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List of works by Takashi Someya

A Pilot Study of Thymosin .ALPHA.1 Therapy for Chronic Hepatitis B Patients ⬇️

scientific article published on October 1, 2003

A long-term glycyrrhizin injection therapy reduces hepatocellular carcinogenesis rate in patients with interferon-resistant active chronic hepatitis C: a cohort study of 1249 patients.

scientific article

Adefovir dipivoxil for treatment of breakthrough hepatitis caused by lamivudine-resistant mutants of hepatitis B virus.

scientific article published in November 2004

Adequate timing of ribavirin reduction in patients with hemolysis during combination therapy of interferon and ribavirin for chronic hepatitis C.

scientific article published in November 2004

Anticarcinogenic impact of interferon on patients with chronic hepatitis C: a large-scale long-term study in a single center

scientific article published in January 2006

Association of amino acid substitution pattern in core protein of hepatitis C virus genotype 1b high viral load and non-virological response to interferon-ribavirin combination therapy.

scientific article published in November 2005

Association of amino acid substitution pattern in nonstructural protein 5A of hepatitis C virus genotype2a low viral load and response to interferon monotherapy.

scientific article published in March 2003

Benefit of lamivudine therapy and factors associated with clinical outcome in spontaneous severe acute exacerbation of chronic hepatitis B virus infection

scientific article published in November 2004

Clinical and pathological characteristics of the autoimmune hepatitis and primary biliary cirrhosis overlap syndrome

scientific article published on 01 June 2004

Clinical and virological characteristics of untreated patients with chronic hepatitis C who develop serum alanine aminotransferase flare-up

scientific article published on February 2005

Clinical and virological features of non-breakthrough and severe exacerbation due to lamivudine-resistant hepatitis B virus mutants

scientific article

Clinical characteristics of patients infected with hepatitis B virus genotypes A, B, and C.

scientific article published in January 2002

Clinical features of hepatitis B virus genotype A in Japanese patients.

scientific article published on January 2003

Consistently low hepatitis B virus DNA saves patients from hepatocellular carcinogenesis in HBV-related cirrhosis. A nested case-control study using 96 untreated patients

scientific article published in January 2003

Cost-effectiveness of radiofrequency ablation and surgical therapy for small hepatocellular carcinoma of 3cm or less in diameter

scientific article published on 02 November 2005

Determinants of serum ALT normalization after phlebotomy in patients with chronic hepatitis C infection

scientific article published in September 2005

Dysplastic nodules frequently develop into hepatocellular carcinoma in patients with chronic viral hepatitis and cirrhosis

scientific article published on February 2006

Early viral kinetics and treatment outcome in combination of high-dose interferon induction vs. pegylated interferon plus ribavirin for naive patients infected with hepatitis C virus of genotype 1b and high viral load.

scientific article published on January 2005

Effect of acute self-limited hepatitis C virus (HCV) superinfection on hepatitis B virus (HBV)-related cirrhosis. Virological features of HBV-HCV dual infection

scientific article published on February 2004

Efficacy of 6-month interferon therapy in chronic hepatitis B virus infection in Japan.

scientific article published in October 2004

Efficacy of interferon monotherapy in young adult patients with chronic hepatitis C virus infection.

scientific article published in May 2006

Efficacy of interferon monotherapy to 394 consecutive naive cases infected with hepatitis C virus genotype 2a in Japan: therapy efficacy as consequence of tripartite interaction of viral, host and interferon treatment-related factors

scientific article published in December 2002

Efficacy of interferon retreatment after relapse for chronic hepatitis C patients with biochemical response after first interferon therapy

scientific article

Efficacy of interferon therapy in elderly patients with chronic hepatitis C.

scientific article published in January 2006

Efficacy of lamivudine therapy and factors associated with emergence of resistance in chronic hepatitis B virus infection in Japan.

scientific article published in January 2003

Efficacy of lamivudine treatment in Japanese patients with hepatitis B virus-related cirrhosis

scientific article published in November 2004

Efficacy of prolonged interferon therapy for patients with chronic hepatitis C with HCV-genotype 1b and high virus load

scientific article published in January 2003

Factors associated with the virological response of lamivudine-resistant hepatitis B virus during combination therapy with adefovir dipivoxil plus lamivudine.

