List of works - Andrea M Hounslow

1H, 15N and 13C backbone resonance assignments of the P146A variant of β-phosphoglucomutase from Lactococcus lactis in its substrate-free form

scientific article published on 08 August 2019

A Trojan horse transition state analogue generated by MgF3- formation in an enzyme active site.

scholarly article

A bacteriophage capsid protein provides a general amyloid interaction motif (GAIM) that binds and remodels misfolded protein assemblies.

scientific article

A combinatorial selective labeling method for the assignment of backbone amide NMR resonances

scientific article published on April 2004

A method for the reversible trapping of proteins in non-native conformations.

scientific article published in December 2008

Allomorphy as a mechanism of post-translational control of enzyme activity

scientific article published on 02 November 2020

Anionic charge is prioritized over geometry in aluminum and magnesium fluoride transition state analogs of phosphoryl transfer enzymes

scientific article published on 5 March 2008

Assignment of 1H, 13C, and 15N resonances for SF2 RNA recognition motif 2

scientific article published on 06 April 2007

Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by Formula rather than by phosphoranes

scientific article

Backbone assignment and secondary structure of the PLAT domain of human polycystin-1.

scientific article

Catalysis by Glomerella cingulata cutinase requires conformational cycling between the active and inactive states of its catalytic triad

scientific article

Charge-balanced metal fluoride complexes for protein kinase A with adenosine diphosphate and substrate peptide SP20.

scientific article

Cystatin forms a tetramer through structural rearrangement of domain-swapped dimers prior to amyloidogenesis

scientific article published in February 2004

Decoration of the enterococcal polysaccharide antigen EPA is essential for virulence, cell surface charge and interaction with effectors of the innate immune system

scientific article published on 02 May 2019

Detection of salt bridges to lysines in solution in barnase

scientific article published on 01 October 2013

Determinants of the endosomal localization of sorting nexin 1.

scientific article

Determination of the microscopic equilibrium dissociation constants for risedronate and its analogues reveals two distinct roles for the nitrogen atom in nitrogen-containing bisphosphonate drugs

scientific article published in July 2008

Effects of domain dissection on the folding and stability of the 43 kDa protein PGK probed by NMR.

scientific article

Evidence Supporting a cis-enediol-based Mechanism for Pyrococcus furiosus Phosphoglucose Isomerase

scientific article published on 24 March 2006

Exclusion of the native alpha-helix from the amyloid fibrils of a mixed alpha/beta protein.

scientific article published on 22 October 2007

Ferrous Iron Binding Key to Mms6 Magnetite Biomineralisation: A Mechanistic Study to Understand Magnetite Formation Using pH Titration and NMR Spectroscopy

scientific article published on 26 April 2016

Mapping local structural perturbations in the native state of stefin B (cystatin B) under amyloid forming conditions.

scientific article published on 12 October 2012

MgF(3)(-) and alpha-galactose 1-phosphate in the active site of beta-phosphoglucomutase form a transition state analogue of phosphoryl transfer

scientific article published in November 2009

Molecular Mechanism for the Hofmeister Effect Derived from NMR and DSC Measurements on Barnase

scientific article published on 25 October 2016

Molecular basis for bacterial peptidoglycan recognition by LysM domains

scientific article

Near attack conformers dominate -phosphoglucomutase complexes where geometry and charge distribution reflect those of substrate

scientific article

Obligate heterodimerization of the archaeal Alba2 protein with Alba1 provides a mechanism for control of DNA packaging

scientific article published in July 2005

Prioritization of charge over geometry in transition state analogues of a dual specificity protein kinase.

scientific article

Regional conformational flexibility couples substrate specificity and scissile phosphate diester selectivity in human flap endonuclease 1.

scientific article

Reprogramming of Escherichia coli K-12 metabolism during the initial phase of transition from an anaerobic to a micro-aerobic environment

scientific article

Solution structure of the helicase-interaction domain of the primase DnaG: a model for helicase activation.

scientific article

Structural and functional analysis of RNA and TAP binding to SF2/ASF

scientific article

Structural effects of the highly protective V127 polymorphism on human prion protein

scientific article published on 29 July 2020

Structural tightening and interdomain communication in the catalytic cycle of phosphoglycerate kinase.

scientific article

Structure and dynamics of coxsackievirus B4 2A proteinase, an enyzme involved in the etiology of heart disease

scientific article

Structure of a Wbl protein and implications for NO sensing by M. tuberculosis.

scientific article published on 22 December 2017

The Polycystin-1, Lipoxygenase, and α-Toxin Domain Regulates Polycystin-1 Trafficking.

scientific article published on 26 August 2015

The denatured state of N-PGK is compact and predominantly disordered

scientific article

The denatured state under native conditions: a non-native-like collapsed state of N-PGK.

scientific article published on 11 January 2006

Transition state analogue structures of human phosphoglycerate kinase establish the importance of charge balance in catalysis

scientific article

Two-site recognition of Staphylococcus aureus peptidoglycan by lysostaphin SH3b

scientific article published on 04 November 2019

When simple sequence comparison fails: the cryptic case of the shared domains of the bacterial replication initiation proteins DnaB and DnaD.

scientific article

List of works by Andrea M Hounslow

1H, 15N and 13C backbone resonance assignments of the P146A variant of β-phosphoglucomutase from Lactococcus lactis in its substrate-free form

A Trojan horse transition state analogue generated by MgF3- formation in an enzyme active site.

