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List of works by Hennie M J Roelofs

A mutation in exon 7 of the human cytochrome P-4501A1 gene as marker for sensitivity to anti-cancer drugs?

scientific article published on January 1997

A polymorphism in the gene for microsomal epoxide hydrolase is associated with pre-eclampsia

scientific article

Activation of human neutrophils by oleic acid involves the production of reactive oxygen species and a rise in cytosolic calcium concentration: a comparison with N-6 polyunsaturated fatty acids ⬇️

scientific article published on August 16, 2011

Activation of mutagens by hepatocytes and liver 9000 X g supernatant from human origin in the Salmonella typhimurium mutagenicity assay. Comparison with rat liver preparations

scientific article published in February 1986

Allopurinol and 5-aminosalicylic acid influence thiopurine-induced hepatotoxicity in vitro

scientific article published on 28 April 2015

Assessment of oxidative stress in chronic pancreatitis patients

scientific article

Barrett associated MHC and FOXF1 variants also increase esophageal carcinoma risk ⬇️

scientific article published on April 16, 2013

COX-2 polymorphisms -765G-->C and -1195A-->G and colorectal cancer risk

scientific article published on September 2009

COX-2 polymorphisms in patients with familial adenomatous polyposis.

scientific article

Celecoxib and tauro-ursodeoxycholic acid co-treatment inhibits cell growth in familial adenomatous polyposis derived LT97 colon adenoma cells ⬇️

scientific article published on February 14, 2012

Combined effect of genetic polymorphisms in phase I and II biotransformation enzymes on head and neck cancer risk.

scientific article published on 19 June 2012

Combined polymorphisms in UDP-glucuronosyltransferases 1A1 and 1A6: implications for patients with Gilbert's syndrome

scientific article (publication date: 2003)

Contribution of Genetic and Clinical Risk Factors to Development of Candidemia in Patients Receiving Home Parenteral Nutrition

scientific article published on 10 May 2019

Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno- or squamous cell carcinoma

scientific article published on July 2009

Decreased levels of mucosal detoxification enzymes in the pouch of patients with familial adenomatous polyposis

scientific article published in September 2006

Deficient UDP-glucuronosyltransferase detoxification enzyme activity in the small intestinal mucosa of patients with coeliac disease

scientific article published in January 2006

Detoxification enzyme polymorphisms are not involved in duodenal adenomatosis in familial adenomatous polyposis

scientific article published in April 2008

Detoxification enzymes in the duodenal mucosa of patients with familial adenomatous polyposis

scientific article published in June 2005

Disparities of conjugating protective enzyme activities in the colon of patients with adenomas and carcinomas

scientific article published on September 2013

Droplet digital polymerase chain reaction for rapid broad-spectrum detection of bloodstream infections

scientific article published on 11 October 2019

Duodenal mucosal risk markers in patients with familial adenomatous polyposis: effects of celecoxib/ursodeoxycholic acid co-treatment and comparison with patient controls

scientific article

EPHX1 polymorphisms do not modify esophageal carcinoma susceptibility in Dutch Caucasians ⬇️

scientific article published on March 19, 2012

Effects of dietary anticarcinogens and nonsteroidal anti-inflammatory drugs on rat gastrointestinal UDP-glucuronosyltransferases.

scientific article

Effects of intervention with sulindac and inulin/VSL#3 on mucosal and luminal factors in the pouch of patients with familial adenomatous polyposis

scientific article

Expression of the glutathione enzyme system of human colon mucosa by localisation, gender and age.

scientific article published in June 2006

GST Theta null genotype is associated with an increased risk for ulcerative colitis: a case-control study and meta-analysis of GST Mu and GST Theta polymorphisms in inflammatory bowel disease

scientific article

GSTP1-1 in ovarian cyst fluid and disease outcome of patients with ovarian cancer

scientific article published in August 2009

GWAS-uncovered SNPs in PLCE1 and RFT2 genes are not implicated in Dutch esophageal adenocarcinoma and squamous cell carcinoma etiology

scientific article published in September 2013

Genetic polymorphism 609C>T in NAD(P)H:quinone oxidoreductase 1 enhances the risk of proximal colon cancer

