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List of works by J Gregory Cairncross

A PHASE III RANDOMIZED CONTROLLED TRIAL OF SHORT-COURSE RADIOTHERAPY WITH OR WITHOUT CONCOMITANT AND ADJUVANT TEMOZOLOMIDE IN ELDERLY PATIENTS WITH GLIOBLASTOMA (NCIC CTG CE.6, EORTC 26062-22061, TROG 08.02, NCT00482677).

scientific article published in July 2014

A better way to find tumor in the CSF?

scientific article published on 01 February 2002

A multigene predictor of outcome in glioblastoma.

scientific article

A novel C19MC amplified cell line links Lin28/let-7 to mTOR signaling in embryonal tumor with multilayered rosettes

scientific article published on 4 December 2013

A phase I trial of intratumoral administration of reovirus in patients with histologically confirmed recurrent malignant gliomas

scientific article

A phase II study of carboplatin and chronic high-dose tamoxifen in patients with recurrent malignant glioma

scientific article published on 19 May 2006

A phase II study of intensified chemotherapy alone as initial treatment for newly diagnosed anaplastic oligodendroglioma: an interim analysis

scientific article

A phase II study of topotecan in patients with anaplastic oligodendroglioma or anaplastic mixed oligoastrocytoma ⬇️

scientific article published on November 1, 2003

A phase III randomized prospective trial of external beam radiotherapy, mitomycin C, carmustine, and 6-mercaptopurine for the treatment of adults with anaplastic glioma of the brain. CNS Cancer Consortium

scientific article

A prospective study of short-course radiotherapy in poor prognosis glioblastoma multiforme.

scientific article

ABT-888 restores sensitivity in temozolomide resistant glioma cells and xenografts

scientific article published in PLoS ONE

ATCT-12RESULTS OF NRG ONCOLOGY/RTOG 9813- A PHASE III RANDOMIZED STUDY OF RADIATION THERAPY (RT) AND TEMOZOLOMIDE (TMZ) VERSUS RT AND NITROSOUREA (NU) THERAPY FOR ANAPLASTIC ASTROCYTOMA (AA).

scientific article published on 9 November 2015

ATCT-16CODEL (ALLIANCE-N0577; EORTC-26081/2208; NRG-1071; NCIC-CEC-2): PHASE III RANDOMIZED STUDY OF RT VS. RT + TMZ VS. TMZ FOR NEWLY DIAGNOSED 1p/19q-CODELETED ANAPLASTIC GLIOMA. ANALYSIS OF PATIENTS TREATED ON THE ORIGINAL PROTOCOL DESIGN.

scientific article

ATPS-50REVISITING CARBOPLATIN AS A THERAPY FOR GLIOBLASTOMA (GBM).

scientific article

ATPS-97TEMOZOLOMIDE RESISTANT GLIOBLASTOMA (GBM) CELLS AND XENOGRAFTS ARE ESPECIALLY SENSITIVE TO PARP-INHIBITION.

scientific article

Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: a prospective randomized clinical trial

scientific article published on 29 March 2004

Absence of hereditary mutations in exons 5 through 9 of the p53 gene and exon 24 of the neurofibromin gene in families with glioma

article

Adjuvant chemotherapy for adults with malignant glioma: a systematic review

scientific article

Adult supratentorial low-grade glioma: long-term experience at a single institution

scientific article published on 22 April 2009

Aggressive oligodendroglioma: a chemosensitive tumor

scientific article

Allelic loss of chromosome 1p and radiotherapy plus chemotherapy in patients with oligodendrogliomas.

scientific article published on October 2000

An analysis of image texture, tumor location, and MGMT promoter methylation in glioblastoma using magnetic resonance imaging

scientific article published on 28 September 2009

An in vivo patient-derived model of endogenous IDH1-mutant glioma

scientific article

Analysis of a molecular genetic neuro-oncology study with partially biased selection

scientific article published in April 2003

Anaplastic oligodendroglial tumors: refining the correlation among histopathology, 1p 19q deletion and clinical outcome in Intergroup Radiation Therapy Oncology Group Trial 9402.

