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List of works by Nobuhiko Hiraga

A case of fulminant hepatic failure caused by hepatitis E virus

scientific article

A first case of hepatic angiosarcoma treated with recombinant interleukin-2.

scientific article published on December 2011

A novel TK-NOG based humanized mouse model for the study of HBV and HCV infections.

scientific article published on 16 October 2013

A translational study of resistance emergence using sequential direct-acting antiviral agents for hepatitis C using ultra-deep sequencing.

scientific article published on 30 July 2013

Absence of viral interference and different susceptibility to interferon between hepatitis B virus and hepatitis C virus in human hepatocyte chimeric mice.

scientific article published on 23 September 2009

Achievement of sustained viral response after switching treatment from pegylated interferon α-2b to α-2a and ribavirin in patients with recurrence of hepatitis C virus genotype 1 infection after liver transplantation: a case report.

scientific article published on 25 August 2011

Acute HBV infection in humanized chimeric mice has multiphasic viral kinetics

scientific article published on 23 March 2018

Adoptive immunotherapy with liver allograft–derived lymphocytes induces anti-HCV activity after liver transplantation in humans and humanized mice

scientific article

Amino acid substitutions in core and NS5A regions of the HCV genome can predict virological decrease with pegylated interferon plus ribavirin therapy

scientific article published in January 2010

Amphipathic DNA Polymers Inhibit Hepatitis C Virus Infection by Blocking Viral Entry

scientific article

Animal model for study of human hepatitis viruses

scientific article published on January 2011

Antiviral effects of anti-HBs immunoglobulin and vaccine on HBs antigen seroclearance for chronic hepatitis B infection

scientific article

Association between variants in the interferon lambda 4 locus and substitutions in the hepatitis C virus non-structural protein 5A.

scientific article published on 4 April 2015

CTL-associated and NK cell-associated immune responses induce different HBV DNA reduction patterns in chronic hepatitis B patients

article

Cell culture and in vivo analyses of cytopathic hepatitis C virus mutants

scientific article published on 6 July 2010

Circulating Tumor DNA Analysis for Liver Cancers and Its Usefulness as a Liquid Biopsy

scientific article published on 17 June 2015

Circulating microRNA-22 correlates with microRNA-122 and represents viral replication and liver injury in patients with chronic hepatitis B.

scientific article published in May 2013

Clinical and virological characteristics of untreated patients with chronic hepatitis C who develop serum alanine aminotransferase flare-up

scientific article published on February 2005

Combination therapies with NS5A, NS3 and NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice

scientific article published on 15 January 2013

Combination therapies with daclatasvir and asunaprevir on NS3-D168 mutated HCV in human hepatocyte chimeric mice.

scientific article

Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients.

scientific article published on 31 May 2010

Comparison of intracellular responses between HBV genotype A and C infection in human hepatocyte chimeric mice

scientific article published on 21 February 2019

Daclatasvir and asunaprevir treatment improves liver function parameters and reduces liver fibrosis markers in chronic hepatitis C patients

scientific article published on 17 November 2015

Development of a Novel Site-Specific Pegylated Interferon Beta for Antiviral Therapy of Chronic Hepatitis B Virus

scientific article published on 3 April 2017

Differences in serum microRNA profiles in hepatitis B and C virus infection.

scientific article published on 5 November 2014

Dual effect of APOBEC3G on Hepatitis B virus

scientific article published on February 2007

Effect of tenofovir disoproxil fumarate on drug-resistant HBV clones

scientific article published on 26 October 2015

Effects of ITPA polymorphism on decrease of hemoglobin during simeprevir, peg-interferon, and ribavirin combination treatment for chronic hepatitis C.

scientific article published on 25 February 2016

Effects of bisphosphonate zoledronic acid in hepatocellular carcinoma, depending on mevalonate pathway.

