List of works - Hanyong Chen

244-MPT overcomes gefitinib resistance in non-small cell lung cancer cells

scientific article published on 26 October 2015

3,3'-Diindolylmethane inhibits patient-derived xenograft colon tumor growth by targeting COX1/2 and ERK1/2

scientific article published on 01 February 2019

3,6,2',4',5'-Pentahydroxyflavone, an orally bioavailable multiple protein kinase inhibitor, overcomes gefitinib resistance in non-small cell lung cancer

scientific article

6-C-(E-phenylethenyl)-naringenin suppresses colorectal cancer growth by inhibiting cyclooxygenase-1.

scientific article

A Novel Cinnamon-Related Natural Product with Pim-1 Inhibitory Activity Inhibits Leukemia and Skin Cancer

scientific article published on 6 May 2015

A Small Molecule Inhibitor of the β-Catenin-TCF4 Interaction Suppresses Colorectal Cancer Growth In Vitro and In Vivo.

scientific article published on 27 September 2017

ADA-07 Suppresses Solar Ultraviolet-Induced Skin Carcinogenesis by Directly Inhibiting TOPK.

scientific article

APIO-EE-9 is a novel Aurora A and B antagonist that suppresses esophageal cancer growth in a PDX mouse model

scientific article published on 16 June 2017

ARC is a critical protector against inflammatory bowel disease (IBD) and IBD-associated colorectal tumorigenesis

scientific article published on 19 August 2020

Aurora B kinase as a novel molecular target for inhibition the growth of osteosarcoma

scientific article published on 01 March 2019

Butein, a novel dual inhibitor of MET and EGFR, overcomes gefitinib-resistant lung cancer growth

scientific article

Caffeic acid directly targets ERK1/2 to attenuate solar UV-induced skin carcinogenesis.

scientific article

Carnosol suppresses patient-derived gastric tumor growth by targeting RSK2

ERK1 phosphorylates Nanog to regulate protein stability and stem cell self-renewal

scientific article published on 13 April 2014

Esculetin suppresses proliferation of human colon cancer cells by directly targeting β-catenin

scientific article

Ethyl gallate as a novel ERK1/2 inhibitor suppresses patient-derived esophageal tumor growth

scientific article published on 21 December 2018

Eupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling

scientific article

GSK3β-mediated expression of CUG-translated WT1 is critical for tumor progression

scientific article published on 12 November 2020

Gossypetin is a novel MKK3 and MKK6 inhibitor that suppresses esophageal cancer growth in vitro and in vivo

scientific article published on 02 November 2018

HI-511 overcomes melanoma drug resistance via targeting AURKB and BRAF V600E

scientific article published on 01 August 2020

Inhibition of LTA4H by bestatin in human and mouse colorectal cancer

scientific article published on 10 May 2019

Isoliquiritigenin induces apoptosis and inhibits xenograft tumor growth of human lung cancer cells by targeting both wild type and L858R/T790M mutant EGFR.

scientific article

JNK1 and 2 play a negative role in reprogramming to pluripotent stem cells by suppressing Klf4 activity

scientific article

Kaempferol targets RSK2 and MSK1 to suppress UV radiation-induced skin cancer

scientific article

Licochalcone A, a natural inhibitor of c-Jun N-terminal kinase 1.

scientific article published on 19 November 2013

PKCι is a target of 7,8,4'-trihydroxyisoflavone for the suppression of UVB-induced MMP-1 expression.

scientific article published on 28 April 2017

PPMP, a novel tubulin-depolymerizing agent against esophageal cancer in patient-derived tumor xenografts

scientific article published on 27 April 2016

Prediction of molecular targets of cancer preventing flavonoid compounds using computational methods

scientific article

Purpurogallin is a novel mitogen-activated protein kinase kinase 1/2 inhibitor that suppresses esophageal squamous cell carcinoma growth in vitro and in vivo

scientific article published on 17 May 2019

RSK2 is required for TRAF6 phosphorylation-mediated colon inflammation.

scientific article published on 22 March 2018

RSK2 phosphorylates T-bet to attenuate colon cancer metastasis and growth

scientific article published on 13 November 2017

Scutellarin Suppresses Patient-Derived Xenograft Tumor Growth by Directly Targeting AKT in Esophageal Squamous Cell Carcinoma

scientific article published on 25 September 2019

Select dietary phytochemicals function as inhibitors of COX-1 but not COX-2

scientific article

Src is a novel potential off-target of RXR agonists, 9-cis-UAB30 and Targretin, in human breast cancer cells

scientific article

TRAF1 Is Critical for Regulating the BRAF/MEK/ERK Pathway in Non-Small Cell Lung Carcinogenesis

scientific article published on 10 May 2018

Targeted therapy of the AKT kinase inhibits esophageal squamous cell carcinoma growth in vitro and in vivo

scientific article published on 03 April 2019

Targeting AKT with oridonin inhibits growth of esophageal squamous cell carcinoma in vitro and patient derived xenografts in vivo.

scientific article published on 25 April 2018

Taxifolin suppresses UV-induced skin carcinogenesis by targeting EGFR and PI3K.