scientific article

Announcing cIMPACT-NOW: the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy

scientific article

Astrocytoma following scalp radiotherapy in infancy

scientific article published in November 1984

BENEFICIAL OUTCOMES AFTER PCV PLUS RT IN OLIGODENDROGLIAL TUMORS ARE ASSOCIATED WITH DETECTION OR RISK OF AN IDH MUTATION.

scientific article published in July 2014

Benefit from procarbazine, lomustine, and vincristine in oligodendroglial tumors is associated with mutation of IDH.

scientific article published on 10 February 2014

Bihemispheric malignant glioma: one size does not fit all.

scientific article

CBIO-42DOWN REGULATION OF PYRUVATE DEHYDROGENASE ACTIVITY IS ESSENTIAL FOR CELL PROLIFERATION IN IDH1 MUTANT GLIOMA CELLS.

scientific article

CODEL: Phase III study of RT, RT + Temozolomide (TMZ), or TMZ for newly-diagnosed 1p/19q Codeleted Oligodendroglioma. Analysis from the initial study design

scientific article published on 17 July 2020

CS-04STAT3 INVOLVEMENT IN AN EMT-LIKE PROCESS IN GLIOBLASTOMA BRAIN TUMOR INITIATING CELLS.

scientific article published in November 2014

Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factors

scientific article published on 01 May 2019

Challenges in the design and conduct of phase III brain tumor therapy trials.

scientific article

Changing paradigms--an update on the multidisciplinary management of malignant glioma

scientific article

Chemosensitive gliomas in adults: which ones and why? ⬇️

scientific article published on December 1, 1997

Chemotherapy for oligodendroglioma. Progress report

scientific article published in February 1991

Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant IDH1.

scientific article published on 15 September 2017

Cognition and quality of life after chemotherapy plus radiotherapy (RT) vs. RT for pure and mixed anaplastic oligodendrogliomas: radiation therapy oncology group trial 9402.

scientific article

Cognitive functioning in long-term survivors of high-grade glioma

scientific article published on February 1994

Comparison of metastatic properties of a variety of mouse, rat, and human cells in assays in nude mice and chick embryos

scientific article published on July 1990

Comprehensive genomic profiling of glioblastoma tumors, BTICs, and xenografts reveals stability and adaptation to growth environments

scientific article published on 30 August 2019

Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers

scientific article

Corticosteroid-induced magnetic resonance imaging changes in patients with recurrent malignant glioma

scientific article published in September 1994

Current treatment of oligodendrogliomas

scientific article

DMBT1 polymorphisms: relationship to malignant glioma tumorigenesis.

scientific article

DNA hypermethylation and 1p Loss silence NHE‐1 in oligodendroglioma ⬇️

scientific article published on June 1, 2012

DRES-04. CHARACTERIZATION OF A MODEL OF TEMOZOLOMIDE RESISTANCE IN GLIOBLASTOMA

scientific article published on 5 November 2018

DRES-06. PREVENTING THE EMERGENCE OF TEMOZOLOMIDE RESISTANCE IN GLIOBLASTOMA BY PARP-1 INHIBITION

scientific article published on 5 November 2018

Development of a peptide-based delivery platform for targeting malignant brain tumors

scientific article published on 07 May 2020

Differential expression of drug resistance genes and chemosensitivity in glial cell lineages correlate with differential response of oligodendrogliomas and astrocytomas to chemotherapy

scientific article published in September 2000

Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma

scientific article published on 22 March 2016

Do epileptic seizures predict outcome in patients with oligodendroglioma? ⬇️

scientific article published on February 18, 2011

Drug Insight: temozolomide as a treatment for malignant glioma--impact of a recent trial

scientific article published on December 2005

Dual mTORC1/2 blockade inhibits glioblastoma brain tumor initiating cells in vitro and in vivo and synergizes with temozolomide to increase orthotopic xenograft survival

scientific article published on 14 October 2014

EXPERIMENTAL THERAPEUTICS AND PHARMACOLOGY

article

Effect of aberrant p53 function on temozolomide sensitivity of glioma cell lines and brain tumor initiating cells from glioblastoma

scientific article

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

scientific article (publication date: May 2009)

