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List of works by Suzy A A Comhair

A Network Medicine Approach to Investigation and Population-based Validation of Disease Manifestations and Drug Repurposing for COVID-19

scientific article published on 02 July 2020

A Novel p38 Mitogen-activated Protein Kinase/Elk-1 Transcription Factor-dependent Molecular Mechanism Underlying Abnormal Endothelial Cell Proliferation in Plexogenic Pulmonary Arterial Hypertension ⬇️

scientific article published on July 26, 2013

A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response

scientific article

A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19

scientific article published on 06 November 2020

A novel method for pulmonary research: assessment of bioenergetic function at the air-liquid interface

scientific article published on 16 January 2014

A novel p38 mitogen-activated protein kinase/Elk-1 transcription factor-dependent molecular mechanism underlying abnormal endothelial cell proliferation in plexogenic pulmonary arterial hypertension

scientific article published in Journal of Biological Chemistry

ALX receptor ligands define a biochemical endotype for severe asthma

scientific article

ALX receptor ligands define a biochemical endotype for severe asthma

scientific article published on 22 March 2018

Abnormalities in nitric oxide and its derivatives in lung cancer

scientific article published on 09 June 2005

Activation of Anoctamin-1 Limits Pulmonary Endothelial Cell Proliferation via p38-MAPK-dependent Apoptosis

scientific article

Airway smooth muscle cells synthesize hyaluronan cable structures independent of inter-alpha-inhibitor heavy chain attachment

scientific article published on 15 December 2008

Alterations of the arginine metabolome in asthma

scientific article

Altered MicroRNA processing in heritable pulmonary arterial hypertension: an important role for Smad-8

scientific article published on 15 September 2011

Altered expression and signal transduction of endothelin-1 receptors in heritable and idiopathic pulmonary arterial hypertension

scientific article

An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype

scientific article

An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension ⬇️

scientific article published on December 23, 2012

Antioxidant defense and oxidative damage vary widely among high-altitude residents

scientific article published on 20 July 2017

Antioxidant responses to oxidant-mediated lung diseases

scientific article

Arginine metabolic endotypes in pulmonary arterial hypertension.

scientific article published on March 2015

Arginine metabolic endotypes related to asthma severity.

scientific article

Asthma Is More Severe in Older Adults

scientific article

Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age.

scientific article published on 30 August 2017

Biochemical Reaction Products of Nitric Oxide as Quantitative Markers of Primary Pulmonary Hypertension ⬇️

scientific article published on 01 September 1998

Biomarker-based asthma phenotypes of corticosteroid response

scientific article

Bone Morphogenetic Protein Receptor II Is a Novel Mediator of Endothelial Nitric-oxide Synthase Activation ⬇️

scientific article published on September 23, 2011

Bone Morphogenic Protein Type 2 Receptor Mutation-Independent Mechanisms of Disrupted Bone Morphogenetic Protein Signaling in Idiopathic Pulmonary Arterial Hypertension.

scientific article

Carboxyhemoglobin and methemoglobin in asthma

scientific article published on 14 February 2015

Ceramide: a key signaling molecule in a Guinea pig model of allergic asthmatic response and airway inflammation

scientific article

Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension

scientific article

Co-Occurrence of Asthma and Nephrolithiasis in Children

scientific article

Coenzyme Q in asthma

scientific article published on June 2015

Coenzyme Q supplementation in pulmonary arterial hypertension

scientific article

Complement C3 Deficiency Attenuates Chronic Hypoxia-Induced Pulmonary Hypertension in Mice ⬇️

scientific article published on December 14, 2011

Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma

scientific article published on 05 May 2005

Cystic Fibrosis and Normal Human Airway Epithelial Cell Response to Influenza A Viral Infection

article

Defective Resensitization in Human Airway Smooth Muscle Cells Evokes β-Adrenergic Receptor Dysfunction in Severe Asthma

scientific article published on 29 May 2015

Deficiency of lung antioxidants in idiopathic pulmonary arterial hypertension

scientific article

Detrimental Effects of Environmental Tobacco Smoke in Relation to Asthma Severity ⬇️

scientific article published on May 4, 2011

Differential expression of manganese superoxide dismutase and catalase in lung cancer ⬇️

scientific article published on December 1, 2001

Differential induction of extracellular glutathione peroxidase and nitric oxide synthase 2 in airways of healthy individuals exposed to 100% O(2) or cigarette smoke

scientific article published on 01 September 2000

Distal vessel stiffening is an early and pivotal mechanobiological regulator of vascular remodeling and pulmonary hypertension

scientific article published on June 2016

Disulfide bond as a switch for copper-zinc superoxide dismutase activity in asthma

