List of works - Gen Arai

18F-fluorodeoxyglucose-PET for patients with suspected spondylitis showing Modic change

scientific article published on December 2010

A case of symptomatic extra-foraminal lumbosacral stenosis ("far-out syndrome") diagnosed by diffusion tensor imaging.

scientific article published in June 2012

Additional decompression at adjacent segments leads to adjacent segment degeneration after PLIF.

scientific article published on 13 February 2013

Assessment of gait in a rat model of myofascial inflammation using the CatWalk system

scientific article published in October 2011

Associations between proinflammatory cytokines in the synovial fluid and radiographic grading and pain-related scores in 47 consecutive patients with osteoarthritis of the knee

scientific article

Brain-derived neurotrophic factor inhibition at the punctured intervertebral disc downregulates the production of calcitonin gene-related peptide in dorsal root ganglia in rats

scientific article

Change in Modic type 1 and 2 signals after posterolateral fusion surgery

scientific article published on 01 May 2010

Clinical applications of diffusion magnetic resonance imaging of the lumbar foraminal nerve root entrapment.

scientific article

Clinical incidence of sacroiliac joint arthritis and pain after sacropelvic fixation for spinal deformity

scientific article published on March 2012

Comparison of CatWalk analysis and von Frey testing for pain assessment in a rat model of nerve crush plus inflammation

scientific article published in July 2013

Differences between tumor necrosis factor-α receptors types 1 and 2 in the modulation of spinal glial cell activation and mechanical allodynia in a rat sciatic nerve injury model

scientific article published on January 2013

Differences in damage to CGRP immunoreactive sensory nerves after two lumbar surgical approaches: investigation using humans and rats

scientific article published in February 2012

Difficulty of diagnosing the origin of lower leg pain in patients with both lumbar spinal stenosis and hip joint osteoarthritis

scientific article

Diffusion magnetic resonance imaging to differentiate degenerative from infectious endplate abnormalities in the lumbar spine

scientific article published on 01 February 2011

Diffusion-weighted magnetic resonance imaging of symptomatic nerve root of patients with lumbar disk herniation.

scientific article published on 16 November 2010

Direct application of the tumor necrosis factor-α inhibitor, etanercept, into a punctured intervertebral disc decreases calcitonin gene-related peptide expression in rat dorsal root ganglion neurons

scientific article published in January 2011

Direct single injection of p38 mitogen-activated protein kinase inhibitor does not affect calcitonin gene-related peptide expression in dorsal root ganglion neurons innervating punctured discs in rats

scientific article

Disk injury in rats produces persistent increases in pain-related neuropeptides in dorsal root ganglia and spinal cord glia but only transient increases in inflammatory mediators: pathomechanism of chronic diskogenic low back pain

scientific article published in December 2011

Effect of applying p75NTR saporin to a punctured intervertebral disc on calcitonin gene-related peptide expression in rat dorsal root ganglion neurons

scientific article published in May 2010

Effectiveness of L2 spinal nerve infiltration for selective discogenic low back pain patients

scientific article

Efficacy of epidural administration of anti-interleukin-6 receptor antibody onto spinal nerve for treatment of sciatica

scientific article

Epidural administration of spinal nerves with the tumor necrosis factor-alpha inhibitor, etanercept, compared with dexamethasone for treatment of sciatica in patients with lumbar spinal stenosis: a prospective randomized study

scientific article

Evaluation of behavior and neuropeptide markers of pain in a simple, sciatic nerve-pinch pain model in rats.

scientific article

Existence of a neuropathic pain component in patients with osteoarthritis of the knee

scientific article

Existence of pyogenic spondylitis in Modic type 1 change without other signs of infection: 2-year follow-up

scientific article

ISSLS prize winner: disc dynamic compression in rats produces long-lasting increases in inflammatory mediators in discs and induces long-lasting nerve injury and regeneration of the afferent fibers innervating discs: a pathomechanism for chronic dis

scientific article

In-vivo transfection of the proopiomelanocortin gene, precursor of endogenous endorphin, by use of radial shock waves alleviates neuropathic pain

scientific article published on 27 April 2013

Inhibiting IκB kinase-β downregulates inflammatory cytokines in injured discs and neuropeptides in dorsal root ganglia innervating injured discs in rats

scientific article published in July 2014

Inhibiting nerve growth factor or its receptors downregulates calcitonin gene-related peptide expression in rat lumbar dorsal root ganglia innervating injured intervertebral discs.

