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List of works by Roy Ummels

Analysis of SecA2-dependent substrates in Mycobacterium marinum identifies protein kinase G (PknG) as a virulence effector

scientific article

Composition of the type VII secretion system membrane complex.

scientific article published on 27 August 2012

Conserved Pro-Glu (PE) and Pro-Pro-Glu (PPE) protein domains target LipY lipases of pathogenic mycobacteria to the cell surface via the ESX-5 pathway

scientific article

Differential detergent extraction of mycobacterium marinum cell envelope proteins identifies an extensively modified threonine-rich outer membrane protein with channel activity.

scientific article published on March 2013

EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF

scientific article published on 13 August 2018

Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria

scientific article published on 4 May 2015

General secretion signal for the mycobacterial type VII secretion pathway

scientific article

Identification of a substrate domain that determines system specificity in mycobacterial type VII secretion systems

scientific article published on 16 February 2017

Identification of mycobacterial alpha-glucan as a novel ligand for DC-SIGN: involvement of mycobacterial capsular polysaccharides in host immune modulation

scientific article published on 25 September 2009

Lipoarabinomannan mannose caps do not affect mycobacterial virulence or the induction of protective immunity in experimental animal models of infection and have minimal impact on in vitro inflammatory responses

scientific article published on 21 November 2012

Modification of a PE/PPE substrate pair reroutes an Esx substrate pair from the mycobacterial ESX-1 type VII secretion system to the ESX-5 system

scientific article published on 17 March 2020

Mutations in ppe38 block PE_PGRS secretion and increase virulence of Mycobacterium tuberculosis

scientific article published on 15 January 2018

Mycobacterium marinum MMAR_2380, a predicted transmembrane acyltransferase, is essential for the presence of the mannose cap on lipoarabinomannan ⬇️

scientific article

Mycosins Are Required for the Stabilization of the ESX-1 and ESX-5 Type VII Secretion Membrane Complexes

scientific article published on 18 October 2016

Protease domain and transmembrane domain of the type VII secretion mycosin protease determine system-specific functioning in mycobacteria

scientific article published on 28 January 2019

Specific chaperones for the type VII protein secretion pathway.

scientific article

Structure and dynamics of a mycobacterial type VII secretion system

scientific article published on 12 May 2021

Structure of the Mycobacterium tuberculosis type VII secretion system chaperone EspG5 in complex with PE25-PPE41 dimer

scientific article

Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis.

scientific article

Type VII Secretion Substrates of Pathogenic Mycobacteria Are Processed by a Surface Protease

scientific article published on 29 October 2019

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