scientific article

Factors contributing to ribavirin dose reduction due to anemia during interferon alfa2b and ribavirin combination therapy for chronic hepatitis C.

scientific article

Favorable efficacy of long-term lamivudine therapy in patients with chronic hepatitis B: an 8-year follow-up study.

scientific article published in April 2005

HBe antigen loss during lamivudine therapy is not caused by mutations in precore and core promoter genes in patients with chronic hepatitis B.

scientific article published in July 2003

Hepatitis B virus-related hepatocellular carcinogenesis and its prevention

scientific article published in January 2005

Hepatocellular carcinoma in noncirrhotic young adult patients with chronic hepatitis B viral infection

scientific article published on 01 June 2004

Hepatocyte steatosis is an important predictor of response to interferon (IFN) monotherapy in Japanese patients infected with HCV genotype 2a: Virological features of IFN-resistant cases with hepatocyte steatosis

scientific article published on April 2005

High-dose interferon alpha-2b induction therapy in combination with ribavirin for Japanese patients infected with hepatitis C virus genotype 1b with a high baseline viral load.

scientific article published on January 2004

Histological improvements after a three-year lamivudine therapy in patients with chronic hepatitis B in whom YMDD mutants did not or did develop

scientific article published in January 2003

Infection with hepatitis B virus genotype A in Tokyo, Japan during 1976 through 2001.

scientific article published in September 2004

Influence of hepatitis C virus subtype on hepatocellular carcinogenesis: a multivariate analysis of a retrospective cohort of 593 patients with cirrhosis

scientific article published in January 2002

Inhibitory effect of branched-chain amino acid granules on progression of compensated liver cirrhosis due to hepatitis C virus

scientific article published on 24 February 2008

Interferon for treatment of breakthrough infection with hepatitis B virus mutants developing during long-term lamivudine therapy

scientific article published in January 2002

Interferon lowers tumor recurrence rate after surgical resection or ablation of hepatocellular carcinoma: a pilot study of patients with hepatitis B virus-related cirrhosis.

scientific article published in December 2006

Interferon monotherapy for patients with chronic hepatitis C and normal serum aminotransferase levels at commencement of treatment.

scientific article published on August 2004

Interferon therapy for 2 years or longer reduces the incidence of hepatocarcinogenesis in patients with chronic hepatitis C viral infection.

scientific article published on November 2004

Interferon-alpha for reinfection with hepatitis C virus in two patients with chronic hepatitis C who had responded to previous therapies

scientific article published in August 2003

Lamivudine monotherapy for spontaneous severe acute exacerbation of chronic hepatitis B.

scientific article published in March 2005

Long-term clinical remission induced by corticosteroid withdrawal therapy (CSWT) in patients with chronic hepatitis B infection: a prospective randomized controlled trial--CSWT with and without follow-up interferon-alpha therapy

scientific article published in February 2002

Long-term follow-up of HBeAg-positive young adult Japanese patients treated with corticosteroid withdrawal therapy for chronic hepatitis B

scientific article published on 21 August 2006

Long-term follow-up of interferon monotherapy in 454 consecutive naive patients infected with hepatitis C virus: multi-course interferon therapy may reduce the risk of hepatocellular carcinoma and increase survival

scientific article

Long-term outcome after hepatitis B surface antigen seroclearance in patients with chronic hepatitis B.

scientific article published in January 2006

Long-term outcome after interferon therapy in elderly patients with chronic hepatitis C.

scientific article published in January 2007

Long-term outcome of HBV carriers with negative HBe antigen and normal aminotransferase.

scientific article published on November 2006

Long-term presence of HBV in the sera of chronic hepatitis B patients with HBsAg seroclearance.

scientific article published on 26 January 2007

Long-term prognosis by lamivudine monotherapy for severe acute exacerbation in chronic hepatitis B infection: emergence of YMDD motif mutant and risk of breakthrough hepatitis -- an open-cohort study

scientific article published on January 2003

Low rate of YMDD motif mutations in polymerase gene of hepatitis B virus in chronically infected patients not treated with lamivudine.

