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List of works by Barbara Renga

3alpha-6alpha-Dihydroxy-7alpha-fluoro-5beta-cholanoate (UPF-680), physicochemical and physiological properties of a new fluorinated bile acid that prevents 17alpha-ethynyl-estradiol-induced cholestasis in rats

scientific article published on 17 February 2006

4-Methylenesterols from Theonella swinhoei sponge are natural pregnane-X-receptor agonists and farnesoid-X-receptor antagonists that modulate innate immunity

scientific article published on 20 January 2012

5-Amino-2-hydroxybenzoic Acid 4-(5-Thioxo-5H-[1,2]dithiol-3yl)-phenyl Ester (ATB-429), a Hydrogen Sulfide-Releasing Derivative of Mesalamine, Exerts Antinociceptive Effects in a Model of Postinflammatory Hypersensitivity

scientific article published on 19 July 2006

A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis

scientific journal article

A nitro-arginine derivative of trimebutine (NO2-Arg-Trim) attenuates pain induced by colorectal distension in conscious rats.

scientific article published on 29 January 2009

Activation of FXR Improves Myocardial Fatty Acid Metabolism in a Rodent Model of Liver Steatosis

scholarly article published in May 2011

Activation of the bile acid receptor GPBAR1 protects against gastrointestinal injury caused by non‐steroidal anti‐inflammatory drugs and aspirin in mice ⬇️

scientific article published on January 1, 2013

Activation of the farnesoid-X receptor protects against gastrointestinal injury caused by non-steroidal anti-inflammatory drugs in mice ⬇️

scientific article published on December 1, 2011

Antiatherosclerotic effect of farnesoid X receptor

scientific article published on 21 November 2008

Bile acid activated receptors are targets for regulation of integrity of gastrointestinal mucosa

scientific article

Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation

scientific article published on May 2009

Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands.

scientific article

CCR5 Antagonism by Maraviroc Reduces the Potential for Gastric Cancer Cell Dissemination.

scientific article

Cardiac safety and antitumoral activity of a new nitric oxide derivative of pegylated epirubicin in mice

scientific article published on October 2007

Chalinulasterol, a chlorinated steroid disulfate from the Caribbean sponge Chalinula molitba. Evaluation of its role as PXR receptor modulator

scientific article

Co-administration of nitric oxide-aspirin (NCX-4016) and aspirin prevents platelet and monocyte activation and protects against gastric damage induced by aspirin in humans

scientific article (publication date: 4 August 2004)

Conicasterol E, a small heterodimer partner sparing farnesoid X receptor modulator endowed with a pregnane X receptor agonistic activity, from the marine sponge Theonella swinhoei.

scientific article

Correction: The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis.

scientific article published on 29 January 2013

Cross-talk between farnesoid-X-receptor (FXR) and peroxisome proliferator-activated receptor gamma contributes to the antifibrotic activity of FXR ligands in rodent models of liver cirrhosis

scientific article published on 24 June 2005

Cystathionine γ-lyase, a H2S-generating enzyme, is a GPBAR1-regulated gene and contributes to vasodilation caused by secondary bile acids

article

Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors.

scientific article published on 17 January 2014

Development of non-antibiotic macrolide that corrects inflammation-driven immune dysfunction in models of inflammatory bowel diseases and arthritis ⬇️

scientific article published on April 28, 2011

Discovery of sulfated sterols from marine invertebrates as a new class of marine natural antagonists of farnesoid-X-receptor

scientific article

Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis

scientific article (publication date: 2012)

Dissociation of intestinal and hepatic activities of FXR and LXRα supports metabolic effects of terminal ileum interposition in rodents.

scientific article published on 08 July 2013

Efficacy of the CCR5 antagonist maraviroc in reducing early, ritonavir-induced atherogenesis and advanced plaque progression in mice.

scientific article published on 30 April 2013

Epigenetic Modulation by Methionine Deficiency Attenuates the Potential for Gastric Cancer Cell Dissemination ⬇️

scientific article published on September 5, 2012

Essential Role of DNAX Adaptor Protein 12 (DAP12) and Spleen Tyrosine Kinase (Syk) in Inflammation-Driven Immune Dysfunction in Rodent Model of Colitis.

scholarly article published in May 2011

Evidence that hydrogen sulfide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channels

scientific article

Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands.

scientific article

FXR mediates a chromatin looping in the GR promoter thus promoting the resolution of colitis in rodents.

