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List of works by Koji Okamoto

A roadmap toward total elimination of cancer

scientific article

ALDH-Dependent Glycolytic Activation Mediates Stemness and Paclitaxel Resistance in Patient-Derived Spheroid Models of Uterine Endometrial Cancer

scientific article published on 26 September 2019

ALDH1A1 in patient-derived bladder cancer spheroids activates retinoic acid signaling leading to TUBB3 overexpression and tumor progression

scientific article published on 24 June 2019

Cancer susceptibility polymorphism of p53 at codon 72 affects phosphorylation and degradation of p53 protein

scientific article

Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3) ⬇️

scientific article published on January 1, 1995

Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2.

scientific article

Differential expression of nanog1 and nanogp8 in colon cancer cells

scientific article published on 31 October 2011

Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage.

scientific article

Establishment and Characterization of an In Vitro Model of Ovarian Cancer Stem-like Cells with an Enhanced Proliferative Capacity.

scientific article published on 15 December 2015

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-like Cells using the Three-dimensional Co-culture System, NICO-1

scientific article published on 05 December 2020

Frequent inactivation of A20 in B-cell lymphomas

scientific article

Frequent inactivation of A20 through gene mutation in B-cell lymphomas

scientific article published on June 1, 2011

Functional role of Mdm2 phosphorylation by ATR in attenuation of p53 nuclear export

scientific article

Functional screening using a microRNA virus library and microarrays: a new high-throughput assay to identify tumor-suppressive microRNAs

scientific article

Genome engineering of mammalian haploid embryonic stem cells using the Cas9/RNA system

scientific article published on 23 December 2013

Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype

scientific article

HDAC4 Levels Control Sensibility toward Cisplatin in Gastric Cancer via the p53-p73/BIK Pathway

scientific article published on 07 November 2019

HIF1α inhibitor 2-methoxyestradiol decreases NRN1 expression and represses in vivo and in vitro growth of patient-derived testicular germ cell tumor spheroids

scientific article published on 13 June 2020

Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2

scientific article

Hormonal Regulation of Patient-Derived Endometrial Cancer Stem-like Cells Generated by Three-Dimensional Culture

scientific article published on 01 August 2019

Induction of the stem-like cell regulator CD44 by Rho kinase inhibition contributes to the maintenance of colon cancer-initiating cells

scientific article published on 20 September 2012

KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction

scientific article

MCM10 compensates for Myc-induced DNA replication stress in breast cancer stem-like cells

scientific article published on 19 December 2020

MKK7 mediates miR-493-dependent suppression of liver metastasis of colon cancer cells

scientific article

Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase

scientific article

MicroRNA Library-Based Functional Screening Identified Androgen-Sensitive miR-216a as a Player in Bicalutamide Resistance in Prostate Cancer

scientific article published on 21 October 2015

NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression

scientific article published on 01 July 2019

Proteasome 26S subunit PSMD1 regulates breast cancer cell growth through p53 protein degradation

scientific article

Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells

article published in the Proceedings of the National Academy of Sciences of the United States of America

Short hairpin RNA library-based functional screening identified ribosomal protein L31 that modulates prostate cancer cell growth via p53 pathway

scientific article

Single-cell DNA and RNA sequencing reveals the dynamics of intra-tumor heterogeneity in a colorectal cancer model

scientific article published on 21 September 2021

Slow-cycling cancer stem cells regulate progression and chemoresistance in colon cancer

scientific article published on 19 August 2020

Sox2-dependent inhibition of p21 is associated with poor prognosis of endometrial cancer.

scientific article published on 11 February 2017

Systematic exploration of cancer-associated microRNA through functional screening assays

scientific article published on 12 July 2011

The Induction of Selected Wnt Target Genes by Tcf1 Mediates Generation of Tumorigenic Colon Stem Cells

scientific article published in May 2017

Tumor suppressor miR-22 determines p53-dependent cellular fate through post-transcriptional regulation of p21.

scientific article published on 12 May 2011

Tumor-derived spheroids: Relevance to cancer stem cells and clinical applications

scientific article published on 08 January 2017

miR-493 induction during carcinogenesis blocks metastatic settlement of colon cancer cells in liver

scientific article

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