects the oesophageal mucosal epithelium in reflux oesophagitis

Activated leukocytes and endothelial cells enhance retention of ultrasound contrast microspheres containing perfluoropropane in inflamed venules

Activation of macrophage function by intraperitoneal administration of the streptococcal antitumor agent OK-432

Acute CO2-independent vasodilatation of penetrating and pre-capillary arterioles in mouse cerebral parenchyma upon hypoxia revealed by a thinned-skull window method.

Adrenocortical zonation in humans under normal and pathological conditions

Alpha-ketoglutarate oxidoreductase, an essential salvage enzyme of energy metabolism, in coccoid form of Helicobacter pylori

Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell.

An ELISA assay for heme oxygenase (HO-1).

Aquaporin AqpZ is involved in cell volume regulation and sensitivity to osmotic stress in Synechocystis sp. strain PCC 6803.

Autophagy regulates lipid metabolism through selective turnover of NCoR1

Biochemical and functional characterization of novel NADH kinase in the enteric protozoan parasite Entamoeba histolytica

CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth

COHb: a stress-induced marker reflecting surgical insults?

Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle.

Carbon monoxide from heme oxygenase-2 Is a tonic regulator against NO-dependent vasodilatation in the adult rat cerebral microcirculation

Carbon monoxide stimulates global protein methylation via its inhibitory action on cystathionine β-synthase.

Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver ⬇️

Cell-free synthesis of cytochrome c oxidase, a multicomponent membrane protein.

Characterization of skin microbiota in patients with atopic dermatitis and in normal subjects using 16S rRNA gene-based comprehensive analysis.

Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye

Cilostazol strengthens the endothelial barrier of postcapillary venules from the rat mesentery in situ

Conditionally immortalized adrenocortical cell lines at undifferentiated states exhibit inducible expression of glucocorticoid-synthesizing genes

Constitutive expression of ICAM-1 in rat microvascular systems analyzed by laser confocal microscopy ⬇️

Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by the autotaxin/lysophosphatidic acid axis

Coupling of angiogenesis and odontogenesis orchestrates tooth mineralization in mice

Crosstalk between glucocorticoid receptor and nutritional sensor mTOR in skeletal muscle.

Cystathionine beta-synthase as a carbon monoxide-sensitive regulator of bile excretion

Cystathionine gamma-Lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury.

Cytochrome P-450(17alpha) in beta-cells of rat pancreas and its local steroidogenesis

Cytotoxic effect of amide derivatives of trifluoromethionine against the enteric protozoan parasite Entamoeba histolytica

Decreased circulating levels of active ghrelin are associated with increased oxidative stress in obese subjects

Decreased high-molecular weight adiponectin-to-total adiponectin ratio in sera is associated with insulin resistance in Japanese metabolically obese, normal-weight men with normal glucose tolerance

Development of functional zonation in the rat adrenal cortex

Disruption of HIF-1α in hepatocytes impairs glucose metabolism in diet-induced obesity mice.

Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes

Distribution of tubulointerstitial nephritis antigen-like 1 and structural matrix proteins in mouse embryos during preimplantation development in vivo and in vitro.

Dynamic simulation and metabolome analysis of long-term erythrocyte storage in adenine-guanosine solution

Effects of serine protease inhibitors on oxyradical burst from phagocytizing neutrophils--analysis by chemiluminescence counting and its microscopic imaging

Endogenous prostaglandin D2 and its metabolites protect the heart against ischemia-reperfusion injury by activating Nrf2.

Endothelial-derived nitric oxide preserves anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells

Energy management by enhanced glycolysis in G1-phase in human colon cancer cells in vitro and in vivo

Epidermal cell turnover across tight junctions based on Kelvin's tetrakaidecahedron cell shape

Expression of heme oxygenase-1 in rat ontogeny

Gas biology: tiny molecules controlling metabolic systems.

Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival.

Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion

HIF-1 in T cells ameliorated dextran sodium sulfate-induced murine colitis

HIF-1α induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice

Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance

Heme oxygenase-1 inhibits cytokine production by activated mast cells

High-performance affinity purification for identification of 15-deoxy-Δ 12,14 -PGJ₂ interacting factors using magnetic nanobeads.

Human serum albumin incorporating synthetic heme: red blood cell substitute without hypertension by nitric oxide scavenging

Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration

Hypotaurine is an Energy-Saving Hepatoprotective Compound against Ischemia-Reperfusion Injury of the Rat Liver

Hypoxia-inducible factor-1 is a determinant of lobular structure and oxygen consumption in the liver

Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression

Hypoxia-sensitive fluorescent probes for in vivo real-time fluorescence imaging of acute ischemia

Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway.

IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

Identification and local manipulation of bone marrow vasculature during intravital imaging

Identification of mutations in the prostaglandin transporter gene SLCO2A1 and its phenotype-genotype correlation in Japanese patients with pachydermoperiostosis

In silico modeling and metabolome analysis of long-stored erythrocytes to improve blood storage methods

Increased oxidative stress is associated with decreased circulating levels of adiponectin in Japanese metabolically obese, normal-weight men with normal glucose tolerance.

Inverse correlation between activated protein C generation and carotid atherosclerosis in Type 2 diabetic patients

Involvement of NF-κB-mediated expression of galectin-3-binding protein in TNF-α-induced breast cancer cell adhesion

Kupffer cell-mediated recruitment of rat dendritic cells to the liver: roles of N-acetylgalactosamine-specific sugar receptors

Maintaining the redox-balance intact: gosha-jinki-gan but not insulin activates retinal soluble guanylate cyclase in diabetic rats

MathDAMP: a package for differential analysis of metabolite profiles

Mechanism of hepatic parenchyma-specific contrast of microbubble-based contrast agent for ultrasonography: microscopic studies in rat liver

Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes

Metabolic profiling of the protozoan parasite Entamoeba invadens revealed activation of unpredicted pathway during encystation

Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior

Metabolome Analysis Revealed Increase in S-Methylcysteine and Phosphatidylisopropanolamine Synthesis upon l-Cysteine Deprivation in the Anaerobic Protozoan Parasite Entamoeba histolytica ⬇️

Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine γ-lyase, an animal model of cystathioninuria

Microscopic imaging mass spectrometry assisted by on-tissue chemical derivatization for visualizing multiple amino acids in human colon cancer xenografts.