List of works - Carol L Farr

A Distinct Type of Pilus from the Human Microbiome

scientific article

A conserved fold for fimbrial components revealed by the crystal structure of a putative fimbrial assembly protein (BT1062) from Bacteroides thetaiotaomicron at 2.2 Å resolution

scientific article

A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymerase

scientific article

Bacterial Pleckstrin Homology Domains: A Prokaryotic Origin for the PH Domain

scientific article

Crystal structure of a member of a novel family of dioxygenases (PF10014) reveals a conserved cupin fold and active site

scientific article

Crystal structure of a metal-dependent phosphoesterase (YP_910028.1) from Bifidobacterium adolescentis: Computational prediction and experimental validation of phosphoesterase activity

scientific article

Crystal structure of a novel Sm-like protein of putative cyanophage origin at 2.60 Å resolution

scientific article

Crystal structure of a putative quorum sensing-regulated protein (PA3611) from the Pseudomonas-specific DUF4146 family

scientific article

Crystal structures of three representatives of a new Pfam family PF14869 (DUF4488) suggest they function in sugar binding/uptake

scientific article

Drosophila melanogaster as a model system to study mitochondrial biology

scientific article published on January 2007

Functional analysis of H. sapiens DNA polymerase gamma spacer mutation W748S with and without common variant E1143G.

scientific article

Insights into Substrate Specificity of Geranylgeranyl Reductases Revealed by the Structure of Digeranylgeranylglycerophospholipid Reductase, an Essential Enzyme in the Biosynthesis of Archaeal Membrane Lipids

scientific article

Insights into Substrate Specificity of NlpC/P60 Cell Wall Hydrolases Containing Bacterial SH3 Domains

scientific article published on 15 September 2015

Ischemic preconditioning regulates expression of microRNAs and a predicted target, MeCP2, in mouse cortex

scientific article

Modular architecture of the hexameric human mitochondrial DNA helicase

scientific article

Muscle-specific overexpression of the catalytic subunit of DNA polymerase γ induces pupal lethality in Drosophila melanogaster

scientific article

Over-expression of the catalytic core of mitochondrial DNA (mtDNA) polymerase in the nervous system of Drosophila melanogaster reduces median life span by inducing mtDNA depletion

scientific article published on 12 November 2007

Physiological and biochemical defects in carboxyl-terminal mutants of mitochondrial DNA helicase

scientific article published on 30 June 2008

Proteomic analysis of native metabotropic glutamate receptor 5 protein complexes reveals novel molecular constituents

scientific article published on October 2004

Structural analysis of arabinose-5-phosphate isomerase from Bacteroides fragilis and functional implications

scientific article

Structural and Sequence Analysis of Imelysin-Like Proteins Implicated in Bacterial Iron Uptake

scientific article

Structural and functional characterization of BaiA, an enzyme involved in secondary bile acid synthesis in human gut microbe ⬇️

scientific article published on October 17, 2013

Structural and functional characterizations of SsgB, a conserved activator of developmental cell division in morphologically complex actinomycetes

scientific article

Structure and Function of the DUF2233 Domain in Bacteria and in the Human Mannose 6-Phosphate Uncovering Enzyme

scientific article

Structure and Function of the First Full-Length Murein Peptide Ligase (Mpl) Cell Wall Recycling Protein

scientific article

Structure and functional characterization of a bile acid 7α dehydratase BaiE in secondary bile acid synthesis

scientific article published on 9 December 2015

Structure of BT_3984, a member of the SusD/RagB family of nutrient-binding molecules

scientific article

Structure of Bacteroides thetaiotaomicron BT2081 at 2.05 Å resolution: the first structural representative of a new protein family that may play a role in carbohydrate metabolism

scientific article

Structure of a Novel Winged-Helix Like Domain from Human NFRKB Protein

scientific article

Structure of a Virulence Regulatory Factor CvfB Reveals a Novel Winged Helix RNA Binding Module

scientific article

Structure of a membrane-attack complex/perforin (MACPF) family protein from the human gut symbiont Bacteroides thetaiotaomicron

scientific article

Structure of the γ- D -glutamyl- L -diamino acid endopeptidase YkfC from Bacillus cereus in complex with L -Ala-γ- D -Glu: insights into substrate recognition by NlpC/P60 cysteine peptidases

scientific article

Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells

scientific article

Structures of a Bifunctional Cell Wall Hydrolase CwlT Containing a Novel Bacterial Lysozyme and an NlpC/P60 dl-Endopeptidase

scientific article

Structures of the first representatives of Pfam family PF06684 (DUF1185) reveal a novel variant of the Bacillus chorismate mutase fold and suggest a role in amino-acid metabolism

scientific article

Structures of three members of Pfam PF02663 (FmdE) implicated in microbial methanogenesis reveal a conserved α+β core domain and an auxiliary C-terminal treble-clef zinc finger

scientific article

The accessory subunit of DNA polymerase gamma is essential for mitochondrial DNA maintenance and development in Drosophila melanogaster

scientific article

The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu

scientific article

The structure of BVU2987 from Bacteroides vulgatus reveals a superfamily of bacterial periplasmic proteins with possible inhibitory function

scientific article

The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae , reveals an OB-fold

scientific article

The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation

scientific article

UHM-ULM interactions in the RBM39-U2AF65 splicing-factor complex

scientific article published on 24 March 2016

List of works by Carol L Farr

A Distinct Type of Pilus from the Human Microbiome

A conserved fold for fimbrial components revealed by the crystal structure of a putative fimbrial assembly protein (BT1062) from Bacteroides thetaiotaomicron at 2.2 Å resolution