Focus on central nervous system neoplasia

scientific article

GENO-10LOSS OF IDH MUTATION IN PATIENT-DERIVED BRAIN TUMOR INITIATING CELLS.

scientific article

GLIOMA SPECIFIC PEPTIDES: A PLATFORM FOR MOLECULAR IMAGING AND THERAPEUTIC TARGETING.

scientific article published in July 2014

Gene expression-based classification of malignant gliomas correlates better with survival than histological classification.

scientific article published in April 2003

Genetic background influences timing, morphology and dissemination of lymphomas in p53-deficient mice ⬇️

scientific article published on November 1, 1998

Genetic landscape of extreme responders with anaplastic oligodendroglioma

scientific article

Glioblastoma in the elderly: an age-old problem

scientific article

Glioma classification: a molecular reappraisal

scientific article

Glioma therapies: how to tell which work?

scientific article published on 11 August 2003

Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression

scientific article published on 05 October 2020

Gliomas in families

scientific article published on November 1, 1992

Gliomas in families: Chromosomal analysis by comparative genomic hybridization ⬇️

scientific article published on January 1, 1998

Gliomas with 1p/19q codeletion: a.k.a. oligodendroglioma

scientific article

High-dose chemotherapy with stem cell rescue as initial therapy for anaplastic oligodendroglioma.

scientific article published in November 2003

High-dose chemotherapy with stem cell rescue as initial therapy for anaplastic oligodendroglioma: long-term follow-up.

scientific article published on 8 March 2006

Histopathological-molecular genetic correlations in referral pathologist-diagnosed low-grade "oligodendroglioma".

scientific article

Homozygous deletions of the CDKN2C/p18INK4C gene on the short arm of chromosome 1 in anaplastic oligodendrogliomas

scientific article published in October 1999

Hyperpolarized (13)C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring.

scientific article published on 23 June 2016

IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism.

scientific article published on 4 June 2015

Imaging correlates of molecular signatures in oligodendrogliomas

scientific article published in July 2004

Importance of dose intensity in neuro-oncology clinical trials: summary report of the Sixth Annual Meeting of the Blood-Brain Barrier Disruption Consortium

scientific article

In Vitro Modeling of GBM Initiation using PDGF-AA and P53-Null Neural Progenitors

scientific article published on 16 April 2020

Inactivation of p53 sensitizes U87MG glioma cells to 1,3-bis(2-chloroethyl)-1-nitrosourea

scientific article published in May 2001

Influence of the type of surgery on the histologic diagnosis in patients with anaplastic gliomas

scientific article published in November 1991

Influence of unrecognized molecular heterogeneity on randomized clinical trials

scientific article

Initial treatment patterns over time for anaplastic oligodendroglial tumors ⬇️

scientific article published on May 31, 2012

Interferon beta for malignant glioma ⬇️

scientific article published on April 1, 1992

International retrospective study of over 1000 adults with anaplastic oligodendroglial tumors

scientific article

Invited article: the expanding impact of molecular biology on the diagnosis and treatment of gliomas

scientific article published on July 2008

Ki-67: a prognostic factor for low-grade glioma?

scientific article published in March 2002

LAB-TUMOR MODELS (IN VIVO/IN VITRO)

Lactate dehydrogenase A silencing in IDH mutant gliomas

scientific article published on 22 December 2013

Leptomeningeal disease from oligodendroglioma: clinical and molecular analysis.