scientific article published on March 2015

Effects of hepatitis B virus infection on the interferon response in immunodeficient human hepatocyte chimeric mice

scientific article published in July 2011

Effects of structural variations of APOBEC3A and APOBEC3B genes in chronic hepatitis B virus infection

scientific article published on 25 September 2009

Efficacy and safety of the anticoagulant drug, danaparoid sodium, in the treatment of portal vein thrombosis in patients with liver cirrhosis

scientific article

Elimination of HCV via a non-ISG-mediated mechanism by vaniprevir and BMS-788329 combination therapy in human hepatocyte chimeric mice

scientific article published on 10 November 2015

Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice

scientific article

Emergence of a novel lamivudine-resistant hepatitis B virus variant with a substitution outside the YMDD motif.

scientific article published on 18 September 2006

Endoplasmic reticulum-mediated induction of interleukin-8 occurs by hepatitis B virus infection and contributes to suppression of interferon responsiveness in human hepatocytes

scientific article published on 18 September 2018

Eradication of hepatitis C virus genotype 1 after liver transplantation by interferon therapy before surgery: Report of three patients with analysis of interleukin-28 polymorphism, hepatitis C virus core region and interferon-sensitivity determining

scientific article published in November 2011

Establishment of an infectious genotype 1b hepatitis C virus clone in human hepatocyte chimeric mice

scientific article

G to A hypermutation of TT virus.

scientific article published on 6 February 2010

G-to-A hypermutation in hepatitis B virus (HBV) and clinical course of patients with chronic HBV infection

scientific article

HBx protein is indispensable for development of viraemia in human hepatocyte chimeric mice.

scientific article published on 10 March 2010

HLA-DQB1*03 confers susceptibility to chronic hepatitis C in Japanese: a genome-wide association study

scientific article

Hepatitis B virus-specific miRNAs and Argonaute2 play a role in the viral life cycle

scientific article

Hepatitis C virus infection suppresses the interferon response in the liver of the human hepatocyte chimeric mouse

scientific article

Human Cytotoxic T Lymphocyte-Mediated Acute Liver Failure and Rescue by Immunoglobulin in Human Hepatocyte Transplant TK-NOG Mice

scientific article

IL-28B predicts response to chronic hepatitis C therapy--fine-mapping and replication study in Asian populations.

scientific article published on 12 January 2011

IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones.

scientific article published on 25 August 2010

IL28 variation affects expression of interferon stimulated genes and peg-interferon and ribavirin therapy.

scientific article published on 4 February 2011

IL28B polymorphism is associated with fatty change in the liver of chronic hepatitis C patients.

scientific article

Identification of novel HCV deletion mutants in chronic hepatitis C patients

scientific article published on 25 July 2012

Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor

scientific article

Impact of viral amino acid substitutions and host interleukin-28b polymorphism on replication and susceptibility to interferon of hepatitis C virus

scientific article published on 2 August 2011

Importance of serum concentration of adefovir for Lamivudine-adefovir combination therapy in patients with lamivudine-resistant chronic hepatitis B.

scientific article

Improvement of renal dysfunction in a patient with hepatitis C virus-related liver cirrhosis by daclatasvir and asunaprevir combination therapy: A case report.

scientific article

In vivo adaptation of hepatitis C virus in chimpanzees for efficient virus production and evasion of apoptosis.

scientific article

Infection of human hepatocyte chimeric mouse with genetically engineered hepatitis B virus

scientific article published on November 2005

Infection of human hepatocyte chimeric mouse with genetically engineered hepatitis C virus and its susceptibility to interferon.

scientific article published on 20 April 2007

Interferon alpha treatment stimulates interferon gamma expression in type I NKT cells and enhances their antiviral effect against hepatitis C virus

scientific article

Interleukin-28B single nucleotide polymorphism of donors and recipients can predict viral response to pegylated interferon/ribavirin therapy in patients with recurrent hepatitis C after living donor liver transplantation

scientific article published on September 2012

Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state.

scientific article published in September 2011

Involvement of Porphyromonas gingivalis in the progression of non-alcoholic fatty liver disease.

scientific article

Limitations of daclatasvir/asunaprevir plus beclabuvir treatment in cases of NS5A inhibitor treatment failure

scientific article published on 19 June 2018

Lipoprotein Receptors Redundantly Participate in Entry of Hepatitis C Virus

scientific article

Long term persistence of NS5A inhibitor-resistant hepatitis C virus in patients who failed daclatasvir and asunaprevir therapy

scientific article

Long-term elimination of hepatitis C virus from human hepatocyte chimeric mice after interferon-γ gene transfer.

