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List of works by Emanuele Sher

5-I A-85380 and TC-2559 differentially activate heterologously expressed alpha4beta2 nicotinic receptors.

scientific article published on 5 April 2006

A novel muscarinic receptor-independent mechanism of KCNQ2/3 potassium channel blockade by Oxotremorine-M.

scientific article published on 30 August 2016

A series of α7 nicotinic acetylcholine receptor allosteric modulators with close chemical similarity but diverse pharmacological properties

scientific article published on 10 February 2012

Chaperone protein 14-3-3 and protein kinase A increase the relative abundance of low agonist sensitivity human alpha 4 beta 2 nicotinic acetylcholine receptors in Xenopus oocytes

scientific article published on 19 June 2006

Development of an Electrophysiological Assay for Kv7 Modulators on IonWorks Barracuda

scientific article published on 01 October 2019

Electrophysiological characterization of human and mouse sodium-dependent citrate transporters (NaCT/SLC13A5) reveal species differences with respect to substrate sensitivity and cation dependence

scientific article published on 31 August 2015

Evaluation of benzyltetrahydroisoquinolines as ligands for neuronal nicotinic acetylcholine receptors

scientific article

Expression and functional characterisation of a human chimeric nicotinic receptor with alpha6beta4 properties

scientific article published on April 2003

Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism.

scientific article published on 7 November 2016

GABA(B) receptor modulators potentiate baclofen-induced depression of dopamine neuron activity in the rat ventral tegmental area

scientific article published in April 2005

Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant M1 muscarinic acetylcholine receptor agonist

scientific article published on 16 November 2018

Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators.

scientific article published on 31 May 2006

Microtransplantation of human brain receptors into oocytes to tackle key questions in drug discovery

scientific article published on 03 November 2018

Modulation of TARP γ8-Containing AMPA Receptors as a Novel Therapeutic Approach for Chronic Pain

scientific article published on 25 March 2019

PSAB-OFP, a selective alpha 7 nicotinic receptor agonist, is also a potent agonist of the 5-HT3 receptor

scientific article published in October 2002

Pharmacological profiling of native group II metabotropic glutamate receptors in primary cortical neuronal cultures using a FLIPR ⬇️

scientific article published on May 30, 2012

Pharmacological properties of alpha 9 alpha 10 nicotinic acetylcholine receptors revealed by heterologous expression of subunit chimeras

scientific article published on February 2004

Proteomic analysis of postsynaptic proteins in regions of the human neocortex

scientific article published on 4 December 2017

Pungency of TRPV1 agonists is directly correlated with kinetics of receptor activation and lipophilicity

scientific article

Reconstitution of synaptic Ion channels from rodent and human brain in Xenopus oocytes: a biochemical and electrophysiological characterization

scientific article published on 24 May 2016

Sazetidine-A is a potent and selective agonist at native and recombinant alpha 4 beta 2 nicotinic acetylcholine receptors

scientific article

Species selectivity of a nicotinic acetylcholine receptor agonist is conferred by two adjacent extracellular beta4 amino acids that are implicated in the coupling of binding to channel gating

scientific article published on 25 October 2006

Stable expression and characterisation of a human alpha 7 nicotinic subunit chimera: a tool for functional high-throughput screening

scientific article

The nicotinic alpha 4 beta 2 receptor selective agonist, TC-2559, increases dopamine neuronal activity in the ventral tegmental area of rat midbrain slices

scientific article published in September 2003

The subtype-selective nicotinic acetylcholine receptor positive allosteric potentiator 2087101 differentially facilitates neurotransmission in the brain

scientific article published on 15 July 2010

Unique pharmacology of heteromeric α7β2 nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes.

scientific article published on March 2014

alpha4beta2 nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine

scientific article published on 23 May 2006

α7 and β2 Nicotinic Acetylcholine Receptor Subunits Form Heteromeric Receptor Complexes that Are Expressed in the Human Cortex and Display Distinct Pharmacological Properties

scientific article

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