List of works - Markus Fridén

A novel in vivo receptor occupancy methodology for the glucocorticoid receptor: toward an improved understanding of lung pharmacokinetic/pharmacodynamic relationships.

scientific article published on 13 February 2015

Benchmarking of Human Dose Prediction for Inhaled Medicines from Preclinical In Vivo Data

scientific article

Building on the success of osimertinib: achieving CNS exposure in oncology drug discovery

scientific article published on 30 January 2019

C-peptide normalizes glomerular filtration rate in hyperfiltrating conscious diabetic rats.

scientific article published in January 2009

Computational modeling of lung deposition of inhaled particles in chronic obstructive pulmonary disease (COPD) patients: identification of gaps in knowledge and data

scientific article published on 01 February 2019

Current Progress Toward a Better Understanding of Drug Disposition Within the Lungs: Summary Proceedings of the First Workshop on Drug Transporters in the Lungs.

scientific article published on 14 April 2017

Development of a Novel Lung Slice Methodology for Profiling of Inhaled Compounds

scientific article published on 15 July 2015

Development of a high-throughput brain slice method for studying drug distribution in the central nervous system

scientific article

Drug-drug interactions of anti-infective drugs: utility of fluorescence cyp inhibition assays in drug discovery

scientific article published on 01 January 2006

Exploring in silico prediction of the unbound brain-to-plasma drug concentration ratio: model validation, renewal, and interpretation

scientific article published on 24 December 2014

Identification of positron emission tomography (PET) tracer candidates by prediction of the target-bound fraction in the brain

scientific article

Improved measurement of drug exposure in the brain using drug-specific correction for residual blood

scientific article published on 16 September 2009

In silico prediction of unbound brain-to-plasma concentration ratio using machine learning algorithms

scientific article

In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids

scientific article published on 25 June 2007

Lung Retention by Lysosomal Trapping of Inhaled Drugs Can Be Predicted In Vitro With Lung Slices

scientific article published on 23 September 2016

Measurement of Unbound Drug Exposure in Brain: Modeling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods ⬇️

scientific article published on December 13, 2010

Mechanisms of a sustained anti-inflammatory drug response in alveolar macrophages unraveled with mathematical modeling

scientific article published on 20 November 2020

Methodologies to assess brain drug delivery in lead optimization

scientific article

On the rate and extent of drug delivery to the brain.

scientific article published on 05 December 2007

Pharmacokinetic considerations of nanodelivery to the brain: Using modeling and simulations to predict the outcome of liposomal formulations

scientific article published on 5 July 2016

Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Accurately Predicts the Better Bronchodilatory Effect of Inhaled Versus Oral Salbutamol Dosage Forms

scientific article published on 07 June 2018

Pulmonary PET imaging confirms preferential lung target occupancy of an inhaled bronchodilator ⬇️

scientific article published on 29 January 2019

Revealing the Regional Localization and Differential Lung Retention of Inhaled Compounds by Mass Spectrometry Imaging

scientific article published on 31 July 2019

Simultaneous determination of renal plasma flow and glomerular filtration rate in conscious mice using dual bolus injection

scientific article published on 30 January 2013

Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids

scientific article

The brain slice method for studying drug distribution in the CNS

scientific article published on 21 January 2013

Translational model to predict pulmonary pharmacokinetics and efficacy in man for inhaled bronchodilators

scientific article

Uncovering the regional localization of inhaled salmeterol retention in the lung

scientific article published in November 2018

Understanding the Influence of Nanocarrier-Mediated Brain Delivery on Therapeutic Performance Through Pharmacokinetic-Pharmacodynamic Modeling

scientific article published on 01 June 2019

List of works by Markus Fridén

A novel in vivo receptor occupancy methodology for the glucocorticoid receptor: toward an improved understanding of lung pharmacokinetic/pharmacodynamic relationships.

Benchmarking of Human Dose Prediction for Inhaled Medicines from Preclinical In Vivo Data

Building on the success of osimertinib: achieving CNS exposure in oncology drug discovery

C-peptide normalizes glomerular filtration rate in hyperfiltrating conscious diabetic rats.

Computational modeling of lung deposition of inhaled particles in chronic obstructive pulmonary disease (COPD) patients: identification of gaps in knowledge and data

Current Progress Toward a Better Understanding of Drug Disposition Within the Lungs: Summary Proceedings of the First Workshop on Drug Transporters in the Lungs.

Development of a Novel Lung Slice Methodology for Profiling of Inhaled Compounds

Development of a high-throughput brain slice method for studying drug distribution in the central nervous system

Drug-drug interactions of anti-infective drugs: utility of fluorescence cyp inhibition assays in drug discovery

Exploring in silico prediction of the unbound brain-to-plasma drug concentration ratio: model validation, renewal, and interpretation

Identification of positron emission tomography (PET) tracer candidates by prediction of the target-bound fraction in the brain

Improved measurement of drug exposure in the brain using drug-specific correction for residual blood

In silico prediction of unbound brain-to-plasma concentration ratio using machine learning algorithms

In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids

Lung Retention by Lysosomal Trapping of Inhaled Drugs Can Be Predicted In Vitro With Lung Slices

Measurement of Unbound Drug Exposure in Brain: Modeling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods ⬇️

Mechanisms of a sustained anti-inflammatory drug response in alveolar macrophages unraveled with mathematical modeling

Methodologies to assess brain drug delivery in lead optimization

On the rate and extent of drug delivery to the brain.

Pharmacokinetic considerations of nanodelivery to the brain: Using modeling and simulations to predict the outcome of liposomal formulations

Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Accurately Predicts the Better Bronchodilatory Effect of Inhaled Versus Oral Salbutamol Dosage Forms

Pulmonary PET imaging confirms preferential lung target occupancy of an inhaled bronchodilator ⬇️

Revealing the Regional Localization and Differential Lung Retention of Inhaled Compounds by Mass Spectrometry Imaging

Simultaneous determination of renal plasma flow and glomerular filtration rate in conscious mice using dual bolus injection

Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids

The brain slice method for studying drug distribution in the CNS

Translational model to predict pulmonary pharmacokinetics and efficacy in man for inhaled bronchodilators

Uncovering the regional localization of inhaled salmeterol retention in the lung

Understanding the Influence of Nanocarrier-Mediated Brain Delivery on Therapeutic Performance Through Pharmacokinetic-Pharmacodynamic Modeling