scientific article published on 15 May 2014

Genetic polymorphism in UDP-glucuronosyltransferase 2B7 and colorectal cancer risk

scientific article published in January 2009

Genetic polymorphism in the conjugating enzyme UGT1A1 and the risk of head and neck cancer ⬇️

scientific article published on December 15, 2010

Genetic polymorphisms in UDP-glucuronosyltransferase 1A6 and 1A7 and the risk for benign Warthin's tumors of the parotid gland

scientific article published on 29 July 2015

Genetic polymorphisms in UDP-glucuronosyltransferase 1A6 are not associated with NSAIDs-related peptic ulcer haemorrhage

scientific article published on 01 August 2009

Genetic polymorphisms in UDP-glucuronosyltransferases and glutathione S-transferases and colorectal cancer risk

scientific article

Genetic polymorphisms in alcohol-metabolizing enzymes and chronic pancreatitis

scientific article published in January 2004

Genetic polymorphisms in the tobacco smoke carcinogens detoxifying enzyme UGT1A7 and the risk of head and neck cancer

scientific article

Glutathione S-transferase Mu null genotype affords protection against alcohol induced chronic pancreatitis.

scientific article

Glutathione S-transferase phenotypes in relation to genetic variation and fruit and vegetable consumption in an endoscopy-based population

scientific article published on 27 October 2006

Glutathione S-transferase pi in colorectal tumors is predictive for overall survival

scientific article published on 01 June 1995

Glutathione S-transferases P1-1 and A1-1 in ovarian cyst fluids.

scientific article published in January 2001

Glutathione S-transferases in esophageal cancer.

scientific article published in July 1993

Glutathione and glutathione S-transferases A1-1 and P1-1 in seminal plasma may play a role in protecting against oxidative damage to spermatozoa

scientific article published in January 2003

Glutathione and glutathione S-transferases in Barrett's epithelium

scientific article

GlutathioneS-transferase M1 and T1 and cytochrome P4501A1 polymorphisms in relation to the risk for benign and malignant head and neck lesions ⬇️

scientific article published on March 1, 1998

High enzyme activity UGT1A1 or low activity UGT1A8 and UGT2B4 genotypes increase esophageal cancer risk ⬇️

scientific article published on February 22, 2012

High oxygen radical production in patients with sporadic colorectal cancer

scientific article published on 31 March 2005

Human intestinal glutathione S-transferases

scientific article published on January 1989

Hydrazine-induced liver toxicity is enhanced by glutathione depletion but is not mediated by oxidative stress in HepG2 cells.

scientific article published on 9 July 2009

Immune activation by medium-chain triglyceride-containing lipid emulsions is not modulated by n-3 lipids or toll-like receptor 4.

scientific article

Induction of rat hepatic and intestinal UDP-glucuronosyltransferases by naturally occurring dietary anticarcinogens

scientific article published on 17 July 2003

Iron handling by the human kidney: glomerular filtration and tubular reabsorption both contribute to urinary iron excretion

scientific article published on 09 January 2019

Isoniazid and its toxic metabolite hydrazine induce in vitro pyrazinamide toxicity

scientific article

LPS-Stimulated Whole Blood Cytokine Production Is Not Related to Disease Behavior in Patients with Quiescent Crohn's Disease

scientific article

Liver manipulation causes hepatocyte injury and precedes systemic inflammation in patients undergoing liver resection

scientific article

Metabolic activation of N-acetylbenzidine and N,N'-diacetylbenzidine to mutagens, using isolated hepatocytes and the 9000 X g liver supernatant from rat, hamster and guinea pig.

scientific article published in September 1985

Metabolism of benzo[a]pyrene in isolated human scalp hair follicles

scientific article

Microsomal epoxide hydrolase genotypes and the risk for head and neck cancer

scientific article published in July 2008

Mutagenicity of benzidine and 4-aminobiphenyl after metabolic activation with isolated hepatocytes and liver 9000 X g supernatant from rat, hamster and guinea pig.

