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List of works by Raymond J. Pickles

A Recombinant Respiratory Syncytial Virus Vaccine Candidate Attenuated by a Low-Fusion F Protein Is Immunogenic and Protective against Challenge in Cotton Rats

scientific article published on 08 June 2016

A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation

scientific article

A single amino acid in the HA of pH1N1 2009 influenza virus affects cell tropism in human airway epithelium, but not transmission in ferrets

scientific article

AAV exploits subcellular stress associated with inflammation, endoplasmic reticulum expansion, and misfolded proteins in models of cystic fibrosis.

scientific article

AAV-6 mediated efficient transduction of mouse lower airways

scientific article

Acute SARS-CoV-2 Infection is Highly Cytopathic, Elicits a Robust Innate Immune Response and is Efficiently Prevented by EIDD-2801

scientific article published on 24 September 2020

Avian Influenza virus glycoproteins restrict virus replication and spread through human airway epithelium at temperatures of the proximal airways

scientific article

CFTR delivery to 25% of surface epithelial cells restores normal rates of mucus transport to human cystic fibrosis airway epithelium

scientific journal article

Challenges and opportunities for antiviral monoclonal antibodies as COVID-19 therapy

scientific article published on 09 December 2020

Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense

scientific article

Chimeric human parainfluenza virus bearing the Ebola virus glycoprotein as the sole surface protein is immunogenic and highly protective against Ebola virus challenge

scientific article

Comparison of differing cytopathic effects in human airway epithelium of parainfluenza virus 5 (W3A), parainfluenza virus type 3, and respiratory syncytial virus.

scientific article published on 8 October 2011

Correction: Vaccine Efficacy in Senescent Mice Challenged with Recombinant SARS-CoV Bearing Epidemic and Zoonotic Spike Variants.

scientific article published on 27 February 2007

Coupled Nucleotide and Mucin Hypersecretion from Goblet-Cell Metaplastic Human Airway Epithelium ⬇️

scientific article published on 08 October 2010

Culturing the unculturable: human coronavirus HKU1 infects, replicates, and produces progeny virions in human ciliated airway epithelial cell cultures

scientific article

Cytokine amplification by respiratory syncytial virus infection in human nasal epithelial cells

scientific article

Effects of vitamin D on airway epithelial cell morphology and rhinovirus replication

scientific article published on 24 January 2014

Efficiency of adenovirus-mediated gene transfer to oropharyngeal epithelial cells correlates with cellular differentiation and human coxsackie and adenovirus receptor expression

scientific article

Efficient adenovirus-mediated gene transfer to basal but not columnar cells of cartilaginous airway epithelia

scientific article

Enhancement of adenovirus vector entry into CD70-positive B-cell Lines by using a bispecific CD70-adenovirus fiber antibody

scientific article

Gene therapy for cystic fibrosis using E1-deleted adenovirus: a phase I trial in the nasal cavity. The University of North Carolina at Chapel Hill.

scientific article published on May 1994

Generation of novel AAV variants by directed evolution for improved CFTR delivery to human ciliated airway epithelium

scientific article published on 14 July 2009

Glycocalyx restricts adenoviral vector access to apical receptors expressed on respiratory epithelium in vitro and in vivo: role for tethered mucins as barriers to lumenal infection

scientific article published on December 2004

Growth restriction of an experimental live attenuated human parainfluenza virus type 2 vaccine in human ciliated airway epithelium in vitro parallels attenuation in African green monkeys

scientific article

Human airway epithelial cell cultures for modeling respiratory syncytial virus infection

scientific article published on January 2013

Human parainfluenza virus serotypes differ in their kinetics of replication and cytokine secretion in human tracheobronchial airway epithelium ⬇️

scientific article published on September 7, 2012

Human parainfluenza virus type 1 C proteins are nonessential proteins that inhibit the host interferon and apoptotic responses and are required for efficient replication in nonhuman primates

scientific article published on 9 July 2008

Human parainfluenza virus type 2 V protein inhibits interferon production and signaling and is required for replication in non-human primates

scientific article

In vitro assessment of variables affecting the efficiency and efficacy of adenovirus-mediated gene transfer to cystic fibrosis airway epithelia

scientific article

Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans ⬇️

scientific article published on October 27, 1994

Infection of ciliated cells by human parainfluenza virus type 3 in an in vitro model of human airway epithelium

scientific article published on January 2005

Infection of human airway epithelium by human and avian strains of influenza a virus.

scientific article

Influenza M2 envelope protein augments avian influenza hemagglutinin pseudotyping of lentiviral vectors

scientific article published on April 2006

Innate immunity and mucus structure and function.

