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List of works by Linda S Steelman

Abilities of berberine and chemically modified berberines to interact with metformin and inhibit proliferation of pancreatic cancer cells

scientific article published on 21 April 2019

Abilities of β-Estradiol to interact with chemotherapeutic drugs, signal transduction inhibitors and nutraceuticals and alter the proliferation of pancreatic cancer cells

scientific article published on 18 October 2019

Advances in targeting signal transduction pathways

scientific article

Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy

scientific article published on 21 February 2008

Combining chemo-, hormonal and targeted therapies to treat breast cancer (Review).

scientific article published on March 2008

Conditional EGFR promotes cell cycle progression and prevention of apoptosis in the absence of autocrine cytokines

scientific article

Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells

scientific article published on August 2011

Critical Roles of EGFR Family Members in Breast Cancer and Breast Cancer Stem Cells: Targets for Therapy

scientific article published on 4 March 2016

Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention

scientific article

Development of a conditional in vivo model to evaluate the efficacy of small molecule inhibitors for the treatment of Raf-transformed hematopoietic cells

scientific article published on November 2005

Diverse roles of GSK-3: tumor promoter-tumor suppressor, target in cancer therapy

scientific article published on 08 October 2013

Dominant roles of the Raf/MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs

scientific article published on 15 April 2010

EGFR family signaling and its association with breast cancer development and resistance to chemotherapy (Review).

scientific article

Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine

scientific article published on 16 November 2012

Effects of ectopic expression of NGAL on doxorubicin sensitivity

scientific article published on October 2012

Effects of endogenous epidermal growth factor receptor signaling on DNA synthesis and ERK activation in a cytokine-dependent hematopoietic cell line

scientific article

Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity-Diverse effects on cell growth, metabolism and cancer

scientific article published on 06 September 2016

Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells.

scientific article published in April 2003

Emerging MEK inhibitors.

scientific article published on June 2010

Emerging Raf inhibitors.

scientific article published on December 2009

Enhancing therapeutic efficacy by targeting non-oncogene addicted cells with combinations of signal transduction inhibitors and chemotherapy

scientific article published on 15 May 2010

Exploiting p53 status to enhance effectiveness of chemotherapy by lowering associated toxicity

scientific article published on March 2011

Fibroblastic, hematopoietic, and hormone responsive epithelial cell lines and culture conditions for elucidation of signal transduction and drug resistance pathways by gene transfer.

scientific article

GSK-3 as potential target for therapeutic intervention in cancer

scientific article

Increased NGAL (Lnc2) expression after chemotherapeutic drug treatment.

scientific article

Inhibition of GSK-3β activity can result in drug and hormonal resistance and alter sensitivity to targeted therapy in MCF-7 breast cancer cells

scientific article published on 09 January 2014

Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells

scientific article published on September 2011

Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapy

scientific article published on July 2011

Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response

scientific article published on September 2012

New landscapes and horizons in hepatocellular carcinoma therapy

scientific article published on 04 February 2020

Novel approaches to target cancer initiating cells-eliminating the root of the cancer

scientific article published on January 2012

Novel roles of androgen receptor, epidermal growth factor receptor, TP53, regulatory RNAs, NF-kappa-B, chromosomal translocations, neutrophil associated gelatinase, and matrix metalloproteinase-9 in prostate cancer and prostate cancer stem cells

scientific article

PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches

scientific article published on 23 May 2009

RAS/RAF/MEK/ERK, PI3K/PTEN/AKT/mTORC1 and TP53 pathways and regulatory miRs as therapeutic targets in hepatocellular carcinoma

scientific article published on 04 November 2019

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance

scientific article

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health

scientific article published on March 2011

Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review).

scientific article

Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells

scientific article published on 17 July 2015

Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells

scientific article

Roles of NGAL and MMP-9 in the tumor microenvironment and sensitivity to targeted therapy

scientific article published on 13 August 2015

Roles of signaling pathways in drug resistance, cancer initiating cells and cancer progression and metastasis

scientific article

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

scientific article

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance

scientific article

Signaling intermediates (MAPK and PI3K) as therapeutic targets in NSCLC.

scientific article published on January 2014

Targeting breast cancer initiating cells: advances in breast cancer research and therapy

scientific article

Targeting prostate cancer based on signal transduction and cell cycle pathways.

scientific article published on 16 June 2008

Targeting signal transduction pathways to eliminate chemotherapeutic drug resistance and cancer stem cells.

scientific article

Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance.

scientific article published on 26 March 2007

Targeting the Raf/MEK/ERK pathway with small-molecule inhibitors.

scientific article

Targeting the cancer initiating cell: the ultimate target for cancer therapy.

scientific article published on January 2012

The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy

scientific article published on 10 May 2010

The complexity of PTEN: mutation, marker and potential target for therapeutic intervention

scientific article

The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what's genetics got to do with it?

scientific article

The therapeutic potential of mTOR inhibitors in breast cancer

scientific article published on 5 April 2016

Therapeutic potential of MEK inhibition in acute myelogenous leukemia: rationale for "vertical" and "lateral" combination strategies

scientific article

Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways.

scientific article

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