A bacteriophage capsid protein provides a general amyloid interaction motif (GAIM) that binds and remodels misfolded protein assemblies.

A combinatorial selective labeling method for the assignment of backbone amide NMR resonances

A method for the reversible trapping of proteins in non-native conformations.

Allomorphy as a mechanism of post-translational control of enzyme activity

Anionic charge is prioritized over geometry in aluminum and magnesium fluoride transition state analogs of phosphoryl transfer enzymes

Assignment of 1H, 13C, and 15N resonances for SF2 RNA recognition motif 2

Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by Formula rather than by phosphoranes

Backbone assignment and secondary structure of the PLAT domain of human polycystin-1.

Catalysis by Glomerella cingulata cutinase requires conformational cycling between the active and inactive states of its catalytic triad

Charge-balanced metal fluoride complexes for protein kinase A with adenosine diphosphate and substrate peptide SP20.

Cystatin forms a tetramer through structural rearrangement of domain-swapped dimers prior to amyloidogenesis

Decoration of the enterococcal polysaccharide antigen EPA is essential for virulence, cell surface charge and interaction with effectors of the innate immune system

Detection of salt bridges to lysines in solution in barnase

Determinants of the endosomal localization of sorting nexin 1.

Determination of the microscopic equilibrium dissociation constants for risedronate and its analogues reveals two distinct roles for the nitrogen atom in nitrogen-containing bisphosphonate drugs

Effects of domain dissection on the folding and stability of the 43 kDa protein PGK probed by NMR.

Evidence Supporting a cis-enediol-based Mechanism for Pyrococcus furiosus Phosphoglucose Isomerase

Exclusion of the native alpha-helix from the amyloid fibrils of a mixed alpha/beta protein.

Ferrous Iron Binding Key to Mms6 Magnetite Biomineralisation: A Mechanistic Study to Understand Magnetite Formation Using pH Titration and NMR Spectroscopy

Mapping local structural perturbations in the native state of stefin B (cystatin B) under amyloid forming conditions.

MgF(3)(-) and alpha-galactose 1-phosphate in the active site of beta-phosphoglucomutase form a transition state analogue of phosphoryl transfer

Molecular Mechanism for the Hofmeister Effect Derived from NMR and DSC Measurements on Barnase

Molecular basis for bacterial peptidoglycan recognition by LysM domains

Near attack conformers dominate -phosphoglucomutase complexes where geometry and charge distribution reflect those of substrate

Obligate heterodimerization of the archaeal Alba2 protein with Alba1 provides a mechanism for control of DNA packaging

Prioritization of charge over geometry in transition state analogues of a dual specificity protein kinase.

Regional conformational flexibility couples substrate specificity and scissile phosphate diester selectivity in human flap endonuclease 1.

Reprogramming of Escherichia coli K-12 metabolism during the initial phase of transition from an anaerobic to a micro-aerobic environment

Solution structure of the helicase-interaction domain of the primase DnaG: a model for helicase activation.

Structural and functional analysis of RNA and TAP binding to SF2/ASF

Structural effects of the highly protective V127 polymorphism on human prion protein

Structural tightening and interdomain communication in the catalytic cycle of phosphoglycerate kinase.

Structure and dynamics of coxsackievirus B4 2A proteinase, an enyzme involved in the etiology of heart disease

Structure of a Wbl protein and implications for NO sensing by M. tuberculosis.

The Polycystin-1, Lipoxygenase, and α-Toxin Domain Regulates Polycystin-1 Trafficking.

The denatured state of N-PGK is compact and predominantly disordered

The denatured state under native conditions: a non-native-like collapsed state of N-PGK.

Transition state analogue structures of human phosphoglycerate kinase establish the importance of charge balance in catalysis

Two-site recognition of Staphylococcus aureus peptidoglycan by lysostaphin SH3b

When simple sequence comparison fails: the cryptic case of the shared domains of the bacterial replication initiation proteins DnaB and DnaD.

Why the Energy Landscape of Barnase Is Hierarchical ⬇️

van der Waals Contact between Nucleophile and Transferring Phosphorus Is Insufficient To Achieve Enzyme Transition-State Architecture