scientific article published on May 2008

Leptomeningeal disease in oligodendroglial tumors: a population-based study ⬇️

scientific article published on March 4, 2011

Long survival and therapeutic responses in patients with histologically disparate high-grade gliomas demonstrating chromosome 1p loss

scientific article published in June 2000

Long-term Glioblastoma Multiforme Survivors: a Population-based Study ⬇️

scientific article published on August 1, 1998

Long-term survivors of glioblastoma: statistical aberration or important unrecognized molecular subtype?

scientific article

Loss of heterozygosity analysis of chromosomes 9, 10 and 17 in gliomas in families.

scientific article published on February 1995

Low-grade glioma. To treat or not to treat?

scientific article published in November 1989

Low-grade gliomas in children: tumor volume response to radiation

scientific article

Low-grade gliomas in children: tumor volume response to radiation

scientific article published on 01 June 1998

MEDICAL AND NEURO-ONCOLOGY

scientific article published on 21 October 2011

MGMT gene silencing and benefit from temozolomide in glioblastoma

scientific article

Malignant glioma--timing of response to radiation therapy

scientific article

Malignant glioma: who benefits from adjuvant chemotherapy?

scientific article published on 01 October 1998

Malignant properties of P635 glioma are independent of glial fibrillary acidic protein expression

scientific article published on August 1991

Measuring Bias in Uncontrolled Brain Tumor Trials – to Randomize or Not to Randomize? ⬇️

scientific article published on November 1, 1997

Metabolic Pathways

scholarly article published in 2013

Metastatic anaplastic oligodendroglioma

scientific article published on December 1989

Methylation status of MGMT gene promoter in meningiomas

scientific article

Molecular background of oligodendroglioma: 1p/19q, IDH, TERT, CIC and FUBP1.

scientific article

Molecular subtypes of anaplastic oligodendroglioma: implications for patient management at diagnosis.

scientific article

Multicenter Phase II Study of Temozolomide and Myeloablative Chemotherapy with Autologous Stem Cell Transplant for Newly Diagnosed Anaplastic Oligodendroglioma

scientific article published on 2 May 2017

Multidisciplinary management of adult anaplastic oligodendrogliomas and anaplastic mixed oligo-astrocytomas

scientific article

Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner.

scientific article published on 3 April 2018

Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity

scientific article

NEURO/MEDICAL ONCOLOGY

Neoadjuvant procarbazine, CCNU, and vincristine for anaplastic and aggressive oligodendroglioma

scientific article

Nomograms for predicting survival of patients with newly diagnosed glioblastoma: prognostic factor analysis of EORTC and NCIC trial 26981-22981/CE.3.

scientific article published on 21 December 2007

Novel MSH6 mutations in treatment-naïve glioblastoma and anaplastic oligodendroglioma contribute to temozolomide resistance independently of MGMT promoter methylation

scientific article published on 30 July 2014

O 6 -Methylguanine-DNA methyltransferase activity, p53 gene status and BCNU resistance in mouse astrocytes

article

O6-Methylguanine-DNA Methyltransferase in Tumors and Cells of the Oligodendrocyte Lineage ⬇️

scientific article published on May 1, 1995

O6-methylguanine-DNA methyltransferase regulation by p53 in astrocytic cells

scientific article published on January 2007

Oligodendroglioma cell lines containing t(1;19)(q10;p10).

scientific article published on 13 April 2010

Oligodendroglioma: a new chemosensitive tumor

scientific article published in December 1990

On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells ⬇️

scientific article published on December 21, 2012

PARP inhibition suppresses the emergence of temozolomide resistance in a model system

scientific article published on 19 June 2020

PCV for oligodendroglial tumors: in search of prognostic factors for response and survival

scientific article

PTEN is a target of chromosome 10q loss in anaplastic oligodendrogliomas and PTEN alterations are associated with poor prognosis

scientific article published on July 2001

Phase I study pilot arms of radiotherapy and carmustine with temozolomide for anaplastic astrocytoma (Radiation Therapy Oncology Group 9813): implications for studies testing initial treatment of brain tumors

scientific article published in July 2004

Phase II diaziquone-based chemotherapy trials in patients with anaplastic supratentorial astrocytic neoplasms

scientific article published in March 1987

Phase II study of tiazofurin in gliomas in adults. A National Cancer Institute of Canada study

scientific article published in February 1993

Phase II study of trimetrexate in recurrent anaplastic glioma. National Cancer Institute of Canada Clinical Trials Group Study.