scientific article

Investigation of dichotomizing sensory nerve fibers projecting to the lumbar multifidus muscles and intervertebral disc or facet joint or sacroiliac joint in rats

scientific article

Low back pain after lumbar discectomy in patients showing endplate modic type 1 change

scientific article published in June 2010

Lumbar disc degeneration induces persistent groin pain

scientific article

One, two-, and three-level instrumented posterolateral fusion of the lumbar spine with a local bone graft: a prospective study with a 2-year follow-up

scientific article published in August 2011

Pain-related sensory innervation in monoiodoacetate-induced osteoarthritis in rat knees that gradually develops neuronal injury in addition to inflammatory pain

scientific article

Percutaneously absorbed NSAIDs attenuate local production of proinflammatory cytokines and suppress the expression of c-Fos in the spinal cord of a rodent model of knee osteoarthritis

scientific article published on 26 November 2011

Platelet-rich plasma combined with hydroxyapatite for lumbar interbody fusion promoted bone formation and decreased an inflammatory pain neuropeptide in rats

scientific article published in September 2012

Primary sensory neurons with dichotomizing axons projecting to the facet joint and the low back muscle in rats

scientific article

Proinflammatory cytokines in the cerebrospinal fluid of patients with lumbar radiculopathy

scientific article published on 17 October 2010

Radiographic evaluation of monocortical versus tricortical purchase approaches in lumbosacral fixation with sacral pedicle screws: a prospective study of ninety consecutive patients

scientific article published in October 2010

Rotational hypermobility of disc wedging using kinematic CT: preliminary study to investigate the instability of discs in degenerated scoliosis in the lumbar spine

scientific article

Sensory and autonomic innervation of the cervical intervertebral disc in rats: the pathomechanics of chronic discogenic neck pain.

scientific article published in July 2012

Severe lumbar retrospondylolisthesis associated with hemodialysis in a patient with chronic renal failure: a case report

scientific article published in July 2005

Single-level instrumented posterolateral fusion of the lumbar spine with a local bone graft versus an iliac crest bone graft: a prospective, randomized study with a 2-year follow-up

scientific article

Single-level instrumented posterolateral fusion versus non-instrumented anterior interbody fusion for lumbar spondylolisthesis: a prospective study with a 2-year follow-up

scientific article published on 13 May 2011

Surgical versus nonsurgical treatment of selected patients with discogenic low back pain: a small-sized randomized trial

scientific article published in March 2011

The effect of platelet-rich plasma on posterolateral lumbar fusion in a rat model

scientific article published in June 2013

The effects of risedronate and exercise on osteoporotic lumbar rat vertebrae and their sensory innervation

scientific article published on October 2010

Transdermal fentanyl for chronic low back pain

scientific article

Tumor necrosis factor-α-immunoreactive cells in nucleus pulposus in adolescent patients with lumbar disc herniation

scientific article published in March 2013

Uni- and bilateral instrumented posterolateral fusion of the lumbar spine with local bone grafting: a prospective study with a 2-year follow-up

scientific article published in December 2011

Vertebral compression exacerbates osteoporotic pain in an ovariectomy-induced osteoporosis rat model

scientific article published in November 2013

List of works by Gen Arai

18F-fluorodeoxyglucose-PET for patients with suspected spondylitis showing Modic change

A case of symptomatic extra-foraminal lumbosacral stenosis ("far-out syndrome") diagnosed by diffusion tensor imaging.

Additional decompression at adjacent segments leads to adjacent segment degeneration after PLIF.

Assessment of gait in a rat model of myofascial inflammation using the CatWalk system

Associations between proinflammatory cytokines in the synovial fluid and radiographic grading and pain-related scores in 47 consecutive patients with osteoarthritis of the knee

Brain-derived neurotrophic factor inhibition at the punctured intervertebral disc downregulates the production of calcitonin gene-related peptide in dorsal root ganglia in rats

Change in Modic type 1 and 2 signals after posterolateral fusion surgery

Clinical applications of diffusion magnetic resonance imaging of the lumbar foraminal nerve root entrapment.

Clinical incidence of sacroiliac joint arthritis and pain after sacropelvic fixation for spinal deformity

Comparison of CatWalk analysis and von Frey testing for pain assessment in a rat model of nerve crush plus inflammation

Differences between tumor necrosis factor-α receptors types 1 and 2 in the modulation of spinal glial cell activation and mechanical allodynia in a rat sciatic nerve injury model

Differences in damage to CGRP immunoreactive sensory nerves after two lumbar surgical approaches: investigation using humans and rats

Difficulty of diagnosing the origin of lower leg pain in patients with both lumbar spinal stenosis and hip joint osteoarthritis

Diffusion magnetic resonance imaging to differentiate degenerative from infectious endplate abnormalities in the lumbar spine

Diffusion-weighted magnetic resonance imaging of symptomatic nerve root of patients with lumbar disk herniation.

