List of works - Leo Heyndrickx

A dual chamber model of female cervical mucosa for the study of HIV transmission and for the evaluation of candidate HIV microbicides

scientific article published on 7 November 2006

Antiviral compounds show enhanced activity in HIV-1 single cycle pseudovirus assays as compared to classical PBMC assays

scientific article published on 14 January 2008

Boosting of HIV-1 neutralizing antibody responses by a distally related retroviral envelope protein

scientific article

CD4 mimetic miniproteins: potent anti-HIV compounds with promising activity as microbicides

scientific article published on 12 February 2008

Characterization of humoral responses to soluble trimeric HIV gp140 from a clade A Ugandan field isolate

scientific article published on 08 July 2013

Characterization of neutralizing profiles in HIV-1 infected patients from whom the HJ16, HGN194 and HK20 mAbs were obtained

scientific article

Comparison of predicted scaffold-compatible sequence variation in the triple-hairpin structure of human imunodeficiency virus type 1 gp41 with patient data

scientific article

Control of viral replication after cessation of HAART

scientific article

Development, Evaluation, and Integration of a Quantitative Reverse-Transcription Polymerase Chain Reaction Diagnostic Test for Ebola Virus on a Molecular Diagnostics Platform

scientific article

Development, evaluation, and validation of an oligonucleotide probe hybridization assay to subtype human immunodeficiency virus type 1 circulating recombinant form CRF02_AG.

scientific article published on April 2004

Diaryltriazine non-nucleoside reverse transcriptase inhibitors are potent candidates for pre-exposure prophylaxis in the prevention of sexual HIV transmission

scientific article

Efficient in vitro expansion of human immunodeficiency virus (HIV)-specific T-cell responses by gag mRNA-electroporated dendritic cells from treated and untreated HIV type 1-infected individuals

scientific article

Efficient stimulation of HIV-1-specific T cells using dendritic cells electroporated with mRNA encoding autologous HIV-1 Gag and Env proteins.

scientific article published on November 2005

Epidemiological and molecular characteristics of HIV infection in Gabon, 1986-1994.

scientific article published on July 1996

Epitopes corresponding to the envelope genetic subtype are present on the surface of free virions of HIV-1 group M primary isolates and can be detected in neutralization assays with extended incubation phases

scientific article published on November 2003

Evolution of antibody landscape and viral envelope escape in an HIV-1 CRF02_AG infected patient with 4E10-like antibodies

scientific article

Genotypic subtypes of HIV-1 in Cameroon

scientific article

HIV type 1 group M clades infecting subjects from rural villages in equatorial rain forests of Cameroon

scientific article published on December 2002

HIV type 1 subtype A envelope genetic evolution in a slow progressing individual with consistent broadly neutralizing antibodies

scientific article

Human Immunodeficiency Virus Type 1 Resistance or Cross-Resistance to Nonnucleoside Reverse Transcriptase Inhibitors Currently under Development as Microbicides

scientific article published in 2011

Human immunodeficiency virus type 1 resistance or cross-resistance to nonnucleoside reverse transcriptase inhibitors currently under development as microbicides

scientific article

Immune and viral correlates of "secondary viral control" after treatment interruption in chronically HIV-1 infected patients

scientific article

Immunization with clinical HIV-1 Env proteins induces broad antibody-dependent cellular cytotoxicity (ADCC)-mediating antibodies in a rabbit vaccination model

scientific article published on 6 October 2017

Induction of HIV-specific T-cell responses by gag.

scientific article published on 21 December 2006

Inhibition of replication of primary HIV-1 isolates in huPBL-NOD/Scid mice by antibodies from HIV-1 infected patients

scientific article

International network for comparison of HIV neutralization assays: the NeutNet report

scientific article

International network for comparison of HIV neutralization assays: the NeutNet report II

scientific article (publication date: 2012)

Interpatient genetic variability of HIV-1 group O

article

Longitudinal study of primary HIV-1 isolates in drug-naïve individuals reveals the emergence of variants sensitive to anti-HIV-1 monoclonal antibodies

scientific article

MiniCD4 microbicide prevents HIV infection of human mucosal explants and vaginal transmission of SHIV(162P3) in cynomolgus macaques

scientific article (publication date: 2012)