scientific article published on January 2006

Lack of transmission of a human influenza virus with avian receptor specificity between ferrets is not due to decreased virus shedding but rather a lower infectivity in vivo

scientific article published on 20 April 2011

Learning from past failures: Challenges with monoclonal antibody therapies for COVID-19

scientific article published on 01 December 2020

Limited Entry of Adenovirus Vectors into Well-Differentiated Airway Epithelium Is Responsible for Inefficient Gene Transfer ⬇️

scientific article published on July 1, 1998

Limited effects of Muc1 deficiency on mouse adenovirus type 1 respiratory infection ⬇️

scientific article published on July 26, 2011

MAVS-mediated apoptosis and its inhibition by viral proteins

scientific article published on 7 March 2009

Mechanisms of zoonotic severe acute respiratory syndrome coronavirus host range expansion in human airway epithelium

scientific article

Mutations in H5N1 influenza virus hemagglutinin that confer binding to human tracheal airway epithelium.

scientific article

Normal and cystic fibrosis airway surface liquid homeostasis. The effects of phasic shear stress and viral infections

scientific article

Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs.

scientific article

Physical and biological barriers to viral vector-mediated delivery of genes to the airway epithelium

scientific article

Precision mouse models with expanded tropism for human pathogens

scientific article published on 26 August 2019

RSV-encoded NS2 promotes epithelial cell shedding and distal airway obstruction

scientific article

RSV604, a novel inhibitor of respiratory syncytial virus replication

scientific article

Receptor binding profiles of avian influenza virus hemagglutinin subtypes on human cells as a predictor of pandemic potential

scientific article

Release of severe acute respiratory syndrome coronavirus nuclear import block enhances host transcription in human lung cells

scientific article published on 30 January 2013

Replication-deficient adenoviral vector for gene transfer potentiates airway neurogenic inflammation

scientific article published in March 1997

Respiratory syncytial virus (RSV) and its propensity for causing bronchiolitis

scientific article

Respiratory syncytial virus engineered to express the cystic fibrosis transmembrane conductance regulator corrects the bioelectric phenotype of human cystic fibrosis airway epithelium in vitro

scientific article

Respiratory syncytial virus grown in Vero cells contains a truncated attachment protein that alters its infectivity and dependence on glycosaminoglycans

scientific article published on 05 August 2009

Respiratory syncytial virus infection of human airway epithelial cells is polarized, specific to ciliated cells, and without obvious cytopathology

scientific article

Resurrection of an "extinct" SARS-CoV isolate GD03 from late 2003

scientific article published on 01 January 2006

Retargeting the coxsackievirus and adenovirus receptor to the apical surface of polarized epithelial cells reveals the glycocalyx as a barrier to adenovirus-mediated gene transfer

scientific article published on July 2000

Role of interferon in the replication of human parainfluenza virus type 1 wild type and mutant viruses in human ciliated airway epithelium

scientific article published on 4 June 2008

SARS CoV replication and pathogenesis in human airway epithelial cultures.

scientific article published in January 2006

SARS-CoV replication and pathogenesis in an in vitro model of the human conducting airway epithelium

scientific article published on 23 April 2007

SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801

scientific article

SARS-like WIV1-CoV poised for human emergence

scientific article published on 14 March 2016

Severe acute respiratory syndrome coronavirus infection of human ciliated airway epithelia: role of ciliated cells in viral spread in the conducting airways of the lungs

scientific article

Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice

scholarly article

Synthetic reconstruction of zoonotic and early human severe acute respiratory syndrome coronavirus isolates that produce fatal disease in aged mice

scientific article published on 16 May 2007

Systematic assembly of a full-length infectious clone of human coronavirus NL63

scientific article published on 25 September 2008

The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA.

scientific article published on 9 April 2009

The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction ⬇️

scientific article published on December 4, 2001

The effect of respiratory synctial virus on chemokine release by differentiated airway epithelium.

scientific article published in January 2004

Tracheobronchial air-liquid interface cell culture: a model for innate mucosal defense of the upper airways?

scientific article published on 17 October 2008

Transduction efficiencies of novel AAV vectors in mouse airway epithelium in vivo and human ciliated airway epithelium in vitro.

scientific article

Transduction of non-small cell lung cancer cells by adenoviral and retroviral vectors

scientific article published in March 1998

Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants

scientific article (publication date: December 2006)

Yeast based small molecule screen for inhibitors of SARS-CoV

scientific article

α-Fetoprotein gene delivery to the nasal epithelium of nonhuman primates by human parainfluenza viral vectors

scientific article

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