A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymerase

Bacterial Pleckstrin Homology Domains: A Prokaryotic Origin for the PH Domain

Crystal structure of a member of a novel family of dioxygenases (PF10014) reveals a conserved cupin fold and active site

Crystal structure of a metal-dependent phosphoesterase (YP_910028.1) from Bifidobacterium adolescentis: Computational prediction and experimental validation of phosphoesterase activity

Crystal structure of a novel Sm-like protein of putative cyanophage origin at 2.60 Å resolution

Crystal structure of a putative quorum sensing-regulated protein (PA3611) from the Pseudomonas-specific DUF4146 family

Crystal structures of three representatives of a new Pfam family PF14869 (DUF4488) suggest they function in sugar binding/uptake

Drosophila melanogaster as a model system to study mitochondrial biology

Functional analysis of H. sapiens DNA polymerase gamma spacer mutation W748S with and without common variant E1143G.

Insights into Substrate Specificity of Geranylgeranyl Reductases Revealed by the Structure of Digeranylgeranylglycerophospholipid Reductase, an Essential Enzyme in the Biosynthesis of Archaeal Membrane Lipids

Insights into Substrate Specificity of NlpC/P60 Cell Wall Hydrolases Containing Bacterial SH3 Domains

Ischemic preconditioning regulates expression of microRNAs and a predicted target, MeCP2, in mouse cortex

Modular architecture of the hexameric human mitochondrial DNA helicase

Muscle-specific overexpression of the catalytic subunit of DNA polymerase γ induces pupal lethality in Drosophila melanogaster

Over-expression of the catalytic core of mitochondrial DNA (mtDNA) polymerase in the nervous system of Drosophila melanogaster reduces median life span by inducing mtDNA depletion

Physiological and biochemical defects in carboxyl-terminal mutants of mitochondrial DNA helicase

Proteomic analysis of native metabotropic glutamate receptor 5 protein complexes reveals novel molecular constituents

Structural analysis of arabinose-5-phosphate isomerase from Bacteroides fragilis and functional implications

Structural and Sequence Analysis of Imelysin-Like Proteins Implicated in Bacterial Iron Uptake

Structural and functional characterization of BaiA, an enzyme involved in secondary bile acid synthesis in human gut microbe ⬇️

Structural and functional characterizations of SsgB, a conserved activator of developmental cell division in morphologically complex actinomycetes

Structure and Function of the DUF2233 Domain in Bacteria and in the Human Mannose 6-Phosphate Uncovering Enzyme

Structure and Function of the First Full-Length Murein Peptide Ligase (Mpl) Cell Wall Recycling Protein

Structure and functional characterization of a bile acid 7α dehydratase BaiE in secondary bile acid synthesis

Structure of BT_3984, a member of the SusD/RagB family of nutrient-binding molecules

Structure of Bacteroides thetaiotaomicron BT2081 at 2.05 Å resolution: the first structural representative of a new protein family that may play a role in carbohydrate metabolism

Structure of a Novel Winged-Helix Like Domain from Human NFRKB Protein

Structure of a Virulence Regulatory Factor CvfB Reveals a Novel Winged Helix RNA Binding Module

Structure of a membrane-attack complex/perforin (MACPF) family protein from the human gut symbiont Bacteroides thetaiotaomicron

Structure of the γ- D -glutamyl- L -diamino acid endopeptidase YkfC from Bacillus cereus in complex with L -Ala-γ- D -Glu: insights into substrate recognition by NlpC/P60 cysteine peptidases

Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells

Structures of a Bifunctional Cell Wall Hydrolase CwlT Containing a Novel Bacterial Lysozyme and an NlpC/P60 dl-Endopeptidase

Structures of the first representatives of Pfam family PF06684 (DUF1185) reveal a novel variant of the Bacillus chorismate mutase fold and suggest a role in amino-acid metabolism

Structures of three members of Pfam PF02663 (FmdE) implicated in microbial methanogenesis reveal a conserved α+β core domain and an auxiliary C-terminal treble-clef zinc finger

The accessory subunit of DNA polymerase gamma is essential for mitochondrial DNA maintenance and development in Drosophila melanogaster

The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu

The structure of BVU2987 from Bacteroides vulgatus reveals a superfamily of bacterial periplasmic proteins with possible inhibitory function

The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae , reveals an OB-fold

The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation

UHM-ULM interactions in the RBM39-U2AF65 splicing-factor complex