scientific article published in January 2004

Mutations of polymerase, precore and core promoter gene in hepatitis B virus during 5-year lamivudine therapy

scientific article

Natural history of compensated cirrhosis in the Child-Pugh class A compared between 490 patients with hepatitis C and 167 with B virus infections.

scientific article published in April 2006

Origin of neovascular structure in an early stage of hepatocellular carcinoma: study of alpha-smooth muscle actin immunohistochemistry in serial thin sections of surgically resected cancer

scientific article

Peripheral CD8+/CD25+ lymphocytes may be implicated in hepatocellular injuries in patients with acute-onset autoimmune hepatitis

scientific article published on 01 July 2004

Persistence of acute infection with hepatitis B virus genotype A and treatment in Japan

scientific article published on May 2005

Precore wild-type hepatitis B virus with G1896 in the resolution of persistent hepatitis B virus infection.

scientific article published in January 2003

Prediction model of hepatocarcinogenesis for patients with hepatitis C virus-related cirrhosis. Validation with internal and external cohorts

scientific article published on 13 March 2006

Predictive factors of virological non-response to interferon-ribavirin combination therapy for patients infected with hepatitis C virus of genotype 1b and high viral load.

scientific article published in January 2006

Randomized trial of prolonged interferon retreatment for chronic hepatitis C patients with HCV-genotype 1b and high virus load ⬇️

scientific article published on April 1, 2003

Randomized, controlled trial of natural interferon-alpha therapy for e-antigen-positive chronic hepatitis B patients

scientific article published in June 2002

Recurrence rate and prognosis of patients with hepatocellular carcinoma that developed after elimination of hepatitis C virus RNA by interferon therapy. A closed cohort study including matched control patients

scientific article published on January 2003

Serum levels of gamma-globulin and total bilirubin influence the prevalence of multiple extrahepatic complication in patients with hepatitis C virus infection

scientific article published in January 2003

Severe acute exacerbation of liver disease may reduce or delay emergence of YMDD motif mutants in long-term lamivudine therapy for hepatitis B e antigen-positive chronic hepatitis B.

scientific article published in May 2004

Significance of hepatitis B virus DNA clearance and early prediction of hepatocellular carcinogenesis in patients with cirrhosis undergoing interferon therapy: long-term follow up of a pilot study

scientific article published in January 2005

Significance of multicentric cancer recurrence after potentially curative ablation of hepatocellular carcinoma: a longterm cohort study of 892 patients with viral cirrhosis.

scientific article

Significance of serum ribavirin concentration in combination therapy of interferon and ribavirin for chronic hepatitis C.

scientific article published in March 2005

Stepwise hook extension technique for radiofrequency ablation therapy of hepatocellular carcinoma

scientific article published on 01 January 2002

Successful control of ruptured hepatocellular carcinoma with radiofrequency ablation.

scientific article

Sustained negativity for HCV-RNA over 24 or more months by long-term interferon therapy correlates with eradication of HCV in patients with hepatitis C virus genotype 1b and high viral load

scientific article published on January 2004

The influence of hepatitis B virus genotype on the development of lamivudine resistance during long-term treatment.

scientific article published on March 2003

Type C-chronic hepatitis patients who had autoimmune phenomenon and developed jaundice during interferon therapy

scientific article published in January 2003

Usefulness of serum KL-6 for early diagnosis of idiopathic pulmonary fibrosis in patients with hepatitis C virus.

scientific article published on October 2003

Usefulness of the serum KL-6 assay in patients with hepatitis C virus

scientific article

Viral genotypes and response to interferon in patients with acute prolonged hepatitis B virus infection of adulthood in Japan

scientific article published in December 2002

Virological and biochemical relapse according to YMDD motif mutant type during long‐term lamivudine monotherapy ⬇️

scientific article published on December 1, 2003

Virological and biochemical relapse after discontinuation of lamivudine monotherapy for chronic hepatitis B in Japan: comparison with breakthrough hepatitis during long-term treatment

scientific article published in March 2005

Virological differences between patients infected with subtypes Ba and Bj of hepatitis B virus genotype B.

scientific article published in April 2005

Virological outcomes in patients infected chronically with hepatitis B virus genotype A in comparison with genotypes B and C.

scientific article

YMDD mutants in patients with chronic hepatitis B before treatment are not selected by lamivudine

scientific article

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