scientific article published in February 1990

Phase II trial of SarCNU in malignant glioma: unexpected pulmonary toxicity with a novel nitrosourea: a phase II trial of the national cancer institute of canada clinical trials group

scientific article published in December 2005

Phase III randomized study of radiation and temozolomide versus radiation and nitrosourea therapy for anaplastic astrocytoma: results of NRG Oncology RTOG 9813.

scientific article

Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: long-term results of RTOG 9402.

scientific article

Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402.

scientific article published in June 2006

Population-based study of medulloblastoma: outcomes in Alberta from 1975 to 1996.

scientific article published on May 2008

Population-based study of pseudoprogression after chemoradiotherapy in GBM.

scientific article published in September 2009

Post-surgical contrast enhancement mimicking residual brain tumour

scientific article published in February 1985

Postoperative contrast enhancement in patients with brain tumor

scientific article published in June 1985

Practice parameter: anticonvulsant prophylaxis in patients with newly diagnosed brain tumors. Report of the Quality Standards Subcommittee of the American Academy of Neurology

scientific article published on 01 May 2000

Precursor States of Brain Tumor Initiating Cell Lines Are Predictive of Survival in Xenografts and Associated with Glioblastoma Subtypes

scientific article

Predicting MGMT methylation status of glioblastomas from MRI texture

scientific article published on 01 January 2009

Pretreatment factors predict overall survival for patients with low-grade glioma: a recursive partitioning analysis

scientific article published on November 1999

Primary cerebral fibrosarcomas. Clinicopathologic study and review of the literature

scientific article

Proceedings of the Comprehensive Oncology Network Evaluating Rare CNS Tumors (NCI-CONNECT) Oligodendroglioma Workshop

scientific article published on 06 December 2019

Proliferation of human glioblastoma stem cells occurs independently of exogenous mitogens

scientific article published in August 2009

Prolonged survival with valproic acid use in the EORTC/NCIC temozolomide trial for glioblastoma.

scientific article published on 31 August 2011

Prospective study of postoperative magnetic resonance imaging in patients with malignant gliomas

scientific article published in May 1997

Radiotherapy and temozolomide for newly diagnosed glioblastoma: recursive partitioning analysis of the EORTC 26981/22981-NCIC CE3 phase III randomized trial.

scientific article published in June 2006

Radiotherapy for newly diagnosed malignant glioma in adults: a systematic review

scientific article

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

scientific article (publication date: 10 March 2005)

Randomized comparison of diaziquone and carmustine in the treatment of adults with anaplastic glioma

scientific article published in January 1993

Recent developments in the molecular characterization and treatment of oligodendroglial tumors

scientific article published in April 2003

Recursive partitioning analysis of prognostic variables in newly diagnosed anaplastic oligodendroglial tumors

scientific article

Regarding, Allison, Schulsinger, Vongtama, I J ROBP 37:399-403;1997.

scientific article published in October 1997

Response and control: lessons from oligodendroglioma ⬇️

scientific article published on September 1, 1995

Response criteria for phase II studies of supratentorial malignant glioma

scientific article published in July 1990

Response to Weltman and Fleury Malheiros, re Lassman et al.