scientific article published on 28 December 2013

Long-term outcome of patients with gastric varices treated by balloon-occluded retrograde transvenous obliteration

scientific article published on 01 May 2014

ME3738 enhances the effect of interferon and inhibits hepatitis C virus replication both in vitro and in vivo.

scientific article published on 29 November 2010

Multicentric hepatocarcinogenesis at 6 and 13 years after sustained viral response to hepatitis C virus

scientific article

Non-invasive liver fibrosis score calculated by combination of virtual touch tissue quantification and serum liver functional tests in chronic hepatitis C patients

scientific article

Persistent Loss of Hepatitis B Virus Markers in Serum without Cellular Immunity by Combination of Peginterferon and Entecavir Therapy in Humanized Mice

scientific article published on 10 July 2017

Practical evaluation of a mouse with chimeric human liver model for hepatitis C virus infection using an NS3-4A protease inhibitor

scientific article published on 17 February 2010

Prediction of response to peginterferon-alfa-2b plus ribavirin therapy in Japanese patients infected with hepatitis C virus genotype 1b.

scientific article published in June 2011

Predictive value of the IFNL4 polymorphism on outcome of telaprevir, peginterferon, and ribavirin therapy for older patients with genotype 1b chronic hepatitis C.

scientific article published on 21 December 2013

Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b.

scientific article published on 19 September 2010

Prolongation of interferon therapy for recurrent hepatitis C after living donor liver transplantation: analysis of predictive factors of sustained virological response, including amino acid sequence of the core and NS5A regions of hepatitis C virus

scientific article published on 22 July 2010

Protease Inhibitor Resistance Remains Even After Mutant Strains Become Undetectable by Deep Sequencing

scientific article published on 20 September 2016

Rapid emergence of telaprevir resistant hepatitis C virus strain from wildtype clone in vivo

scientific article published on 2 August 2011

Rapid, Sensitive, and Accurate Evaluation of Drug Resistant Mutant (NS5A-Y93H) Strain Frequency in Genotype 1b HCV by Invader Assay

scientific article

Regular surveillance by imaging for early detection and better prognosis of hepatocellular carcinoma in patients infected with hepatitis C virus

scientific article published on 29 October 2009

Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection.

scientific article

Serum HBV RNA and HBeAg are useful markers for the safe discontinuation of nucleotide analogue treatments in chronic hepatitis B patients.

scientific article

Serum HBV RNA is a predictor of early emergence of the YMDD mutant in patients treated with lamivudine

scientific article published in May 2007

Severe necroinflammatory reaction caused by natural killer cell-mediated Fas/Fas ligand interaction and dendritic cells in human hepatocyte chimeric mouse.

scientific article published on 10 July 2012

Successful treatment of an entecavir-resistant hepatitis B virus variant

scientific article published in December 2007

Susceptibility of chimeric mice with livers repopulated by serially subcultured human hepatocytes to hepatitis B virus

scientific article published in February 2008

TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis

scientific article published on 4 May 2016

The first Japanese case of COACH syndrome

scientific article

The long-term outcome of patients with bleeding gastric varices after balloon-occluded retrograde transvenous obliteration

scientific article published on 24 August 2007

Thromboxane A2 synthase inhibitors prevent production of infectious hepatitis C virus in mice with humanized livers

scientific article published on 16 May 2013

Two patients treated with pegylated interferon/ribavirin/telaprevir triple therapy for recurrent hepatitis C after living donor liver transplantation.

scientific article published on 17 February 2014

Ultradeep sequencing study of chronic hepatitis C virus genotype 1 infection in patients treated with daclatasvir, peginterferon, and ribavirin.

scientific article

Usefulness of humanized cDNA-uPA/SCID mice for the study of hepatitis B virus and hepatitis C virus virology

scientific article published on 28 January 2017

Utility of controlled attenuation parameter measurement for assessing liver steatosis in Japanese patients with chronic liver diseases

scientific article published on 02 April 2013

[A case of clonorchiasis complicated with the expansion of liver cyst]

scientific article published on 01 March 2013

[HCV replication animal model]

scientific article published on 01 May 2011

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