MiniCD4 protein resistance mutations affect binding to the HIV-1 gp120 CD4 binding site and decrease entry efficiency ⬇️

scientific article published on May 2, 2012

Molecular epidemiology of HIV-1 transmission in a cohort of HIV-1 concordant heterosexual couples from Dakar, Senegal

scientific article

Monocytes contribute to differential immune pressure on R5 versus X4 HIV through the adipocytokine visfatin/NAMPT

scientific article (publication date: 2012)

Neutralization and infectivity characteristics of envelope glycoproteins from human immunodeficiency virus type 1 infected donors whose sera exhibit broadly cross-reactive neutralizing activity

scientific article

Neutralization patterns and evolution of sequential HIV type 1 envelope sequences in HIV type 1 subtype B-infected drug-naive individuals

scientific article

Neutralizing Antibody Response and Antibody-Dependent Cellular Cytotoxicity in HIV-1-Infected Individuals from Guinea-Bissau and Denmark

scientific article published on December 2015

Optimization of HIV-1 Envelope DNA Vaccine Candidates within Three Different Animal Models, Guinea Pigs, Rabbits and Cynomolgus Macaques

scientific article published on 19 July 2013

Performance evaluation of the two protease sequencing primers of the Trugene HIV-1 genotyping kit.

scientific article

Predominance of infection with HIV-1 circulating recombinant form CRF02_AG in major Cameroonian cities and towns

scientific article published on 01 January 2002

Production of human immunodeficiency virus type 1 (HIV-1) pseudoviruses using linear HIV-1 envelope expression cassettes

scientific article

Replicative fitness of CCR5-using and CXCR4-using human immunodeficiency virus type 1 biological clones

scientific article published on 28 December 2005

Resistance and cross-resistance profile of the diaryltriazine NNRTI and candidate microbicide UAMC01398.

scientific article published on 4 February 2016

Risk of Misinterpretation of Ebola Virus PCR Results After rVSV ZEBOV-GP Vaccination

scientific article published on 18 February 2015

Selected HIV-1 Env trimeric formulations act as potent immunogens in a rabbit vaccination model

scientific article

The N276 glycosylation site is required for HIV-1 neutralization by the CD4 binding site specific HJ16 monoclonal antibody

scientific article

Unravelling the antigenic landscape of the HIV-1 subtype A envelope of an individual with broad cross-neutralizing antibodies using phage display peptide libraries.

scientific article

Visualization of X4- and R5-Tropic HIV-1 Viruses Expressing Fluorescent Proteins in Human Endometrial Cells: Application to Tropism Study

scientific article

List of works by Leo Heyndrickx

A dual chamber model of female cervical mucosa for the study of HIV transmission and for the evaluation of candidate HIV microbicides

Antiviral compounds show enhanced activity in HIV-1 single cycle pseudovirus assays as compared to classical PBMC assays

Boosting of HIV-1 neutralizing antibody responses by a distally related retroviral envelope protein

CD4 mimetic miniproteins: potent anti-HIV compounds with promising activity as microbicides

Characterization of humoral responses to soluble trimeric HIV gp140 from a clade A Ugandan field isolate

Characterization of neutralizing profiles in HIV-1 infected patients from whom the HJ16, HGN194 and HK20 mAbs were obtained

Comparison of predicted scaffold-compatible sequence variation in the triple-hairpin structure of human imunodeficiency virus type 1 gp41 with patient data

Control of viral replication after cessation of HAART

Development, Evaluation, and Integration of a Quantitative Reverse-Transcription Polymerase Chain Reaction Diagnostic Test for Ebola Virus on a Molecular Diagnostics Platform

Development, evaluation, and validation of an oligonucleotide probe hybridization assay to subtype human immunodeficiency virus type 1 circulating recombinant form CRF02_AG.

Diaryltriazine non-nucleoside reverse transcriptase inhibitors are potent candidates for pre-exposure prophylaxis in the prevention of sexual HIV transmission

Efficient in vitro expansion of human immunodeficiency virus (HIV)-specific T-cell responses by gag mRNA-electroporated dendritic cells from treated and untreated HIV type 1-infected individuals

Efficient stimulation of HIV-1-specific T cells using dendritic cells electroporated with mRNA encoding autologous HIV-1 Gag and Env proteins.