scientific article published in September 2013

Farnesoid X receptor suppresses constitutive androstane receptor activity at the multidrug resistance protein-4 promoter.

scientific article published on 4 February 2011

Gene expression changes induced by HIPEC in a murine model of gastric cancer.

scientific article published in January 2012

Glucocorticoid receptor mediates the gluconeogenic activity of the farnesoid X receptor in the fasting condition.

scientific article published on 23 March 2012

HIV-1 infection is associated with changes in nuclear receptor transcriptome, pro-inflammatory and lipid profile of monocytes.

scientific article

Hydrogen sulphide induces micro opioid receptor-dependent analgesia in a rodent model of visceral pain

scientific article published on 11 June 2010

Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling

scientific article published on 15 July 2015

In vivo administration of ritonavir worsens intestinal damage caused by cyclooxygease inhibitors

scientific article published on 4 December 2013

Incisterols, highly degraded marine sterols, are a new chemotype of PXR agonists.

scientific article

Inhibition of NF-kB by a PXR-Dependent Pathway Mediates Counter-regulatory Activities of Rifaximin on Innate Immunity in Intestinal Epithelial Cells

scholarly article published in May 2011

Inhibition of NF-κB by a PXR-dependent pathway mediates counter-regulatory activities of rifaximin on innate immunity in intestinal epithelial cells ⬇️

scientific article published on July 26, 2011

Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs

scientific article (publication date: October 2005)

Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective agonists.

scientific article published on 7 January 2016

Insights on pregnane-X-receptor modulation. Natural and semisynthetic steroids from Theonella marine sponges.

scientific article

Interactions Between Nuclear Receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice

scientific article

Investigation on bile acid receptor regulators. Discovery of cholanoic acid derivatives with dual G-protein coupled bile acid receptor 1 (GPBAR1) antagonistic and farnesoid X receptor (FXR) modulatory activity

scientific article published on 19 November 2015

Isoswinholide B and swinholide K, potently cytotoxic dimeric macrolides from Theonella swinhoei.

scientific article published on 15 June 2013

Marine and semi-synthetic hydroxysteroids as new scaffolds for pregnane X receptor modulation

scientific article

Mechanistic role of p38 MAPK in gastric cancer dissemination in a rodent model peritoneal metastasis.

scientific article

Modification in the side chain of solomonsterol A: discovery of cholestan disulfate as a potent pregnane-X-receptor agonist.

scientific article

Modification on ursodeoxycholic acid (UDCA) scaffold. discovery of bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 (GP-BAR1)

scientific article published on 07 September 2014

Modulation of intestinal microbiota by the probiotic VSL#3 resets brain gene expression and ameliorates the age-related deficit in LTP

scientific article

Molecular Determinants of Gastrointestinal and Liver Cancers: Role of Bile Acid Activated Nuclear Receptors ⬇️

scientific article published on January 1, 2012

Molecular Determinants of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in a Model of Peritoneal Gastric Cancer Carcinogenesis

scholarly article

Molecular decodification of gymnemic acids from Gymnema sylvestre. Discovery of a new class of liver X receptor antagonists.

scientific article

Navigation in bile acid chemical space: discovery of novel FXR and GPBAR1 ligands

scientific article

New tridecapeptides of the theonellapeptolide family from the Indonesian sponge Theonella swinhoei.

scientific article published on 13 August 2013

Nitric oxide modulates proapoptotic and antiapoptotic properties of chemotherapy agents: the case of NO-pegylated epirubicin

scientific article published on 2 February 2006

Oxygenated polyketides from Plakinastrella mamillaris as a new chemotype of PXR agonists.

scientific article published on 2 July 2013

Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor γ.

scientific article

Polyhydroxylated sterols from the Indonesian soft coral Sinularia sp. and their effect on farnesoid X-activated receptor.

scientific article

Pregnane-X-receptor mediates the anti-inflammatory activities of rifaximin on detoxification pathways in intestinal epithelial cells ⬇️

scientific article published on September 9, 2010

Preliminary structure-activity relationship on theonellasterol, a new chemotype of FXR antagonist, from the marine sponge Theonella swinhoei

scientific article published on 5 November 2012

Probiotics VSL#3 protect against development of visceral pain in murine model of irritable bowel syndrome

scientific article

Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation

scientific article

Quantitative NMR-derived interproton distances combined with quantum mechanical calculations of 13C chemical shifts in the stereochemical determination of conicasterol F, a nuclear receptor ligand from Theonella swinhoei

scientific article published on 23 January 2012

Reciprocal regulation of the bile acid-activated receptor FXR and the interferon-gamma-STAT-1 pathway in macrophages

scientific article published on 22 April 2009

Reversal of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a AKT/FOXOA1 Dependent Regulation of H2S Generation and Endothelin-1.