scientific article published in October 1984

Mutagenicity towards Salmonella typhimurium of some known genotoxic agents, activated by isolated hepatocytes of monkey (Macaca fascicularis). Comparison with isolated human hepatocytes

scientific article published in June 1986

No Clinical or Biochemical Evidence for Essential Fatty Acid Deficiency in Home Patients Who Depend on Long-Term Mixed Olive Oil- and Soybean Oil-Based Parenteral Nutrition

scientific article

No association between genetic polymorphisms in NAD(P)H oxidase p22phox and paraoxonase 1 and colorectal cancer risk.

scientific article published in March 2005

No evidence for oxidative stress in patients on home parenteral nutrition

scientific article published on 14 June 2006

No role for glutathione S-transferase genotypes in Caucasian esophageal squamous cell or adenocarcinoma etiology: an European case-control study

scientific article

Over-expression of COX-2 mRNA in colorectal cancer

scientific article

Parenteral lipids modulate leukocyte phenotypes in whole blood, depending on their fatty acid composition

scientific article published on 01 October 2005

Parenteral medium-chain triglyceride-induced neutrophil activation is not mediated by a Pertussis Toxin sensitive receptor

scientific article published on 25 October 2008

Polymorphic expression of the glutathione S-transferase P1 gene and its susceptibility to Barrett's esophagus and esophageal carcinoma

scientific article published on 01 February 1999

Polymorphisms in alcohol-metabolizing enzymes and esophageal carcinoma susceptibility: a Dutch Caucasian case-control study

scientific article

Polymorphisms in the insulin-like growth factor axis are associated with gastrointestinal cancer

scientific article

Polymorphisms of the glutathione S-transferase P1 gene and head and neck cancer susceptibility

scientific article published in January 2003

Protein carbonyls in decidua and placenta of pre-eclamptic women as markers for oxidative stress

scientific article published on 01 February 2001

Response to adjuvant chemotherapy in primary breast cancer: no correlation with expression of glutathione S-transferases

scientific article

Role of epoxide hydrolase, NAD(P)H:quinone oxidoreductase, cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer

scientific article published on 21 July 2005

Salvia Miltiorrhiza Root Water-Extract (Danshen) Has No Beneficial Effect on Cardiovascular Risk Factors. A Randomized Double-Blind Cross-Over Trial

scientific article published on 20 July 2015

Serial cultivation of human scalp hair follicle keratinocytes

scientific article published on January 1, 1983

Serially cultured keratinocytes from human scalp hair follicles: a tool for cytogenetic studies.

scientific article published on May 1983

Smoking, genetic polymorphisms in biotransformation enzymes, and nonsyndromic oral clefting: a gene-environment interaction

scientific article

Supplemental antioxidants do not ameliorate colitis development in HLA-B27 transgenic rats despite extremely low glutathione levels in colonic mucosa

scientific article published on 22 December 2010

Susceptibility to pre-eclampsia is associated with multiple genetic polymorphisms in maternal biotransformation enzymes

scientific article published on 13 December 2006

The I,105V polymorphism in glutathione S-transferase P1, parental smoking and the risk for nonsyndromic cleft lip with or without cleft palate

scientific article published on 9 January 2008

The Influence of Curcumin, Quercetin, and Eicosapentaenoic Acid on the Expression of Phase II Detoxification Enzymes in the Intestinal Cell Lines HT-29, Caco-2, HuTu 80, and LT97 ⬇️

scientific article published on July 25, 2012

The association between glutathione S-transferase P1 genotype and plasma level in head and neck cancer

scientific article published in March 2002

Time-dependent activity and expression of glutathione S-transferases in the human colon adenocarcinoma cell line Caco-2.

scientific article published on December 1989

Tubular Injury Biomarkers to Detect Gentamicin-Induced Acute Kidney Injury in the Neonatal Intensive Care Unit.

scientific article published on 7 September 2015

Urinary GSTP1-1 excretion is markedly increased in normotensive pregnancy as well as in preeclampsia.

scientific article published in July 2005

Ursodeoxycholic acid counteracts celecoxib in reduction of duodenal polyps in patients with familial adenomatous polyposis: a multicentre, randomized controlled trial

scientific article published on 06 August 2013

Ursodeoxycholic acid intervention in patients with familial adenomatous polyposis: a pilot study.

scientific article published on 25 May 2007

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