scientific article

Role of surgery for high-grade astrocytomas

scientific article published in June 1991

Salvage chemotherapy for oligodendroglioma

scientific article published in October 1996

Selection bias in clinical trials of anaplastic glioma

scientific article published in October 1989

Selection bias, survival, and brachytherapy for glioma ⬇️

scientific article published on February 1, 1992

Sensitivity to temozolomide in brain tumor initiating cells

scientific article published on 13 April 2010

Short-Course Radiation plus Temozolomide in Elderly Patients with Glioblastoma

scientific article published on March 2017

Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas

scientific article published in October 1998

Spontaneous loss of heterozygosity leading to homozygous R132H in a patient-derived IDH1 mutant cell line ⬇️

scientific article published on June 11, 2013

Stem cell-related "self-renewal" signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma

scientific article

Successful chemotherapy for newly diagnosed aggressive oligodendroglioma

scientific article

Successful chemotherapy for recurrent malignant oligodendroglioma

scientific article published in April 1988

Supratentorial anaplastic gliomas in adults. The prognostic importance of extent of resection and prior low-grade glioma

scientific article published on October 1989

Supratentorial malignant glioma: patterns of recurrence and implications for external beam local treatment

scientific article published in January 1992

Surgery for single brain metastasis

scientific article published in July 1990

Surgical management of incidentally discovered diffusely infiltrating low-grade glioma

scientific article published on 6 October 2017

Survey of treatment recommendations for anaplastic oligodendroglioma

scientific article

TMOD-14CHARACTERIZING SIGNALING PATHWAYS IN A MOUSE MODEL OF GLIOBLASTOMA.

scientific article

Temozolomide and seizure outcomes in a randomized clinical trial of elderly glioblastoma patients

scientific article published on 06 July 2020

Tests of association under misclassification: application to histological sampling in oncology

scientific article

The dose-volume interaction in adult supratentorial low-grade glioma: higher radiation dose is beneficial among patients with partial resection.

scientific article published on 14 February 2007

The hPMS2 exon 5 mutation and malignant glioma. Case report

scientific article published in May 1999

The prognostic value of health-related quality-of-life data in predicting survival in glioblastoma cancer patients: results from an international randomised phase III EORTC Brain Tumour and Radiation Oncology Groups, and NCIC Clinical Trials Group s

scientific article

The use of frailty hazard models for unrecognized heterogeneity that interacts with treatment: considerations of efficiency and power.

scientific article published in March 2002

The use of magnetic resonance imaging to noninvasively detect genetic signatures in oligodendroglioma

scientific article

Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells

scientific article published on 08 December 2013

Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells

scientific article published on October 2013

Toxicity from chemoradiotherapy in older patients with glioblastoma multiforme.

scientific article published on 9 April 2008

Treating brain tumor-initiating cells using a combination of myxoma virus and rapamycin

scientific article published on 12 April 2013

Treatment of oligodendroglioma: an update

scientific article

Treatment of oligodendrogliomas

scientific article published in January 1989

Tumor location and growth pattern correlate with genetic signature in oligodendroglial neoplasms

scientific article

Use of peri-operative anti-epileptic drugs in patients with newly diagnosed high grade malignant glioma: a single center experience.

scientific article published on 08 August 2009

Which glioblastoma multiforme patient will become a long-term survivor? A population-based study

scientific article

Wild-type p53 renders mouse astrocytes resistant to 1,3-Bis(2-chloroethyl)-1-nitrosourea despite the absence of a p53-dependent cell cycle arrest [corrected]

scientific article published on June 1996

cIMPACT-NOW (the consortium to inform molecular and practical approaches to CNS tumor taxonomy): a new initiative in advancing nervous system tumor classification

scientific article published on 20 December 2016

cIMPACT-NOW update 1: Not Otherwise Specified (NOS) and Not Elsewhere Classified (NEC).

scientific article

cIMPACT-NOW update 2: diagnostic clarifications for diffuse midline glioma, H3 K27M-mutant and diffuse astrocytoma/anaplastic astrocytoma, IDH-mutant

scientific article published in March 2018

p53 mutation, expression, and DNA ploidy in evolving gliomas: evidence for two pathways of progression

scientific article published in July 1994

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