scientific article

Endothelial Phenotype Evoked by Low Dose Carvedilol in Pulmonary Hypertension

Endothelial chromosome 13 deletion in congenital heart disease-associated pulmonary arterial hypertension dysregulates SMAD9 signaling

scientific article published on April 2015

Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma

scientific article published on September 2016

Eosinophils are a major source of nitric oxide-derived oxidants in severe asthma: characterization of pathways available to eosinophils for generating reactive nitrogen species

scientific article published in May 2001

Eosinophils generate brominating oxidants in allergen-induced asthma

scientific article

Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma

scientific article published on 01 May 2019

Extracellular glutathione peroxidase induction in asthmatic lungs: evidence for redox regulation of expression in human airway epithelial cells

scientific article

Fasting 2-Deoxy-2-[18F]fluoro-d-glucose Positron Emission Tomography to Detect Metabolic Changes in Pulmonary Arterial Hypertension Hearts over 1 Year ⬇️

scientific article published on February 1, 2013

Fatty acid binding protein 4 regulates VEGF-induced airway angiogenesis and inflammation in a transgenic mouse model: implications for asthma

scientific article

Gene expression profile of human airway epithelium induced by hyperoxia in vivo

scientific article published on 11 May 2006

Genomic stability of pulmonary artery endothelial colony-forming cells in culture

scientific article

HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma

scientific article published on 13 January 2020

High Levels of Zinc-Protoporphyrin Identify Iron Metabolic Abnormalities in Pulmonary Arterial Hypertension ⬇️

scientific article published on August 1, 2011

High levels of hyaluronan in idiopathic pulmonary arterial hypertension

scientific article published on 05 September 2008

High mobility group box 1 contributes to the pathogenesis of experimental pulmonary hypertension via activation of Toll-like receptor 4

scientific article published on January 2012

Human Primary Lung Endothelial Cells in Culture ⬇️

scientific article published on March 15, 2012

Hyaluronan and Its Heavy Chain Modification in Asthma Severity and Experimental Asthma Exacerbation

scientific article

Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension

scientific article published on 25 May 2007

Hypoxia inducible-factor1alpha regulates the metabolic shift of pulmonary hypertensive endothelial cells

scientific article

Hypoxia-inducible factors in human pulmonary arterial hypertension: a link to the intrinsic myeloid abnormalities ⬇️

scientific article published on January 21, 2011

IL-27 targets Foxp3+ Tregs to mediate antiinflammatory functions during experimental allergic airway inflammation

scholarly article by Quang Tam Nguyen et al published 24 January 2019 in JCI insight

Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program

scientific article

Imatinib in pulmonary arterial hypertension: c-Kit inhibition

scientific article

Impact of Age and Sex on Outcomes and Hospital Cost of Acute Asthma in the United States, 2011-2012

scientific article published on 13 June 2016

Impaired Global Right Ventricular Longitudinal Strain Predicts Long-Term Adverse Outcomes in Patients with Pulmonary Arterial Hypertension

scientific article published on 26 June 2015

Impaired Innate Host Defense Causes Susceptibility to Respiratory Virus Infections in Cystic Fibrosis ⬇️

scientific article published on May 1, 2003

Increased Mutagen Sensitivity and DNA Damage in Pulmonary Arterial Hypertension

scientific article

Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension

scientific article published on 13 September 2004

Increased glutathione and glutathione peroxidase in lungs of individuals with chronic beryllium disease

scientific article published on 01 June 1999

Increased mitochondrial arginine metabolism supports bioenergetics in asthma

scientific article published on 23 May 2016

Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations

scientific article

Injury-Induced Shedding of Extracellular Vesicles Depletes Endothelial Cells of Cav-1 (Caveolin-1) and Enables TGF-β (Transforming Growth Factor-β)-Dependent Pulmonary Arterial Hypertension

scientific article published on 01 June 2019

Integrative proteomics and phosphoproteomics in pulmonary arterial hypertension

scientific article published on 09 December 2019

Interleukin-9 receptor expression in asthmatic airways In vivo

scientific article published in January 2000

Isolation and analysis of sugar nucleotides using solid phase extraction and fluorophore assisted carbohydrate electrophoresis

scientific article published on 14 March 2016

Mast Cell Number, Phenotype, and Function in Human Pulmonary Arterial Hypertension ⬇️

scientific article published on April 1, 2012

Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program

scientific article

Melanoma antigen A4 is expressed in non-small cell lung cancers and promotes apoptosis

scientific article (publication date: May 2006)