scientific article published on 5 November 2015

Ritonavir-induced lipoatrophy and dyslipidaemia is reversed by the anti-inflammatory drug leflunomide in a PPAR-γ-dependent manner

scientific article published on 25 January 2012

Role of FXR in regulating bile acid homeostasis and relevance for human diseases

scientific article

Role of nuclear receptors in lipid dysfunction and obesity-related diseases.

scientific article

SHP-dependent and -independent induction of peroxisome proliferator-activated receptor-γ by the bile acid sensor farnesoid X receptor counter-regulates the pro-inflammatory phenotype of liver myofibroblasts ⬇️

scientific article published on January 29, 2011

Solomonsterol A, a marine pregnane-X-receptor agonist, attenuates inflammation and immune dysfunction in a mouse model of arthritis.

scientific article published on 24 December 2013

Solomonsterols A and B from Theonella swinhoei. The first example of C-24 and C-23 sulfated sterols from a marine source endowed with a PXR agonistic activity

scientific article published on 9 December 2010

Structural insights into Estrogen Related Receptor-β modulation: 4-methylenesterols from Theonella swinhoei sponge as the first example of marine natural antagonists.

scientific article published on 4 December 2013

Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism

scientific article published on 16 November 2015

The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis ⬇️

scientific article published on October 27, 2011

The Bile Acid Sensor FXR Protects against Dyslipidemia and Aortic Plaques Development Induced by the HIV Protease Inhibitor Ritonavir in Mice ⬇️

scientific article published on October 8, 2010

The Bile Acids Receptor TGR5 is an Essential Modulator of Intestinal Membrane Permeability and Exerts Anti-Inflammatory Activities in Rodent Model of Colitis

scholarly article published in May 2011

The First Total Synthesis of Solomonsterol B, a Marine Pregnane X Receptor Agonist

The HIV matrix protein p17 induces hepatic lipid accumulation via modulation of nuclear receptor transcriptoma.

scientific article published on 15 October 2015

The HIV matrix protein p17 promotes the activation of human hepatic stellate cells through interactions with CXCR2 and Syndecan-2.

scientific article

The HIV matrix protein p17 subverts nuclear receptors expression and induces a STAT1-dependent proinflammatory phenotype in monocytes ⬇️

scientific article published on April 30, 2012

The bile acid receptor FXR is a modulator of intestinal innate immunity

scientific journal article

The bile acid sensor FXR is required for immune-regulatory activities of TLR-9 in intestinal inflammation

scientific journal article

The bile acid sensor FXR regulates insulin transcription and secretion

scientific article

The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis

scientific article published on 30 October 2009

The farnesoid X receptor promotes adipocyte differentiation and regulates adipose cell function in vivo

scientific article published on 15 June 2006

The methionine connection: homocysteine and hydrogen sulfide exert opposite effects on hepatic microcirculation in rats

scientific article published in February 2008

The methyl transferase PRMT1 functions as co-activator of farnesoid X receptor (FXR)/9-cis retinoid X receptor and regulates transcription of FXR responsive genes

scientific article

The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate

scientific article

The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis

scientific article published in November 2004

The plant sterol guggulsterone attenuates inflammation and immune dysfunction in murine models of inflammatory bowel disease

scientific article published on 23 June 2009

The third gas: H2S regulates perfusion pressure in both the isolated and perfused normal rat liver and in cirrhosis

scientific article published in September 2005

Theonellasterols and conicasterols from Theonella swinhoei. Novel marine natural ligands for human nuclear receptors.

scientific article

Total synthesis and pharmacological characterization of solomonsterol A, a potent marine pregnane-X-receptor agonist endowed with anti-inflammatory activity

scientific article published on 3 June 2011

Towards new ligands of nuclear receptors. Discovery of malaitasterol A, an unique bis-secosterol from marine sponge Theonella swinhoei

scientific article published on 16 May 2011

VSL#3 Resets Insulin Signaling and Protects against NASH and Atherosclerosis in a Model of Genetic Dyslipidemia and Intestinal Inflammation ⬇️

scientific article published on September 21, 2012

the Bile Acid Sensor FXR Induces the Glucocorticoid Receptor in the Liver in a Promoter-Dependent Manner

scholarly article published in May 2011

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