Direct application of the tumor necrosis factor-α inhibitor, etanercept, into a punctured intervertebral disc decreases calcitonin gene-related peptide expression in rat dorsal root ganglion neurons

Direct single injection of p38 mitogen-activated protein kinase inhibitor does not affect calcitonin gene-related peptide expression in dorsal root ganglion neurons innervating punctured discs in rats

Disk injury in rats produces persistent increases in pain-related neuropeptides in dorsal root ganglia and spinal cord glia but only transient increases in inflammatory mediators: pathomechanism of chronic diskogenic low back pain

Effect of applying p75NTR saporin to a punctured intervertebral disc on calcitonin gene-related peptide expression in rat dorsal root ganglion neurons

Effectiveness of L2 spinal nerve infiltration for selective discogenic low back pain patients

Efficacy of epidural administration of anti-interleukin-6 receptor antibody onto spinal nerve for treatment of sciatica

Epidural administration of spinal nerves with the tumor necrosis factor-alpha inhibitor, etanercept, compared with dexamethasone for treatment of sciatica in patients with lumbar spinal stenosis: a prospective randomized study

Evaluation of behavior and neuropeptide markers of pain in a simple, sciatic nerve-pinch pain model in rats.

Existence of a neuropathic pain component in patients with osteoarthritis of the knee

Existence of pyogenic spondylitis in Modic type 1 change without other signs of infection: 2-year follow-up

ISSLS prize winner: disc dynamic compression in rats produces long-lasting increases in inflammatory mediators in discs and induces long-lasting nerve injury and regeneration of the afferent fibers innervating discs: a pathomechanism for chronic dis

In-vivo transfection of the proopiomelanocortin gene, precursor of endogenous endorphin, by use of radial shock waves alleviates neuropathic pain

Inhibiting IκB kinase-β downregulates inflammatory cytokines in injured discs and neuropeptides in dorsal root ganglia innervating injured discs in rats

Inhibiting nerve growth factor or its receptors downregulates calcitonin gene-related peptide expression in rat lumbar dorsal root ganglia innervating injured intervertebral discs.

Investigation of dichotomizing sensory nerve fibers projecting to the lumbar multifidus muscles and intervertebral disc or facet joint or sacroiliac joint in rats

Low back pain after lumbar discectomy in patients showing endplate modic type 1 change

Lumbar disc degeneration induces persistent groin pain

One, two-, and three-level instrumented posterolateral fusion of the lumbar spine with a local bone graft: a prospective study with a 2-year follow-up

Pain-related sensory innervation in monoiodoacetate-induced osteoarthritis in rat knees that gradually develops neuronal injury in addition to inflammatory pain

Percutaneously absorbed NSAIDs attenuate local production of proinflammatory cytokines and suppress the expression of c-Fos in the spinal cord of a rodent model of knee osteoarthritis

Platelet-rich plasma combined with hydroxyapatite for lumbar interbody fusion promoted bone formation and decreased an inflammatory pain neuropeptide in rats

Primary sensory neurons with dichotomizing axons projecting to the facet joint and the low back muscle in rats

Proinflammatory cytokines in the cerebrospinal fluid of patients with lumbar radiculopathy

Radiographic evaluation of monocortical versus tricortical purchase approaches in lumbosacral fixation with sacral pedicle screws: a prospective study of ninety consecutive patients

Rotational hypermobility of disc wedging using kinematic CT: preliminary study to investigate the instability of discs in degenerated scoliosis in the lumbar spine

Sensory and autonomic innervation of the cervical intervertebral disc in rats: the pathomechanics of chronic discogenic neck pain.

Severe lumbar retrospondylolisthesis associated with hemodialysis in a patient with chronic renal failure: a case report

Single-level instrumented posterolateral fusion of the lumbar spine with a local bone graft versus an iliac crest bone graft: a prospective, randomized study with a 2-year follow-up

Single-level instrumented posterolateral fusion versus non-instrumented anterior interbody fusion for lumbar spondylolisthesis: a prospective study with a 2-year follow-up

Surgical versus nonsurgical treatment of selected patients with discogenic low back pain: a small-sized randomized trial

The effect of platelet-rich plasma on posterolateral lumbar fusion in a rat model

The effects of risedronate and exercise on osteoporotic lumbar rat vertebrae and their sensory innervation

Transdermal fentanyl for chronic low back pain

Tumor necrosis factor-α-immunoreactive cells in nucleus pulposus in adolescent patients with lumbar disc herniation

Uni- and bilateral instrumented posterolateral fusion of the lumbar spine with local bone grafting: a prospective study with a 2-year follow-up

Vertebral compression exacerbates osteoporotic pain in an ovariectomy-induced osteoporosis rat model