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List of works by Ulf Bredberg

A new oral anticoagulant: the 50-year challenge

scientific article published in August 2004

Absorption, distribution, metabolism, and excretion of ximelagatran, an oral direct thrombin inhibitor, in rats, dogs, and humans

scientific article published in March 2003

Development of a high-throughput brain slice method for studying drug distribution in the central nervous system

scientific article

Early integration of pharmacokinetic and dynamic reasoning is essential for optimal development of lead compounds: strategic considerations

scientific article published on 20 January 2009

Hepatic disposition of ximelagatran and its metabolites in pig; prediction of the impact of membrane transporters through a simple disposition model.

scientific article published on 6 February 2010

Improved measurement of drug exposure in the brain using drug-specific correction for residual blood

scientific article published on 16 September 2009

In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids

scientific article published on 25 June 2007

Measurement of Unbound Drug Exposure in Brain: Modeling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods ⬇️

scientific article published on December 13, 2010

Metabolic stability for drug discovery and development: pharmacokinetic and biochemical challenges

scientific article

Methodologies to assess brain drug delivery in lead optimization

scientific article

Model-based drug discovery: implementation and impact.

scientific article published on 29 May 2013

Optimal experimental design for assessment of enzyme kinetics in a drug discovery screening environment.

scientific article published on 2 February 2011

Pharmacokinetics and pharmacodynamics of ximelagatran, a novel oral direct thrombin inhibitor, in young healthy male subjects ⬇️

scientific article published on March 27, 2003

Prediction of drug tissue to plasma concentration ratios using a measured volume of distribution in combination with lipophilicity

scientific article published on 01 June 2008

Regional intestinal absorption and biliary excretion of fluvastatin in the rat: possible involvement of mrp2.

scientific article published in September 2004

Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids

scientific article

The multiple depletion curves method provides accurate estimates of intrinsic clearance (CLint), maximum velocity of the metabolic reaction (Vmax), and Michaelis constant (Km): accuracy and robustness evaluated through experimental data and Monte Ca

scientific article

The pharmacokinetics and hepatic disposition of repaglinide in pigs: mechanistic modeling of metabolism and transport.

scientific article published on 6 March 2012

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