Search filters

List of works by David E Paschon

A TALE nuclease architecture for efficient genome editing

scientific article

Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington's disease

scientific article published on 01 July 2019

An engineered zinc finger protein activator of the endogenous glial cell line-derived neurotrophic factor gene provides functional neuroprotection in a rat model of Parkinson's disease.

scientific article published on December 2010

Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma.

scientific article published on 5 May 2015

Construction of protein fragment complementation libraries using incremental truncation

scientific article published in January 2004

Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells

scientific article published on 2 March 2015

Diversifying the structure of zinc finger nucleases for high-precision genome editing

scientific article published on 08 March 2019

Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer

scientific article

Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases. ⬇️

scientific article

Enhanced catalytic efficiency of aminoglycoside phosphotransferase (3')-IIa achieved through protein fragmentation and reassembly

scientific article published in October 2005

Enhancing gene editing specificity by attenuating DNA cleavage kinetics

scientific article published on 29 July 2019

Functional footprinting of regulatory DNA.

scientific article published on 31 August 2015

Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome

scientific article

Gene Correction of iPSCs from a Wiskott-Aldrich Syndrome Patient Normalizes the Lymphoid Developmental and Functional Defects.

scientific article published on 06 July 2016

Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity.

scientific article

Humanized Mouse Model of HIV-1 Latency with Enrichment of Latent Virus in PD-1+ and TIGIT+ CD4 T Cells

scientific article published on 01 May 2019

Improved specificity of TALE-based genome editing using an expanded RVD repertoire

scientific article published on 23 March 2015

In vivo genome editing of the albumin locus as a platform for protein replacement therapy

scientific article

In vivo genome editing restores haemostasis in a mouse model of haemophilia

scientific article (publication date: 26 June 2011)

LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction

scientific article published on 19 October 2013

Mammalian interspecies substitution of immune modulatory alleles by genome editing

scientific article published on 22 February 2016

Non-viral Delivery of Zinc Finger Nuclease mRNA Enables Highly Efficient In Vivo Genome Editing of Multiple Therapeutic Gene Targets

scientific article published on 07 March 2019

Rapid and efficient clathrin-mediated endocytosis revealed in genome-edited mammalian cells ⬇️

scientific article published on February 6, 2011

Targeted correction and restored function of the CFTR gene in cystic fibrosis induced pluripotent stem cells.

scientific article

Targeted gene addition in human CD34(+) hematopoietic cells for correction of X-linked chronic granulomatous disease

scientific article published on 7 March 2016

Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells

scientific article

Paulina is supported by:

About Paulina

Help