scientific article

The Ashitaba (Angelica keiskei) Chalcones 4-hydroxyderricin and Xanthoangelol Suppress Melanomagenesis By Targeting BRAF and PI3K

scientific article published on 06 July 2018

The CUG-translated WT1, not AUG-WT1, is an oncogene

scientific article published on 10 October 2017

The Prolyl Isomerase Pin1 Is a Novel Target of 6,7,4'-Trihydroxyisoflavone for Suppressing Esophageal Cancer Growth

scientific article published on 21 March 2017

The daidzein metabolite, 6,7,4'-Trihydroxyisoflavone, is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1.

scientific article

List of works by Hanyong Chen

244-MPT overcomes gefitinib resistance in non-small cell lung cancer cells

3,3'-Diindolylmethane inhibits patient-derived xenograft colon tumor growth by targeting COX1/2 and ERK1/2

3,6,2',4',5'-Pentahydroxyflavone, an orally bioavailable multiple protein kinase inhibitor, overcomes gefitinib resistance in non-small cell lung cancer

6-C-(E-phenylethenyl)-naringenin suppresses colorectal cancer growth by inhibiting cyclooxygenase-1.

A Novel Cinnamon-Related Natural Product with Pim-1 Inhibitory Activity Inhibits Leukemia and Skin Cancer

A Small Molecule Inhibitor of the β-Catenin-TCF4 Interaction Suppresses Colorectal Cancer Growth In Vitro and In Vivo.

ADA-07 Suppresses Solar Ultraviolet-Induced Skin Carcinogenesis by Directly Inhibiting TOPK.

APIO-EE-9 is a novel Aurora A and B antagonist that suppresses esophageal cancer growth in a PDX mouse model

ARC is a critical protector against inflammatory bowel disease (IBD) and IBD-associated colorectal tumorigenesis

Aurora B kinase as a novel molecular target for inhibition the growth of osteosarcoma

Butein, a novel dual inhibitor of MET and EGFR, overcomes gefitinib-resistant lung cancer growth

Caffeic acid directly targets ERK1/2 to attenuate solar UV-induced skin carcinogenesis.

Carnosol suppresses patient-derived gastric tumor growth by targeting RSK2

ERK1 phosphorylates Nanog to regulate protein stability and stem cell self-renewal

Esculetin suppresses proliferation of human colon cancer cells by directly targeting β-catenin

Ethyl gallate as a novel ERK1/2 inhibitor suppresses patient-derived esophageal tumor growth

Eupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling

GSK3β-mediated expression of CUG-translated WT1 is critical for tumor progression

Gossypetin is a novel MKK3 and MKK6 inhibitor that suppresses esophageal cancer growth in vitro and in vivo

HI-511 overcomes melanoma drug resistance via targeting AURKB and BRAF V600E

Inhibition of LTA4H by bestatin in human and mouse colorectal cancer

Isoliquiritigenin induces apoptosis and inhibits xenograft tumor growth of human lung cancer cells by targeting both wild type and L858R/T790M mutant EGFR.

JNK1 and 2 play a negative role in reprogramming to pluripotent stem cells by suppressing Klf4 activity

Kaempferol targets RSK2 and MSK1 to suppress UV radiation-induced skin cancer

Licochalcone A, a natural inhibitor of c-Jun N-terminal kinase 1.

PKCι is a target of 7,8,4'-trihydroxyisoflavone for the suppression of UVB-induced MMP-1 expression.

PPMP, a novel tubulin-depolymerizing agent against esophageal cancer in patient-derived tumor xenografts

Prediction of molecular targets of cancer preventing flavonoid compounds using computational methods

Purpurogallin is a novel mitogen-activated protein kinase kinase 1/2 inhibitor that suppresses esophageal squamous cell carcinoma growth in vitro and in vivo

RSK2 is required for TRAF6 phosphorylation-mediated colon inflammation.

RSK2 phosphorylates T-bet to attenuate colon cancer metastasis and growth

Scutellarin Suppresses Patient-Derived Xenograft Tumor Growth by Directly Targeting AKT in Esophageal Squamous Cell Carcinoma

Select dietary phytochemicals function as inhibitors of COX-1 but not COX-2

Src is a novel potential off-target of RXR agonists, 9-cis-UAB30 and Targretin, in human breast cancer cells

TRAF1 Is Critical for Regulating the BRAF/MEK/ERK Pathway in Non-Small Cell Lung Carcinogenesis

Targeted therapy of the AKT kinase inhibits esophageal squamous cell carcinoma growth in vitro and in vivo

Targeting AKT with oridonin inhibits growth of esophageal squamous cell carcinoma in vitro and patient derived xenografts in vivo.

Taxifolin suppresses UV-induced skin carcinogenesis by targeting EGFR and PI3K.

The Ashitaba (Angelica keiskei) Chalcones 4-hydroxyderricin and Xanthoangelol Suppress Melanomagenesis By Targeting BRAF and PI3K

The CUG-translated WT1, not AUG-WT1, is an oncogene

The Prolyl Isomerase Pin1 Is a Novel Target of 6,7,4'-Trihydroxyisoflavone for Suppressing Esophageal Cancer Growth

The daidzein metabolite, 6,7,4'-Trihydroxyisoflavone, is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1.