Epidemiological and molecular characteristics of HIV infection in Gabon, 1986-1994.

Epitopes corresponding to the envelope genetic subtype are present on the surface of free virions of HIV-1 group M primary isolates and can be detected in neutralization assays with extended incubation phases

Evolution of antibody landscape and viral envelope escape in an HIV-1 CRF02_AG infected patient with 4E10-like antibodies

Genotypic subtypes of HIV-1 in Cameroon

HIV type 1 group M clades infecting subjects from rural villages in equatorial rain forests of Cameroon

HIV type 1 subtype A envelope genetic evolution in a slow progressing individual with consistent broadly neutralizing antibodies

Human Immunodeficiency Virus Type 1 Resistance or Cross-Resistance to Nonnucleoside Reverse Transcriptase Inhibitors Currently under Development as Microbicides

Human immunodeficiency virus type 1 resistance or cross-resistance to nonnucleoside reverse transcriptase inhibitors currently under development as microbicides

Immune and viral correlates of "secondary viral control" after treatment interruption in chronically HIV-1 infected patients

Immunization with clinical HIV-1 Env proteins induces broad antibody-dependent cellular cytotoxicity (ADCC)-mediating antibodies in a rabbit vaccination model

Induction of HIV-specific T-cell responses by gag.

Inhibition of replication of primary HIV-1 isolates in huPBL-NOD/Scid mice by antibodies from HIV-1 infected patients

International network for comparison of HIV neutralization assays: the NeutNet report

International network for comparison of HIV neutralization assays: the NeutNet report II

Interpatient genetic variability of HIV-1 group O

Longitudinal study of primary HIV-1 isolates in drug-naïve individuals reveals the emergence of variants sensitive to anti-HIV-1 monoclonal antibodies

MiniCD4 microbicide prevents HIV infection of human mucosal explants and vaginal transmission of SHIV(162P3) in cynomolgus macaques

MiniCD4 protein resistance mutations affect binding to the HIV-1 gp120 CD4 binding site and decrease entry efficiency ⬇️

Molecular epidemiology of HIV-1 transmission in a cohort of HIV-1 concordant heterosexual couples from Dakar, Senegal

Monocytes contribute to differential immune pressure on R5 versus X4 HIV through the adipocytokine visfatin/NAMPT

Neutralization and infectivity characteristics of envelope glycoproteins from human immunodeficiency virus type 1 infected donors whose sera exhibit broadly cross-reactive neutralizing activity

Neutralization patterns and evolution of sequential HIV type 1 envelope sequences in HIV type 1 subtype B-infected drug-naive individuals

Neutralizing Antibody Response and Antibody-Dependent Cellular Cytotoxicity in HIV-1-Infected Individuals from Guinea-Bissau and Denmark

Optimization of HIV-1 Envelope DNA Vaccine Candidates within Three Different Animal Models, Guinea Pigs, Rabbits and Cynomolgus Macaques

Performance evaluation of the two protease sequencing primers of the Trugene HIV-1 genotyping kit.

Predominance of infection with HIV-1 circulating recombinant form CRF02_AG in major Cameroonian cities and towns

Production of human immunodeficiency virus type 1 (HIV-1) pseudoviruses using linear HIV-1 envelope expression cassettes

Replicative fitness of CCR5-using and CXCR4-using human immunodeficiency virus type 1 biological clones

Resistance and cross-resistance profile of the diaryltriazine NNRTI and candidate microbicide UAMC01398.

Risk of Misinterpretation of Ebola Virus PCR Results After rVSV ZEBOV-GP Vaccination

Selected HIV-1 Env trimeric formulations act as potent immunogens in a rabbit vaccination model

The N276 glycosylation site is required for HIV-1 neutralization by the CD4 binding site specific HJ16 monoclonal antibody

Unravelling the antigenic landscape of the HIV-1 subtype A envelope of an individual with broad cross-neutralizing antibodies using phage display peptide libraries.

Visualization of X4- and R5-Tropic HIV-1 Viruses Expressing Fluorescent Proteins in Human Endometrial Cells: Application to Tropism Study