Metabolic endophenotype associated with right ventricular glucose uptake in pulmonary hypertension

scientific article published on 01 October 2021

Metabolomic Endotype of Asthma

scientific article published on 5 June 2015

MicroRNA-1 Is Decreased by Hypoxia and Contributes to the Development of Pulmonary Vascular Remodeling via Regulation of Sphingosine Kinase 1.

scientific article published on 22 November 2017

Mitochondrial Haplogroups and Risk of Pulmonary Arterial Hypertension

scientific article

Modification of hyaluronan by heavy chains of inter-α-inhibitor in idiopathic pulmonary arterial hypertension

scientific article published on 08 January 2014

Modulation of Endothelial Bone Morphogenetic Protein Receptor Type 2 Activity by Vascular Endothelial Growth Factor Receptor 3 in Pulmonary Arterial Hypertension

scientific article published on 29 March 2017

Molecular mechanisms of increased nitric oxide (NO) in asthma: evidence for transcriptional and post-translational regulation of NO synthesis

scientific article

NO chemical events in the human airway during the immediate and late antigen-induced asthmatic response

scientific article

Natural killer cell-mediated inflammation resolution is disabled in severe asthma.

scientific article published in March 2017

Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension

scientific article published on 15 February 2017

Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension

scientific article

Nitrotyrosine proteome survey in asthma identifies oxidative mechanism of catalase inactivation

scientific article published in May 2006

Noninvasive markers of airway inflammation in asthma

scientific article

O-GlcNAc Transferase Regulates Angiogenesis in Idiopathic Pulmonary Arterial Hypertension ⬇️

scientific article published on 13 December 2019

O-linked β-N-acetylglucosamine transferase directs cell proliferation in idiopathic pulmonary arterial hypertension.

scientific article

Oxidative and nitrosative events in asthma

scientific article

PVDOMICS: A Multi-Center Study to Improve Understanding of Pulmonary Vascular Disease Through Phenomics

scientific article published in October 2017

Pathological Hyaluronan Matrices in Cystic Fibrosis Airways and Secretions

scientific article published on 31 May 2016

Phosphorylation inactivation of endothelial nitric oxide synthesis in pulmonary arterial hypertension

scientific article published on 29 April 2016

Pivotal role of c-Fos in nitric oxide synthase 2 expression in airway epithelial cells

scientific article

Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts

scientific article

Protein disulfide isomerase-endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness

scientific article

Pulmonary Artery Endothelium Resident Endothelial Colony‐Forming Cells in Pulmonary Arterial Hypertension ⬇️

scientific article published on October 1, 2011

Pulmonary arterial hypertension treatment with carvedilol for heart failure: a randomized controlled trial

scientific article

Rapid loss of superoxide dismutase activity during antigen-induced asthmatic response

scientific article published on 01 February 2000

Redox control of asthma: molecular mechanisms and therapeutic opportunities

scientific article

Redox imaging of inflammation in asthma

scientific article published on March 2014

Reduction of antigen-induced respiratory abnormalities and airway inflammation in sensitized guinea pigs by a superoxide dismutase mimetic

scientific article published in August 2005

Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids

scientific article published on 7 March 2018

Reply: To PMID 25488689

scientific article published on 9 June 2015

Restoration of impaired endothelial myocyte enhancer factor 2 function rescues pulmonary arterial hypertension

scientific article

Role of hypoxia-induced transglutaminase 2 in pulmonary artery smooth muscle cell proliferation

scientific article published on 15 August 2014

STAT-1 and c-Fos interaction in nitric oxide synthase-2 gene activation

scientific article

Serotonylated fibronectin is elevated in pulmonary hypertension

scientific article

Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program

scientific article

Shot-noise limited Faraday rotation spectroscopy for detection of nitric oxide isotopes in breath, urine, and blood

scientific article

Signal transduction and oxidative processes in sinonasal polyposis

scientific article published in November 2007

Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma

scientific article published on 11 April 2016

Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension

scientific article

Superoxide dismutase inactivation in pathophysiology of asthmatic airway remodeling and reactivity

scientific article

The regulation and role of extracellular glutathione peroxidase

scientific article

The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with <i>in utero</i> SARS-CoV-2

scientific article published on 27 October 2021

The utility of biomarkers in diagnosis of aspirin exacerbated respiratory disease

scientific article published on 30 October 2018

Therapeutic Engagement of the Histone Deacetylase IIA-Myocyte Enhancer Factor 2 Axis Improves Experimental Pulmonary Hypertension

scientific article published on 01 November 2018

Urinary Bromotyrosine Measures Asthma Control and Predicts Asthma Exacerbations in Children ⬇️

scientific article published on March 10, 2011

Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma

scientific article

Viral Mimicry of Interleukin-17A by SARS-CoV-2 ORF8

scientific article

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