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List of works by Bradley T Scroggins

An acetylation site in the middle domain of Hsp90 regulates chaperone function

scientific article published on January 2007

Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins

scientific article published on 5 April 2012

Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants

scientific article

Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90

scientific article

Differential inhibition of Hsc70 activities by two Hsc70-binding peptides

scientific article published in March 2002

Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine

scientific article

Emetine Promotes von Hippel-Lindau-Independent Degradation of Hypoxia-Inducible Factor-2α in Clear Cell Renal Carcinoma ⬇️

scientific article published on September 2, 2010

Englerin A stimulates PKCθ to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality

scientific article

Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.

scientific article published on 26 May 2009

Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness

scientific article

Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response

scientific article

High Affinity Binding of Hsp90 Is Triggered by Multiple Discrete Segments of Its Kinase Clients ⬇️

scientific article published on November 4, 2003

Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain

scientific article published on 18 October 2009

Hyperpolarized [1-13C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer In Vivo Predicts Efficacy of Targeting the Warburg Effect

scientific article published on 29 March 2018

IL-13 is a therapeutic target in radiation lung injury.

scientific article published on 22 December 2016

Just say NO: nitric oxide regulation of Hsp90.

scientific article published on 18 September 2009

MEK1/2 inhibition enhances the radiosensitivity of cancer cells by downregulating survival and growth signals mediated by EGFR ligands ⬇️

scientific article published on April 10, 2013

Mesenchymal stem cells inhibit cutaneous radiation-induced fibrosis by suppressing chronic inflammation

scientific article published in October 2013

Mithramycin A Enhances Tumor Sensitivity to Mitotic Catastrophe Resulting From DNA Damage

scientific article published on 12 October 2017

Post-translational modification of heat-shock protein 90: impact on chaperone function ⬇️

scientific article published on 01 October 2007

Posttranslational modification and conformational state of heat shock protein 90 differentially affect binding of chemically diverse small molecule inhibitors

scientific article

Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function

scientific article

Targeting loss of the Hippo signaling pathway in NF2-deficient papillary kidney cancers

scientific article published on 10 January 2018

Tonantzitlolone cytotoxicity toward renal cancer cells is PKCθ- and HSF1-dependent

scientific article published on 20 July 2015

Transforming growth factor alpha is a critical mediator of radiation lung injury

scientific article

Truncated Plasminogen Activator Inhibitor-1 Protein Protects From Pulmonary Fibrosis Mediated by Irradiation in a Murine Model

scientific article published on 14 December 2015

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